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Carmen Cristina Sucharov

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-5409

    Collapse Overview 
    Collapse overview
    The goal of our research group is to identify mechanisms of heart failure in the pediatric population. We are interested in transcriptional and post-transcriptional regulation, mitochondria function and metabolic dysfunction. I will be serving as a cardiology mentor for the 2018-2019 academic year.

    Collapse Research 
    Collapse research activities and funding
    K01HL088708     (SUCHAROV, CARMEN C)Apr 13, 2007 - Mar 31, 2012
    NIH/NHLBI
    Mechanisms of YY1 Inhibition of Cardiac Hypertrophy
    Role: Principal Investigator

    R21HL097123     (MIYAMOTO, SHELLEY DEANNE)Sep 1, 2009 - Aug 31, 2011
    NIH/NHLBI
    Cardiac Beta-Adrenergic Adaptation in Pediatric Heart Failure
    Role: Co-Principal Investigator

    R01HL119533     (GRAYCK, EVA NOZIK)Sep 1, 2014 - Jun 30, 2018
    NIH/NHLBI
    miRNA Regulation of Vascular Permeability and Inflammation in the Lung Injury
    Role: Co-Principal Investigator

    R41HL137564     (SUCHAROV, CARMEN C)Sep 1, 2017 - Feb 28, 2018
    NIH/NHLBI
    Non-invasive risk assessment tool for pediatric heart failure
    Role: Principal Investigator

    R01HL139968     (LIPSHULTZ, STEVEN EDWARD)Feb 17, 2018 - Jan 31, 2022
    NIH/NHLBI
    Prognostic Significance of microRNA Expression in Children with Cardiomyopathy
    Role: Co-Principal Investigator

    K24HL150630     (SUCHAROV, CARMEN C)Dec 1, 2019 - Nov 30, 2024
    NIH/NHLBI
    Investigations of Pathologic Remodeling Using Pediatric Heart Failure Serum
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jone PN, Korst A, Karimpour-Fard A, Thomas T, Dominguez SR, Heizer H, Anderson MS, Glode MP, Sucharov CC, Miyamoto SD. Circulating microRNAs differentiate Kawasaki Disease from infectious febrile illnesses in childhood. J Mol Cell Cardiol. 2020 Jul 04; 146:12-18. PMID: 32634388.
      View in: PubMed
    2. Ohlstrom D, Hernandez-Lagunas L, Garcia AM, Allawzi A, Karimpour-Fard A, Sucharov CC, Nozik-Grayck E. MicroRNA regulation postbleomycin due to the R213G extracellular superoxide dismutase variant is predicted to suppress inflammatory and immune pathways. Physiol Genomics. 2020 06 01; 52(6):245-254. PMID: 32421439.
      View in: PubMed
    3. Toni L, Hailu F, Sucharov CC. Dysregulated micro-RNAs and long noncoding RNAs in cardiac development and pediatric heart failure. Am J Physiol Heart Circ Physiol. 2020 05 01; 318(5):H1308-H1315. PMID: 32216613.
      View in: PubMed
    4. Sucharov CC. Paracrine Factors in Uremic Cardiomyopathy. JACC Basic Transl Sci. 2020 Feb; 5(2):167-168. PMID: 32142069.
      View in: PubMed
    5. Garcia AM, McPhaul JC, Sparagna GC, Jeffrey DA, Jonscher R, Patel SS, Sucharov CC, Stauffer BL, Miyamoto SD, Chatfield KC. Alteration of cardiolipin biosynthesis and remodeling in single right ventricle congenital heart disease. Am J Physiol Heart Circ Physiol. 2020 04 01; 318(4):H787-H800. PMID: 32056460.
      View in: PubMed
    6. Nakano SJ, Walker JS, Walker LA, Li X, Du Y, Miyamoto SD, Sucharov CC, Garcia AM, Mitchell MB, Ambardekar AV, Stauffer BL. Increased myocyte calcium sensitivity in end-stage pediatric dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2019 12 01; 317(6):H1221-H1230. PMID: 31625780.
