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Natalie J. Nokoff

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone720/777-3607

    Collapse Biography 
    Collapse education and training
    Brown University, Providence, RIBA05/2006Gender Studies
    Alpert Medical School at Brown University, Providence, RIMD05/2010Medicine
    University of Colorado Graduate School, Aurora, COMSCS05/2020Clinical Science
    University of Colorado, Aurora, CO06/2013Pediatrics
    University of Colorado, Aurora, CO06/2017Pediatric Endocrinology
    Collapse awards and honors
    2010Alpha Omega Alpha
    2010Gold Humanism Honor Society
    2017Endocrine Society Outstanding Abstract Award
    2019Endocrine Society Outstanding Abstract Award

    Collapse Overview 
    Collapse overview
    Natalie Nokoff, MD is a pediatric endocrinologist who specializes in research and clinical care for children with sex and gender differences.

    Collapse Research 
    Collapse research activities and funding
    R01 HD074579     (Larry Mullins & Larry Mullins)Jul 1, 2013 - Apr 1, 2018
    NIH/NICHD
    Short-term outcomes of interventions for reproductive dysfunction
    Role Description: Goal: Multi-center, prospective, observational study to evaluate cosmetic and surgical outcomes in children with disorders of sex development who received genitoplasty and psychosocial outcomes in their parents
    Role: Key Personnel
    T32 DK 63687-12/13     (Georgeanna Klingensmith)Jul 1, 2015 - Jun 30, 2017
    NIH Ruth L Kirschstein National Research Service Award,
    Fellowship Training Grant in Pediatric Diabetes
    Role Description: Goal: Provides salary support for pediatric endocrinology fellows receiving training in diabetes
    Role: Trainee Appointment
         (Natalie Nokoff)Oct 1, 2015 - Sep 30, 2018
    University of Colorado CTRC
    Trans Health: evaluation of markers of cardiometabolic health and well-being in transgender youth
    Role Description: Goal: evaluate markers of cardiometabolic health in a cross-sectional study of youth on either a puberty blocker, testosterone or estradiol
    Role: PI
         (Natalie Nokoff)Aug 1, 2017 - Sep 1, 2019
    University of Colorado COEPS Small Grants Program
    Improving clinical encounters for transgender and gender expansive youth
    Role Description: Goal: identify which departments in Children's Hospital Colorado to target for Gender Inclusivity Training, provide training and evaluate effectiveness
    Role: PI
         (Melanie Cree-Green)Nov 15, 2017 - Nov 14, 2019
    University of Colorado GALLIP Transformational Research Funding
    Do alterations in testosterone concentrations mediate improvements in insulin sensitivity and hepatic health via microbiota taxa abundance changes?
    Role Description: Goal: evaluate the relationship between testosterone, systemic post-prandial metabolism, hepatic steatosis/mitochondrial and gut microbiota in female-male-transgender adolescents and girls with polycystic ovarian syndrome
    Role: Key Personnel
         (Natalie Nokoff)Dec 1, 2017 - Dec 1, 2019
    Center for Women's Health Research
    Effects of pubertal blockade and testosterone therapy on insulin sensitivity and vascular health in female-to-male transgender adolescents
    Role Description: Goal: evaluate effects of pubertal blockade and testosterone therapy at baseline and 1 month after starting testosterone
    Role: PI
    K12 HD 057022-11     (Judith Regensteiner)Jan 1, 2018 - Dec 31, 2019
    NIH
    Effects of pubertal blockade and hormone therapy on cardiometabolic risk markers in transgender adolescents
    Role Description: Goal: to evaluate cardiometabolic effects of hormone therapy in female-to-male adolescents before and after starting testosterone who did and did not receive prior pubertal blockade
    Role: Trainee Appointment
         (Natalie Nokoff)Apr 1, 2018 - Mar 30, 2021
    CTRC Microgrant Program for Early Investigators
    Effects of pubertal blockade and hormone therapy on cardiometabolic risk markers in transgender adolescents
    Role Description: Goal: to evaluate cardiometabolic effects of hormone therapy in female-to-male adolescents before and after starting testosterone who did and did not receive prior pubertal blockade
    Role: PI
         (Melanie Cree-Green)May 1, 2018 - Apr 30, 2019
    CCTSI CO-Pilot Junior Faculty Awards
    Do alterations in serum testosterone mediate systemic insulin sensitivity and hepatic health via this gut microbiota?
