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Kristen E. Boyle

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone303/724-5969

    Collapse Research 
    Collapse research activities and funding
    F32DK089743     (BOYLE, KRISTEN ELIZABETH)Jan 1, 2011 - Dec 31, 2012
    NIH
    Cellular Mechanisms for Insulin Resistance in Human Gestational Diabetes Mellitus
    Role: Principal Investigator
    K01DK106347     (BOYLE, KRISTEN ELIZABETH)Jul 15, 2015 - Apr 30, 2019
    NIH
    Human Mesenchymal Stem Cells and the Epigenetic Programming of Obesity
    Role: Principal Investigator
    UG3OD023248     (DABELEA, DANA)Sep 21, 2016 - Aug 31, 2018
    NIH
    The Early Life Exposome and Childhood Health - The Colorado Healthy Start 3 Cohort Study
    Role: Co-Investigator
    UH3OD023248     (DABELEA, DANA)Sep 21, 2016 - Aug 31, 2023
    NIH
    The Early Life Exposome and Childhood Health - The Colorado Healthy Start 3 Cohort Study
    Role: Co-Investigator
    ADA CORE 1-18-ICTS-016     (BOYLE, KRISTEN ELIZABETH)Jan 1, 2018 - Jun 30, 2021
    American Diabetes Association
    Umbilical cord-derived stem cell metabolism: Understanding mechanisms for childhood obesity risk
    Role: Principle Investigator
    R01DK117168     (BOYLE, KRISTEN ELIZABETH)Jul 25, 2018 - Jun 30, 2023
    NIH
    Epigenetic programming of infant mesenchymal stem cells: mechanisms for obesity and diabetes risk in humans
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Keleher MR, Erickson K, Smith HA, Kechris KJ, Yang IV, Dabelea D, Friedman JE, Boyle KE, Jansson T. Placental Insulin/IGF-1 Signaling, PGC-1a, and Inflammatory Pathways Are Associated With Metabolic Outcomes at 4-6 Years of Age: The ECHO Healthy Start Cohort. Diabetes. 2021 Mar; 70(3):745-751. PMID: 33414248.
      View in: PubMed
    2. Starling AP, Liu C, Shen G, Yang IV, Kechris K, Borengasser SJ, Boyle KE, Zhang W, Smith HA, Calafat AM, Hamman RF, Adgate JL, Dabelea D. Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Umbilical Cord Blood DNA Methylation, and Cardio-Metabolic Indicators in Newborns: The Healthy Start Study. Environ Health Perspect. 2020 12; 128(12):127014. PMID: 33356526.
      View in: PubMed
    3. Keleher MR, Erickson K, Kechris K, Yang IV, Dabelea D, Friedman JE, Boyle KE, Jansson T. Associations between the activity of placental nutrient-sensing pathways and neonatal and postnatal metabolic health: the ECHO Healthy Start cohort. Int J Obes (Lond). 2020 Nov; 44(11):2203-2212. PMID: 32327723.
      View in: PubMed
    4. Boyle KE, Magill-Collins MJ, Newsom SA, Janssen RC, Friedman JE. Maternal Fat-1 Transgene Protects Offspring from Excess Weight Gain, Oxidative Stress, and Reduced Fatty Acid Oxidation in Response to High-Fat Diet. Nutrients. 2020 Mar 14; 12(3). PMID: 32183350.
      View in: PubMed
    5. Janssen RC, Boyle KE. Microplate Assays for Spectrophotometric Measurement of Mitochondrial Enzyme Activity. Methods Mol Biol. 2019; 1978:355-368. PMID: 31119674.
      View in: PubMed
    6. Bruce KD, Gorkhali S, Given K, Coates AM, Boyle KE, Macklin WB, Eckel RH. Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination. Front Mol Neurosci. 2018; 11:57. PMID: 29599706.
      View in: PubMed
    7. Baker PR, Patinkin Z, Shapiro AL, De La Houssaye BA, Woontner M, Boyle KE, Vanderlinden L, Dabelea D, Friedman JE. Maternal obesity and increased neonatal adiposity correspond with altered infant mesenchymal stem cell metabolism. JCI Insight. 2017 11 02; 2(21). PMID: 29093265.
      View in: PubMed
    8. Boyle KE, Patinkin ZW, Shapiro ALB, Bader C, Vanderlinden L, Kechris K, Janssen RC, Ford RJ, Smith BK, Steinberg GR, Davidson EJ, Yang IV, Dabelea D, Friedman JE. Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants. Mol Metab. 2017 11; 6(11):1503-1516. PMID: 29107296.
      View in: PubMed
    9. Cavalli G, Justice JN, Boyle KE, D'Alessandro A, Eisenmesser EZ, Herrera JJ, Hansen KC, Nemkov T, Stienstra R, Garlanda C, Mantovani A, Seals DR, Dagna L, Joosten LA, Ballak DB, Dinarello CA. Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2313-2318. PMID: 28193888.
