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Kristen E. Boyle

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone303/724-5969

    Collapse Research 
    Collapse research activities and funding
    R01MD017387     (WADHWA, PATHIK D)Sep 26, 2022 - Jun 30, 2027
    NIH
    BIOLOGICAL EMBEDDING OF SOCIAL DISADVANTAGE IN HUMAN STEM CELLS: IMPLICATIONS FOR HEALTH DISPARITIES
    Role: Principal Investigator
    R01HD107176     (WADHWA, PATHIK D)Aug 15, 2022 - Jun 30, 2027
    NIH
    Stress and Human Stem/Progenitor Cells: Biobehavioral Mechanisms
    Role: Principal Investigator
    R01HD102726     (BARBOUR, LINDA ANNE)May 7, 2021 - Mar 31, 2027
    NIH
    Triglycerides as a Predictor of Newborn Subcutaneous and Liver Fat: Contributors to Fetal Fat Accretion in Obese Pregnancies
    Role: Co-Investigator
    R01DK117168     (BOYLE, KRISTEN ELIZABETH)Jul 25, 2018 - Jun 30, 2024
    NIH
    Epigenetic programming of infant mesenchymal stem cells: mechanisms for obesity and diabetes risk in humans
    Role: Principal Investigator
    ADA CORE 1-18-ICTS-016     (BOYLE, KRISTEN ELIZABETH)Jan 1, 2018 - Jun 30, 2021
    American Diabetes Association
    Umbilical cord-derived stem cell metabolism: Understanding mechanisms for childhood obesity risk
    Role: Principle Investigator
    UG3OD023248     (DABELEA, DANA)Sep 21, 2016 - May 31, 2025
    NIH
    Environmental influences on Child Health Outcomes - The Colorado ECHO Pediatric Cohort
    Role: Co-Investigator
    UH3OD023248     (DABELEA, DANA)Sep 21, 2016 - Aug 31, 2023
    NIH
    The Early Life Exposome and Childhood Health - The Colorado Healthy Start 3 Cohort Study
    Role: Co-Investigator
    K01DK106347     (BOYLE, KRISTEN ELIZABETH)Jul 15, 2015 - Apr 30, 2019
    NIH
    Human Mesenchymal Stem Cells and the Epigenetic Programming of Obesity
    Role: Principal Investigator
    F32DK089743     (BOYLE, KRISTEN ELIZABETH)Jan 1, 2011 - Dec 31, 2012
    NIH
    Cellular Mechanisms for Insulin Resistance in Human Gestational Diabetes Mellitus
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Semnani-Azad Z, Gaillard R, Hughes AE, Boyle KE, Tobias DK, Perng W. Precision stratification of prognostic risk factors associated with outcomes in gestational diabetes mellitus: a systematic review. Commun Med (Lond). 2024 Jan 12; 4(1):9. PMID: 38216688.
      View in: PubMed
    2. Erickson ML, Dobias D, Keleher MR, Dabelea D, Bergman BC, Broussard JL, Boyle KE. In Vitro Circadian Clock Gene Expression Assessments in Mesenchymal Stem Cells from Human Infants: A Pilot Study. Nutrients. 2023 Dec 23; 16(1). PMID: 38201882.
      View in: PubMed
    3. Starling AP, Friedman C, Boyle KE, Adgate JL, Glueck DH, Allshouse WB, Calafat AM, Bloemsma LD, Dabelea D. Prenatal exposure to per- and polyfluoroalkyl substances and early childhood adiposity and cardiometabolic health in the Healthy Start study. Int J Obes (Lond). 2024 02; 48(2):276-283. PMID: 38042932.
      View in: PubMed
    4. Song AY, Bulka CM, Niemiec SS, Kechris K, Boyle KE, Marsit CJ, O'Shea TM, Fry RC, Lyall K, Fallin MD, Volk HE, Ladd-Acosta C. Accelerated epigenetic age at birth and child emotional and behavioura development in early childhood: a meta-analysis of four prospective cohort studies in ECHO. Epigenetics. 2023 12; 18(1):2254971. PMID: 37691382.
