Roberta Pelanda
Title | Professor |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-IMM MICRO GENERAL OPER |
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Phone | 303/724-8666 |
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Research R01AI181854 (PELANDA, ROBERTA)May 10, 2024 - Mar 31, 2029 NIH Contribution and interplay of CXCR4 and integrins in central B cell tolerance Role: Principal Investigator |
| R21AI156232 (PELANDA, ROBERTA)Jan 28, 2021 - Jun 30, 2023 NIH Contribution of c-Maf to regulatory B cells and antibody-secreting cells Role: Principal Investigator |
| R01AI152535 (PELANDA, ROBERTA)Feb 25, 2020 - Jan 31, 2025 NIH Role and mechanisms of the PI3K pathway in B cell tolerance Role: Principal Investigator |
| R21AI131639 (PELANDA, ROBERTA)Feb 10, 2017 - Jan 31, 2020 NIH Testing an alternative model of central B cell tolerance Role: Principal Investigator |
| R01AI124474 (PELANDA, ROBERTA)Feb 5, 2016 - Jan 31, 2021 NIH Studies of human B cell tolerance, from a humanized mouse model to human beings Role: Principal Investigator |
| R21AI122670 (PELANDA, ROBERTA)Jan 1, 2016 - Jun 30, 2018 NIH Developing a new model for EBV-mediated T cell diseases Role: Principal Investigator |
| R21AI105523 (PELANDA, ROBERTA)Jan 15, 2013 - Dec 31, 2015 NIH Human B Cell Development and Function in Humanized Mice Expressing Human BAFF Role: Principal Investigator |
| R21AI073629 (PELANDA, ROBERTA)Jun 5, 2008 - May 31, 2010 NIH Analysis of Human B Cell Tolerance in Humanized Mice Role: Principal Investigator |
| T32AI074491 (PELANDA, ROBERTA)Jul 1, 2007 - Jun 30, 2025 NIH Molecular Mechanisms of Immune Tolerance Role: Principal Investigator |
| R21AI063321 (PELANDA, ROBERTA)Jul 1, 2005 - Jun 30, 2008 NIH Modulatory signaling motifs in B cell antigen receptor function Role: Principal Investigator |
| R56AI052310 (PELANDA, ROBERTA)Jul 1, 2003 - Mar 31, 2008 NIH Tolerance in Polyclonal and Oligoclonal Immune Systems Role: Principal Investigator |
| R01AI052310 (PELANDA, ROBERTA)Jul 1, 2002 - Nov 30, 2018 NIH Tolerance in polyclonal and oligoclonal immune systems Role: Principal Investigator |
Bibliographic
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Castleman MJ, Santos AL, Lesteberg KE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. Activation and pro-inflammatory cytokine production by unswitched memory B cells during SARS-CoV-2 infection. Front Immunol. 2023; 14:1213344. PMID: 37638016.
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Turner JA, Fredrickson MA, D'Antonio M, Katsnelson E, MacBeth M, Van Gulick R, Chimed TS, McCarter M, D'Alessandro A, Robinson WA, Couts KL, Pelanda R, Klarquist J, Tobin RP, Torres RM. Lysophosphatidic acid modulates CD8 T cell immunosurveillance and metabolism to impair anti-tumor immunity. Nat Commun. 2023 06 03; 14(1):3214. PMID: 37270644.
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Torres RM, Turner JA, D'Antonio M, Pelanda R, Kremer KN. Regulation of CD8 T-cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid. Immunol Rev. 2023 08; 317(1):203-222. PMID: 37096808.
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McCaleb MR, Miranda AM, Ratliff KC, Torres RM, Pelanda R. CD19 Is Internalized Together with IgM in Proportion to B Cell Receptor Stimulation and Is Modulated by Phosphatidylinositol 3-Kinase in Bone Marrow Immature B Cells. Immunohorizons. 2023 01 01; 7(1):49-63. PMID: 36637517.
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Lanis JM, Lewis MS, Strassburger H, Larsen K, Bagby SM, Dominguez ATA, Mar?n-Jim?nez JA, Pelanda R, Pitts TM, Lang J. Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors. J Vis Exp. 2022 12 16; (190). PMID: 36591990.
