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Andrew Peter Bradford

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-OB/GYN BRS
Phone303/724-3507

    Collapse Research 
    Collapse research activities and funding
    R01DK053496     (BRADFORD, ANDREW P)Aug 14, 1998 - Jun 30, 2003
    NIH/NIDDK
    FGF SIGNALING AND PITUITARY TUMORIGENESIS
    Role: Principal Investigator

    R01CA104875     (BRADFORD, ANDREW P)Apr 1, 2004 - Feb 28, 2010
    NIH/NCI
    THE ROLE OF PROTEIN KINASE C IN ENDOMETRIAL CANCER
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chosich J, Bradford AP, Allshouse AA, Reusch JE, Santoro N, Schauer IE. Acute recapitulation of the hyperinsulinemia and hyperlipidemia characteristic of metabolic syndrome suppresses gonadotropins. Obesity (Silver Spring). 2017 Mar; 25(3):553-560. PMID: 28158916.
      View in: PubMed
    2. Kurayoshi K, Shiromoto A, Ozono E, Iwanaga R, Bradford AP, Araki K, Ohtani K. Ectopic expression of the CDK inhibitor p21Cip1 enhances deregulated E2F activity and increases cancer cell-specific cytotoxic gene expression mediated by the ARF tumor suppressor promoter. Biochem Biophys Res Commun. 2017 Jan 29; 483(1):107-114. PMID: 28042030.
      View in: PubMed
    3. Kurayoshi K, Okuno J, Ozono E, Iwanaga R, Bradford AP, Kugawa K, Araki K, Ohtani K. The phosphatidyl inositol 3 kinase pathway does not suppress activation of the ARF and BIM genes by deregulated E2F1 activity. Biochem Biophys Res Commun. 2017 Jan 22; 482(4):784-790. PMID: 27888102.
      View in: PubMed
    4. Kuokkanen S, Polotsky AJ, Chosich J, Bradford AP, Jasinska A, Phang T, Santoro N, Appt SE. Corpus luteum as a novel target of weight changes that contribute to impaired female reproductive physiology and function. Syst Biol Reprod Med. 2016 Aug; 62(4):227-42. PMID: 27187064; PMCID: PMC4996623 [Available on 08/01/17].
    5. Al-Safi ZA, Liu H, Carlson NE, Chosich J, Harris M, Bradford AP, Robledo C, Eckel RH, Polotsky AJ. Omega-3 Fatty Acid Supplementation Lowers Serum FSH in Normal Weight But Not Obese Women. J Clin Endocrinol Metab. 2016 Jan; 101(1):324-33. PMID: 26523525; PMCID: PMC4701838 [Available on 01/01/17].
    6. Al-Safi ZA, Liu H, Carlson NE, Chosich J, Lesh J, Robledo C, Bradford AP, Gee NA, Phang T, Santoro N, Kohrt W, Polotsky AJ. Estradiol Priming Improves Gonadotrope Sensitivity and Pro-Inflammatory Cytokines in Obese Women. J Clin Endocrinol Metab. 2015 Nov; 100(11):4372-81. PMID: 26425884; PMCID: PMC4702462 [Available on 11/01/16].
    7. Noshchenko A, Hoffecker L, Lindley EM, Burger EL, Cain CM, Patel VV, Bradford AP. Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis. World J Orthop. 2015 Aug 18; 6(7):537-58. PMID: 26301183; PMCID: PMC4539477.
    8. Bradford AP, Jones K, Kechris K, Chosich J, Montague M, Warren WC, May MC, Al-Safi Z, Kuokkanen S, Appt SE, Polotsky AJ. Joint MiRNA/mRNA expression profiling reveals changes consistent with development of dysfunctional corpus luteum after weight gain. PLoS One. 2015; 10(8):e0135163. PMID: 26258540; PMCID: PMC4530955.
