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Christopher M Evans

InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Overview 
    Collapse overview
    Research in the Evans lab focuses on how airway mucins regulate respiratory health and disease. Two secreted mucins--MUC5AC and MUC5B--are the predominant macromolecular components of airway mucus. MUC5AC and MUC5B regulate host mucosal defense in health, but their excessive or aberrant expression is associated with transient infections and with a wide range of lung diseases such as asthma, cystic fibrosis, chronic obstructive pulmonary disease, pulmonary fibrosis, and lung cancer.

    Using genetic and respiratory challenge models, our group has pioneered efforts to determine the significance of Muc5ac and Muc5b in mouse lungs (‘MUC’ in humans, ‘Muc’ in mice). We have discovered critical beneficial roles for Muc5b in homeostasis and responses to infection. Conversely, we have identified required detrimental roles for Muc5ac in airflow obstruction and lung injury.

    Current research programs involve investigating how these two mucins perform their specific functions. Efforts are underway to determine whether and how the effects of MUC5AC/Muc5ac and MUC5B/Muc5b are mediated intrinsically by their differential expression and structural heterogeneity. Additional projects focus on how Muc5ac and Muc5b interact with leukocytes and structural cells in the lungs to regulate tissue inflammation, injury, and repair.

    These projects use of genetically engineered mice, including over-expressing, knockout, and gene-edited lines, to address how Muc5ac and Muc5b function singly and in combination. Projects include studies of the mucin proteins, their assembly, and their glycosylation.

    Collapse Research 
    Collapse research activities and funding
    R01HL080396     (EVANS, CHRISTOPHER M)Aug 1, 2009 - Nov 30, 2018
    Role of Mucin in Lung Homeostasis and Pathophysiology
    Role: Principal Investigator

    R01HL130938     (JANSSEN, WILLIAM)Aug 1, 2016 - Jul 31, 2020
    Mechanisms of lung macrophage programming by MUC5B during health and disease
    Role: Co-Principal Investigator

    PR160247     (SCHWARTZ, DAVID)Jul 1, 2017 - Jun 30, 2021
    Department of Defense
    MUC5B, a novel therapeutic target for Idiopathic Pulmonary Fibrosis (IPF)
    Role: Project Director

    EVANS18IO     (EVANS, CHRISTOPHER M)Nov 1, 2018 - Oct 31, 2020
    Cystic Fibrosis Foundation
    Requirements for Polymeric Mucin Disulfide Assembly in Vivo
    Role: Principal Investigator

    R13HL145807     (EVANS, CHRISTOPHER M)Feb 15, 2019 - Jan 31, 2020
    2019 Cilia, Mucus and Mucociliary Interactions GRC & GRS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Svedberg FR, Brown SL, Krauss MZ, Campbell L, Sharpe C, Clausen M, Howell GJ, Clark H, Madsen J, Evans CM, Sutherland TE, Ivens AC, Thornton DJ, Grencis RK, Hussell T, Cunoosamy DM, Cook PC, MacDonald AS. The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation. Nat Immunol. 2019 May; 20(5):571-580. PMID: 30936493.
      View in: PubMed
    2. Jaramillo AM, Piccotti L, Velasco WV, Delgado ASH, Azzegagh Z, Chung F, Nazeer U, Farooq J, Brenner J, Parker-Thornburg J, Scott BL, Evans CM, Adachi R, Burns AR, Kreda SM, Tuvim MJ, Dickey BF. Different Munc18 proteins mediate baseline and stimulated airway mucin secretion. JCI Insight. 2019 Mar 21; 4(6). PMID: 30721150.
      View in: PubMed
    3. Kim V, Evans CM, Dickey BF. Dawn of a New Era in the Diagnosis and Treatment of Airway Mucus Dysfunction. Am J Respir Crit Care Med. 2019 Jan 15; 199(2):133-134. PMID: 30252497.
      View in: PubMed
    4. Hancock LA, Hennessy CE, Solomon GM, Dobrinskikh E, Estrella A, Hara N, Hill DB, Kissner WJ, Markovetz MR, Grove Villalon DE, Voss ME, Tearney GJ, Carroll KS, Shi Y, Schwarz MI, Thelin WR, Rowe SM, Yang IV, Evans CM, Schwartz DA. Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice. Nat Commun. 2018 12 18; 9(1):5363. PMID: 30560893.