      View in: PubMed
    5. Bulka CM, Everson TM, Burt AA, Marsit CJ, Karagas MR, Boyle KE, Niemiec S, Kechris K, Davidson EJ, Yang IV, Feinberg JI, Volk HE, Ladd-Acosta C, Breton CV, O'Shea TM, Fry RC. Sex-based differences in placental DNA methylation profiles related to gestational age: an NIH ECHO meta-analysis. Epigenetics. 2023 Dec; 18(1):2179726. PMID: 36840948.
      View in: PubMed
    6. Starling AP, Liu C, Shen G, Yang IV, Kechris K, Borengasser SJ, Boyle KE, Zhang W, Smith HA, Calafat AM, Hamman RF, Adgate JL, Dabelea D. Erratum: "Prenatal Exposure to per- and Polyfluoroalkyl Substances, Umbilical Cord Blood DNA Methylation, and Cardio-Metabolic Indicators in Newborns: The Healthy Start Study". Environ Health Perspect. 2023 Nov; 131(11):119001. PMID: 38033175.
      View in: PubMed
    7. Waldrop SW, Niemiec S, Wood C, Gyllenhammer LE, Jansson T, Friedman JE, Tryggestad JB, Borengasser SJ, Davidson EJ, Yang IV, Kechris K, Dabelea D, Boyle KE. Cord blood DNA methylation of immune and lipid metabolism genes is associated with maternal triglycerides and child adiposity. Obesity (Silver Spring). 2024 01; 32(1):187-199. PMID: 37869908.
      View in: PubMed
    8. Tobias DK, Merino J, Ahmad A, Aiken C, Benham JL, Bodhini D, Clark AL, Colclough K, Corcoy R, Cromer SJ, Duan D, Felton JL, Francis EC, Gillard P, Gingras V, Gaillard R, Haider E, Hughes A, Ikle JM, Jacobsen LM, Kahkoska AR, Kettunen JLT, Kreienkamp RJ, Lim LL, M?nnist? JME, Massey R, Mclennan NM, Miller RG, Morieri ML, Most J, Naylor RN, Ozkan B, Patel KA, Pilla SJ, Prystupa K, Raghavan S, Rooney MR, Sch?n M, Semnani-Azad Z, Sevilla-Gonzalez M, Svalastoga P, Takele WW, Tam CH, Thuesen ACB, Tosur M, Wallace AS, Wang CC, Wong JJ, Yamamoto JM, Young K, Amouyal C, Andersen MK, Bonham MP, Chen M, Cheng F, Chikowore T, Chivers SC, Clemmensen C, Dabelea D, Dawed AY, Deutsch AJ, Dickens LT, DiMeglio LA, Dudenh?ffer-Pfeifer M, Evans-Molina C, Fern?ndez-Balsells MM, Fitipaldi H, Fitzpatrick SL, Gitelman SE, Goodarzi MO, Grieger JA, Guasch-Ferr? M, Habibi N, Hansen T, Huang C, Harris-Kawano A, Ismail HM, Hoag B, Johnson RK, Jones AG, Koivula RW, Leong A, Leung GKW, Libman IM, Liu K, Long SA, Lowe WL, Morton RW, Motala AA, Onengut-Gumuscu S, Pankow JS, Pathirana M, Pazmino S, Perez D, Petrie JR, Powe CE, Quinteros A, Jain R, Ray D, Ried-Larsen M, Saeed Z, Santhakumar V, Kanbour S, Sarkar S, Monaco GSF, Scholtens DM, Selvin E, Sheu WH, Speake C, Stanislawski MA, Steenackers N, Steck AK, Stefan N, St?y J, Taylor R, Tye SC, Ukke GG, Urazbayeva M, Van der Schueren B, Vatier C, Wentworth JM, Hannah W, White SL, Yu G, Zhang Y, Zhou SJ, Beltrand J, Polak M, Aukrust I, de Franco E, Flanagan SE, Maloney KA, McGovern A, Molnes J, Nakabuye M, Nj?lstad PR, Pomares-Millan H, Provenzano M, Saint-Martin C, Zhang C, Zhu Y, Auh S, de Souza R, Fawcett AJ, Gruber C, Mekonnen EG, Mixter E, Sherifali D, Eckel RH, Nolan JJ, Philipson LH, Brown RJ, Billings LK, Boyle K, Costacou T, Dennis JM, Florez JC, Gloyn AL, Gomez MF, Gottlieb PA, Greeley SAW, Griffin K, Hattersley AT, Hirsch IB, Hivert MF, Hood KK, Josefson JL, Kwak SH, Laffel LM, Lim SS, Loos RJF, Ma RCW, Mathieu C, Mathioudakis N, Meigs JB, Misra S, Mohan V, Murphy R, Oram R, Owen KR, Ozanne SE, Pearson ER, Perng W, Pollin TI, Pop-Busui R, Pratley RE, Redman LM, Redondo MJ, Reynolds RM, Semple RK, Sherr JL, Sims EK, Sweeting A, Tuomi T, Udler MS, Vesco KK, Vilsb?ll T, Wagner R, Rich SS, Franks PW. Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine. Nat Med. 2023 Oct; 29(10):2438-2457. PMID: 37794253.