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Lang J, Leal AD, Mar?n-Jim?nez JA, Hartman SJ, Shulman J, Navarro NM, Lewis MS, Capasso A, Bagby SM, Yacob BW, MacBeth M, Freed BM, Eckhardt SG, Jordan K, Blatchford PJ, Pelanda R, Lieu CH, Messersmith WA, Pitts TM. Cabozantinib sensitizes microsatellite stable colorectal cancer to immune checkpoint blockade by immune modulation in human immune system mouse models. Front Oncol. 2022; 12:877635. PMID: 36419897.
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Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cells. Front Immunol. 2022; 13:988125. PMID: 36131937.
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Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. SARS-CoV-2 infection relaxes peripheral B cell tolerance. J Exp Med. 2022 06 06; 219(6). PMID: 35420627.
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Kremer KN, Buser A, Thumkeo D, Narumiya S, Jacobelli J, Pelanda R, Torres RM. LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2118816119. PMID: 35394866.
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Pelanda R, Zikherman J. Many Achilles' heels of B and T cell tolerance. Immunol Rev. 2022 05; 307(1):5-11. PMID: 35301733.
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Peterson JN, Boackle SA, Taitano SH, Sang A, Lang J, Kelly M, Rahkola JT, Miranda AM, Sheridan RM, Thurman JM, Rao VK, Torres RM, Pelanda R. Elevated Detection of Dual Antibody B Cells Identifies Lupus Patients With B Cell-Reactive VH4-34 Autoantibodies. Front Immunol. 2022; 13:795209. PMID: 35185888.
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Pelanda R, Greaves SA, Alves da Costa T, Cedrone LM, Campbell ML, Torres RM. B-cell intrinsic and extrinsic signals that regulate central tolerance of mouse and human B cells. Immunol Rev. 2022 05; 307(1):12-26. PMID: 34997597.
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Alves da Costa T, Peterson JN, Lang J, Shulman J, Liang X, Freed BM, Boackle SA, Lauzurica P, Torres RM, Pelanda R. Central human B cell tolerance manifests with a distinctive cell phenotype and is enforced via CXCR4 signaling in hu-mice. Proc Natl Acad Sci U S A. 2021 04 20; 118(16). PMID: 33850015.
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Mar?n-Jim?nez JA, Capasso A, Lewis MS, Bagby SM, Hartman SJ, Shulman J, Navarro NM, Yu H, Rivard CJ, Wang X, Barkow JC, Geng D, Kar A, Yingst A, Tufa DM, Dolan JT, Blatchford PJ, Freed BM, Torres RM, Davila E, Slansky JE, Pelanda R, Eckhardt SG, Messersmith WA, Diamond JR, Lieu CH, Verneris MR, Wang JH, Kiseljak-Vassiliades K, Pitts TM, Lang J. Testing Cancer Immunotherapy in a Human Immune System Mouse Model: Correlating Treatment Responses to Human Chimerism, Therapeutic Variables and Immune Cell Phenotypes. Front Immunol. 2021; 12:607282. PMID: 33854497.
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Zeng F, Chen Z, Chen R, Shufesky WJ, Bandyopadhyay M, Camirand G, Oberbarnscheidt MH, Sullivan MLG, Baty CJ, Yang MQ, Calderon M, Stolz DB, Erdos G, Pelanda R, Brennan TV, Catz SD, Watkins SC, Larregina AT, Morelli AE. Graft-derived extracellular vesicles transported across subcapsular sinus macrophages elicit B cell alloimmunity after transplantation. Sci Transl Med. 2021 03 17; 13(585). PMID: 33731430.
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Tentler JJ, Lang J, Capasso A, Kim DJ, Benaim E, Lee YB, Eisen A, Bagby SM, Hartman SJ, Yacob BW, Gittleman B, Pitts TM, Pelanda R, Eckhardt SG, Diamond JR. RX-5902, a novel ?-catenin modulator, potentiates the efficacy of immune checkpoint inhibitors in preclinical models of triple-negative breast Cancer. BMC Cancer. 2020 Nov 04; 20(1):1063. PMID: 33148223.
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Agazio A, Cimons J, Shotts KM, Guo K, Santiago ML, Pelanda R, Torres RM. Histone H2A-Reactive B Cells Are Functionally Anergic in Healthy Mice With Potential to Provide Humoral Protection Against HIV-1. Front Immunol. 2020; 11:1565. PMID: 32849530.
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Alves da Costa T, Lang J, Torres RM, Pelanda R. The development of human immune system mice and their use to study tolerance and autoimmunity. J Transl Autoimmun. 2019 Dec; 2:100021. PMID: 32743507.