      View in: PubMed
    5. Benam KH, Vladar EK, Janssen WJ, Evans CM. Mucociliary Defense: Emerging Cellular, Molecular, and Animal Models. Ann Am Thorac Soc. 2018 Nov; 15(Supplement_3):S210-S215. PMID: 30431350.
      View in: PubMed
    6. Fernández-Blanco JA, Fakih D, Arike L, Rodríguez-Piñeiro AM, Martínez-Abad B, Skansebo E, Jackson S, Root J, Singh D, McCrae C, Evans CM, Åstrand A, Ermund A, Hansson GC. Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs. JCI Insight. 2018 Sep 06; 3(17). PMID: 30185674.
      View in: PubMed
    7. Evans CM, Seibold MA, Gerber AN. SPDEFending the Lung through Mucin Expression. Am J Respir Cell Mol Biol. 2018 Sep; 59(3):287-288. PMID: 29723043.
      View in: PubMed
    8. De la Garza MM, Cumpian AM, Daliri S, Castro-Pando S, Umer M, Gong L, Khosravi N, Caetano MS, Ramos-Castañeda M, Flores AG, Beltran EC, Tran HT, Tuvim MJ, Ostrin EJ, Dickey BF, Evans CM, Moghaddam SJ. COPD-Type lung inflammation promotes K-ras mutant lung cancer through epithelial HIF-1a mediated tumor angiogenesis and proliferation. Oncotarget. 2018 Aug 31; 9(68):32972-32983. PMID: 30250643.
      View in: PubMed
    9. Bauer AK, Umer M, Richardson VL, Cumpian AM, Harder AQ, Khosravi N, Azzegagh Z, Hara NM, Ehre C, Mohebnasab M, Caetano MS, Merrick DT, van Bokhoven A, Wistuba II, Kadara H, Dickey BF, Velmurugan K, Mann PR, Lu X, Barón AE, Evans CM, Moghaddam SJ. Requirement for MUC5AC in KRAS-dependent lung carcinogenesis. JCI Insight. 2018 Aug 09; 3(15). PMID: 30089720.
      View in: PubMed
    10. Symmes BA, Stefanski AL, Magin CM, Evans CM. Role of mucins in lung homeostasis: regulated expression and biosynthesis in health and disease. Biochem Soc Trans. 2018 06 19; 46(3):707-719. PMID: 29802217.
      View in: PubMed
    11. Monte AA, Sun H, Rapp-Olsson AM, Mohamed F, Gawarammana I, Buckley NA, Evans CM, Yang IV, Schwartz DA. The Plasma Concentration of MUC5B Is Associated with Clinical Outcomes in Paraquat-poisoned Patients. Am J Respir Crit Care Med. 2018 03 01; 197(5):663-665. PMID: 28719757.
      View in: PubMed
    12. Evans CM, Dickey BF, Schwartz DA. E-Cigarettes: Mucus Measurements Make Marks. Am J Respir Crit Care Med. 2018 Feb 15; 197(4):420-422. PMID: 29161057.
      View in: PubMed
    13. Stefanski AL, Raclawska DS, Evans CM. Modulation of Lung Epithelial Cell Function Using Conditional and Inducible Transgenic Approaches. Methods Mol Biol. 2018; 1809:169-201. PMID: 29987791.
      View in: PubMed
    14. Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Sci Transl Med. 2017 Sep 20; 9(408). PMID: 28931657.
      View in: PubMed
    15. Helling BA, Gerber AN, Kadiyala V, Sasse SK, Pedersen BS, Sparks L, Nakano Y, Okamoto T, Evans CM, Yang IV, Schwartz DA. Regulation of MUC5B Expression in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2017 07; 57(1):91-99. PMID: 28272906.
      View in: PubMed
    16. Kumar R, Mickael C, Kassa B, Gebreab L, Robinson JC, Koyanagi DE, Sanders L, Barthel L, Meadows C, Fox D, Irwin D, Li M, McKeon BA, Riddle S, Dale Brown R, Morgan LE, Evans CM, Hernandez-Saavedra D, Bandeira A, Maloney JP, Bull TM, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. TGF-ß activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension. Nat Commun. 2017 05 30; 8:15494. PMID: 28555642.