      View in: PubMed
    7. Allawzi A, McDermott I, Delaney C, Nguyen K, Banimostafa L, Trumpie A, Hernandez-Lagunas L, Riemondy K, Gillen A, Hesselberth J, El Kasmi K, Sucharov CC, Janssen WJ, Stenmark K, Bowler R, Nozik-Grayck E. Redistribution of EC-SOD resolves bleomycin-induced inflammation via increased apoptosis of recruited alveolar macrophages. FASEB J. 2019 12; 33(12):13465-13475. PMID: 31560857.
      View in: PubMed
    8. Aguado BA, Schuetze KB, Grim JC, Walker CJ, Cox AC, Ceccato TL, Tan AC, Sucharov CC, Leinwand LA, Taylor MRG, McKinsey TA, Anseth KS. Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation. Sci Transl Med. 2019 09 11; 11(509). PMID: 31511425.
      View in: PubMed
    9. Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL. Elamipretide Improves Mitochondrial Function in the Failing Human Heart. JACC Basic Transl Sci. 2019 Apr; 4(2):147-157. PMID: 31061916.
      View in: PubMed
    10. Sucharov CC, Nakano SJ, Slavov D, Schwisow JA, Rodriguez E, Nunley K, Medway A, Stafford N, Nelson P, McKinsey TA, Movsesian M, Minobe W, Carroll IA, Taylor MRG, Bristow MR. A PDE3A Promoter Polymorphism Regulates cAMP-Induced Transcriptional Activity in Failing Human Myocardium. J Am Coll Cardiol. 2019 03 19; 73(10):1173-1184. PMID: 30871701.
      View in: PubMed
    11. Patil MA, Upadhyay AK, Hernandez-Lagunas L, Good R, Carpenter TC, Sucharov CC, Nozik-Grayck E, Kompella UB. Targeted delivery of YSA-functionalized and non-functionalized polymeric nanoparticles to injured pulmonary vasculature. Artif Cells Nanomed Biotechnol. 2018; 46(sup3):S1059-S1066. PMID: 30450979.
      View in: PubMed
    12. Garcia AM, Nakano SJ, Karimpour-Fard A, Nunley K, Blain-Nelson P, Stafford NM, Stauffer BL, Sucharov CC, Miyamoto SD. Phosphodiesterase-5 Is Elevated in Failing Single Ventricle Myocardium and Affects Cardiomyocyte Remodeling In Vitro. Circ Heart Fail. 2018 09; 11(9):e004571. PMID: 30354365.
      View in: PubMed
    13. Coverstone ED, Bach RG, Chen L, Bierut LJ, Li AY, Lenzini PA, O'Neill HC, Spertus JA, Sucharov CC, Stitzel JA, Schilling JD, Cresci S. A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction. Basic Res Cardiol. 2018 08 10; 113(5):38. PMID: 30097758.
      View in: PubMed
    14. Woulfe KC, Wilson CE, Nau S, Chau S, Phillips EK, Zang S, Tompkins C, Sucharov CC, Miyamoto SD, Stauffer BL. Acute isoproterenol leads to age-dependent arrhythmogenesis in guinea pigs. Am J Physiol Heart Circ Physiol. 2018 10 01; 315(4):H1051-H1062. PMID: 30028197.
      View in: PubMed
    15. Good RJ, Hernandez-Lagunas L, Allawzi A, Maltzahn JK, Vohwinkel CU, Upadhyay AK, Kompella UB, Birukov KG, Carpenter TC, Sucharov CC, Nozik-Grayck E. MicroRNA dysregulation in lung injury: the role of the miR-26a/EphA2 axis in regulation of endothelial permeability. Am J Physiol Lung Cell Mol Physiol. 2018 10 01; 315(4):L584-L594. PMID: 30024304.
