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David J Barton

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Immunology Microbiology
Phone303 7244215

    Collapse Research 
    Collapse research activities and funding
    R56AI042189     (BARTON, DAVID J)Jul 1, 1998 - Apr 30, 2010
    NIH/NIAID
    Enterovirus RNA Translation and Replication
    Role: Principal Investigator

    R01AI042189     (BARTON, DAVID J)Jul 1, 1998 - Apr 30, 2019
    NIH/NIAID
    Enterovirus RNA translation and replication.
    Role: Principal Investigator

    R21AI042189     (BARTON, DAVID J)Sep 15, 2003 - Aug 31, 2004
    NIH/NIAID
    Enterovirus RNA Translation and Replication
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Kempf BJ, Peersen OB, Barton DJ. Poliovirus Polymerase Leu420 Facilitates RNA Recombination and Ribavirin Resistance. J Virol. 2016 Oct 01; 90(19):8410-21. PMID: 27412593; PMCID: PMC5021434 [Available on 03/12/17].
    2. Barton DJ, Kumar RG, McCullough EH, Galang G, Arenth PM, Berga SL, Wagner AK. Persistent Hypogonadotropic Hypogonadism in Men After Severe Traumatic Brain Injury: Temporal Hormone Profiles and Outcome Prediction. J Head Trauma Rehabil. 2016 Jul-Aug; 31(4):277-87. PMID: 26360007; PMCID: PMC4786474 [Available on 07/01/17].
    3. Winston CN, Noël A, Neustadtl A, Parsadanian M, Barton DJ, Chellappa D, Wilkins TE, Alikhani AD, Zapple DN, Villapol S, Planel E, Burns MP. Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma. Am J Pathol. 2016 Mar; 186(3):552-67. PMID: 26857506; PMCID: PMC4816714 [Available on 03/01/17].
    4. Barton DJ, Tift FW, Cournoyer LE, Vieth JT, Hudson KB. Acute Alcohol Use and Injury Patterns in Young Adult Prehospital Patients. Prehosp Emerg Care. 2016; 20(2):206-11. PMID: 27002348.
      View in: PubMed
    5. Kempf BJ, Barton DJ. Picornavirus RNA polyadenylation by 3D(pol), the viral RNA-dependent RNA polymerase. Virus Res. 2015 Aug 03; 206:3-11. PMID: 25559071; PMCID: PMC4801031.
    6. Cooper DA, Banerjee S, Chakrabarti A, García-Sastre A, Hesselberth JR, Silverman RH, Barton DJ. RNase L targets distinct sites in influenza A virus RNAs. J Virol. 2015 Mar; 89(5):2764-76. PMID: 25540362; PMCID: PMC4325751.
    7. Cooper DA, Jha BK, Silverman RH, Hesselberth JR, Barton DJ. Ribonuclease L and metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs. Nucleic Acids Res. 2014 Apr; 42(8):5202-16. PMID: 24500209; PMCID: PMC4005677.
    8. Winston CN, Chellappa D, Wilkins T, Barton DJ, Washington PM, Loane DJ, Zapple DN, Burns MP. Controlled cortical impact results in an extensive loss of dendritic spines that is not mediated by injury-induced amyloid-beta accumulation. J Neurotrauma. 2013 Dec 01; 30(23):1966-72. PMID: 23879560; PMCID: PMC3837436.
    9. Kempf BJ, Kelly MM, Springer CL, Peersen OB, Barton DJ. Structural features of a picornavirus polymerase involved in the polyadenylation of viral RNA. J Virol. 2013 May; 87(10):5629-44. PMID: 23468507; PMCID: PMC3648189.
    10. Katzer R, Barton DJ, Adelman S, Clark S, Seaman EL, Hudson KB. Impact of implementing an EMR on physical exam documentation by ambulance personnel. Appl Clin Inform. 2012; 3(3):301-8. PMID: 23646077; PMCID: PMC3613032.
    11. Schuessler A, Funk A, Lazear HM, Cooper DA, Torres S, Daffis S, Jha BK, Kumagai Y, Takeuchi O, Hertzog P, Silverman R, Akira S, Barton DJ, Diamond MS, Khromykh AA. West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response. J Virol. 2012 May; 86(10):5708-18. PMID: 22379089; PMCID: PMC3347305.
    12. Kortus MG, Kempf BJ, Haworth KG, Barton DJ, Peersen OB. A template RNA entry channel in the fingers domain of the poliovirus polymerase. J Mol Biol. 2012 Apr 06; 417(4):263-78. PMID: 22321798; PMCID: PMC3325025.
    13. Shimakami T, Yamane D, Jangra RK, Kempf BJ, Spaniel C, Barton DJ, Lemon SM. Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):941-6. PMID: 22215596; PMCID: PMC3271899.