      View in: PubMed
    10. Boyle KE, Friedman JE, Janssen RC, Underkofler C, Houmard JA, Rasouli N. Metabolic Inflexibility with Obesity and the Effects of Fenofibrate on Skeletal Muscle Fatty Acid Oxidation. Horm Metab Res. 2017 Jan; 49(1):50-57. PMID: 28103623.
      View in: PubMed
    11. Shapiro AL, Boyle KE, Dabelea D, Patinkin ZW, De la Houssaye B, Ringham BM, Glueck DH, Barbour LA, Norris JM, Friedman JE. Nicotinamide Promotes Adipogenesis in Umbilical Cord-Derived Mesenchymal Stem Cells and Is Associated with Neonatal Adiposity: The Healthy Start BabyBUMP Project. PLoS One. 2016; 11(7):e0159575. PMID: 27414406.
      View in: PubMed
    12. Boyle KE, Patinkin ZW, Shapiro AL, Baker PR, Dabelea D, Friedman JE. Mesenchymal Stem Cells From Infants Born to Obese Mothers Exhibit Greater Potential for Adipogenesis: The Healthy Start BabyBUMP Project. Diabetes. 2016 Mar; 65(3):647-59. PMID: 26631736.
      View in: PubMed
    13. Schlaepfer IR, Glodé LM, Hitz CA, Pac CT, Boyle KE, Maroni P, Deep G, Agarwal R, Lucia SM, Cramer SD, Serkova NJ, Eckel RH. Inhibition of Lipid Oxidation Increases Glucose Metabolism and Enhances 2-Deoxy-2-[(18)F]Fluoro-D-Glucose Uptake in Prostate Cancer Mouse Xenografts. Mol Imaging Biol. 2015 Aug; 17(4):529-38. PMID: 25561013.
      View in: PubMed
    14. Baker PR, Boyle KE, Koves TR, Ilkayeva OR, Muoio DM, Houmard JA, Friedman JE. Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans. Obesity (Silver Spring). 2015 May; 23(5):981-988. PMID: 25864501.
      View in: PubMed
    15. Boyle KE, Hwang H, Janssen RC, DeVente JM, Barbour LA, Hernandez TL, Mandarino LJ, Lappas M, Friedman JE. Gestational diabetes is characterized by reduced mitochondrial protein expression and altered calcium signaling proteins in skeletal muscle. PLoS One. 2014; 9(9):e106872. PMID: 25216282.
      View in: PubMed
    16. Boyle KE, Newsom SA, Janssen RC, Lappas M, Friedman JE. Skeletal muscle MnSOD, mitochondrial complex II, and SIRT3 enzyme activities are decreased in maternal obesity during human pregnancy and gestational diabetes mellitus. J Clin Endocrinol Metab. 2013 Oct; 98(10):E1601-9. PMID: 23956348.
      View in: PubMed
    17. Newsom SA, Boyle KE, Friedman JE. Sirtuin 3: A major control point for obesity-related metabolic diseases? Drug Discov Today Dis Mech. 2013 Jun 01; 10(1-2):e35-e40. PMID: 23997790.
      View in: PubMed
    18. Boyle KE, Zheng D, Anderson EJ, Neufer PD, Houmard JA. Mitochondrial lipid oxidation is impaired in cultured myotubes from obese humans. Int J Obes (Lond). 2012 Aug; 36(8):1025-31. PMID: 22024640.
      View in: PubMed
    19. Boyle KE, Canham JP, Consitt LA, Zheng D, Koves TR, Gavin TP, Holbert D, Neufer PD, Ilkayeva O, Muoio DM, Houmard JA. A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals. J Clin Endocrinol Metab. 2011 Mar; 96(3):775-81. PMID: 21190973.
      View in: PubMed
    20. Howe HR, Heidal K, Choi MD, Kraus RM, Boyle K, Hickner RC. Increased adipose tissue lipolysis after a 2-week high-fat diet in sedentary overweight/obese men. Metabolism. 2011 Jul; 60(7):976-81. PMID: 21040937.
      View in: PubMed
    21. Anderson EJ, Lustig ME, Boyle KE, Woodlief TL, Kane DA, Lin CT, Price JW, Kang L, Rabinovitch PS, Szeto HH, Houmard JA, Cortright RN, Wasserman DH, Neufer PD. Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J Clin Invest. 2009 Mar; 119(3):573-81. PMID: 19188683.
      View in: PubMed
    22. Hittel DS, Berggren JR, Shearer J, Boyle K, Houmard JA. Increased secretion and expression of myostatin in skeletal muscle from extremely obese women. Diabetes. 2009 Jan; 58(1):30-8. PMID: 18835929.
      View in: PubMed
    23. Berggren JR, Boyle KE, Chapman WH, Houmard JA. Skeletal muscle lipid oxidation and obesity: influence of weight loss and exercise. Am J Physiol Endocrinol Metab. 2008 Apr; 294(4):E726-32. PMID: 18252891.
      View in: PubMed
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