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Allen TM, Brehm MA, Bridges S, Ferguson S, Kumar P, Mirochnitchenko O, Palucka K, Pelanda R, Sanders-Beer B, Shultz LD, Su L, PrabhuDas M. Humanized immune system mouse models: progress, challenges and opportunities. Nat Immunol. 2019 07; 20(7):770-774. PMID: 31160798.
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Mathew D, Kremer KN, Strauch P, Tigyi G, Pelanda R, Torres RM. LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling. Front Immunol. 2019; 10:1159. PMID: 31231367.
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Greaves SA, Peterson JN, Strauch P, Torres RM, Pelanda R. Active PI3K abrogates central tolerance in high-avidity autoreactive B cells. J Exp Med. 2019 05 06; 216(5):1135-1153. PMID: 30948496.
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Capasso A, Lang J, Pitts TM, Jordan KR, Lieu CH, Davis SL, Diamond JR, Kopetz S, Barbee J, Peterson J, Freed BM, Yacob BW, Bagby SM, Messersmith WA, Slansky JE, Pelanda R, Eckhardt SG. Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts. J Immunother Cancer. 2019 02 08; 7(1):37. PMID: 30736857.
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Coleman CB, Lang J, Sweet LA, Smith NA, Freed BM, Pan Z, Haverkos B, Pelanda R, Rochford R. Epstein-Barr Virus Type 2 Infects T Cells and Induces B Cell Lymphomagenesis in Humanized Mice. J Virol. 2018 11 01; 92(21). PMID: 30089703.
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Sang A, Danhorn T, Peterson JN, Rankin AL, O'Connor BP, Leach SM, Torres RM, Pelanda R. Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus. Nat Commun. 2018 09 28; 9(1):3973. PMID: 30266981.
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Greaves SA, Peterson JN, Torres RM, Pelanda R. Corrigendum: Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance. Front Immunol. 2018; 9:2218. PMID: 30323810.
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Agazio AE, Pelanda R, Torres RM. Silencing of TLM B cells by chronic HIV infection. Nat Immunol. 2018 09; 19(9):902-903. PMID: 30104630.
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Hobeika E, Dautzenberg M, Levit-Zerdoun E, Pelanda R, Reth M. Conditional Selection of B Cells in Mice With an Inducible B Cell Development. Front Immunol. 2018; 9:1806. PMID: 30127788.
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Bednarek J, Traxinger B, Brigham D, Roach J, Orlicky D, Wang D, Pelanda R, Mack CL. Cytokine-Producing B Cells Promote Immune-Mediated Bile Duct Injury in Murine Biliary Atresia. Hepatology. 2018 11; 68(5):1890-1904. PMID: 29679373.
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Greaves SA, Peterson JN, Torres RM, Pelanda R. Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance. Front Immunol. 2018; 9:707. PMID: 29686680.
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Lang J, Zhang B, Kelly M, Peterson JN, Barbee J, Freed BM, Di Santo JP, Matsuda JL, Torres RM, Pelanda R. Replacing mouse BAFF with human BAFF does not improve B-cell maturation in hematopoietic humanized mice. Blood Adv. 2017 Dec 26; 1(27):2729-2741. PMID: 29296925.
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Schroeder KMS, Agazio A, Strauch PJ, Jones ST, Thompson SB, Harper MS, Pelanda R, Santiago ML, Torres RM. Breaching peripheral tolerance promotes the production of HIV-1-neutralizing antibodies. J Exp Med. 2017 Aug 07; 214(8):2283-2302. PMID: 28698284.
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Lang J, Ota T, Kelly M, Strauch P, Freed BM, Torres RM, Nemazee D, Pelanda R. Receptor editing and genetic variability in human autoreactive B cells. J Exp Med. 2016 Jan 11; 213(1):93-108. PMID: 26694971.
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Hobeika E, Levit-Zerdoun E, Anastasopoulou V, Pohlmeyer R, Altmeier S, Alsadeq A, Dobenecker MW, Pelanda R, Reth M. CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk. EMBO J. 2015 Apr 01; 34(7):925-39. PMID: 25630702.
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Teodorovic LS, Babolin C, Rowland SL, Greaves SA, Baldwin DP, Torres RM, Pelanda R. Activation of Ras overcomes B-cell tolerance to promote differentiation of autoreactive B cells and production of autoantibodies. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):E2797-806. PMID: 24958853.
