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Roberta Pelanda

InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Immunology Microbiology

    Collapse Research 
    Collapse research activities and funding
    R01AI052310     (PELANDA, ROBERTA)Jul 1, 2002 - May 31, 2018
    Tolerance in polyclonal and oligoclonal immune systems
    Role: Principal Investigator

    R56AI052310     (PELANDA, ROBERTA)Jul 1, 2003 - Mar 31, 2008
    Tolerance in Polyclonal and Oligoclonal Immune Systems
    Role: Principal Investigator

    R21AI063321     (PELANDA, ROBERTA)Jul 1, 2005 - Jun 30, 2008
    Modulatory signaling motifs in B cell antigen receptor function
    Role: Principal Investigator

    R21AI073629     (PELANDA, ROBERTA)Jun 5, 2008 - May 31, 2010
    Analysis of Human B Cell Tolerance in Humanized Mice
    Role: Principal Investigator

    R21AI105523     (PELANDA, ROBERTA)Jan 15, 2013 - Dec 31, 2014
    Human B Cell Development and Function in Humanized Mice Expressing Human BAFF
    Role: Principal Investigator

    R21AI122670     (PELANDA, ROBERTA)Jan 1, 2016 - Dec 31, 2017
    Developing a new model for EBV-mediated T cell diseases
    Role: Principal Investigator

    R01AI124474     (PELANDA, ROBERTA)Feb 5, 2016 - Jan 31, 2021
    Studies of human B cell tolerance, from a humanized mouse model to human beings
    Role: Principal Investigator