    14. Malathi K, Saito T, Crochet N, Barton DJ, Gale M, Silverman RH. RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP. RNA. 2010 Nov; 16(11):2108-19. PMID: 20833746; PMCID: PMC2957051.
    15. Hobdey SE, Kempf BJ, Steil BP, Barton DJ, Peersen OB. Poliovirus polymerase residue 5 plays a critical role in elongation complex stability. J Virol. 2010 Aug; 84(16):8072-84. PMID: 20534858; PMCID: PMC2916510.
    16. Steil BP, Kempf BJ, Barton DJ. Poly(A) at the 3' end of positive-strand RNA and VPg-linked poly(U) at the 5' end of negative-strand RNA are reciprocal templates during replication of poliovirus RNA. J Virol. 2010 Mar; 84(6):2843-58. PMID: 20071574; PMCID: PMC2826026.
    17. Steil BP, Barton DJ. Conversion of VPg into VPgpUpUOH before and during poliovirus negative-strand RNA synthesis. J Virol. 2009 Dec; 83(24):12660-70. PMID: 19812161; PMCID: PMC2786823.
    18. Townsend HL, Jha BK, Silverman RH, Barton DJ. A putative loop E motif and an H-H kissing loop interaction are conserved and functional features in a group C enterovirus RNA that inhibits ribonuclease L. RNA Biol. 2008 Oct-Dec; 5(4):263-72. PMID: 19088502; PMCID: PMC2953469.
    19. Steil BP, Barton DJ. Cis-active RNA elements (CREs) and picornavirus RNA replication. Virus Res. 2009 Feb; 139(2):240-52. PMID: 18773930; PMCID: PMC2692539.
    20. Steil BP, Barton DJ. Poliovirus cis-acting replication element-dependent VPg Uridylylation lowers the Km of the initiating nucleoside triphosphate for viral RNA replication. J Virol. 2008 Oct; 82(19):9400-8. PMID: 18653453; PMCID: PMC2546976.
    21. Owrutsky JC, Pomfret MB, Barton DJ, Kidwell DA. Fourier transform infrared spectroscopy of azide and cyanate ion pairs in AOT reverse micelles. J Chem Phys. 2008 Jul 14; 129(2):024513. PMID: 18624544.
      View in: PubMed
    22. Townsend HL, Jha BK, Han JQ, Maluf NK, Silverman RH, Barton DJ. A viral RNA competitively inhibits the antiviral endoribonuclease domain of RNase L. RNA. 2008 Jun; 14(6):1026-36. PMID: 18426919; PMCID: PMC2390801.
    23. Kempf BJ, Barton DJ. Poly(rC) binding proteins and the 5' cloverleaf of uncapped poliovirus mRNA function during de novo assembly of polysomes. J Virol. 2008 Jun; 82(12):5835-46. PMID: 18400854; PMCID: PMC2395131.
    24. Kempf BJ, Barton DJ. Poliovirus 2A(Pro) increases viral mRNA and polysome stability coordinately in time with cleavage of eIF4G. J Virol. 2008 Jun; 82(12):5847-59. PMID: 18400852; PMCID: PMC2395153.
    25. Washenberger CL, Han JQ, Kechris KJ, Jha BK, Silverman RH, Barton DJ. Hepatitis C virus RNA: dinucleotide frequencies and cleavage by RNase L. Virus Res. 2007 Dec; 130(1-2):85-95. PMID: 17604869; PMCID: PMC2186174.
    26. Han JQ, Townsend HL, Jha BK, Paranjape JM, Silverman RH, Barton DJ. A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L. J Virol. 2007 Jun; 81(11):5561-72. PMID: 17344297; PMCID: PMC1900262.
    27. Jurgens CK, Barton DJ, Sharma N, Morasco BJ, Ogram SA, Flanegan JB. 2Apro is a multifunctional protein that regulates the stability, translation and replication of poliovirus RNA. Virology. 2006 Feb 20; 345(2):346-57. PMID: 16297952.
      View in: PubMed
    28. Han JQ, Wroblewski G, Xu Z, Silverman RH, Barton DJ. Sensitivity of hepatitis C virus RNA to the antiviral enzyme ribonuclease L is determined by a subset of efficient cleavage sites. J Interferon Cytokine Res. 2004 Nov; 24(11):664-76. PMID: 15684820.
      View in: PubMed
    29. Murray KE, Steil BP, Roberts AW, Barton DJ. Replication of poliovirus RNA with complete internal ribosome entry site deletions. J Virol. 2004 Feb; 78(3):1393-402. PMID: 14722294; PMCID: PMC321374.
    30. Murray KE, Barton DJ. Poliovirus CRE-dependent VPg uridylylation is required for positive-strand RNA synthesis but not for negative-strand RNA synthesis. J Virol. 2003 Apr; 77(8):4739-50. PMID: 12663781; PMCID: PMC152113.