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Hu J, Oda SK, Shotts K, Donovan EE, Strauch P, Pujanauski LM, Victorino F, Al-Shami A, Fujiwara Y, Tigyi G, Oravecz T, Pelanda R, Torres RM. Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody response. J Immunol. 2014 Jul 01; 193(1):85-95. PMID: 24890721.
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Pelanda R. Dual immunoglobulin light chain B cells: Trojan horses of autoimmunity? Curr Opin Immunol. 2014 Apr; 27:53-9. PMID: 24549093.
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Oda SK, Strauch P, Fujiwara Y, Al-Shami A, Oravecz T, Tigyi G, Pelanda R, Torres RM. Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression. Cancer Immunol Res. 2013 Oct; 1(4):245-55. PMID: 24455753.
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Feldman AG, Tucker RM, Fenner EK, Pelanda R, Mack CL. B cell deficient mice are protected from biliary obstruction in the rotavirus-induced mouse model of biliary atresia. PLoS One. 2013; 8(8):e73644. PMID: 23991203.
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Fuquay R, Renner B, Kulik L, McCullough JW, Amura C, Strassheim D, Pelanda R, Torres R, Thurman JM. Renal ischemia-reperfusion injury amplifies the humoral immune response. J Am Soc Nephrol. 2013 Jun; 24(7):1063-72. PMID: 23641055.
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Rowland SL, Tuttle K, Torres RM, Pelanda R. Antigen and cytokine receptor signals guide the development of the na?ve mature B cell repertoire. Immunol Res. 2013 Mar; 55(1-3):231-40. PMID: 22941591.
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Swanson CL, Pelanda R, Torres RM. Division of labor during primary humoral immunity. Immunol Res. 2013 Mar; 55(1-3):277-86. PMID: 22945808.
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Lang J, Kelly M, Freed BM, McCarter MD, Kedl RM, Torres RM, Pelanda R. Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation. J Immunol. 2013 Mar 01; 190(5):2090-101. PMID: 23335750.
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Pujanauski LM, Janoff EN, McCarter MD, Pelanda R, Torres RM. Mouse marginal zone B cells harbor specificities similar to human broadly neutralizing HIV antibodies. Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1422-7. PMID: 23288906.
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Fournier EM, Velez MG, Leahy K, Swanson CL, Rubtsov AV, Torres RM, Pelanda R. Dual-reactive B cells are autoreactive and highly enriched in the plasmablast and memory B cell subsets of autoimmune mice. J Exp Med. 2012 Sep 24; 209(10):1797-812. PMID: 22927551.
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Hartney JM, Chu H, Pelanda R, Torres RM. Sub-chronic exposure to second hand smoke induces airspace leukocyte infiltration and decreased lung elastance. Front Physiol. 2012; 3:300. PMID: 22934051.
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Larson JD, Thurman JM, Rubtsov AV, Claypool D, Marrack P, van Dyk LF, Torres RM, Pelanda R. Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity. Proc Natl Acad Sci U S A. 2012 May 01; 109(18):E1092-100. PMID: 22474381.
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Pelanda R, Torres RM. Central B-cell tolerance: where selection begins. Cold Spring Harb Perspect Biol. 2012 Apr 01; 4(4):a007146. PMID: 22378602.
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Teodorovic LS, Riccardi C, Torres RM, Pelanda R. Murine B cell development and antibody responses to model antigens are not impaired in the absence of the TNF receptor GITR. PLoS One. 2012; 7(2):e31632. PMID: 22328941.
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Hartney JM, Gustafson CE, Bowler RP, Pelanda R, Torres RM. Thromboxane receptor signaling is required for fibronectin-induced matrix metalloproteinase 9 production by human and murine macrophages and is attenuated by the Arhgef1 molecule. J Biol Chem. 2011 Dec 30; 286(52):44521-31. PMID: 22086927.
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Eschbach C, Bach MP, Fidler I, Pelanda R, K?hler F, Rajewsky K, Jumaa H. Efficient generation of B lymphocytes by recognition of self-antigens. Eur J Immunol. 2011 Aug; 41(8):2397-403. PMID: 21604259.
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Lang J, Weiss N, Freed BM, Torres RM, Pelanda R. Generation of hematopoietic humanized mice in the newborn BALB/c-Rag2null Il2r?null mouse model: a multivariable optimization approach. Clin Immunol. 2011 Jul; 140(1):102-16. PMID: 21536497.
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Santiago ML, Smith DS, Barrett BS, Montano M, Benitez RL, Pelanda R, Hasenkrug KJ, Greene WC. Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor. J Virol. 2011 Jan; 85(1):189-99. PMID: 20980520.