      View in: PubMed
    17. Colbert JF, Ford JA, Haeger SM, Yang Y, Dailey KL, Allison KC, Neudecker V, Evans CM, Richardson VL, Brodsky KS, Faubel S, Eltzschig HK, Schmidt EP, Ginde AA. A model-specific role of microRNA-223 as a mediator of kidney injury during experimental sepsis. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F553-F559. PMID: 28515178.
      View in: PubMed
    18. Dickey BF, Fahy JV, Kesimer M, Boucher RC, Evans CM, Thornton D. Measuring Airway Mucin 2 in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization. Ann Am Thorac Soc. 2016 11; 13(11):2103-2104. PMID: 27831803.
      View in: PubMed
    19. Evans CM, Fingerlin TE, Schwarz MI, Lynch D, Kurche J, Warg L, Yang IV, Schwartz DA. Idiopathic Pulmonary Fibrosis: A Genetic Disease That Involves Mucociliary Dysfunction of the Peripheral Airways. Physiol Rev. 2016 10; 96(4):1567-91. PMID: 27630174.
      View in: PubMed
    20. Gong L, da Silva Caetano M, Cumpian AM, Daliri S, Garza Flores A, Chang SH, Ochoa CE, Evans CM, Yu Z, Moghaddam SJ. Tumor necrosis factor links chronic obstructive pulmonary disease and K-ras mutant lung cancer through induction of an immunosuppressive pro-tumor microenvironment. Oncoimmunology. 2016; 5(10):e1229724. PMID: 27853654.
      View in: PubMed
    21. Janssen WJ, Stefanski AL, Bochner BS, Evans CM. Control of lung defence by mucins and macrophages: ancient defence mechanisms with modern functions. Eur Respir J. 2016 10; 48(4):1201-1214. PMID: 27587549.
      View in: PubMed
    22. Livraghi-Butrico A, Grubb BR, Wilkinson KJ, Volmer AS, Burns KA, Evans CM, O'Neal WK, Boucher RC. Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease. Mucosal Immunol. 2017 03; 10(2):395-407. PMID: 27435107.
      View in: PubMed
    23. Raclawska DS, Ttofali F, Fletcher AA, Harper DN, Bochner BS, Janssen WJ, Evans CM. Mucins and Their Sugars. Critical Mediators of Hyperreactivity and Inflammation. Ann Am Thorac Soc. 2016 Mar; 13 Suppl 1:S98-9. PMID: 27027967; PMCID: PMC5015746 [Available on 03/01/17].
    24. Nakano Y, Yang IV, Walts AD, Watson AM, Helling BA, Fletcher AA, Lara AR, Schwarz MI, Evans CM, Schwartz DA. MUC5B Promoter Variant rs35705950 Affects MUC5B Expression in the Distal Airways in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2016 Feb 15; 193(4):464-6. PMID: 26871673; PMCID: PMC4803086 [Available on 02/15/17].
    25. Yang IV, Fingerlin TE, Evans CM, Schwarz MI, Schwartz DA. MUC5B and Idiopathic Pulmonary Fibrosis. Ann Am Thorac Soc. 2015 Nov; 12 Suppl 2:S193-9. PMID: 26595739; PMCID: PMC4722833 [Available on 11/01/16].
    26. Chandler JD, Min E, Huang J, McElroy CS, Dickerhof N, Mocatta T, Fletcher AA, Evans CM, Liang L, Patel M, Kettle AJ, Nichols DP, Day BJ. Antiinflammatory and Antimicrobial Effects of Thiocyanate in a Cystic Fibrosis Mouse Model. Am J Respir Cell Mol Biol. 2015 Aug; 53(2):193-205. PMID: 25490247.
      View in: PubMed
    27. Ren B, Azzegagh Z, Jaramillo AM, Zhu Y, Pardo-Saganta A, Bagirzadeh R, Flores JR, Han W, Tang YJ, Tu J, Alanis DM, Evans CM, Guindani M, Roche PA, Rajagopal J, Chen J, Davis CW, Tuvim MJ, Dickey BF. SNAP23 is selectively expressed in airway secretory cells and mediates baseline and stimulated mucin secretion. Biosci Rep. 2015 Apr 28; 35(3). PMID: 26182382.