      View in: PubMed
    9. Keleher MR, Shubhangi S, Brown A, Duensing AM, Lixandr?o ME, Gavin KM, Smith HA, Kechris KJ, Yang IV, Dabelea D, Boyle KE. Adipocyte hypertrophy in mesenchymal stem cells from infants of mothers with obesity. Obesity (Silver Spring). 2023 08; 31(8):2090-2102. PMID: 37475691.
      View in: PubMed
    10. Semnani-Azad Z, Gaillard R, Hughes AE, Boyle KE, Tobias DK, Perng W. Predictors and risk factors of short-term and long-term outcomes among women with gestational diabetes mellitus (GDM) and their offspring: Moving toward precision prognosis? medRxiv. 2023 Apr 19. PMID: 37131686.
      View in: PubMed
    11. Gyllenhammer LE, Duensing AM, Keleher MR, Kechris K, Dabelea D, Boyle KE. Fat content in infant mesenchymal stem cells prospectively associates with childhood adiposity and fasting glucose. Obesity (Silver Spring). 2023 01; 31(1):37-42. PMID: 36541155.
      View in: PubMed
    12. Chaves AB, Zheng D, Johnson JA, Bergman BC, Patinkin ZW, Zaegel V, Biagioni EM, Krassovskaia P, Broskey NT, May LE, Dabelea D, Houmard JA, Boyle KE. Infant Mesenchymal Stem Cell Insulin Action Is Associated With Maternal Plasma Free Fatty Acids, Independent of Obesity Status: The Healthy Start Study. Diabetes. 2022 08 01; 71(8):1649-1659. PMID: 35621990.
      View in: PubMed
    13. Gyllenhammer LE, Picard M, McGill MA, Boyle KE, Vawter MP, Rasmussen JM, Buss C, Entringer S, Wadhwa PD. Prospective association between maternal allostatic load during pregnancy and child mitochondrial content and bioenergetic capacity. Psychoneuroendocrinology. 2022 10; 144:105868. PMID: 35853381.
      View in: PubMed
    14. Chaves A, Weyrauch LA, Zheng D, Biagioni EM, Krassovskaia PM, Davidson BL, Broskey NT, Boyle KE, May LE, Houmard JA. Influence of Maternal Exercise on Glucose and Lipid Metabolism in Offspring Stem Cells: ENHANCED by Mom. J Clin Endocrinol Metab. 2022 07 14; 107(8):e3353-e3365. PMID: 35511592.
      View in: PubMed
    15. Francis EC, Dabelea D, Boyle KE, Jansson T, Perng W. Maternal Diet Quality Is Associated with Placental Proteins in the Placental Insulin/Growth Factor, Environmental Stress, Inflammation, and mTOR Signaling Pathways: The Healthy Start ECHO Cohort. J Nutr. 2022 03 03; 152(3):816-825. PMID: 34850052.
      View in: PubMed
    16. Flanagan EW, Most J, Altazan AD, Boyle KE, Redman LM. A role for the early pregnancy maternal milieu in the intergenerational transmission of obesity. Obesity (Silver Spring). 2021 11; 29(11):1780-1786. PMID: 34734494.
      View in: PubMed
    17. Erickson ML, Patinkin ZW, Duensing AM, Dabelea D, Redman LM, Boyle KE. Maternal metabolic health drives mesenchymal stem cell metabolism and infant fat mass at birth. JCI Insight. 2021 07 08; 6(13). PMID: 34061777.