      View in: PubMed
    16. Garcia AM, Allawzi A, Tatman P, Hernandez-Lagunas L, Swain K, Mouradian G, Bowler R, Karimpour-Fard A, Sucharov CC, Nozik-Grayck E. R213G polymorphism in SOD3 protects against bleomycin-induced inflammation and attenuates induction of proinflammatory pathways. Physiol Genomics. 2018 09 01; 50(9):807-816. PMID: 30004839.
      View in: PubMed
    17. Miyamoto SD, Sucharov CC, Woulfe KC. Differential Response to Heart Failure Medications in Children. Prog Pediatr Cardiol. 2018 Jun; 49:27-30. PMID: 29962825.
      View in: PubMed
    18. Toni LS, Garcia AM, Jeffrey DA, Jiang X, Stauffer BL, Miyamoto SD, Sucharov CC. Optimization of phenol-chloroform RNA extraction. MethodsX. 2018; 5:599-608. PMID: 29984193.
      View in: PubMed
    19. Jeffrey DA, Sucharov CC. CELF1 regulates gap junction integrity contributing to dilated cardiomyopathy. Noncoding RNA Investig. 2018 Mar; 2. PMID: 30198017.
      View in: PubMed
    20. Mariner PD, Korst A, Karimpour-Fard A, Stauffer BL, Miyamoto SD, Sucharov CC. Improved Detection of Circulating miRNAs in Serum and Plasma Following Rapid Heat/Freeze Cycling. Microrna. 2018; 7(2):138-147. PMID: 29658445.
      View in: PubMed
    21. Nakano SJ, Siomos AK, Garcia AM, Nguyen H, SooHoo M, Galambos C, Nunley K, Stauffer BL, Sucharov CC, Miyamoto SD. Fibrosis-Related Gene Expression in Single Ventricle Heart Disease. J Pediatr. 2017 12; 191:82-90.e2. PMID: 29050751.
      View in: PubMed
    22. Woulfe KC, Sucharov CC. Midkine's Role in Cardiac Pathology. J Cardiovasc Dev Dis. 2017 Sep; 4(3). PMID: 28920060.
      View in: PubMed
    23. Kheyfets VO, Sucharov CC, Truong U, Dunning J, Hunter K, Ivy D, Miyamoto S, Shandas R. Circulating miRNAs in Pediatric Pulmonary Hypertension Show Promise as Biomarkers of Vascular Function. Oxid Med Cell Longev. 2017; 2017:4957147. PMID: 28819545.
      View in: PubMed
    24. Tatman PD, Woulfe KC, Karimpour-Fard A, Jeffrey DA, Jaggers J, Cleveland JC, Nunley K, Taylor MR, Miyamoto SD, Stauffer BL, Sucharov CC. Pediatric dilated cardiomyopathy hearts display a unique gene expression profile. JCI Insight. 2017 Jul 20; 2(14). PMID: 28724804.
      View in: PubMed
    25. Jiang X, Sucharov J, Stauffer BL, Miyamoto SD, Sucharov CC. Exosomes from pediatric dilated cardiomyopathy patients modulate a pathological response in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2017 Apr 01; 312(4):H818-H826. PMID: 28130338.
      View in: PubMed
    26. Sucharov CC, Kao DP, Port JD, Karimpour-Fard A, Quaife RA, Minobe W, Nunley K, Lowes BD, Gilbert EM, Bristow MR. Myocardial microRNAs associated with reverse remodeling in human heart failure. JCI Insight. 2017 01 26; 2(2):e89169. PMID: 28138556.
      View in: PubMed
    27. Medina E, Sucharov CC, Nelson P, Miyamoto SD, Stauffer BL. Molecular Changes in Children with Heart Failure Undergoing Left Ventricular Assist Device Therapy. J Pediatr. 2017 03; 182:184-189.e1. PMID: 27908653.