    31. Pathak HB, Ghosh SK, Roberts AW, Sharma SD, Yoder JD, Arnold JJ, Gohara DW, Barton DJ, Paul AV, Cameron CE. Structure-function relationships of the RNA-dependent RNA polymerase from poliovirus (3Dpol). A surface of the primary oligomerization domain functions in capsid precursor processing and VPg uridylylation. J Biol Chem. 2002 Aug 30; 277(35):31551-62. PMID: 12077141.
      View in: PubMed
    32. Han JQ, Barton DJ. Activation and evasion of the antiviral 2'-5' oligoadenylate synthetase/ribonuclease L pathway by hepatitis C virus mRNA. RNA. 2002 Apr; 8(4):512-25. PMID: 11991644; PMCID: PMC1370272.
    33. Lyons T, Murray KE, Roberts AW, Barton DJ. Poliovirus 5'-terminal cloverleaf RNA is required in cis for VPg uridylylation and the initiation of negative-strand RNA synthesis. J Virol. 2001 Nov; 75(22):10696-708. PMID: 11602711; PMCID: PMC114651.
    34. Murray KE, Roberts AW, Barton DJ. Poly(rC) binding proteins mediate poliovirus mRNA stability. RNA. 2001 Aug; 7(8):1126-41. PMID: 11497431; PMCID: PMC1370160.
    35. Barton DJ, O'Donnell BJ, Flanegan JB. 5' cloverleaf in poliovirus RNA is a cis-acting replication element required for negative-strand synthesis. EMBO J. 2001 Mar 15; 20(6):1439-48. PMID: 11250909; PMCID: PMC145522.
    36. Barton DJ, Morasco BJ, Flanegan JB. Translating ribosomes inhibit poliovirus negative-strand RNA synthesis. J Virol. 1999 Dec; 73(12):10104-12. PMID: 10559325; PMCID: PMC113062.
    37. Barton DJ, Flanegan JB. Synchronous replication of poliovirus RNA: initiation of negative-strand RNA synthesis requires the guanidine-inhibited activity of protein 2C. J Virol. 1997 Nov; 71(11):8482-9. PMID: 9343205; PMCID: PMC192311.
    38. Tang RS, Barton DJ, Flanegan JB, Kirkegaard K. Poliovirus RNA recombination in cell-free extracts. RNA. 1997 Jun; 3(6):624-33. PMID: 9174097; PMCID: PMC1369511.
    39. Barton DJ, Morasco BJ, Eisner-Smerage L, Collis PS, Diamond SE, Hewlett MJ, Merchant MA, O'Donnell BJ, Flanegan JB. Poliovirus RNA polymerase mutation 3D-M394T results in a temperature-sensitive defect in RNA synthesis. Virology. 1996 Mar 15; 217(2):459-69. PMID: 8610437.
      View in: PubMed
    40. Barton DJ, Morasco BJ, Flanegan JB. Assays for poliovirus polymerase, 3D(Pol), and authentic RNA replication in HeLa S10 extracts. Methods Enzymol. 1996; 275:35-57. PMID: 9026649.
      View in: PubMed
    41. Barton DJ, Black EP, Flanegan JB. Complete replication of poliovirus in vitro: preinitiation RNA replication complexes require soluble cellular factors for the synthesis of VPg-linked RNA. J Virol. 1995 Sep; 69(9):5516-27. PMID: 7636997; PMCID: PMC189403.
    42. Barton DJ, Flanegan JB. Coupled translation and replication of poliovirus RNA in vitro: synthesis of functional 3D polymerase and infectious virus. J Virol. 1993 Feb; 67(2):822-31. PMID: 8380467; PMCID: PMC237436.
    43. Collis PS, O'Donnell BJ, Barton DJ, Rogers JA, Flanegan JB. Replication of poliovirus RNA and subgenomic RNA transcripts in transfected cells. J Virol. 1992 Nov; 66(11):6480-8. PMID: 1328676; PMCID: PMC240140.
    44. Phair IC, Barton DJ, Allen MJ, Barnes MR. Preventable deaths after head injury: a clinical audit of performance. Injury. 1991 Sep; 22(5):353-6. PMID: 1806492.
      View in: PubMed
    45. Barton DJ, Sawicki SG, Sawicki DL. Solubilization and immunoprecipitation of alphavirus replication complexes. J Virol. 1991 Mar; 65(3):1496-506. PMID: 1847467; PMCID: PMC239930.
    46. Phair IC, Barton DJ, Barnes MR, Allen MJ. Deaths following trauma: an audit of performance. Ann R Coll Surg Engl. 1991 Jan; 73(1):53-7. PMID: 1996865; PMCID: PMC2499332.
    47. Barton DJ, Sawicki SG, Sawicki DL. Demonstration in vitro of temperature-sensitive elongation of RNA in Sindbis virus mutant ts6. J Virol. 1988 Oct; 62(10):3597-602. PMID: 3418782; PMCID: PMC253499.
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