    Role Description: Goal: evaluate the relationship between testosterone, systemic post-prandial metabolism, hepatic steatosis/mitochondrial and gut microbiota in female-male-transgender adolescents and girls with polycystic ovarian syndrome
    Role: Key Personnel
         (Natalie Nokoff)May 1, 2018 - Apr 30, 2020
    Endocrine Fellow Foundation
    Effects of pubertal blockade and testosterone therapy on insulin sensitivity, vascular health and physical fitness in female-to-male transgender adolescents
    Role Description: Goal: additional funding to evaluate effects of pubertal blockade and testosterone therapy at baseline, 1 and 12 months after starting testosterone
    Role: PI
    R01 HD074579-08,     (Larry Mullins & Amy Wisniewski)May 1, 2018 - Feb 28, 2023
    NIH/NICHD
    Long-Term Outcomes of Interventions for Reproductive Dysfunction: Continence, Behavioral Outcomes, and Predictors of Brain Masculinization
    Role: Key Personnel
         (Judith Regensteiner)Jun 1, 2018 - May 31, 2020
    Doris Duke University of Colorado School of Medicine Fund to Retain Clinical Scientists
    Role: Trainee Appointment
    K23HL151868     (NOKOFF, NATALIE J)Aug 15, 2020 - Jul 31, 2025
    NIH
    Pubertal Blockade and Estradiol Effects on Cardiometabolic Health for Transitioning Youth (PUBERTY)
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Pitzer LM, Moroney MR, Nokoff NJ, Sikora MJ. WNT4 Balances Development vs Disease in Gynecologic Tissues and Women's Health. Endocrinology. 2021 Jul 01; 162(7). PMID: 33963381.
      View in: PubMed
    2. Perez MN, Clawson AH, Baudino MN, Austin PF, Baskin LS, Chan YM, Cheng EY, Coplen D, Diamond DA, Fried AJ, Kolon T, Kropp B, Lakshmanan Y, Meyer T, Nokoff NJ, Palmer BW, Paradis A, Poppas DP, Reyes KJS, Williot P, Wolfe-Christensen C, Yerkes EB, Wisniewski AB, Mullins LL. Distress Trajectories for Parents of Children With DSD: A Growth Mixture Model. J Pediatr Psychol. 2021 Jun 03; 46(5):588-598. PMID: 33594414.
      View in: PubMed
    3. van Velzen DM, Smits MM, van Bommel EJM, Muskiet MHA, Tonneijck L, Kramer MHH, Joles JA, den Heijer M, Nokoff N, Bjornstad P, van Raalte DH. Kidney hemodynamic function in men and postmenopausal women with type 2 diabetes and preserved kidney function. Am J Physiol Renal Physiol. 2021 06 01; 320(6):F1152-F1158. PMID: 33900855.
      View in: PubMed
    4. Nokoff NJ, Scarbro SL, Moreau KL, Zeitler P, Nadeau KJ, Reirden D, Juarez-Colunga E, Kelsey MM. Body Composition and Markers of Cardiometabolic Health in Transgender Youth on Gonadotropin-Releasing Hormone Agonists. Transgend Health. 2021 Apr; 6(2):111-119. PMID: 33937527.
      View in: PubMed
    5. Bowen AE, Staggs S, Kaar J, Nokoff N, Simon SL. Short sleep, insomnia symptoms, and evening chronotype are correlated with poorer mood and quality of life in adolescent transgender males. Sleep Health. 2021 Aug; 7(4):445-450. PMID: 33875385.
      View in: PubMed
    6. Torres-Zegarra C, Sundararajan D, Benson J, Seagle H, Witten M, Walders-Abramson N, Simon SL, Huguelet P, Nokoff NJ, Cree-Green M. Care for Adolescents With Polycystic Ovary Syndrome: Development and Prescribing Patterns of a Multidisciplinary Clinic. J Pediatr Adolesc Gynecol. 2021 Oct; 34(5):617-625. PMID: 33794340.
      View in: PubMed
    7. Guzewicz L, Howell S, Crerand CE, Umbaugh H, Nokoff NJ, Barker J, Davis SM. Clinical phenotype and management of individuals with mosaic monosomy X with Y chromosome material stratified by genital phenotype. Am J Med Genet A. 2021 05; 185(5):1437-1447. PMID: 33616298.