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Rowland SL, Leahy KF, Halverson R, Torres RM, Pelanda R. BAFF receptor signaling aids the differentiation of immature B cells into transitional B cells following tonic BCR signaling. J Immunol. 2010 Oct 15; 185(8):4570-81. PMID: 20861359.
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Swanson CL, Wilson TJ, Strauch P, Colonna M, Pelanda R, Torres RM. Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response. J Exp Med. 2010 Jul 05; 207(7):1485-500. PMID: 20566717.
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Donovan EE, Pelanda R, Torres RM. S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development. Eur J Immunol. 2010 Mar; 40(3):688-98. PMID: 20039302.
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Rowland SL, DePersis CL, Torres RM, Pelanda R. Ras activation of Erk restores impaired tonic BCR signaling and rescues immature B cell differentiation. J Exp Med. 2010 Mar 15; 207(3):607-21. PMID: 20176802.
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Hartney JM, Brown J, Chu HW, Chang LY, Pelanda R, Torres RM. Arhgef1 regulates alpha5beta1 integrin-mediated matrix metalloproteinase expression and is required for homeostatic lung immunity. Am J Pathol. 2010 Mar; 176(3):1157-68. PMID: 20093499.
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Pelanda R, Piccirillo CA. Tolerance, immune regulation, and autoimmunity: cells and cytokines that make a difference. Curr Opin Immunol. 2008 Dec; 20(6):629-31. PMID: 18977298.
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Rubtsov AV, Swanson CL, Troy S, Strauch P, Pelanda R, Torres RM. TLR agonists promote marginal zone B cell activation and facilitate T-dependent IgM responses. J Immunol. 2008 Mar 15; 180(6):3882-8. PMID: 18322196.
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Hu J, Strauch P, Rubtsov A, Donovan EE, Pelanda R, Torres RM. Lsc activity is controlled by oligomerization and regulates integrin adhesion. Mol Immunol. 2008 Apr; 45(7):1825-36. PMID: 18157933.
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Velez MG, Kane M, Liu S, Gauld SB, Cambier JC, Torres RM, Pelanda R. Ig allotypic inclusion does not prevent B cell development or response. J Immunol. 2007 Jul 15; 179(2):1049-57. PMID: 17617597.
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Fraenkel S, Mostoslavsky R, Novobrantseva TI, Pelanda R, Chaudhuri J, Esposito G, Jung S, Alt FW, Rajewsky K, Cedar H, Bergman Y. Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus. Nat Immunol. 2007 Jul; 8(7):715-22. PMID: 17546032.
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Liu H, Schmidt-Supprian M, Shi Y, Hobeika E, Barteneva N, Jumaa H, Pelanda R, Reth M, Skok J, Rajewsky K, Shi Y. Yin Yang 1 is a critical regulator of B-cell development. Genes Dev. 2007 May 15; 21(10):1179-89. PMID: 17504937.
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Brown JP, Taube C, Miyahara N, Koya T, Pelanda R, Gelfand EW, Torres RM. Arhgef1 is required by T cells for the development of airway hyperreactivity and inflammation. Am J Respir Crit Care Med. 2007 Jul 01; 176(1):10-9. PMID: 17463415.
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Hobeika E, Thiemann S, Storch B, Jumaa H, Nielsen PJ, Pelanda R, Reth M. Testing gene function early in the B cell lineage in mb1-cre mice. Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37):13789-94. PMID: 16940357.
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Sasaki Y, Derudder E, Hobeika E, Pelanda R, Reth M, Rajewsky K, Schmidt-Supprian M. Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. Immunity. 2006 Jun; 24(6):729-739. PMID: 16782029.
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Pelanda R, Torres RM. Receptor editing for better or for worse. Curr Opin Immunol. 2006 Apr; 18(2):184-90. PMID: 16460922.
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Rubtsov A, Strauch P, Digiacomo A, Hu J, Pelanda R, Torres RM. Lsc regulates marginal-zone B cell migration and adhesion and is required for the IgM T-dependent antibody response. Immunity. 2005 Nov; 23(5):527-38. PMID: 16286020.
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Liu S, Velez MG, Humann J, Rowland S, Conrad FJ, Halverson R, Torres RM, Pelanda R. Receptor editing can lead to allelic inclusion and development of B cells that retain antibodies reacting with high avidity autoantigens. J Immunol. 2005 Oct 15; 175(8):5067-76. PMID: 16210610.
