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Andrew Getahun

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER
Phone303/724-7279

    Collapse Research 
    Collapse research activities and funding
    R01AI182423     (GETAHUN, ANDREW)Aug 12, 2024 - Jul 31, 2029
    NIH
    CD79A as a molecular switch regulating B cell activation
    Role: Principal Investigator
    R21AI149019     (GETAHUN, ANDREW)Jun 9, 2020 - May 31, 2022
    NIH
    Identification of novel Inhibitory receptors Involved In B cell tolerance
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Fiske BE, Wemlinger SM, Crute BW, Getahun A. The Src-family kinase Lyn plays a critical role in establishing and maintaining B cell anergy by suppressing PI3K-dependent signaling. bioRxiv. 2024 May 24. PMID: 38826354.
      View in: PubMed
    2. Fiske BE, Getahun A. Failed Downregulation of PI3K Signaling Makes Autoreactive B Cells Receptive to Bystander T Cell Help. J Immunol. 2024 Apr 01; 212(7):1150-1160. PMID: 38353615.
      View in: PubMed
    3. Palmer WH, Leaton LA, Campos Codo A, Crute B, Roest J, Zhu S, Petersen J, Tobin RP, Hume PS, Stone M, van Bokhoven A, Gerich ME, McCarter MD, Zhu Y, Janssen WJ, Vivian JP, Trowsdale J, Getahun A, Rossjohn J, Cambier J, Loh L, Norman PJ. Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells. Sci Immunol. 2023 06 30; 8(84):eade5343. PMID: 37390222.
      View in: PubMed
    4. Banach M, Harley ITW, Getahun A, Cambier JC. Comparative analysis of the repertoire of insulin-reactive B cells in type 1 diabetes-prone and resistant mice. Front Immunol. 2022; 13:961209. PMID: 36275764.
      View in: PubMed
    5. Wemlinger SM, Parker Harp CR, Yu B, Hardy IR, Seefeldt M, Matsuda J, Mingueneau M, Spilker KA, Cameron TO, Larrick JW, Getahun A, Cambier JC. Preclinical Analysis of Candidate Anti-Human CD79 Therapeutic Antibodies Using a Humanized CD79 Mouse Model. J Immunol. 2022 04 01; 208(7):1566-1584. PMID: 35321883.
      View in: PubMed
    6. Getahun A. Role of inhibitory signaling in peripheral B cell tolerance. Immunol Rev. 2022 05; 307(1):27-42. PMID: 35128676.
      View in: PubMed
    7. Klarquist J, Cross EW, Thompson SB, Willett B, Aldridge DL, Caffrey-Carr AK, Xu Z, Hunter CA, Getahun A, Kedl RM. B cells promote CD8 T?cell primary and memory responses to subunit vaccines. Cell Rep. 2021 08 24; 36(8):109591. PMID: 34433030.
      View in: PubMed
    8. Crute BW, Sheraden R, Ott VL, Harley ITW, Getahun A, Cambier JC. Inhibitory Receptor Trap: A Platform for Discovery of Inhibitory Receptors That Utilize Inositol Lipid and Phosphotyrosine Phosphatase Effectors. Front Immunol. 2020; 11:592329. PMID: 33193438.
      View in: PubMed
    9. Walker MM, Kim S, Crisler WJ, Nguyen K, Lenz LL, Cambier JC, Getahun A. Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H. Front Immunol. 2020; 11:238. PMID: 32153571.
      View in: PubMed
    10. Phalke SP, Huang Y, Rubtsova K, Getahun A, Sun D, Reinhardt RL, O'Brien RL, Born WK. ?d T cells shape memory-phenotype a? T cell populations in non-immunized mice. PLoS One. 2019; 14(6):e0218827. PMID: 31237933.
      View in: PubMed
    11. Atif SM, Mack DG, McKee AS, Rangel-Moreno J, Martin AK, Getahun A, Maier LA, Cambier JC, Tuder R, Fontenot AP. Protective role of B cells in sterile particulate-induced lung injury. JCI Insight. 2019 05 16; 5. PMID: 31094704.
      View in: PubMed
    12. Franks SE, Getahun A, Cambier JC. A Precision B Cell-Targeted Therapeutic Approach to Autoimmunity Caused by Phosphatidylinositol 3-Kinase Pathway Dysregulation. J Immunol. 2019 06 15; 202(12):3381-3393. PMID: 31076529.
      View in: PubMed
    13. Getahun A, Cambier JC. Non-Antibody-Secreting Functions of B Cells and Their Contribution to Autoimmune Disease. Annu Rev Cell Dev Biol. 2019 10 06; 35:337-356. PMID: 30883216.
      View in: PubMed
    14. Smith MJ, Ford BR, Rihanek M, Coleman BM, Getahun A, Sarapura VD, Gottlieb PA, Cambier JC. Elevated PTEN expression maintains anergy in human B cells and reveals unexpectedly high repertoire autoreactivity. JCI Insight. 2019 Feb 07; 4(3). PMID: 30728334.
