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Carmen Cristina Sucharov

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-5409

    Collapse Research 
    Collapse research activities and funding
    K01HL088708     (SUCHAROV, CARMEN C)Apr 13, 2007 - Mar 31, 2012
    NIH/NHLBI
    Mechanisms of YY1 Inhibition of Cardiac Hypertrophy
    Role: Principal Investigator

    R21HL097123     (MIYAMOTO, SHELLEY DEANNE)Sep 1, 2009 - Aug 31, 2011
    NIH/NHLBI
    Cardiac Beta-Adrenergic Adaptation in Pediatric Heart Failure
    Role: Co-Principal Investigator

    R01HL119533     (GRAYCK, EVA NOZIK)Sep 1, 2014 - Jun 30, 2018
    NIH/NHLBI
    miRNA Regulation of Vascular Permeability and Inflammation in the Lung Injury
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jiang X, Sucharov J, Stauffer BL, Miyamoto SD, Sucharov CC. Exosomes from pediatric dilated cardiomyopathy patients modulate a pathological response in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2017 Apr 01; 312(4):H818-H826. PMID: 28130338.
      View in: PubMed
    2. Sucharov CC, Kao DP, Port JD, Karimpour-Fard A, Quaife RA, Minobe W, Nunley K, Lowes BD, Gilbert EM, Bristow MR. Myocardial microRNAs associated with reverse remodeling in human heart failure. JCI Insight. 2017 Jan 26; 2(2):e89169. PMID: 28138556.
      View in: PubMed
    3. Medina E, Sucharov CC, Nelson P, Miyamoto SD, Stauffer BL. Molecular Changes in Children with Heart Failure Undergoing Left Ventricular Assist Device Therapy. J Pediatr. 2017 Mar; 182:184-189.e1. PMID: 27908653.
      View in: PubMed
    4. Woulfe KC, Siomos AK, Nguyen H, SooHoo M, Galambos C, Stauffer BL, Sucharov C, Miyamoto S. Fibrosis and Fibrotic Gene Expression in Pediatric and Adult Patients With Idiopathic Dilated Cardiomyopathy. J Card Fail. 2017 Apr; 23(4):314-324. PMID: 27890770.
      View in: PubMed
    5. Nakano SJ, Sucharov J, van Dusen R, Cecil M, Nunley K, Wickers S, Karimpur-Fard A, Stauffer BL, Miyamoto SD, Sucharov CC. Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment. J Card Fail. 2017 Jan; 23(1):72-80. PMID: 27427220.
      View in: PubMed
    6. Stratton MS, Lin CY, Anand P, Tatman PD, Ferguson BS, Wickers ST, Ambardekar AV, Sucharov CC, Bradner JE, Haldar SM, McKinsey TA. Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA. Cell Rep. 2016 Aug 02; 16(5):1366-78. PMID: 27425608; PMCID: PMC4972677 [Available on 08/02/17].
    7. Nakano SJ, Nelson P, Sucharov CC, Miyamoto SD. Myocardial Response to Milrinone in Single Right Ventricle Heart Disease. J Pediatr. 2016 Jul; 174:199-203.e5. PMID: 27181939; PMCID: PMC4925285 [Available on 07/01/17].
    8. Stauffer BL, Dockstader K, Russell G, Hijmans J, Walker L, Cecil M, Demos-Davies K, Medway A, McKinsey TA, Sucharov CC. Transgenic over-expression of YY1 induces pathologic cardiac hypertrophy in a sex-specific manner. Biochem Biophys Res Commun. 2015 Jun 26; 462(2):131-7. PMID: 25935483; PMCID: PMC4449792.
    9. Miyamoto SD, Karimpour-Fard A, Peterson V, Auerbach SR, Stenmark KR, Stauffer BL, Sucharov CC. Circulating microRNA as a biomarker for recovery in pediatric dilated cardiomyopathy. J Heart Lung Transplant. 2015 May; 34(5):724-33. PMID: 25840506.
      View in: PubMed
    10. Sucharov CC, Sucharov J, Karimpour-Fard A, Nunley K, Stauffer BL, Miyamoto SD. Micro-RNA expression in hypoplastic left heart syndrome. J Card Fail. 2015 Jan; 21(1):83-8. PMID: 25291457; PMCID: PMC4276459.