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Novobrantseva T, Xu S, Tan JE, Maruyama M, Schwers S, Pelanda R, Lam KP. Stochastic pairing of Ig heavy and light chains frequently generates B cell antigen receptors that are subject to editing in vivo. Int Immunol. 2005 Apr; 17(4):343-50. PMID: 15710909.
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Galler GR, Mundt C, Parker M, Pelanda R, M?rtensson IL, Winkler TH. Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components. J Exp Med. 2004 Jun 07; 199(11):1523-32. PMID: 15173209.
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Halverson R, Torres RM, Pelanda R. Receptor editing is the main mechanism of B cell tolerance toward membrane antigens. Nat Immunol. 2004 Jun; 5(6):645-50. PMID: 15156139.
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Heinrich AC, Pelanda R, Klingm?ller U. A mouse model for visualization and conditional mutations in the erythroid lineage. Blood. 2004 Aug 01; 104(3):659-66. PMID: 15090451.
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Pelanda R, Braun U, Hobeika E, Nussenzweig MC, Reth M. B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta. J Immunol. 2002 Jul 15; 169(2):865-72. PMID: 12097390.
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Pelanda R, Hobeika E, Kurokawa T, Zhang Y, Kuppig S, Reth M. Cre recombinase-controlled expression of the mb-1 allele. Genesis. 2002 Feb; 32(2):154-7. PMID: 11857807.
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Braun U, Rajewsky K, Pelanda R. Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenes. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7429-34. PMID: 10829061.
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Korganow AS, Ji H, Mangialaio S, Duchatelle V, Pelanda R, Martin T, Degott C, Kikutani H, Rajewsky K, Pasquali JL, Benoist C, Mathis D. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity. 1999 Apr; 10(4):451-61. PMID: 10229188.
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Novobrantseva TI, Martin VM, Pelanda R, M?ller W, Rajewsky K, Ehlich A. Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice. J Exp Med. 1999 Jan 04; 189(1):75-88. PMID: 9874565.
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Mostoslavsky R, Singh N, Kirillov A, Pelanda R, Cedar H, Chess A, Bergman Y. Kappa chain monoallelic demethylation and the establishment of allelic exclusion. Genes Dev. 1998 Jun 15; 12(12):1801-11. PMID: 9637682.
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Casellas R, Nussenzweig A, Wuerffel R, Pelanda R, Reichlin A, Suh H, Qin XF, Besmer E, Kenter A, Rajewsky K, Nussenzweig MC. Ku80 is required for immunoglobulin isotype switching. EMBO J. 1998 Apr 15; 17(8):2404-11. PMID: 9545251.
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Pelanda R, Schwers S, Sonoda E, Torres RM, Nemazee D, Rajewsky K. Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification. Immunity. 1997 Dec; 7(6):765-75. PMID: 9430222.
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Papavasiliou F, Casellas R, Suh H, Qin XF, Besmer E, Pelanda R, Nemazee D, Rajewsky K, Nussenzweig MC. V(D)J recombination in mature B cells: a mechanism for altering antibody responses. Science. 1997 Oct 10; 278(5336):298-301. PMID: 9323210.
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Pelanda R, Schaal S, Torres RM, Rajewsky K. A prematurely expressed Ig(kappa) transgene, but not V(kappa)J(kappa) gene segment targeted into the Ig(kappa) locus, can rescue B cell development in lambda5-deficient mice. Immunity. 1996 Sep; 5(3):229-39. PMID: 8808678.
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Pelanda R, Vanoni MA, Perego M, Piubelli L, Galizzi A, Curti B, Zanetti G. Glutamate synthase genes of the diazotroph Azospirillum brasilense. Cloning, sequencing, and analysis of functional domains. J Biol Chem. 1993 Feb 15; 268(5):3099-106. PMID: 8428988.
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Year | Publications |
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1996 | 1 | 1997 | 2 | 1998 | 2 | 1999 | 2 | 2000 | 1 | 2002 | 2 | 2004 | 3 | 2005 | 3 | 2006 | 3 | 2007 | 5 | 2008 | 2 | 2010 | 6 | 2011 | 3 | 2012 | 5 | 2013 | 7 | 2014 | 3 | 2015 | 2 | 2017 | 2 | 2018 | 7 | 2019 | 5 | 2020 | 2 | 2021 | 3 | 2022 | 8 | 2023 | 4 |
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