      View in: PubMed
    18. Keleher MR, Erickson K, Smith HA, Kechris KJ, Yang IV, Dabelea D, Friedman JE, Boyle KE, Jansson T. Placental Insulin/IGF-1 Signaling, PGC-1a, and Inflammatory Pathways Are Associated With Metabolic Outcomes at 4-6 Years of Age: The ECHO Healthy Start Cohort. Diabetes. 2021 03; 70(3):745-751. PMID: 33414248.
      View in: PubMed
    19. Starling AP, Liu C, Shen G, Yang IV, Kechris K, Borengasser SJ, Boyle KE, Zhang W, Smith HA, Calafat AM, Hamman RF, Adgate JL, Dabelea D. Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Umbilical Cord Blood DNA Methylation, and Cardio-Metabolic Indicators in Newborns: The Healthy Start Study. Environ Health Perspect. 2020 12; 128(12):127014. PMID: 33356526.
      View in: PubMed
    20. Keleher MR, Erickson K, Kechris K, Yang IV, Dabelea D, Friedman JE, Boyle KE, Jansson T. Associations between the activity of placental nutrient-sensing pathways and neonatal and postnatal metabolic health: the ECHO Healthy Start cohort. Int J Obes (Lond). 2020 11; 44(11):2203-2212. PMID: 32327723.
      View in: PubMed
    21. Boyle KE, Magill-Collins MJ, Newsom SA, Janssen RC, Friedman JE. Maternal Fat-1 Transgene Protects Offspring from Excess Weight Gain, Oxidative Stress, and Reduced Fatty Acid Oxidation in Response to High-Fat Diet. Nutrients. 2020 Mar 14; 12(3). PMID: 32183350.
      View in: PubMed
    22. Janssen RC, Boyle KE. Microplate Assays for Spectrophotometric Measurement of Mitochondrial Enzyme Activity. Methods Mol Biol. 2019; 1978:355-368. PMID: 31119674.
      View in: PubMed
    23. Bruce KD, Gorkhali S, Given K, Coates AM, Boyle KE, Macklin WB, Eckel RH. Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination. Front Mol Neurosci. 2018; 11:57. PMID: 29599706.
      View in: PubMed
    24. Baker PR, Patinkin Z, Shapiro AL, De La Houssaye BA, Woontner M, Boyle KE, Vanderlinden L, Dabelea D, Friedman JE. Maternal obesity and increased neonatal adiposity correspond with altered infant mesenchymal stem cell metabolism. JCI Insight. 2017 11 02; 2(21). PMID: 29093265.
      View in: PubMed
    25. Boyle KE, Patinkin ZW, Shapiro ALB, Bader C, Vanderlinden L, Kechris K, Janssen RC, Ford RJ, Smith BK, Steinberg GR, Davidson EJ, Yang IV, Dabelea D, Friedman JE. Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants. Mol Metab. 2017 11; 6(11):1503-1516. PMID: 29107296.
      View in: PubMed
    26. Cavalli G, Justice JN, Boyle KE, D'Alessandro A, Eisenmesser EZ, Herrera JJ, Hansen KC, Nemkov T, Stienstra R, Garlanda C, Mantovani A, Seals DR, Dagna L, Joosten LA, Ballak DB, Dinarello CA. Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2313-2318. PMID: 28193888.
      View in: PubMed
    27. Boyle KE, Friedman JE, Janssen RC, Underkofler C, Houmard JA, Rasouli N. Metabolic Inflexibility with Obesity and the Effects of Fenofibrate on Skeletal Muscle Fatty Acid Oxidation. Horm Metab Res. 2017 Jan; 49(1):50-57. PMID: 28103623.
      View in: PubMed
    28. Shapiro AL, Boyle KE, Dabelea D, Patinkin ZW, De la Houssaye B, Ringham BM, Glueck DH, Barbour LA, Norris JM, Friedman JE. Nicotinamide Promotes Adipogenesis in Umbilical Cord-Derived Mesenchymal Stem Cells and Is Associated with Neonatal Adiposity: The Healthy Start BabyBUMP Project. PLoS One. 2016; 11(7):e0159575. PMID: 27414406.