      View in: PubMed
    8. Long CJ, Van Batavia J, Wisniewski AB, Aston CE, Baskin L, Cheng EY, Lakshmanan Y, Meyer T, Kropp B, Palmer B, Nokoff NJ, Paradis A, VanderBrink B, Scott Reyes KJ, Yerkes E, Poppas DP, Mullins LL, Kolon TF. Post-operative complications following masculinizing genitoplasty in moderate to severe genital atypia: results from a multicenter, observational prospective cohort study. J Pediatr Urol. 2021 06; 17(3):379-386. PMID: 33726972.
      View in: PubMed
    9. Minturn MS, Martinez EI, Le T, Nokoff N, Fitch L, Little CE, Lee RS. Early Intervention for LGBTQ Health: A 10-Hour Curriculum for Preclinical Health Professions Students. MedEdPORTAL. 2021 01 07; 17:11072. PMID: 33473382.
      View in: PubMed
    10. Finn E, Kripps K, Chambers C, Rapp M, Meeks NJL, Xu F, Chen W, Larson AA, Nokoff NJ. A Novel Intronic Pathogenic Variant in STAR With a Dominant Negative Mechanism Causes Attenuated Lipoid Congenital Adrenal Hyperplasia. J Investig Med High Impact Case Rep. 2021 Jan-Dec; 9:23247096211014685. PMID: 33966472.
      View in: PubMed
    11. Piani F, Melena I, Tommerdahl KL, Nokoff N, Nelson RG, Pavkov ME, van Raalte DH, Cherney DZ, Johnson RJ, Nadeau KJ, Bjornstad P. Sex-related differences in diabetic kidney disease: A review on the mechanisms and potential therapeutic implications. J Diabetes Complications. 2021 04; 35(4):107841. PMID: 33423908.
      View in: PubMed
    12. Roberts CM, Sharkey CM, Bakula DM, Perez MN, Delozier AJ, Austin PF, Baskin LS, Chan YM, Cheng EY, Diamond DA, Fried AJ, Kropp B, Lakshmanan Y, Meyer SZ, Meyer T, Nokoff NJ, Palmer BW, Paradis A, Reyes KJS, Tishelman A, Williot P, Wolfe-Christensen C, Yerkes EB, Aston C, Wisniewski AB, Mullins LL. Illness Uncertainty Longitudinally Predicts Distress Among Caregivers of Children Born With DSD. J Pediatr Psychol. 2020 10 01; 45(9):1053-1062. PMID: 32929478.
      View in: PubMed
    13. Cree-Green M, Carreau AM, Davis SM, Frohnert BI, Kaar JL, Ma NS, Nokoff NJ, Reusch JEB, Simon SL, Nadeau KJ. Peer mentoring for professional and personal growth in academic medicine. J Investig Med. 2020 08; 68(6):1128-1134. PMID: 32641352.
      View in: PubMed
    14. Baskin A, Wisniewski AB, Aston CE, Austin P, Chan YM, Cheng EY, Diamond DA, Fried A, Kolon T, Lakshmanan Y, Williot P, Meyer S, Meyer T, Kropp B, Nokoff N, Palmer B, Paradis A, Poppas D, VanderBrink B, Scott Reyes KJ, Tishelman A, Wolfe-Christensen C, Yerkes E, Mullins LL, Baskin L. Post-operative complications following feminizing genitoplasty in moderate to severe genital atypia: Results from a multicenter, observational prospective cohort study. J Pediatr Urol. 2020 Oct; 16(5):568-575. PMID: 32624410.
      View in: PubMed
    15. Nokoff NJ, Scarbro SL, Moreau KL, Zeitler P, Nadeau KJ, Juarez-Colunga E, Kelsey MM. Body Composition and Markers of Cardiometabolic Health in Transgender Youth Compared With Cisgender Youth. J Clin Endocrinol Metab. 2020 03 01; 105(3). PMID: 31544944.
      View in: PubMed
    16. Nokoff N. Response to Letter to the Editor: "Body Composition and Markers of Cardiometabolic Health in Transgender Youth Compared to Cisgender Youth". J Clin Endocrinol Metab. 2020 03 01; 105(3). PMID: 31974575.
      View in: PubMed
    17. Davis S, Ware MA, Zeiger J, Deardorff MA, Grand K, Grimberg A, Hsu S, Kelsey M, Majidi S, Matthew RP, Napier M, Nokoff N, Prasad C, Riggs AC, McKinnon ML, Mirzaa G. Growth hormone deficiency in megalencephaly-capillary malformation syndrome: An association with activating mutations in PIK3CA. Am J Med Genet A. 2020 01; 182(1):162-168. PMID: 31729162.