      View in: PubMed
    15. Benhamou D, Labi V, Getahun A, Benchetrit E, Dowery R, Rajewsky K, Cambier JC, Melamed D. The c-Myc/miR17-92/PTEN Axis Tunes PI3K Activity to Control Expression of Recombination Activating Genes in Early B Cell Development. Front Immunol. 2018; 9:2715. PMID: 30524445.
      View in: PubMed
    16. Walker MM, Crute BW, Cambier JC, Getahun A. B Cell-Intrinsic STING Signaling Triggers Cell Activation, Synergizes with B Cell Receptor Signals, and Promotes Antibody Responses. J Immunol. 2018 11 01; 201(9):2641-2653. PMID: 30282750.
      View in: PubMed
    17. Smith MJ, Hinman RM, Getahun A, Kim S, Packard TA, Cambier JC. Silencing of high-affinity insulin-reactive B lymphocytes by anergy and impact of the NOD genetic background in mice. Diabetologia. 2018 12; 61(12):2621-2632. PMID: 30255377.
      View in: PubMed
    18. Kogut I, McCarthy SM, Pavlova M, Astling DP, Chen X, Jakimenko A, Jones KL, Getahun A, Cambier JC, Pasmooij AMG, Jonkman MF, Roop DR, Bilousova G. High-efficiency RNA-based reprogramming of human primary fibroblasts. Nat Commun. 2018 02 21; 9(1):745. PMID: 29467427.
      View in: PubMed
    19. Getahun A, Wemlinger SM, Rudra P, Santiago ML, van Dyk LF, Cambier JC. Impaired B cell function during viral infections due to PTEN-mediated inhibition of the PI3K pathway. J Exp Med. 2017 04 03; 214(4):931-941. PMID: 28341640.
      View in: PubMed
    20. Packard TA, Smith MJ, Conrad FJ, Johnson SA, Getahun A, Lindsay RS, Hinman RM, Friedman RS, Thomas JW, Cambier JC. B Cell Receptor Affinity for Insulin Dictates Autoantigen Acquisition and B Cell Functionality in Autoimmune Diabetes. J Clin Med. 2016 Nov 08; 5(11). PMID: 27834793.
      View in: PubMed
    21. Franks SE, Getahun A, Hogarth PM, Cambier JC. Targeting B cells in treatment of autoimmunity. Curr Opin Immunol. 2016 12; 43:39-45. PMID: 27718447.
      View in: PubMed
    22. Getahun A, Beavers NA, Larson SR, Shlomchik MJ, Cambier JC. Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells. J Exp Med. 2016 05 02; 213(5):751-69. PMID: 27114609.
      View in: PubMed
    23. Huang Y, Getahun A, Heiser RA, Detanico TO, Aviszus K, Kirchenbaum GA, Casper TL, Huang C, Aydintug MK, Carding SR, Ikuta K, Huang H, Wysocki LJ, Cambier JC, O'Brien RL, Born WK. ?d T Cells Shape Preimmune Peripheral B Cell Populations. J Immunol. 2016 Jan 01; 196(1):217-31. PMID: 26582947.
      View in: PubMed
    24. Getahun A, Cambier JC. Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling. Immunol Rev. 2015 Nov; 268(1):66-73. PMID: 26497513.
      View in: PubMed
    25. Chen Z, Getahun A, Chen X, Dollin Y, Cambier JC, Wang JH. Imbalanced PTEN and PI3K Signaling Impairs Class Switch Recombination. J Immunol. 2015 Dec 01; 195(11):5461-5471. PMID: 26500350.
      View in: PubMed
    26. Akerlund J, Getahun A, Cambier JC. B cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigens. J Autoimmun. 2015 Aug; 62:45-54. PMID: 26152931.
      View in: PubMed
    27. Huang Y, Heiser RA, Detanico TO, Getahun A, Kirchenbaum GA, Casper TL, Aydintug MK, Carding SR, Ikuta K, Huang H, Cambier JC, Wysocki LJ, O'Brien RL, Born WK. ?d T cells affect IL-4 production and B-cell tolerance. Proc Natl Acad Sci U S A. 2015 Jan 06; 112(1):E39-48. PMID: 25535377.
      View in: PubMed
    28. Luo W, Mayeux J, Gutierrez T, Russell L, Getahun A, M?ller J, Tedder T, Parnes J, Rickert R, Nitschke L, Cambier J, Satterthwaite AB, Garrett-Sinha LA. A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels. J Immunol. 2014 Jul 15; 193(2):909-920. PMID: 24929000.
      View in: PubMed
    29. Hardy IR, Anceriz N, Rousseau F, Seefeldt MB, Hatterer E, Irla M, Buatois V, Chatel LE, Getahun A, Fletcher A, Cons L, Pontini G, Hertzberg NA, Magistrelli G, Malinge P, Smith MJ, Reith W, Kosco-Vilbois MH, Ferlin WG, Cambier JC. Anti-CD79 antibody induces B cell anergy that protects against autoimmunity. J Immunol. 2014 Feb 15; 192(4):1641-50. PMID: 24442438.
