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Chelsea Marie Magin

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentCEDC-Bioengineering
Phone303/724-3344

    Collapse Biography 
    Collapse education and training
    University of Colorado, Boulder, COPostdoc08/2013Chemical & Biological Engineering
    University of Florida, Gainesville, FLPhD12/2010Biomedical Engineering
    University of Florida, Gainesville, FLBS05/2006Materials Science & Engineering

    Collapse Overview 
    Collapse overview
    Dr. Magin is the principal investigator of the Bio-Inspired Pulmonary Engineering Laboratory at the University of Colorado, Anschutz Medical Campus in the Division of Pulmonary Sciences and Critical Care Medicine and the Department of Bioengineering. She has extensive experience in the conception, development and translation of medical devices. Her laboratory develops bio-inspired, engineered cell culture platforms, that precisely and consistently recapitulate the extracellular microenvironment and complex 3D micro-architecture of lung tissue. These bioengineered lung models will provide a foundation for development of precision therapies and patient-specific tissue engineering.

    https://maginlab.com

    Collapse Research 
    Collapse research activities and funding
    Unrestricted Grant: Pulmonary     (Chelsea M. Magin, PhD)Dec 31, 2017 - Nov 30, 2018
    American Thoracic Society Foundation
    Bio-inspired 3D Cell Culture Platforms for Improved Modeling of Lung Epithelium In Vitro
    Role Description: The goals of this project are to 1) consistently produce synthetic 3D templates that can be used to pattern primary lung cells within a well-defined hydrogel matrix that mimics healthy or fibrotic ECM to replicate alveolar structure, and 2) determine the contribution of extracellular matrix stiffness to the initiation of a profibrotic phenotype in alveolar epithelial cells and subsequent signaling in vitro.
    Role: PI
    Sponsored Research Agreement     (Chelsea M. Magin, PhD)Nov 1, 2017 - Oct 31, 2018
    Sharklet Technologies, Inc.
    Evaluation of micropatterned surfaces for minimizing percutaneous gastrostomy tube complications
    Role Description: The goal of this project is to test Sharklet micropatterns in both 2D and 3D apical cell migration models that will be developed and implemented in the Magin laboratory.
    Role: PI
    Seed Grant     (Chelsea M. Magin, PhD)Jun 1, 2016 - Jun 30, 2017
    Skin Disease Research Center
    Bio-inspired 3D Microenvironments for Improved Patient-Specific Keratinocyte Differentiation
    Role Description: We propose to develop an engineered cell culture platform that will better recapitulate the native extracellular microenvironment for efficient and consistent differentiation of patient-specific iPSCs to keratinocytes.
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Mueller MC, Du Y, Walker LA, Magin CM. Dynamically stiffening biomaterials reveal age- and sex-specific differences in pulmonary arterial adventitial fibroblast activation. bioRxiv. 2024 Mar 10. PMID: 38168342.
      View in: PubMed
    2. Montesi SB, Gomez CR, Beers M, Brown R, Chattopadhyay I, Flaherty KR, Garcia CK, Gomperts B, Hariri LP, Hogaboam CM, Jenkins RG, Kaminski N, Kim GHJ, K?nigshoff M, Kolb M, Kotton DN, Kropski JA, Lasky J, Magin CM, Maher TM, McCormick M, Moore BB, Nickerson-Nutter C, Oldham J, Podolanczuk AJ, Raghu G, Rosas I, Rowe SM, Schmidt WT, Schwartz D, Shore JE, Spino C, Craig JM, Martinez FJ. Pulmonary Fibrosis Stakeholder Summit: A Joint NHLBI, Three Lakes Foundation, and Pulmonary Fibrosis Foundation Workshop Report. Am J Respir Crit Care Med. 2024 02 15; 209(4):362-373. PMID: 38113442.
      View in: PubMed
    3. Vukmirovic M, Benam KH, Rose JJ, Turner S, Magin CM, Lagares D, Cohen AH, Kaminski N, Hirota JA, Maher TM, Konigshoff M, Mallampalli RK, Sheppard D, Tarran R, Gomer RH, Kenyon NJ, Morris D, Hobbie S, Raju SV, Petrache I, Watkins T, Kumar R, Lam WA, Sherer T, Hecker L. Challenges and Opportunities for Commercializing Technologies in the Pulmonary Arena: An Official American Thoracic Society Report. Ann Am Thorac Soc. 2024 Jan; 21(1):1-11. PMID: 37903340.