      View in: PubMed
    28. Liptzin DR, Watson AM, Murphy E, Kroehl ME, Dishop MK, Galambos C, Evans CM, Schwarz MI, Deterding RR, Schwartz DA. MUC5B expression and location in surfactant protein C mutations in children. Pediatr Pulmonol. 2015 Dec; 50(12):1270-6. PMID: 25858779; PMCID: PMC4596737 [Available on 12/01/16].
    29. Evans CM, Raclawska DS, Ttofali F, Liptzin DR, Fletcher AA, Harper DN, McGing MA, McElwee MM, Williams OW, Sanchez E, Roy MG, Kindrachuk KN, Wynn TA, Eltzschig HK, Blackburn MR, Tuvim MJ, Janssen WJ, Schwartz DA, Dickey BF. The polymeric mucin Muc5ac is required for allergic airway hyperreactivity. Nat Commun. 2015 Feb 17; 6:6281. PMID: 25687754; PMCID: PMC4333679.
    30. Weng T, Poth JM, Karmouty-Quintana H, Garcia-Morales LJ, Melicoff E, Luo F, Chen NY, Evans CM, Bunge RR, Bruckner BA, Loebe M, Volcik KA, Eltzschig HK, Blackburn MR. Hypoxia-induced deoxycytidine kinase contributes to epithelial proliferation in pulmonary fibrosis. Am J Respir Crit Care Med. 2014 Dec 15; 190(12):1402-12. PMID: 25358054; PMCID: PMC4299646.
    31. Kiwamoto T, Katoh T, Evans CM, Janssen WJ, Brummet ME, Hudson SA, Zhu Z, Tiemeyer M, Bochner BS. Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis. J Allergy Clin Immunol. 2015 May; 135(5):1329-1340.e9. PMID: 25497369.
      View in: PubMed
    32. Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, Sisson JH, Woodruff PG, Thornton DJ, Rousseau K, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, O'Neal WK, Flores SC, Cota-Gomez A, Lozupone CA, Donnelly JM, Watson AM, Hennessy CE, Keith RC, Yang IV, Barthel L, Henson PM, Janssen WJ, Schwartz DA, Boucher RC, Dickey BF, Evans CM. Muc5b is required for airway defence. Nature. 2014 Jan 16; 505(7483):412-6. PMID: 24317696.
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    33. Jing J, Yang IV, Hui L, Patel JA, Evans CM, Prikeris R, Kobzik L, O'Connor BP, Schwartz DA. Role of macrophage receptor with collagenous structure in innate immune tolerance. J Immunol. 2013 Jun 15; 190(12):6360-7. PMID: 23667110; PMCID: PMC3679202.
    34. Harrop CA, Gore RB, Evans CM, Thornton DJ, Herrick SE. TGF-ß2 decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells. Exp Lung Res. 2013 Feb; 39(1):39-47. PMID: 23249391.
      View in: PubMed
    35. Koeppen M, McNamee EN, Brodsky KS, Aherne CM, Faigle M, Downey GP, Colgan SP, Evans CM, Schwartz DA, Eltzschig HK. Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury. Mucosal Immunol. 2013 Jul; 6(4):762-75. PMID: 23187315; PMCID: PMC3890100.
    36. Kim K, Petrova YM, Scott BL, Nigam R, Agrawal A, Evans CM, Azzegagh Z, Gomez A, Rodarte EM, Olkkonen VM, Bagirzadeh R, Piccotti L, Ren B, Yoon JH, McNew JA, Adachi R, Tuvim MJ, Dickey BF. Munc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cells. Biochem J. 2012 Sep 15; 446(3):383-94. PMID: 22694344; PMCID: PMC3430001.
    37. Piccotti L, Dickey BF, Evans CM. Assessment of intracellular mucin content in vivo. Methods Mol Biol. 2012; 842:279-95. PMID: 22259143; PMCID: PMC3751172.
    38. Roy MG, Rahmani M, Hernandez JR, Alexander SN, Ehre C, Ho SB, Evans CM. Mucin production during prenatal and postnatal murine lung development. Am J Respir Cell Mol Biol. 2011 Jun; 44(6):755-60. PMID: 21653907; PMCID: PMC3135838.