    11. Nakano SJ, Miyamoto SD, Movsesian M, Nelson P, Stauffer BL, Sucharov CC. Age-related differences in phosphodiesterase activity and effects of chronic phosphodiesterase inhibition in idiopathic dilated cardiomyopathy. Circ Heart Fail. 2015 Jan; 8(1):57-63. PMID: 25278000; PMCID: PMC4303519.
    12. Chatfield KC, Sparagna GC, Sucharov CC, Miyamoto SD, Grudis JE, Sobus RD, Hijmans J, Stauffer BL. Dysregulation of cardiolipin biosynthesis in pediatric heart failure. J Mol Cell Cardiol. 2014 Sep; 74:251-9. PMID: 24937604; PMCID: PMC4114989.
    13. Miyamoto SD, Stauffer BL, Polk J, Medway A, Friedrich M, Haubold K, Peterson V, Nunley K, Nelson P, Sobus R, Stenmark KR, Sucharov CC. Gene expression and ß-adrenergic signaling are altered in hypoplastic left heart syndrome. J Heart Lung Transplant. 2014 Aug; 33(8):785-93. PMID: 24793904; PMCID: PMC4111994.
    14. Wang D, Zhang H, Li M, Frid MG, Flockton AR, McKeon BA, Yeager ME, Fini MA, Morrell NW, Pullamsetti SS, Velegala S, Seeger W, McKinsey TA, Sucharov CC, Stenmark KR. MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts. Circ Res. 2014 Jan 03; 114(1):67-78. PMID: 24122720; PMCID: PMC4117588.
    15. Sucharov CC, Hijmans JG, Sobus RD, Melhado WF, Miyamoto SD, Stauffer BL. ß-Adrenergic receptor antagonism in mice: a model for pediatric heart disease. J Appl Physiol (1985). 2013 Oct 01; 115(7):979-87. PMID: 23887897; PMCID: PMC3798823.
    16. Stauffer BL, Russell G, Nunley K, Miyamoto SD, Sucharov CC. miRNA expression in pediatric failing human heart. J Mol Cell Cardiol. 2013 Apr; 57:43-6. PMID: 23333438; PMCID: PMC3694420.
    17. Miyamoto SD, Stauffer BL, Nakano S, Sobus R, Nunley K, Nelson P, Sucharov CC. Beta-adrenergic adaptation in paediatric idiopathic dilated cardiomyopathy. Eur Heart J. 2014 Jan; 35(1):33-41. PMID: 22843448; PMCID: PMC3877432.
    18. Dockstader K, Nunley K, Karimpour-Fard A, Medway A, Nelson P, Port JD, Liggett SB, Bristow MR, Sucharov CC. Temporal analysis of mRNA and miRNA expression in transgenic mice overexpressing Arg- and Gly389 polymorphic variants of the ß1-adrenergic receptor. Physiol Genomics. 2011 Dec 05; 43(23):1294-306. PMID: 21954455; PMCID: PMC3233820.
    19. Port JD, Walker LA, Polk J, Nunley K, Buttrick PM, Sucharov CC. Temporal expression of miRNAs and mRNAs in a mouse model of myocardial infarction. Physiol Genomics. 2011 Oct 06; 43(19):1087-95. PMID: 21771878; PMCID: PMC3217325.
    20. Stauffer BL, Sobus RD, Sucharov CC. Sex differences in cardiomyocyte connexin43 expression. J Cardiovasc Pharmacol. 2011 Jul; 58(1):32-9. PMID: 21753256; PMCID: PMC3136750.
    21. Sucharov CC, Dockstader K, Nunley K, McKinsey TA, Bristow M. ß-Adrenergic receptor stimulation and activation of protein kinase A protect against a1-adrenergic-mediated phosphorylation of protein kinase D and histone deacetylase 5. J Card Fail. 2011 Jul; 17(7):592-600. PMID: 21703532; PMCID: PMC3128428.
    22. Port JD, Sucharov C. Role of microRNAs in cardiovascular disease: therapeutic challenges and potentials. J Cardiovasc Pharmacol. 2010 Nov; 56(5):444-53. PMID: 20729754.
      View in: PubMed
    23. Sihag S, Cresci S, Li AY, Sucharov CC, Lehman JJ. PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart. J Mol Cell Cardiol. 2009 Feb; 46(2):201-12. PMID: 19061896; PMCID: PMC2681265.
    24. Cresci S, Jones PG, Sucharov CC, Marsh S, Lanfear DE, Garsa A, Courtois M, Weinheimer CJ, Wu J, Province MA, Kelly DP, McLeod HL, Spertus JA. Interaction between PPARA genotype and beta-blocker treatment influences clinical outcomes following acute coronary syndromes. Pharmacogenomics. 2008 Oct; 9(10):1403-17. PMID: 18855529; PMCID: PMC2586954.