      View in: PubMed
    4. Blomberg R, Sompel K, Hauer C, Smith AJ, Pe?a B, Driscoll J, Hume PS, Merrick DT, Tennis MA, Magin CM. Hydrogel-Embedded Precision-Cut Lung Slices Model Lung Cancer Premalignancy Ex Vivo. Adv Healthc Mater. 2024 02; 13(4):e2302246. PMID: 37953708.
      View in: PubMed
    5. Tanneberger AE, Blair L, Davis-Hall D, Magin CM. 3D Bioprinting Phototunable Hydrogels to Study Fibroblast Activation. J Vis Exp. 2023 06 30; (196). PMID: 37458469.
      View in: PubMed
    6. Blomberg R, Sompel K, Hauer C, Pe A B, Driscoll J, Hume PS, Merrick DT, Tennis MA, Magin CM. Tissue-engineered models of lung cancer premalignancy. bioRxiv. 2023 Mar 16. PMID: 36993773.
      View in: PubMed
    7. Hewawasam RS, Blomberg R, ?erbed?ija P, Magin CM. Chemical Modification of Human Decellularized Extracellular Matrix for Incorporation into Phototunable Hybrid-Hydrogel Models of Tissue Fibrosis. ACS Appl Mater Interfaces. 2023 Mar 29; 15(12):15071-15083. PMID: 36917510.
      View in: PubMed
    8. Da Palma RK, Uriarte JJ, Magin CM. Editorial: Unraveling the physiology of cells and extracellular matrix: Techniques for biochemical and biophysical characterization. Front Physiol. 2022; 13:1123223. PMID: 36685203.
      View in: PubMed
    9. Tanneberger AE, Weiss DJ, Magin CM. An Introduction to Engineering and Modeling the Lung. Adv Exp Med Biol. 2023; 1413:1-13. PMID: 37195523.
      View in: PubMed
    10. Blomberg R, Hewawasam RS, ?erbed?ija P, Saleh K, Caracena T, Magin CM. Engineering Dynamic 3D Models of Lung. Adv Exp Med Biol. 2023; 1413:155-189. PMID: 37195531.
      View in: PubMed
    11. Davis-Hall D, Thomas E, Pe?a B, Magin CM. 3D-bioprinted, phototunable hydrogel models for studying adventitial fibroblast activation in pulmonary arterial hypertension. Biofabrication. 2022 12 19; 15(1). PMID: 36533728.
      View in: PubMed
    12. Caracena T, Blomberg R, Hewawasam RS, Fry ZE, Riches DWH, Magin CM. Alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung models. Biomater Sci. 2022 Dec 06; 10(24):7133-7148. PMID: 36366982.
      View in: PubMed
    13. Saleh KS, Hewawasam R, ?erbed?ija P, Blomberg R, Noreldeen SE, Edelman B, Smith BJ, Riches DWH, Magin CM. Engineering Hybrid-Hydrogels Comprised of Healthy or Diseased Decellularized Extracellular Matrix to Study Pulmonary Fibrosis. Cell Mol Bioeng. 2022 Oct; 15(5):505-519. PMID: 36444345.
      View in: PubMed
    14. Stancil IT, Michalski JE, Davis-Hall D, Chu HW, Park JA, Magin CM, Yang IV, Smith BJ, Dobrinskikh E, Schwartz DA. Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional. Nat Commun. 2021 07 27; 12(1):4566. PMID: 34315881.
      View in: PubMed
    15. Campbell DR, Senger CN, Ryan AL, Magin CM. Engineering Tissue-Informed Biomaterials to Advance Pulmonary Regenerative Medicine. Front Med (Lausanne). 2021; 8:647834. PMID: 33898484.
      View in: PubMed
    16. Morgan LE, Jaramillo AM, Shenoy SK, Raclawska D, Emezienna NA, Richardson VL, Hara N, Harder AQ, NeeDell JC, Hennessy CE, El-Batal HM, Magin CM, Grove Villalon DE, Duncan G, Hanes JS, Suk JS, Thornton DJ, Holguin F, Janssen WJ, Thelin WR, Evans CM. Disulfide disruption reverses mucus dysfunction in allergic airway disease. Nat Commun. 2021 01 11; 12(1):249. PMID: 33431872.
      View in: PubMed
    17. Wagner DE, Ikonomou L, Gilpin SE, Magin CM, Cruz F, Greaney A, Magnusson M, Chen YW, Davis B, Vanuytsel K, Rolandsson Enes S, Krasnodembskaya A, Lehmann M, Westergren-Thorsson G, Stegmayr J, Alsafadi HN, Hoffman ET, Weiss DJ, Ryan AL. Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019. ERJ Open Res. 2020 Oct; 6(4). PMID: 33123557.
      View in: PubMed
    18. George MP, Maier LA, Kasperbauer S, Eddy J, Mayer AS, Magin CM. How to Leverage Collaborations Between the BME Community and Local Hospitals to Address Critical Personal Protective Equipment Shortages During the COVID-19 Pandemic. Ann Biomed Eng. 2020 Sep; 48(9):2281-2284. PMID: 32710248.
      View in: PubMed