      View in: PubMed
    28. Woulfe KC, Siomos AK, Nguyen H, SooHoo M, Galambos C, Stauffer BL, Sucharov C, Miyamoto S. Fibrosis and Fibrotic Gene Expression in Pediatric and Adult Patients With Idiopathic Dilated Cardiomyopathy. J Card Fail. 2017 Apr; 23(4):314-324. PMID: 27890770.
      View in: PubMed
    29. Nakano SJ, Sucharov J, van Dusen R, Cecil M, Nunley K, Wickers S, Karimpur-Fard A, Stauffer BL, Miyamoto SD, Sucharov CC. Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment. J Card Fail. 2017 Jan; 23(1):72-80. PMID: 27427220.
      View in: PubMed
    30. Stratton MS, Lin CY, Anand P, Tatman PD, Ferguson BS, Wickers ST, Ambardekar AV, Sucharov CC, Bradner JE, Haldar SM, McKinsey TA. Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA. Cell Rep. 2016 08 02; 16(5):1366-1378. PMID: 27425608.
      View in: PubMed
    31. Nakano SJ, Nelson P, Sucharov CC, Miyamoto SD. Myocardial Response to Milrinone in Single Right Ventricle Heart Disease. J Pediatr. 2016 07; 174:199-203.e5. PMID: 27181939.
      View in: PubMed
    32. Stauffer BL, Dockstader K, Russell G, Hijmans J, Walker L, Cecil M, Demos-Davies K, Medway A, McKinsey TA, Sucharov CC. Transgenic over-expression of YY1 induces pathologic cardiac hypertrophy in a sex-specific manner. Biochem Biophys Res Commun. 2015 Jun 26; 462(2):131-7. PMID: 25935483.
      View in: PubMed
    33. Miyamoto SD, Karimpour-Fard A, Peterson V, Auerbach SR, Stenmark KR, Stauffer BL, Sucharov CC. Circulating microRNA as a biomarker for recovery in pediatric dilated cardiomyopathy. J Heart Lung Transplant. 2015 May; 34(5):724-33. PMID: 25840506.
      View in: PubMed
    34. Sucharov CC, Sucharov J, Karimpour-Fard A, Nunley K, Stauffer BL, Miyamoto SD. Micro-RNA expression in hypoplastic left heart syndrome. J Card Fail. 2015 Jan; 21(1):83-8. PMID: 25291457.
      View in: PubMed
    35. Nakano SJ, Miyamoto SD, Movsesian M, Nelson P, Stauffer BL, Sucharov CC. Age-related differences in phosphodiesterase activity and effects of chronic phosphodiesterase inhibition in idiopathic dilated cardiomyopathy. Circ Heart Fail. 2015 Jan; 8(1):57-63. PMID: 25278000.
      View in: PubMed
    36. Chatfield KC, Sparagna GC, Sucharov CC, Miyamoto SD, Grudis JE, Sobus RD, Hijmans J, Stauffer BL. Dysregulation of cardiolipin biosynthesis in pediatric heart failure. J Mol Cell Cardiol. 2014 Sep; 74:251-9. PMID: 24937604.
      View in: PubMed
    37. Miyamoto SD, Stauffer BL, Polk J, Medway A, Friedrich M, Haubold K, Peterson V, Nunley K, Nelson P, Sobus R, Stenmark KR, Sucharov CC. Gene expression and ß-adrenergic signaling are altered in hypoplastic left heart syndrome. J Heart Lung Transplant. 2014 Aug; 33(8):785-93. PMID: 24793904.
      View in: PubMed
    38. Wang D, Zhang H, Li M, Frid MG, Flockton AR, McKeon BA, Yeager ME, Fini MA, Morrell NW, Pullamsetti SS, Velegala S, Seeger W, McKinsey TA, Sucharov CC, Stenmark KR. MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts. Circ Res. 2014 Jan 03; 114(1):67-78. PMID: 24122720.