    R21AI131639     (PELANDA, ROBERTA)Feb 10, 2017 - Jan 31, 2019
    Testing an alternative model of central B cell tolerance
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bednarek J, Traxinger B, Brigham D, Roach J, Orlicky D, Wang D, Pelanda R, Mack CL. Cytokine-producing B cells promote immune-mediated bile duct injury in murine biliary atresia. Hepatology. 2018 Apr 20. PMID: 29679373.
      View in: PubMed
    2. Greaves SA, Peterson JN, Torres RM, Pelanda R. Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance. Front Immunol. 2018; 9:707. PMID: 29686680.
      View in: PubMed
    3. Lang J, Zhang B, Kelly M, Peterson JN, Barbee J, Freed BM, Di Santo JP, Matsuda JL, Torres RM, Pelanda R. Replacing mouse BAFF with human BAFF does not improve B-cell maturation in hematopoietic humanized mice. Blood Adv. 2017 Dec 26; 1(27):2729-2741. PMID: 29296925.
      View in: PubMed
    4. Schroeder KMS, Agazio A, Strauch PJ, Jones ST, Thompson SB, Harper MS, Pelanda R, Santiago ML, Torres RM. Breaching peripheral tolerance promotes the production of HIV-1-neutralizing antibodies. J Exp Med. 2017 Aug 07; 214(8):2283-2302. PMID: 28698284.
      View in: PubMed
    5. Lang J, Ota T, Kelly M, Strauch P, Freed BM, Torres RM, Nemazee D, Pelanda R. Receptor editing and genetic variability in human autoreactive B cells. J Exp Med. 2016 Jan 11; 213(1):93-108. PMID: 26694971; PMCID: PMC4710202.
    6. Hobeika E, Levit-Zerdoun E, Anastasopoulou V, Pohlmeyer R, Altmeier S, Alsadeq A, Dobenecker MW, Pelanda R, Reth M. CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk. EMBO J. 2015 Apr 01; 34(7):925-39. PMID: 25630702; PMCID: PMC4388600.
    7. Teodorovic LS, Babolin C, Rowland SL, Greaves SA, Baldwin DP, Torres RM, Pelanda R. Activation of Ras overcomes B-cell tolerance to promote differentiation of autoreactive B cells and production of autoantibodies. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):E2797-806. PMID: 24958853; PMCID: PMC4103347.
    8. Hu J, Oda SK, Shotts K, Donovan EE, Strauch P, Pujanauski LM, Victorino F, Al-Shami A, Fujiwara Y, Tigyi G, Oravecz T, Pelanda R, Torres RM. Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody response. J Immunol. 2014 Jul 01; 193(1):85-95. PMID: 24890721; PMCID: PMC4128188.
    9. Pelanda R. Dual immunoglobulin light chain B cells: Trojan horses of autoimmunity? Curr Opin Immunol. 2014 Apr; 27:53-9. PMID: 24549093; PMCID: PMC3972342.
    10. Oda SK, Strauch P, Fujiwara Y, Al-Shami A, Oravecz T, Tigyi G, Pelanda R, Torres RM. Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression. Cancer Immunol Res. 2013 Oct; 1(4):245-55. PMID: 24455753; PMCID: PMC3893823.
    11. Feldman AG, Tucker RM, Fenner EK, Pelanda R, Mack CL. B cell deficient mice are protected from biliary obstruction in the rotavirus-induced mouse model of biliary atresia. PLoS One. 2013; 8(8):e73644. PMID: 23991203; PMCID: PMC3749125.
    12. Fuquay R, Renner B, Kulik L, McCullough JW, Amura C, Strassheim D, Pelanda R, Torres R, Thurman JM. Renal ischemia-reperfusion injury amplifies the humoral immune response. J Am Soc Nephrol. 2013 Jun; 24(7):1063-72. PMID: 23641055; PMCID: PMC3699821.
    13. Rowland SL, Tuttle K, Torres RM, Pelanda R. Antigen and cytokine receptor signals guide the development of the naïve mature B cell repertoire. Immunol Res. 2013 Mar; 55(1-3):231-40. PMID: 22941591; PMCID: PMC3924590.
    14. Swanson CL, Pelanda R, Torres RM. Division of labor during primary humoral immunity. Immunol Res. 2013 Mar; 55(1-3):277-86. PMID: 22945808; PMCID: PMC3997297.
    15. Lang J, Kelly M, Freed BM, McCarter MD, Kedl RM, Torres RM, Pelanda R. Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation. J Immunol. 2013 Mar 01; 190(5):2090-101. PMID: 23335750; PMCID: PMC3578183.
    16. Pujanauski LM, Janoff EN, McCarter MD, Pelanda R, Torres RM. Mouse marginal zone B cells harbor specificities similar to human broadly neutralizing HIV antibodies. Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1422-7. PMID: 23288906; PMCID: PMC3557101.
    17. Fournier EM, Velez MG, Leahy K, Swanson CL, Rubtsov AV, Torres RM, Pelanda R. Dual-reactive B cells are autoreactive and highly enriched in the plasmablast and memory B cell subsets of autoimmune mice. J Exp Med. 2012 Sep 24; 209(10):1797-812. PMID: 22927551; PMCID: PMC3457739.
    18. Hartney JM, Chu H, Pelanda R, Torres RM. Sub-chronic exposure to second hand smoke induces airspace leukocyte infiltration and decreased lung elastance. Front Physiol. 2012; 3:300. PMID: 22934051; PMCID: PMC3429071.