    19. Petrou CL, D'Ovidio TJ, B?l?kbas DA, Tas S, Brown RD, Allawzi A, Lindstedt S, Nozik-Grayck E, Stenmark KR, Wagner DE, Magin CM. Clickable decellularized extracellular matrix as a new tool for building hybrid-hydrogels to model chronic fibrotic diseases in vitro. J Mater Chem B. 2020 08 21; 8(31):6814-6826. PMID: 32343292.
      View in: PubMed
    20. Bailey KE, Pino C, Lennon ML, Lyons A, Jacot JG, Lammers SR, K?nigshoff M, Magin CM. Embedding of Precision-Cut Lung Slices in Engineered Hydrogel Biomaterials Supports Extended Ex Vivo Culture. Am J Respir Cell Mol Biol. 2020 01; 62(1):14-22. PMID: 31513744.
      View in: PubMed
    21. Davis-Hall D, Nguyen V, D'Ovidio TJ, Tsai E, Bilousova G, Magin CM. Peptide-Functionalized Hydrogels Modulate Integrin Expression and Stemness in Adult Human Epidermal Keratinocytes. Adv Biosyst. 2019 10; 3(10):e1900022. PMID: 32648724.
      View in: PubMed
    22. Bailey KE, Floren ML, D'Ovidio TJ, Lammers SR, Stenmark KR, Magin CM. Tissue-informed engineering strategies for modeling human pulmonary diseases. Am J Physiol Lung Cell Mol Physiol. 2019 02 01; 316(2):L303-L320. PMID: 30461289.
      View in: PubMed
    23. Symmes BA, Stefanski AL, Magin CM, Evans CM. Role of mucins in lung homeostasis: regulated expression and biosynthesis in health and disease. Biochem Soc Trans. 2018 06 19; 46(3):707-719. PMID: 29802217.
      View in: PubMed
    24. Mann EE, Magin CM, Mettetal MR, May RM, Henry MM, DeLoid H, Prater J, Sullivan L, Thomas JG, Twite MD, Parker AE, Brennan AB, Reddy ST. Micropatterned Endotracheal Tubes Reduce Secretion-Related Lumen Occlusion. Ann Biomed Eng. 2016 12; 44(12):3645-3654. PMID: 27535564.
      View in: PubMed
    25. Magin CM, Neale DB, Drinker MC, Willenberg BJ, Reddy ST, La Perle KM, Schultz GS, Brennan AB. Evaluation of a bilayered, micropatterned hydrogel dressing for full-thickness wound healing. Exp Biol Med (Maywood). 2016 05; 241(9):986-95. PMID: 27037279.
      View in: PubMed
    26. Magin CM, Alge DL, Anseth KS. Bio-inspired 3D microenvironments: a new dimension in tissue engineering. Biomed Mater. 2016 Mar 04; 11(2):022001. PMID: 26942469.
      View in: PubMed
    27. Magin CM, May RM, Drinker MC, Cuevas KH, Brennan AB, Reddy ST. Micropatterned Protective Membranes Inhibit Lens Epithelial Cell Migration in Posterior Capsule Opacification Model. Transl Vis Sci Technol. 2015 Mar; 4(2):9. PMID: 25883876.
      View in: PubMed
    28. May RM, Magin CM, Mann EE, Drinker MC, Fraser JC, Siedlecki CA, Brennan AB, Reddy ST. An engineered micropattern to reduce bacterial colonization, platelet adhesion and fibrin sheath formation for improved biocompatibility of central venous catheters. Clin Transl Med. 2015; 4:9. PMID: 25852825.
      View in: PubMed
    29. Kirschner CM, Alge DL, Gould ST, Anseth KS. Clickable, photodegradable hydrogels to dynamically modulate valvular interstitial cell phenotype. Adv Healthc Mater. 2014 May; 3(5):649-57. PMID: 24459068.
      View in: PubMed
    30. Decker JT, Magin CM, Long CJ, Finlay JA, Callow ME, Callow JA, Brennan AB. Engineered antifouling microtopographies: an energetic model that predicts cell attachment. Langmuir. 2013 10 22; 29(42):13023-30. PMID: 24044383.
      View in: PubMed
    31. Kirschner CM, Anseth KS. Hydrogels in Healthcare: From Static to Dynamic Material Microenvironments. Acta Mater. 2013 Feb 01; 61(3):931-944. PMID: 23929381.
      View in: PubMed
    32. Kirschner CM, Anseth KS. In situ control of cell substrate microtopographies using photolabile hydrogels. Small. 2013 Feb 25; 9(4):578-84. PMID: 23074095.
      View in: PubMed
    33. Magin CM, Finlay JA, Clay G, Callow ME, Callow JA, Brennan AB. Antifouling performance of cross-linked hydrogels: refinement of an attachment model. Biomacromolecules. 2011 Apr 11; 12(4):915-22. PMID: 21401017.
      View in: PubMed
    34. Magin CM, Long CJ, Cooper SP, Ista LK, L?pez GP, Brennan AB. Engineered antifouling microtopographies: the role of Reynolds number in a model that predicts attachment of zoospores of Ulva and cells of Cobetia marina. Biofouling. 2010 Aug; 26(6):719-27. PMID: 20706891.
      View in: PubMed
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