      View in: PubMed
    30. Bounab Y, Getahun A, Cambier JC, Da?ron M. Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells. Curr Opin Immunol. 2013 Jun; 25(3):313-20. PMID: 23684445.
      View in: PubMed
    31. Jin L, Getahun A, Knowles HM, Mogan J, Akerlund LJ, Packard TA, Perraud AL, Cambier JC. STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration. J Immunol. 2013 Mar 15; 190(6):2835-43. PMID: 23378430.
      View in: PubMed
    32. Getahun A, Smith MJ, Kogut I, van Dyk LF, Cambier JC. Retention of anergy and inhibition of antibody responses during acute ? herpesvirus 68 infection. J Immunol. 2012 Sep 15; 189(6):2965-74. PMID: 22904300.
      View in: PubMed
    33. Rutemark C, Bergman A, Getahun A, Hallgren J, Henningsson F, Heyman B. Complement receptors 1 and 2 in murine antibody responses to IgM-complexed and uncomplexed sheep erythrocytes. PLoS One. 2012; 7(7):e41968. PMID: 22848677.
      View in: PubMed
    34. O'Neill SK, Getahun A, Gauld SB, Merrell KT, Tamir I, Smith MJ, Dal Porto JM, Li QZ, Cambier JC. Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy. Immunity. 2011 Nov 23; 35(5):746-56. PMID: 22078222.
      View in: PubMed
    35. Rutemark C, Alicot E, Bergman A, Ma M, Getahun A, Ellmerich S, Carroll MC, Heyman B. Requirement for complement in antibody responses is not explained by the classic pathway activator IgM. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):E934-42. PMID: 21987785.
      View in: PubMed
    36. Yarkoni Y, Getahun A, Cambier JC. Molecular underpinning of B-cell anergy. Immunol Rev. 2010 Sep; 237(1):249-63. PMID: 20727040.
      View in: PubMed
    37. Getahun A, O'Neill SK, Cambier JC. Establishing anergy as a bona fide in vivo mechanism of B cell tolerance. J Immunol. 2009 Nov 01; 183(9):5439-41. PMID: 19843930.
      View in: PubMed
    38. Getahun A, Heyman B. Studies on the mechanism by which antigen-specific IgG suppresses primary antibody responses: evidence for epitope masking and decreased localization of antigen in the spleen. Scand J Immunol. 2009 Sep; 70(3):277-87. PMID: 19703017.
      View in: PubMed
    39. Carlsson F, Getahun A, Rutemark C, Heyman B. Impaired antibody responses but normal proliferation of specific CD4+ T cells in mice lacking complement receptors 1 and 2. Scand J Immunol. 2009 Aug; 70(2):77-84. PMID: 19630912.
      View in: PubMed
    40. Hjelm F, Carlsson F, Getahun A, Heyman B. Antibody-mediated regulation of the immune response. Scand J Immunol. 2006 Sep; 64(3):177-84. PMID: 16918684.
      View in: PubMed
    41. Getahun A, Heyman B. How antibodies act as natural adjuvants. Immunol Lett. 2006 Apr 15; 104(1-2):38-45. PMID: 16364455.
      View in: PubMed
    42. Getahun A, Hjelm F, Heyman B. IgE enhances antibody and T cell responses in vivo via CD23+ B cells. J Immunol. 2005 Aug 01; 175(3):1473-82. PMID: 16034084.
      View in: PubMed
    43. Getahun A, Dahlstr?m J, Wernersson S, Heyman B. IgG2a-mediated enhancement of antibody and T cell responses and its relation to inhibitory and activating Fc gamma receptors. J Immunol. 2004 May 01; 172(9):5269-76. PMID: 15100265.
      View in: PubMed
    44. Getahun A, Heyman B. IgG- and IgE-mediated antigen presentation on MHC class II. Immunol Lett. 2004 Mar 29; 92(1-2):33-8. PMID: 15081524.
      View in: PubMed
    45. Karlsson MC, Getahun A, Heyman B. FcgammaRIIB in IgG-mediated suppression of antibody responses: different impact in vivo and in vitro. J Immunol. 2001 Nov 15; 167(10):5558-64. PMID: 11698426.
      View in: PubMed
    46. Heyman B, Dahlstr?m J, Diaz De St?hl T, Getahun A, Wernersson S, Karlsson MC. No evidence for a role of FcgammaRIIB in suppression of in vivo antibody responses to erythrocytes by passively administered IgG. Scand J Immunol. 2001 Apr; 53(4):331-4; discussion 339-45. PMID: 11285111.
      View in: PubMed
    47. Getahun A, Lundqvist M, Middleton D, Warr G, Pilstr?m L. Influence of the mu-chain C-terminal sequence on polymerization of immunoglobulin M. Immunology. 1999 Jul; 97(3):408-13. PMID: 10447761.
      View in: PubMed
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