      View in: PubMed
    29. Boyle KE, Patinkin ZW, Shapiro AL, Baker PR, Dabelea D, Friedman JE. Mesenchymal Stem Cells From Infants Born to Obese Mothers Exhibit Greater Potential for Adipogenesis: The Healthy Start BabyBUMP Project. Diabetes. 2016 Mar; 65(3):647-59. PMID: 26631736.
      View in: PubMed
    30. Schlaepfer IR, Glod? LM, Hitz CA, Pac CT, Boyle KE, Maroni P, Deep G, Agarwal R, Lucia SM, Cramer SD, Serkova NJ, Eckel RH. Inhibition of Lipid Oxidation Increases Glucose Metabolism and Enhances 2-Deoxy-2-[(18)F]Fluoro-D-Glucose Uptake in Prostate Cancer Mouse Xenografts. Mol Imaging Biol. 2015 Aug; 17(4):529-38. PMID: 25561013.
      View in: PubMed
    31. Baker PR, Boyle KE, Koves TR, Ilkayeva OR, Muoio DM, Houmard JA, Friedman JE. Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans. Obesity (Silver Spring). 2015 May; 23(5):981-988. PMID: 25864501.
      View in: PubMed
    32. Boyle KE, Hwang H, Janssen RC, DeVente JM, Barbour LA, Hernandez TL, Mandarino LJ, Lappas M, Friedman JE. Gestational diabetes is characterized by reduced mitochondrial protein expression and altered calcium signaling proteins in skeletal muscle. PLoS One. 2014; 9(9):e106872. PMID: 25216282.
      View in: PubMed
    33. Boyle KE, Newsom SA, Janssen RC, Lappas M, Friedman JE. Skeletal muscle MnSOD, mitochondrial complex II, and SIRT3 enzyme activities are decreased in maternal obesity during human pregnancy and gestational diabetes mellitus. J Clin Endocrinol Metab. 2013 Oct; 98(10):E1601-9. PMID: 23956348.
      View in: PubMed
    34. Newsom SA, Boyle KE, Friedman JE. Sirtuin 3: A major control point for obesity-related metabolic diseases? Drug Discov Today Dis Mech. 2013 Jun 01; 10(1-2):e35-e40. PMID: 23997790.
      View in: PubMed
    35. Boyle KE, Zheng D, Anderson EJ, Neufer PD, Houmard JA. Mitochondrial lipid oxidation is impaired in cultured myotubes from obese humans. Int J Obes (Lond). 2012 Aug; 36(8):1025-31. PMID: 22024640.
      View in: PubMed
    36. Boyle KE, Canham JP, Consitt LA, Zheng D, Koves TR, Gavin TP, Holbert D, Neufer PD, Ilkayeva O, Muoio DM, Houmard JA. A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals. J Clin Endocrinol Metab. 2011 Mar; 96(3):775-81. PMID: 21190973.
      View in: PubMed
    37. Howe HR, Heidal K, Choi MD, Kraus RM, Boyle K, Hickner RC. Increased adipose tissue lipolysis after a 2-week high-fat diet in sedentary overweight/obese men. Metabolism. 2011 Jul; 60(7):976-81. PMID: 21040937.
      View in: PubMed
    38. Anderson EJ, Lustig ME, Boyle KE, Woodlief TL, Kane DA, Lin CT, Price JW, Kang L, Rabinovitch PS, Szeto HH, Houmard JA, Cortright RN, Wasserman DH, Neufer PD. Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J Clin Invest. 2009 Mar; 119(3):573-81. PMID: 19188683.
      View in: PubMed
    39. Hittel DS, Berggren JR, Shearer J, Boyle K, Houmard JA. Increased secretion and expression of myostatin in skeletal muscle from extremely obese women. Diabetes. 2009 Jan; 58(1):30-8. PMID: 18835929.
      View in: PubMed
    40. Berggren JR, Boyle KE, Chapman WH, Houmard JA. Skeletal muscle lipid oxidation and obesity: influence of weight loss and exercise. Am J Physiol Endocrinol Metab. 2008 Apr; 294(4):E726-32. PMID: 18252891.
      View in: PubMed
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