      View in: PubMed
    39. Sucharov CC, Hijmans JG, Sobus RD, Melhado WF, Miyamoto SD, Stauffer BL. ß-Adrenergic receptor antagonism in mice: a model for pediatric heart disease. J Appl Physiol (1985). 2013 Oct 01; 115(7):979-87. PMID: 23887897.
      View in: PubMed
    40. Stauffer BL, Russell G, Nunley K, Miyamoto SD, Sucharov CC. miRNA expression in pediatric failing human heart. J Mol Cell Cardiol. 2013 Apr; 57:43-6. PMID: 23333438.
      View in: PubMed
    41. Miyamoto SD, Stauffer BL, Nakano S, Sobus R, Nunley K, Nelson P, Sucharov CC. Beta-adrenergic adaptation in paediatric idiopathic dilated cardiomyopathy. Eur Heart J. 2014 Jan; 35(1):33-41. PMID: 22843448.
      View in: PubMed
    42. Dockstader K, Nunley K, Karimpour-Fard A, Medway A, Nelson P, Port JD, Liggett SB, Bristow MR, Sucharov CC. Temporal analysis of mRNA and miRNA expression in transgenic mice overexpressing Arg- and Gly389 polymorphic variants of the ß1-adrenergic receptor. Physiol Genomics. 2011 Dec 05; 43(23):1294-306. PMID: 21954455.
      View in: PubMed
    43. Port JD, Walker LA, Polk J, Nunley K, Buttrick PM, Sucharov CC. Temporal expression of miRNAs and mRNAs in a mouse model of myocardial infarction. Physiol Genomics. 2011 Oct 06; 43(19):1087-95. PMID: 21771878.
      View in: PubMed
    44. Stauffer BL, Sobus RD, Sucharov CC. Sex differences in cardiomyocyte connexin43 expression. J Cardiovasc Pharmacol. 2011 Jul; 58(1):32-9. PMID: 21753256.
      View in: PubMed
    45. Sucharov CC, Dockstader K, Nunley K, McKinsey TA, Bristow M. ß-Adrenergic receptor stimulation and activation of protein kinase A protect against a1-adrenergic-mediated phosphorylation of protein kinase D and histone deacetylase 5. J Card Fail. 2011 Jul; 17(7):592-600. PMID: 21703532.
      View in: PubMed
    46. Port JD, Sucharov C. Role of microRNAs in cardiovascular disease: therapeutic challenges and potentials. J Cardiovasc Pharmacol. 2010 Nov; 56(5):444-53. PMID: 20729754.
      View in: PubMed
    47. Calalb MB, McKinsey TA, Newkirk S, Huynh K, Sucharov CC, Bristow MR. Increased phosphorylation-dependent nuclear export of class II histone deacetylases in failing human heart. Clin Transl Sci. 2009 Oct; 2(5):325-32. PMID: 20443916.
      View in: PubMed
    48. Sihag S, Cresci S, Li AY, Sucharov CC, Lehman JJ. PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart. J Mol Cell Cardiol. 2009 Feb; 46(2):201-12. PMID: 19061896.
      View in: PubMed
    49. Cresci S, Jones PG, Sucharov CC, Marsh S, Lanfear DE, Garsa A, Courtois M, Weinheimer CJ, Wu J, Province MA, Kelly DP, McLeod HL, Spertus JA. Interaction between PPARA genotype and beta-blocker treatment influences clinical outcomes following acute coronary syndromes. Pharmacogenomics. 2008 Oct; 9(10):1403-17. PMID: 18855529.
      View in: PubMed
    50. Sucharov CC, Dockstader K, McKinsey TA. YY1 protects cardiac myocytes from pathologic hypertrophy by interacting with HDAC5. Mol Biol Cell. 2008 Oct; 19(10):4141-53. PMID: 18632988.
