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Chelsea Marie Magin

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Biography 
    Collapse education and training
    University of Colorado, Boulder, COPostdoc08/2013Chemical & Biological Engineering
    University of Florida, Gainesville, FLPhD12/2010Biomedical Engineering
    University of Florida, Gainesville, FLBS05/2006Materials Science & Engineering

    Collapse Overview 
    Collapse overview
    Dr. Magin is the principal investigator of the Bio-Inspired Pulmonary Engineering Laboratory at the University of Colorado, Anschutz Medical Campus in the Division of Pulmonary Sciences and Critical Care Medicine and the Department of Bioengineering. She has extensive experience in the conception, development and translation of medical devices. Her laboratory develops bio-inspired, engineered cell culture platforms, that precisely and consistently recapitulate the extracellular microenvironment and complex 3D micro-architecture of lung tissue. These bioengineered lung models will provide a foundation for development of precision therapies and patient-specific tissue engineering.

    https://maginlab.com


    Collapse Research 
    Collapse research activities and funding
    Seed Grant     (Chelsea M. Magin, PhD)Jun 1, 2016 - Jun 30, 2017
    Skin Disease Research Center
    Bio-inspired 3D Microenvironments for Improved Patient-Specific Keratinocyte Differentiation
    Role Description: We propose to develop an engineered cell culture platform that will better recapitulate the native extracellular microenvironment for efficient and consistent differentiation of patient-specific iPSCs to keratinocytes.
    Role: PI

    Sponsored Research Agreement     (Chelsea M. Magin, PhD)Nov 1, 2017 - Oct 31, 2018
    Sharklet Technologies, Inc.
    Evaluation of micropatterned surfaces for minimizing percutaneous gastrostomy tube complications
    Role Description: The goal of this project is to test Sharklet micropatterns in both 2D and 3D apical cell migration models that will be developed and implemented in the Magin laboratory.
    Role: PI

    Unrestricted Grant: Pulmonary     (Chelsea M. Magin, PhD)Dec 31, 2017 - Nov 30, 2018
    American Thoracic Society Foundation
    Bio-inspired 3D Cell Culture Platforms for Improved Modeling of Lung Epithelium In Vitro
    Role Description: The goals of this project are to 1) consistently produce synthetic 3D templates that can be used to pattern primary lung cells within a well-defined hydrogel matrix that mimics healthy or fibrotic ECM to replicate alveolar structure, and 2) determine the contribution of extracellular matrix stiffness to the initiation of a profibrotic phenotype in alveolar epithelial cells and subsequent signaling in vitro.
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Bailey KE, Floren ML, D'Ovidio TJ, Lammers SR, Stenmark KR, Magin CM. Tissue-Informed Engineering Strategies for Modeling Human Pulmonary Diseases. Am J Physiol Lung Cell Mol Physiol. 2018 Nov 21. PMID: 30461289.
      View in: PubMed
    2. Symmes BA, Stefanski AL, Magin CM, Evans CM. Role of mucins in lung homeostasis: regulated expression and biosynthesis in health and disease. Biochem Soc Trans. 2018 06 19; 46(3):707-719. PMID: 29802217.
      View in: PubMed
    3. Mann EE, Magin CM, Mettetal MR, May RM, Henry MM, DeLoid H, Prater J, Sullivan L, Thomas JG, Twite MD, Parker AE, Brennan AB, Reddy ST. Micropatterned Endotracheal Tubes Reduce Secretion-Related Lumen Occlusion. Ann Biomed Eng. 2016 12; 44(12):3645-3654. PMID: 27535564.
      View in: PubMed
    4. Magin CM, Neale DB, Drinker MC, Willenberg BJ, Reddy ST, La Perle KM, Schultz GS, Brennan AB. Evaluation of a bilayered, micropatterned hydrogel dressing for full-thickness wound healing. Exp Biol Med (Maywood). 2016 05; 241(9):986-95. PMID: 27037279.
      View in: PubMed
    5. Magin CM, Alge DL, Anseth KS. Bio-inspired 3D microenvironments: a new dimension in tissue engineering. Biomed Mater. 2016 Mar 04; 11(2):022001. PMID: 26942469.
      View in: PubMed
    6. Magin CM, May RM, Drinker MC, Cuevas KH, Brennan AB, Reddy ST. Micropatterned Protective Membranes Inhibit Lens Epithelial Cell Migration in Posterior Capsule Opacification Model. Transl Vis Sci Technol. 2015 Mar; 4(2):9. PMID: 25883876.
      View in: PubMed
    7. May RM, Magin CM, Mann EE, Drinker MC, Fraser JC, Siedlecki CA, Brennan AB, Reddy ST. An engineered micropattern to reduce bacterial colonization, platelet adhesion and fibrin sheath formation for improved biocompatibility of central venous catheters. Clin Transl Med. 2015; 4:9. PMID: 25852825; PMCID: PMC4385044.
    8. Kirschner CM, Alge DL, Gould ST, Anseth KS. Clickable, photodegradable hydrogels to dynamically modulate valvular interstitial cell phenotype. Adv Healthc Mater. 2014 May; 3(5):649-57. PMID: 24459068.
      View in: PubMed
    9. Decker JT, Kirschner CM, Long CJ, Finlay JA, Callow ME, Callow JA, Brennan AB. Engineered antifouling microtopographies: an energetic model that predicts cell attachment. Langmuir. 2013 Oct 22; 29(42):13023-30. PMID: 24044383.
      View in: PubMed
    10. Kirschner CM, Anseth KS. Hydrogels in Healthcare: From Static to Dynamic Material Microenvironments. Acta Mater. 2013 Feb 01; 61(3):931-944. PMID: 23929381.
      View in: PubMed
    11. Kirschner CM, Anseth KS. In situ control of cell substrate microtopographies using photolabile hydrogels. Small. 2013 Feb 25; 9(4):578-84. PMID: 23074095; PMCID: PMC3574214.
    12. Magin CM, Finlay JA, Clay G, Callow ME, Callow JA, Brennan AB. Antifouling performance of cross-linked hydrogels: refinement of an attachment model. Biomacromolecules. 2011 Apr 11; 12(4):915-22. PMID: 21401017.
      View in: PubMed
    13. Magin CM, Long CJ, Cooper SP, Ista LK, López GP, Brennan AB. Engineered antifouling microtopographies: the role of Reynolds number in a model that predicts attachment of zoospores of Ulva and cells of Cobetia marina. Biofouling. 2010 Aug; 26(6):719-27. PMID: 20706891.
      View in: PubMed
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