    9. Kitamura H, Ozono E, Iwanaga R, Bradford AP, Okuno J, Shimizu E, Kurayoshi K, Kugawa K, Toh H, Ohtani K. Identification of novel target genes specifically activated by deregulated E2F in human normal fibroblasts. Genes Cells. 2015 Sep; 20(9):739-57. PMID: 26201719.
      View in: PubMed
    10. Merhi Z, Polotsky AJ, Bradford AP, Buyuk E, Chosich J, Phang T, Jindal S, Santoro N. Adiposity Alters Genes Important in Inflammation and Cell Cycle Division in Human Cumulus Granulosa Cell. Reprod Sci. 2015 Oct; 22(10):1220-8. PMID: 25676576.
      View in: PubMed
    11. Wooding KM, Hankin JA, Johnson CA, Chosich JD, Baek SW, Bradford AP, Murphy RC, Santoro N. Measurement of estradiol, estrone, and testosterone in postmenopausal human serum by isotope dilution liquid chromatography tandem mass spectrometry without derivatization. Steroids. 2015 Apr; 96:89-94. PMID: 25617740; PMCID: PMC4366052.
    12. Kurayoshi K, Ozono E, Iwanaga R, Bradford AP, Komori H, Ohtani K. Cancer cell specific cytotoxic gene expression mediated by ARF tumor suppressor promoter constructs. Biochem Biophys Res Commun. 2014 Jul 18; 450(1):240-6. PMID: 24893334.
      View in: PubMed
    13. Roth LW, Allshouse AA, Bradshaw-Pierce EL, Lesh J, Chosich J, Kohrt W, Bradford AP, Polotsky AJ, Santoro N. Luteal phase dynamics of follicle-stimulating and luteinizing hormones in obese and normal weight women. Clin Endocrinol (Oxf). 2014 Sep; 81(3):418-25. PMID: 24576183; PMCID: PMC4115008.
    14. Roth LW, Bradshaw-Pierce EL, Allshouse AA, Lesh J, Chosich J, Bradford AP, Polotsky AJ, Santoro N. Evidence of GnRH antagonist escape in obese women. J Clin Endocrinol Metab. 2014 May; 99(5):E871-5. PMID: 24650013; PMCID: PMC4010706.
    15. Ross LA, Polotsky AJ, Kucherov A, Bradford AP, Lesh J, Chosich J, Gee N, Santoro N. Profound reduction of ovarian estrogen by aromatase inhibition in obese women. Obesity (Silver Spring). 2014 Jun; 22(6):1464-9. PMID: 24482405; PMCID: PMC4037337.
    16. Dai D, Bradford AP, Prossnitz ER. Endometrial cancer: molecular and cellular basis of tumor development, novel biomarkers and therapeutic agents, and innovative research approaches. Obstet Gynecol Int. 2014; 2014:710405. PMID: 24550988; PMCID: PMC3914482.
    17. Wooding KM, Barkley RM, Hankin JA, Johnson CA, Bradford AP, Santoro N, Murphy RC. Mechanism of formation of the major estradiol product ions following collisional activation of the molecular anion in a tandem quadrupole mass spectrometer. J Am Soc Mass Spectrom. 2013 Oct; 24(10):1451-5. PMID: 23955001; PMCID: PMC3786604.
    18. Thorne AM, Jackson TA, Willis VC, Bradford AP. Protein Kinase C a Modulates Estrogen-Receptor-Dependent Transcription and Proliferation in Endometrial Cancer Cells. Obstet Gynecol Int. 2013; 2013:537479. PMID: 23843797; PMCID: PMC3703424.
    19. Kundu MC, May MC, Chosich J, Bradford AP, Lasley B, Gee N, Santoro N, Appt SE, Polotsky AJ. Assessment of luteal function in the vervet monkey as a means to develop a model for obesity-related reproductive phenotype. Syst Biol Reprod Med. 2013 Apr; 59(2):74-81. PMID: 23278149; PMCID: PMC4349572.