      View in: PubMed
    18. Perez MN, Delozier AM, Aston CE, Austin P, Baskin L, Chan YM, Cheng EY, Diamond DA, Fried A, Greenfield S, Kolon T, Kropp B, Lakshmanan Y, Meyer S, Meyer T, Nokoff N, Palmer B, Paradis A, Poppas D, Scott Reyes KJ, Swartz JM, Tishelman A, Wisniewski AB, Wolfe-Christensen C, Yerkes E, Mullins LL. Predictors of Psychosocial Distress in Parents of Young Children with Disorders of Sex Development. J Urol. 2019 11; 202(5):1046-1051. PMID: 31268850.
      View in: PubMed
    19. Nokoff N, Thurston J, Hilkin A, Pyle L, Zeitler PS, Nadeau KJ, Santoro N, Kelsey MM. Sex Differences in Effects of Obesity on Reproductive Hormones and Glucose Metabolism in Early Puberty. J Clin Endocrinol Metab. 2019 10 01; 104(10):4390-4397. PMID: 30985874.
      View in: PubMed
    20. Nokoff N, Ariefdjohan M, Travers S, Buchanan C. Parent experience with volunteers and support groups in a multidisciplinary DSD clinic. Clin Pract Pediatr Psychol. 2020 Dec; 8(4):348-358. PMID: 33777596.
      View in: PubMed
    21. Delozier AM, Gamwell KL, Sharkey C, Bakula DM, Perez MN, Wolfe-Christensen C, Austin P, Baskin L, Bernabé KJ, Chan YM, Cheng EY, Diamond DA, Ellens REH, Fried A, Galan D, Greenfield S, Kolon T, Kropp B, Lakshmanan Y, Meyer S, Meyer T, Nokoff NJ, Reyes KJ, Palmer B, Poppas DP, Paradis A, Tishelman AC, Yerkes EB, Chaney JM, Wisniewski AB, Mullins LL. Uncertainty and Posttraumatic Stress: Differences Between Mothers and Fathers of Infants with Disorders of Sex Development. Arch Sex Behav. 2019 07; 48(5):1617-1624. PMID: 31144217.
      View in: PubMed
    22. Sharkey CM, Bakula DM, Wolfe-Christensen C, Austin P, Baskin L, Bernabé KJ, Chan YM, Cheng EY, Delozier AM, Diamond DA, Ellens REH, Fried A, Galan D, Greenfield S, Kolon T, Kropp B, Lakshmanan Y, Meyer S, Meyer T, Nokoff NJ, Scott Reyes KJ, Palmer B, Poppas DP, Paradis A, Tishelman A, Yerkes EB, Chaney JM, Wisniewski AB, Mullins LL. Parent-Rated Severity of Illness and Anxiety among Caregivers of Children Born with a Disorder of Sex Development Including Ambiguous Genitalia. Horm Res Paediatr. 2018; 90(5):308-313. PMID: 30566934.
      View in: PubMed
    23. Finlayson C, Rosoklija I, Aston CE, Austin P, Bakula D, Baskin L, Chan YM, Delozier AM, Diamond DA, Fried A, Greenfield S, Kolon T, Kropp B, Lakshmanan Y, Meyer S, Meyer T, Nokoff N, Mullins LL, Palmer B, Perez MN, Poppas DP, Reddy P, Reyes KJS, Schulte M, Sharkey CM, Yerkes E, Wolfe-Christensen C, Wisniewski AB, Cheng EY. Baseline Characteristics of Infants With Atypical Genital Development: Phenotypes, Diagnoses, and Sex of Rearing. J Endocr Soc. 2019 Jan 01; 3(1):264-272. PMID: 30623164.
      View in: PubMed
    24. Nokoff NJ, Scarbro S, Juarez-Colunga E, Moreau KL, Kempe A. Health and Cardiometabolic Disease in Transgender Adults in the United States: Behavioral Risk Factor Surveillance System 2015. J Endocr Soc. 2018 Apr 01; 2(4):349-360. PMID: 29577110.
      View in: PubMed
    25. Bernabé KJ, Nokoff NJ, Galan D, Felsen D, Aston CE, Austin P, Baskin L, Chan YM, Cheng EY, Diamond DA, Ellens R, Fried A, Greenfield S, Kolon T, Kropp B, Lakshmanan Y, Meyer S, Meyer T, Delozier AM, Mullins LL, Palmer B, Paradis A, Reddy P, Reyes KJS, Schulte M, Swartz JM, Yerkes E, Wolfe-Christensen C, Wisniewski AB, Poppas DP. Preliminary report: Surgical outcomes following genitoplasty in children with moderate to severe genital atypia. J Pediatr Urol. 2018 04; 14(2):157.e1-157.e8. PMID: 29398588.