    39. Seibold MA, Wise AL, Speer MC, Steele MP, Brown KK, Loyd JE, Fingerlin TE, Zhang W, Gudmundsson G, Groshong SD, Evans CM, Garantziotis S, Adler KB, Dickey BF, du Bois RM, Yang IV, Herron A, Kervitsky D, Talbert JL, Markin C, Park J, Crews AL, Slifer SH, Auerbach S, Roy MG, Lin J, Hennessy CE, Schwarz MI, Schwartz DA. A common MUC5B promoter polymorphism and pulmonary fibrosis. N Engl J Med. 2011 Apr 21; 364(16):1503-12. PMID: 21506741.
      View in: PubMed
    40. Hasnain SZ, Evans CM, Roy M, Gallagher AL, Kindrachuk KN, Barron L, Dickey BF, Wilson MS, Wynn TA, Grencis RK, Thornton DJ. Muc5ac: a critical component mediating the rejection of enteric nematodes. J Exp Med. 2011 May 09; 208(5):893-900. PMID: 21502330; PMCID: PMC3092342.
    41. Kelada SN, Wilson MS, Tavarez U, Kubalanza K, Borate B, Whitehead GS, Maruoka S, Roy MG, Olive M, Carpenter DE, Brass DM, Wynn TA, Cook DN, Evans CM, Schwartz DA, Collins FS. Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice. Am J Respir Cell Mol Biol. 2011 Oct; 45(4):817-24. PMID: 21378263; PMCID: PMC3208613.
    42. Ochoa CE, Mirabolfathinejad SG, Ruiz VA, Evans SE, Gagea M, Evans CM, Dickey BF, Moghaddam SJ. Interleukin 6, but not T helper 2 cytokines, promotes lung carcinogenesis. Cancer Prev Res (Phila). 2011 Jan; 4(1):51-64. PMID: 21098042; PMCID: PMC3058282.
    43. Moghaddam SJ, Barta P, Mirabolfathinejad SG, Ammar-Aouchiche Z, Garza NT, Vo TT, Newman RA, Aggarwal BB, Evans CM, Tuvim MJ, Lotan R, Dickey BF. Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. Carcinogenesis. 2009 Nov; 30(11):1949-56. PMID: 19793800; PMCID: PMC2783007.
    44. Jin N, Cho SN, Raso MG, Wistuba I, Smith Y, Yang Y, Kurie JM, Yen R, Evans CM, Ludwig T, Jeong JW, DeMayo FJ. Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis. Development. 2009 Oct; 136(19):3347-56. PMID: 19710174.
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    45. Clement CG, Tuvim MJ, Evans CM, Tuvin DM, Dickey BF, Evans SE. Allergic lung inflammation alters neither susceptibility to Streptococcus pneumoniae infection nor inducibility of innate resistance in mice. Respir Res. 2009 Jul 27; 10:70. PMID: 19635139; PMCID: PMC2724420.
    46. Evans CM, Kim K, Tuvim MJ, Dickey BF. Mucus hypersecretion in asthma: causes and effects. Curr Opin Pulm Med. 2009 Jan; 15(1):4-11. PMID: 19077699; PMCID: PMC2709596.
    47. Kim V, Kelemen SE, Abuel-Haija M, Gaughan JP, Sharafkaneh A, Evans CM, Dickey BF, Solomides CC, Rogers TJ, Criner GJ. Small airway mucous metaplasia and inflammation in chronic obstructive pulmonary disease. COPD. 2008 Dec; 5(6):329-38. PMID: 19353346.
      View in: PubMed
    48. Evans CM, Koo JS. Airway mucus: the good, the bad, the sticky. Pharmacol Ther. 2009 Mar; 121(3):332-48. PMID: 19059283.
      View in: PubMed
    49. Li H, Cho SN, Evans CM, Dickey BF, Jeong JW, DeMayo FJ. Cre-mediated recombination in mouse Clara cells. Genesis. 2008 Jun; 46(6):300-7. PMID: 18543320; PMCID: PMC4539156.
    50. Clement CG, Evans SE, Evans CM, Hawke D, Kobayashi R, Reynolds PR, Moghaddam SJ, Scott BL, Melicoff E, Adachi R, Dickey BF, Tuvim MJ. Stimulation of lung innate immunity protects against lethal pneumococcal pneumonia in mice. Am J Respir Crit Care Med. 2008 Jun 15; 177(12):1322-30. PMID: 18388354; PMCID: PMC2427056.