    20. Iwanaga R, Wang CA, Micalizzi DS, Harrell JC, Jedlicka P, Sartorius CA, Kabos P, Farabaugh SM, Bradford AP, Ford HL. Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated kinase and transforming growth factor-beta signaling pathways. Breast Cancer Res. 2012 Jul 05; 14(4):R100. PMID: 22765220; PMCID: PMC3680936.
    21. Korch C, Spillman MA, Jackson TA, Jacobsen BM, Murphy SK, Lessey BA, Jordan VC, Bradford AP. DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination. Gynecol Oncol. 2012 Oct; 127(1):241-8. PMID: 22710073; PMCID: PMC3432677.
    22. Georgieva B, Milev I, Minkov I, Dimitrova I, Bradford AP, Baev V. Characterization of the uterine leiomyoma microRNAome by deep sequencing. Genomics. 2012 May; 99(5):275-81. PMID: 22446413.
      View in: PubMed
    23. Kucherov A, Polotsky AJ, Menke M, Isaac B, McAvey B, Buyuk E, Bradford AP, Hickmon C, Babbs B, Berga S, Loucks T, Santoro N. Aromatase inhibition causes increased amplitude, but not frequency, of hypothalamic-pituitary output in normal women. Fertil Steril. 2011 May; 95(6):2063-6. PMID: 21353673; PMCID: PMC3080458.
    24. Haughian JM, Reno EM, Thorne AM, Bradford AP. Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis. Int J Cancer. 2009 Dec 01; 125(11):2556-64. PMID: 19672862; PMCID: PMC2777752.
    25. Haughian JM, Bradford AP. Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells. J Cell Physiol. 2009 Jul; 220(1):112-8. PMID: 19235902.
      View in: PubMed
    26. Reno EM, Haughian JM, Jackson TA, Thorne AM, Bradford AP. c-Jun N-terminal kinase regulates apoptosis in endometrial cancer cells. Apoptosis. 2009 Jun; 14(6):809-20. PMID: 19424800.
      View in: PubMed
    27. Dimitrova IK, Richer JK, Rudolph MC, Spoelstra NS, Reno EM, Medina TM, Bradford AP. Gene expression profiling of multiple leiomyomata uteri and matched normal tissue from a single patient. Fertil Steril. 2009 Jun; 91(6):2650-63. PMID: 18672237; PMCID: PMC2738624.
    28. Reno EM, Haughian JM, Dimitrova IK, Jackson TA, Shroyer KR, Bradford AP. Analysis of protein kinase C delta (PKC delta) expression in endometrial tumors. Hum Pathol. 2008 Jan; 39(1):21-9. PMID: 17959229; PMCID: PMC2180423.
    29. Gutierrez-Hartmann A, Duval DL, Bradford AP. ETS transcription factors in endocrine systems. Trends Endocrinol Metab. 2007 May-Jun; 18(4):150-8. PMID: 17387021.
      View in: PubMed
    30. Haughian JM, Jackson TA, Koterwas DM, Bradford AP. Endometrial cancer cell survival and apoptosis is regulated by protein kinase C alpha and delta. Endocr Relat Cancer. 2006 Dec; 13(4):1251-67. PMID: 17158769.
      View in: PubMed
    31. Siriwardana G, Bradford A, Coy D, Zeitler P. Autocrine/paracrine regulation of breast cancer cell proliferation by growth hormone releasing hormone via Ras, Raf, and mitogen-activated protein kinase. Mol Endocrinol. 2006 Sep; 20(9):2010-9. PMID: 16613992.
      View in: PubMed
    32. Jackson TA, Koterwas DM, Bradford AP. Differential regulation of cell growth and gene expression by FGF-2 and FGF-4 in pituitary lactotroph GH4 cells. Mol Cell Endocrinol. 2006 Mar 09; 247(1-2):183-91. PMID: 16469431.