    25. Sucharov CC, Dockstader K, McKinsey TA. YY1 protects cardiac myocytes from pathologic hypertrophy by interacting with HDAC5. Mol Biol Cell. 2008 Oct; 19(10):4141-53. PMID: 18632988; PMCID: PMC2555926.
    26. Sucharov C, Bristow MR, Port JD. miRNA expression in the failing human heart: functional correlates. J Mol Cell Cardiol. 2008 Aug; 45(2):185-92. PMID: 18582896; PMCID: PMC2561965.
    27. Sucharov CC. Role of p38MAPK in beta(2)AR-induced cardiomyopathy: at the heart of the matter? Future Cardiol. 2007 Jul; 3(4):387-9. PMID: 19804229.
      View in: PubMed
    28. Taylor MR, Slavov D, Ku L, Di Lenarda A, Sinagra G, Carniel E, Haubold K, Boucek MM, Ferguson D, Graw SL, Zhu X, Cavanaugh J, Sucharov CC, Long CS, Bristow MR, Lavori P, Mestroni L. Prevalence of desmin mutations in dilated cardiomyopathy. Circulation. 2007 Mar 13; 115(10):1244-51. PMID: 17325244.
      View in: PubMed
    29. Sucharov CC. Beta-adrenergic pathways in human heart failure. Expert Rev Cardiovasc Ther. 2007 Jan; 5(1):119-24. PMID: 17187463.
      View in: PubMed
    30. Sucharov CC, Langer S, Bristow M, Leinwand L. Shuttling of HDAC5 in H9C2 cells regulates YY1 function through CaMKIV/PKD and PP2A. Am J Physiol Cell Physiol. 2006 Nov; 291(5):C1029-37. PMID: 16822951.
      View in: PubMed
    31. Sucharov CC, Mariner PD, Nunley KR, Long C, Leinwand L, Bristow MR. A beta1-adrenergic receptor CaM kinase II-dependent pathway mediates cardiac myocyte fetal gene induction. Am J Physiol Heart Circ Physiol. 2006 Sep; 291(3):H1299-308. PMID: 16501029.
      View in: PubMed
    32. Sucharov CC. Gene expression and heart failure. 24-27 July 2005, 2nd Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences, Keystone, CO, USA. Expert Rev Cardiovasc Ther. 2005 Nov; 3(6):983-4. PMID: 16292988.
      View in: PubMed
    33. Mariner PD, Luckey SW, Long CS, Sucharov CC, Leinwand LA. Yin Yang 1 represses alpha-myosin heavy chain gene expression in pathologic cardiac hypertrophy. Biochem Biophys Res Commun. 2005 Jan 07; 326(1):79-86. PMID: 15567155.
      View in: PubMed
    34. Sucharov CC, Helmke SM, Langer SJ, Perryman MB, Bristow M, Leinwand L. The Ku protein complex interacts with YY1, is up-regulated in human heart failure, and represses alpha myosin heavy-chain gene expression. Mol Cell Biol. 2004 Oct; 24(19):8705-15. PMID: 15367688; PMCID: PMC516749.
    35. Sucharov CC, Mariner P, Long C, Bristow M, Leinwand L. Yin Yang 1 is increased in human heart failure and represses the activity of the human alpha-myosin heavy chain promoter. J Biol Chem. 2003 Aug 15; 278(33):31233-9. PMID: 12754214.
      View in: PubMed
    36. Sucharov CC, Silva R, Rondinelli E, Moura-Neto RS. Fragile X trinucleotide repeats from a normal population in Rio de Janeiro, Brazil. Hereditas. 1999; 130(2):189-90. PMID: 10480000.
      View in: PubMed
    37. Mullick J, Addya S, Sucharov C, Avadhani NG. Localization of a transcription promoter within the second exon of the cytochrome P-450c27/25 gene for the expression of the major species of two-kilobase mRNA. Biochemistry. 1995 Oct 24; 34(42):13729-42. PMID: 7577965.
      View in: PubMed
    38. Sucharov C, Basu A, Carter RS, Avadhani NG. A novel transcriptional initiator activity of the GABP factor binding ets sequence repeat from the murine cytochrome c oxidase Vb gene. Gene Expr. 1995; 5(2):93-111. PMID: 8821623.
      View in: PubMed
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