    51. Iwanaga K, Yang Y, Raso MG, Ma L, Hanna AE, Thilaganathan N, Moghaddam S, Evans CM, Li H, Cai WW, Sato M, Minna JD, Wu H, Creighton CJ, Demayo FJ, Wistuba II, Kurie JM. Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer. Cancer Res. 2008 Feb 15; 68(4):1119-27. PMID: 18281487; PMCID: PMC2750029.
    52. Zhu Y, Ehre C, Abdullah LH, Sheehan JK, Roy M, Evans CM, Dickey BF, Davis CW. Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways. J Physiol. 2008 Apr 01; 586(7):1977-92. PMID: 18258655; PMCID: PMC2375724.
    53. Moghaddam SJ, Clement CG, De la Garza MM, Zou X, Travis EL, Young HW, Evans CM, Tuvim MJ, Dickey BF. Haemophilus influenzae lysate induces aspects of the chronic obstructive pulmonary disease phenotype. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):629-38. PMID: 18096867; PMCID: PMC2396243.
    54. Young HW, Williams OW, Chandra D, Bellinghausen LK, Pérez G, Suárez A, Tuvim MJ, Roy MG, Alexander SN, Moghaddam SJ, Adachi R, Blackburn MR, Dickey BF, Evans CM. Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements. Am J Respir Cell Mol Biol. 2007 Sep; 37(3):273-90. PMID: 17463395; PMCID: PMC1994232.
    55. Young HW, Sun CX, Evans CM, Dickey BF, Blackburn MR. A3 adenosine receptor signaling contributes to airway mucin secretion after allergen challenge. Am J Respir Cell Mol Biol. 2006 Nov; 35(5):549-58. PMID: 16763221; PMCID: PMC2643274.
    56. Adler KB, Shapiro SD, Gallup M, Wu R, Randell SH, Holtzman MJ, Evans CM, Jacoby DB, Tesfaigzi Y, Rose MC, Mossman BT, Prince A, Reddy SP, Davis CW, Matthay MA. Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum. Am J Respir Cell Mol Biol. 2006 May; 34(5):523-6. PMID: 16618787.
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    57. Williams OW, Sharafkhaneh A, Kim V, Dickey BF, Evans CM. Airway mucus: From production to secretion. Am J Respir Cell Mol Biol. 2006 May; 34(5):527-36. PMID: 16415249; PMCID: PMC2644218.
    58. Fryer AD, Stein LH, Nie Z, Curtis DE, Evans CM, Hodgson ST, Jose PJ, Belmonte KE, Fitch E, Jacoby DB. Neuronal eotaxin and the effects of CCR3 antagonist on airway hyperreactivity and M2 receptor dysfunction. J Clin Invest. 2006 Jan; 116(1):228-36. PMID: 16374515; PMCID: PMC1319219.
    59. Evans CM, Williams OW, Tuvim MJ, Nigam R, Mixides GP, Blackburn MR, DeMayo FJ, Burns AR, Smith C, Reynolds SD, Stripp BR, Dickey BF. Mucin is produced by clara cells in the proximal airways of antigen-challenged mice. Am J Respir Cell Mol Biol. 2004 Oct; 31(4):382-94. PMID: 15191915.
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    60. Evans CM, Jacoby DB, Fryer AD. Effects of dexamethasone on antigen-induced airway eosinophilia and M(2) receptor dysfunction. Am J Respir Crit Care Med. 2001 May; 163(6):1484-92. PMID: 11371422.
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    61. Evans CM, Belmonte KE, Costello RW, Jacoby DB, Gleich GJ, Fryer AD. Substance P-induced airway hyperreactivity is mediated by neuronal M(2) receptor dysfunction. Am J Physiol Lung Cell Mol Physiol. 2000 Sep; 279(3):L477-86. PMID: 10956622.
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    62. Costello RW, Evans CM, Yost BL, Belmonte KE, Gleich GJ, Jacoby DB, Fryer AD. Antigen-induced hyperreactivity to histamine: role of the vagus nerves and eosinophils. Am J Physiol. 1999 05; 276(5):L709-14. PMID: 10330026.
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    63. Evans CM, Fryer AD, Jacoby DB, Gleich GJ, Costello RW. Pretreatment with antibody to eosinophil major basic protein prevents hyperresponsiveness by protecting neuronal M2 muscarinic receptors in antigen-challenged guinea pigs. J Clin Invest. 1997 Nov 01; 100(9):2254-62. PMID: 9410903; PMCID: PMC508421.
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