      View in: PubMed
    33. Farrow KN, Bradford AP, Tentler JJ, Gutierrez-Hartmann A. Structural and functional analysis of the differential effects of c-Jun and v-Jun on prolactin gene expression. Mol Endocrinol. 2004 Oct; 18(10):2479-90. PMID: 15231872.
      View in: PubMed
    34. Jackson TA, Koterwas DM, Morgan MA, Bradford AP. Fibroblast growth factors regulate prolactin transcription via an atypical Rac-dependent signaling pathway. Mol Endocrinol. 2003 Oct; 17(10):1921-30. PMID: 12843210.
      View in: PubMed
    35. Tentler JJ, Bradford AP, Schweppe RE, Gutierrez-Hartmann A. Selective repression of rat prolactin gene by stable expression of dominant-negative Ets in GH4 pituitary cells. Endocrine. 2003 Feb-Mar; 20(1-2):3-12. PMID: 12668863.
      View in: PubMed
    36. Jackson TA, Schweppe RE, Koterwas DM, Bradford AP. Fibroblast growth factor activation of the rat PRL promoter is mediated by PKCdelta. Mol Endocrinol. 2001 Sep; 15(9):1517-28. PMID: 11518800.
      View in: PubMed
    37. Bradford AP, Brodsky KS, Diamond SE, Kuhn LC, Liu Y, Gutierrez-Hartmann A. The Pit-1 homeodomain and beta-domain interact with Ets-1 and modulate synergistic activation of the rat prolactin promoter. J Biol Chem. 2000 Feb 04; 275(5):3100-6. PMID: 10652292.
      View in: PubMed
    38. Schweppe RE, Frazer-Abel AA, Gutierrez-Hartmann A, Bradford AP. Functional components of fibroblast growth factor (FGF) signal transduction in pituitary cells. Identification of FGF response elements in the prolactin gene. J Biol Chem. 1997 Dec 05; 272(49):30852-9. PMID: 9388230.
      View in: PubMed
    39. Bradford AP, Wasylyk C, Wasylyk B, Gutierrez-Hartmann A. Interaction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression. Mol Cell Biol. 1997 Mar; 17(3):1065-74. PMID: 9032233; PMCID: PMC231831.
    40. Wasylyk C, Bradford AP, Gutierrez-Hartmann A, Wasylyk B. Conserved mechanisms of Ras regulation of evolutionary related transcription factors, Ets1 and Pointed P2. Oncogene. 1997 Feb 27; 14(8):899-913. PMID: 9050989.
      View in: PubMed
    41. Bradford AP, Conrad KE, Tran PH, Ostrowski MC, Gutierrez-Hartmann A. GHF-1/Pit-1 functions as a cell-specific integrator of Ras signaling by targeting the Ras pathway to a composite Ets-1/GHF-1 response element. J Biol Chem. 1996 Oct 04; 271(40):24639-48. PMID: 8798730.
      View in: PubMed
    42. Bradford AP, Conrad KE, Wasylyk C, Wasylyk B, Gutierrez-Hartmann A. Functional interaction of c-Ets-1 and GHF-1/Pit-1 mediates Ras activation of pituitary-specific gene expression: mapping of the essential c-Ets-1 domain. Mol Cell Biol. 1995 May; 15(5):2849-57. PMID: 7739565; PMCID: PMC230516.
    43. Wolfe L, Bradford AP, Klarlund JK, Czech MP. Purification and characterization of a cytosolic insulin-stimulated serine kinase from rat liver. J Biol Chem. 1992 May 15; 267(14):9749-56. PMID: 1533638.
      View in: PubMed
    44. Klarlund JK, Jaspers SR, Khalaf N, Bradford AP, Miller TB, Czech MP. An insulin-stimulated kemptide kinase purified from rat liver is deactivated by phosphatase 2A. J Biol Chem. 1991 Mar 05; 266(7):4052-5. PMID: 1847913.
      View in: PubMed
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