    19. Larson JD, Thurman JM, Rubtsov AV, Claypool D, Marrack P, van Dyk LF, Torres RM, Pelanda R. Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity. Proc Natl Acad Sci U S A. 2012 May 01; 109(18):E1092-100. PMID: 22474381; PMCID: PMC3345002.
    20. Pelanda R, Torres RM. Central B-cell tolerance: where selection begins. Cold Spring Harb Perspect Biol. 2012 Apr 01; 4(4):a007146. PMID: 22378602; PMCID: PMC3312675.
    21. Teodorovic LS, Riccardi C, Torres RM, Pelanda R. Murine B cell development and antibody responses to model antigens are not impaired in the absence of the TNF receptor GITR. PLoS One. 2012; 7(2):e31632. PMID: 22328941; PMCID: PMC3273462.
    22. Hartney JM, Gustafson CE, Bowler RP, Pelanda R, Torres RM. Thromboxane receptor signaling is required for fibronectin-induced matrix metalloproteinase 9 production by human and murine macrophages and is attenuated by the Arhgef1 molecule. J Biol Chem. 2011 Dec 30; 286(52):44521-31. PMID: 22086927; PMCID: PMC3247948.
    23. Eschbach C, Bach MP, Fidler I, Pelanda R, Köhler F, Rajewsky K, Jumaa H. Efficient generation of B lymphocytes by recognition of self-antigens. Eur J Immunol. 2011 Aug; 41(8):2397-403. PMID: 21604259; PMCID: PMC3302163.
    24. Lang J, Weiss N, Freed BM, Torres RM, Pelanda R. Generation of hematopoietic humanized mice in the newborn BALB/c-Rag2null Il2r?null mouse model: a multivariable optimization approach. Clin Immunol. 2011 Jul; 140(1):102-16. PMID: 21536497; PMCID: PMC3115423.
    25. Santiago ML, Smith DS, Barrett BS, Montano M, Benitez RL, Pelanda R, Hasenkrug KJ, Greene WC. Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor. J Virol. 2011 Jan; 85(1):189-99. PMID: 20980520; PMCID: PMC3014173.
    26. Rowland SL, Leahy KF, Halverson R, Torres RM, Pelanda R. BAFF receptor signaling aids the differentiation of immature B cells into transitional B cells following tonic BCR signaling. J Immunol. 2010 Oct 15; 185(8):4570-81. PMID: 20861359; PMCID: PMC2950883.
    27. Swanson CL, Wilson TJ, Strauch P, Colonna M, Pelanda R, Torres RM. Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response. J Exp Med. 2010 Jul 05; 207(7):1485-500. PMID: 20566717; PMCID: PMC2901065.
    28. Donovan EE, Pelanda R, Torres RM. S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development. Eur J Immunol. 2010 Mar; 40(3):688-98. PMID: 20039302; PMCID: PMC2924669.
    29. Rowland SL, DePersis CL, Torres RM, Pelanda R. Ras activation of Erk restores impaired tonic BCR signaling and rescues immature B cell differentiation. J Exp Med. 2010 Mar 15; 207(3):607-21. PMID: 20176802; PMCID: PMC2839140.
    30. Hartney JM, Brown J, Chu HW, Chang LY, Pelanda R, Torres RM. Arhgef1 regulates alpha5beta1 integrin-mediated matrix metalloproteinase expression and is required for homeostatic lung immunity. Am J Pathol. 2010 Mar; 176(3):1157-68. PMID: 20093499; PMCID: PMC2832139.
    31. Pelanda R, Piccirillo CA. Tolerance, immune regulation, and autoimmunity: cells and cytokines that make a difference. Curr Opin Immunol. 2008 Dec; 20(6):629-31. PMID: 18977298; PMCID: PMC3927419.
    32. Rubtsov AV, Swanson CL, Troy S, Strauch P, Pelanda R, Torres RM. TLR agonists promote marginal zone B cell activation and facilitate T-dependent IgM responses. J Immunol. 2008 Mar 15; 180(6):3882-8. PMID: 18322196.
      View in: PubMed
    33. Hu J, Strauch P, Rubtsov A, Donovan EE, Pelanda R, Torres RM. Lsc activity is controlled by oligomerization and regulates integrin adhesion. Mol Immunol. 2008 Apr; 45(7):1825-36. PMID: 18157933; PMCID: PMC2315659.
    34. Velez MG, Kane M, Liu S, Gauld SB, Cambier JC, Torres RM, Pelanda R. Ig allotypic inclusion does not prevent B cell development or response. J Immunol. 2007 Jul 15; 179(2):1049-57. PMID: 17617597.
      View in: PubMed
    35. Fraenkel S, Mostoslavsky R, Novobrantseva TI, Pelanda R, Chaudhuri J, Esposito G, Jung S, Alt FW, Rajewsky K, Cedar H, Bergman Y. Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus. Nat Immunol. 2007 Jul; 8(7):715-22. PMID: 17546032.
      View in: PubMed
    36. Liu H, Schmidt-Supprian M, Shi Y, Hobeika E, Barteneva N, Jumaa H, Pelanda R, Reth M, Skok J, Rajewsky K, Shi Y. Yin Yang 1 is a critical regulator of B-cell development. Genes Dev. 2007 May 15; 21(10):1179-89. PMID: 17504937; PMCID: PMC1865490.
    37. Brown JP, Taube C, Miyahara N, Koya T, Pelanda R, Gelfand EW, Torres RM. Arhgef1 is required by T cells for the development of airway hyperreactivity and inflammation. Am J Respir Crit Care Med. 2007 Jul 01; 176(1):10-9. PMID: 17463415; PMCID: PMC2049063.
    38. Hobeika E, Thiemann S, Storch B, Jumaa H, Nielsen PJ, Pelanda R, Reth M. Testing gene function early in the B cell lineage in mb1-cre mice. Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37):13789-94. PMID: 16940357; PMCID: PMC1564216.