      View in: PubMed
    26. Ellens REH, Bakula DM, Mullins AJ, Scott Reyes KJ, Austin P, Baskin L, Bernabé K, Cheng EY, Fried A, Frimberger D, Galan D, Gonzalez L, Greenfield S, Kolon T, Kropp B, Lakshmanan Y, Meyer S, Meyer T, Mullins LL, Nokoff NJ, Palmer B, Poppas D, Paradis A, Yerkes E, Wisniewski AB, Wolfe-Christensen C. Psychological Adjustment of Parents of Children Born with Atypical Genitalia 1 Year after Genitoplasty. J Urol. 2017 10; 198(4):914-920. PMID: 28504212.
      View in: PubMed
    27. Wolfe-Christensen C, Wisniewski AB, Mullins AJ, Reyes KJ, Austin P, Baskin L, Bernabé K, Cheng E, Fried A, Frimberger D, Galan D, Gonzalez L, Greenfield S, Kolon T, Kropp B, Lakshmanan Y, Meyer S, Meyer T, Nokoff NJ, Palmer B, Poppas D, Paradis A, Yerkes E, Mullins LL. Changes in levels of parental distress after their child with atypical genitalia undergoes genitoplasty. J Pediatr Urol. 2017 Feb; 13(1):32.e1-32.e6. PMID: 28041823.
      View in: PubMed
    28. Nokoff NJ, Palmer B, Mullins AJ, Aston CE, Austin P, Baskin L, Bernabé K, Chan YM, Cheng EY, Diamond DA, Fried A, Frimberger D, Galan D, Gonzalez L, Greenfield S, Kolon T, Kropp B, Lakshmanan Y, Meyer S, Meyer T, Mullins LL, Paradis A, Poppas D, Reddy P, Schulte M, Reyes KJ, Swartz JM, Wolfe-Christensen C, Yerkes E, Wisniewski AB. Prospective assessment of cosmesis before and after genital surgery. J Pediatr Urol. 2017 Feb; 13(1):28.e1-28.e6. PMID: 27887913.
      View in: PubMed
    29. Shumer DE, Nokoff NJ, Spack NP. Advances in the Care of Transgender Children and Adolescents. Adv Pediatr. 2016 08; 63(1):79-102. PMID: 27426896.
      View in: PubMed
    30. Suorsa KI, Mullins AJ, Tackett AP, Reyes KJ, Austin P, Baskin L, Bernabé K, Cheng E, Fried A, Frimberger D, Galan D, Gonzalez L, Greenfield S, Kropp B, Meyer S, Meyer T, Nokoff N, Palmer B, Poppas D, Paradis A, Yerkes E, Wisniewski AB, Mullins LL. Characterizing Early Psychosocial Functioning of Parents of Children with Moderate to Severe Genital Ambiguity due to Disorders of Sex Development. J Urol. 2015 Dec; 194(6):1737-42. PMID: 26196734.
      View in: PubMed
    31. Larson A, Nokoff NJ, Meeks NJ. Genetic causes of pituitary hormone deficiencies. Discov Med. 2015 Mar; 19(104):175-83. PMID: 25828521.
      View in: PubMed
    32. Nokoff N, Brunner AM, Linakis JG, Amanullah S. Presentation to either the pediatric emergency department or primary care clinic for acute illness: the caregivers' perspective. Pediatr Emerg Care. 2014 Mar; 30(3):146-50. PMID: 24583577.
      View in: PubMed
    33. Nokoff N, Rewers M. Pathogenesis of type 1 diabetes: lessons from natural history studies of high-risk individuals. Ann N Y Acad Sci. 2013 Apr; 1281:1-15. PMID: 23360422.
      View in: PubMed
    34. Larson A, Nokoff NJ, Travers S. Disorders of sex development: clinically relevant genes involved in gonadal differentiation. Discov Med. 2012 Nov; 14(78):301-9. PMID: 23200061.
      View in: PubMed
    35. Nokoff NJ, Rewers M, Cree Green M. The interplay of autoimmunity and insulin resistance in type 1 diabetes. Discov Med. 2012 Feb; 13(69):115-22. PMID: 22369970.
      View in: PubMed
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