      View in: PubMed
    51. Sucharov C, Bristow MR, Port JD. miRNA expression in the failing human heart: functional correlates. J Mol Cell Cardiol. 2008 Aug; 45(2):185-92. PMID: 18582896.
      View in: PubMed
    52. Sucharov CC. Role of p38MAPK in beta(2)AR-induced cardiomyopathy: at the heart of the matter? Future Cardiol. 2007 Jul; 3(4):387-9. PMID: 19804229.
      View in: PubMed
    53. Taylor MR, Slavov D, Ku L, Di Lenarda A, Sinagra G, Carniel E, Haubold K, Boucek MM, Ferguson D, Graw SL, Zhu X, Cavanaugh J, Sucharov CC, Long CS, Bristow MR, Lavori P, Mestroni L. Prevalence of desmin mutations in dilated cardiomyopathy. Circulation. 2007 Mar 13; 115(10):1244-51. PMID: 17325244.
      View in: PubMed
    54. Sucharov CC. Beta-adrenergic pathways in human heart failure. Expert Rev Cardiovasc Ther. 2007 Jan; 5(1):119-24. PMID: 17187463.
      View in: PubMed
    55. Sucharov CC, Langer S, Bristow M, Leinwand L. Shuttling of HDAC5 in H9C2 cells regulates YY1 function through CaMKIV/PKD and PP2A. Am J Physiol Cell Physiol. 2006 Nov; 291(5):C1029-37. PMID: 16822951.
      View in: PubMed
    56. Sucharov CC, Mariner PD, Nunley KR, Long C, Leinwand L, Bristow MR. A beta1-adrenergic receptor CaM kinase II-dependent pathway mediates cardiac myocyte fetal gene induction. Am J Physiol Heart Circ Physiol. 2006 Sep; 291(3):H1299-308. PMID: 16501029.
      View in: PubMed
    57. Sucharov CC. Gene expression and heart failure. 24-27 July 2005, 2nd Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences, Keystone, CO, USA. Expert Rev Cardiovasc Ther. 2005 Nov; 3(6):983-4. PMID: 16292988.
      View in: PubMed
    58. Mariner PD, Luckey SW, Long CS, Sucharov CC, Leinwand LA. Yin Yang 1 represses alpha-myosin heavy chain gene expression in pathologic cardiac hypertrophy. Biochem Biophys Res Commun. 2005 Jan 07; 326(1):79-86. PMID: 15567155.
      View in: PubMed
    59. Sucharov CC, Helmke SM, Langer SJ, Perryman MB, Bristow M, Leinwand L. The Ku protein complex interacts with YY1, is up-regulated in human heart failure, and represses alpha myosin heavy-chain gene expression. Mol Cell Biol. 2004 Oct; 24(19):8705-15. PMID: 15367688.
      View in: PubMed
    60. Sucharov CC, Mariner P, Long C, Bristow M, Leinwand L. Yin Yang 1 is increased in human heart failure and represses the activity of the human alpha-myosin heavy chain promoter. J Biol Chem. 2003 Aug 15; 278(33):31233-9. PMID: 12754214.
      View in: PubMed
    61. Sucharov CC, Silva R, Rondinelli E, Moura-Neto RS. Fragile X trinucleotide repeats from a normal population in Rio de Janeiro, Brazil. Hereditas. 1999; 130(2):189-90. PMID: 10480000.
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    62. Mullick J, Addya S, Sucharov C, Avadhani NG. Localization of a transcription promoter within the second exon of the cytochrome P-450c27/25 gene for the expression of the major species of two-kilobase mRNA. Biochemistry. 1995 Oct 24; 34(42):13729-42. PMID: 7577965.
      View in: PubMed
    63. Sucharov C, Basu A, Carter RS, Avadhani NG. A novel transcriptional initiator activity of the GABP factor binding ets sequence repeat from the murine cytochrome c oxidase Vb gene. Gene Expr. 1995; 5(2):93-111. PMID: 8821623.
      View in: PubMed
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