    39. Sasaki Y, Derudder E, Hobeika E, Pelanda R, Reth M, Rajewsky K, Schmidt-Supprian M. Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. Immunity. 2006 Jun; 24(6):729-39. PMID: 16782029.
      View in: PubMed
    40. Pelanda R, Torres RM. Receptor editing for better or for worse. Curr Opin Immunol. 2006 Apr; 18(2):184-90. PMID: 16460922.
      View in: PubMed
    41. Rubtsov A, Strauch P, Digiacomo A, Hu J, Pelanda R, Torres RM. Lsc regulates marginal-zone B cell migration and adhesion and is required for the IgM T-dependent antibody response. Immunity. 2005 Nov; 23(5):527-38. PMID: 16286020.
      View in: PubMed
    42. Liu S, Velez MG, Humann J, Rowland S, Conrad FJ, Halverson R, Torres RM, Pelanda R. Receptor editing can lead to allelic inclusion and development of B cells that retain antibodies reacting with high avidity autoantigens. J Immunol. 2005 Oct 15; 175(8):5067-76. PMID: 16210610.
      View in: PubMed
    43. Novobrantseva T, Xu S, Tan JE, Maruyama M, Schwers S, Pelanda R, Lam KP. Stochastic pairing of Ig heavy and light chains frequently generates B cell antigen receptors that are subject to editing in vivo. Int Immunol. 2005 Apr; 17(4):343-50. PMID: 15710909.
      View in: PubMed
    44. Galler GR, Mundt C, Parker M, Pelanda R, Mårtensson IL, Winkler TH. Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components. J Exp Med. 2004 Jun 07; 199(11):1523-32. PMID: 15173209; PMCID: PMC2211789.
    45. Halverson R, Torres RM, Pelanda R. Receptor editing is the main mechanism of B cell tolerance toward membrane antigens. Nat Immunol. 2004 Jun; 5(6):645-50. PMID: 15156139.
      View in: PubMed
    46. Heinrich AC, Pelanda R, Klingmüller U. A mouse model for visualization and conditional mutations in the erythroid lineage. Blood. 2004 Aug 01; 104(3):659-66. PMID: 15090451.
      View in: PubMed
    47. Pelanda R, Braun U, Hobeika E, Nussenzweig MC, Reth M. B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta. J Immunol. 2002 Jul 15; 169(2):865-72. PMID: 12097390.
      View in: PubMed
    48. Pelanda R, Hobeika E, Kurokawa T, Zhang Y, Kuppig S, Reth M. Cre recombinase-controlled expression of the mb-1 allele. Genesis. 2002 Feb; 32(2):154-7. PMID: 11857807.
      View in: PubMed
    49. Braun U, Rajewsky K, Pelanda R. Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenes. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7429-34. PMID: 10829061; PMCID: PMC16562.
    50. Korganow AS, Ji H, Mangialaio S, Duchatelle V, Pelanda R, Martin T, Degott C, Kikutani H, Rajewsky K, Pasquali JL, Benoist C, Mathis D. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity. 1999 Apr; 10(4):451-61. PMID: 10229188.
      View in: PubMed
    51. Novobrantseva TI, Martin VM, Pelanda R, Müller W, Rajewsky K, Ehlich A. Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice. J Exp Med. 1999 Jan 04; 189(1):75-88. PMID: 9874565; PMCID: PMC1887695.
    52. Mostoslavsky R, Singh N, Kirillov A, Pelanda R, Cedar H, Chess A, Bergman Y. Kappa chain monoallelic demethylation and the establishment of allelic exclusion. Genes Dev. 1998 Jun 15; 12(12):1801-11. PMID: 9637682; PMCID: PMC316908.
    53. Casellas R, Nussenzweig A, Wuerffel R, Pelanda R, Reichlin A, Suh H, Qin XF, Besmer E, Kenter A, Rajewsky K, Nussenzweig MC. Ku80 is required for immunoglobulin isotype switching. EMBO J. 1998 Apr 15; 17(8):2404-11. PMID: 9545251; PMCID: PMC1170583.
    54. Pelanda R, Schwers S, Sonoda E, Torres RM, Nemazee D, Rajewsky K. Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification. Immunity. 1997 Dec; 7(6):765-75. PMID: 9430222.
      View in: PubMed
    55. Papavasiliou F, Casellas R, Suh H, Qin XF, Besmer E, Pelanda R, Nemazee D, Rajewsky K, Nussenzweig MC. V(D)J recombination in mature B cells: a mechanism for altering antibody responses. Science. 1997 Oct 10; 278(5336):298-301. PMID: 9323210.
      View in: PubMed
    56. Pelanda R, Schaal S, Torres RM, Rajewsky K. A prematurely expressed Ig(kappa) transgene, but not V(kappa)J(kappa) gene segment targeted into the Ig(kappa) locus, can rescue B cell development in lambda5-deficient mice. Immunity. 1996 Sep; 5(3):229-39. PMID: 8808678.
      View in: PubMed
    57. Pelanda R, Vanoni MA, Perego M, Piubelli L, Galizzi A, Curti B, Zanetti G. Glutamate synthase genes of the diazotroph Azospirillum brasilense. Cloning, sequencing, and analysis of functional domains. J Biol Chem. 1993 Feb 15; 268(5):3099-106. PMID: 8428988.
      View in: PubMed
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