Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Dennis R Roop

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Dermatology
Phone303/724-3042

    Collapse Research 
    Collapse research activities and funding
    T32AR007411     (ROOP, DENNIS)Jul 1, 1981 - Jun 30, 2020
    NIH/NIAMS
    Training in Immunodermatology
    Role: Principal Investigator

    R01HD025479     (ROOP, DENNIS)Apr 1, 1989 - Mar 31, 2004
    NIH/NICHD
    REGULATION AND FUNCTION OF KERATINS IN THE EPIDERMIS
    Role: Principal Investigator

    R01AR052263     (ROOP, DENNIS)Apr 1, 1989 - Aug 31, 2011
    NIH/NIAMS
    Regulation and Function of Keratins in the Epidermis
    Role: Principal Investigator

    R01AR040240     (ROOP, DENNIS)Dec 1, 1989 - Feb 28, 2001
    NIH/NIAMS
    REGULATION AND FUNCTION OF A MAJOR CELL ENVELOPE PROTEIN
    Role: Principal Investigator

    R01CA052607     (ROOP, DENNIS)Aug 1, 1990 - Jul 31, 2016
    NIH/NCI
    Targeting Oncogene Expression to Skin in Transgenic Mice
    Role: Principal Investigator

    R01AI030283     (ROOP, DENNIS)Sep 30, 1990 - Jul 31, 1995
    NIH/NIAID
    TARGETING HUMAN PAPILLOMA VIRUS GENE EXPRESSION IN MICE
    Role: Principal Investigator

    N01AR062228     (ROOP, DENNIS)Sep 30, 1996 - Sep 29, 2001
    NIH/NIAMS
    DEVELOPMENT OF EXPERIMENTAL MODELS OF EB SIMPLEX
    Role: Principal Investigator

    R13AR044651     (ROOP, DENNIS)Jul 1, 1997 - Jun 30, 1998
    NIH/NIAMS
    EPITHELIAL DIFFERENTIATION/KERATINIZATION GORDON CONFER
    Role: Principal Investigator

    P01AR047898     (ROOP, DENNIS)Sep 27, 2001 - Aug 31, 2008
    NIH/NIAMS
    Molecular Mechanisms of Skin and Appendage Development
    Role: Principal Investigator

    R01AR050252     (ROOP, DENNIS)Jul 7, 2003 - May 31, 2009
    NIH/NIAMS
    TESTING GENE THERAPY FOR EPIDERMOLYSIS BULLOSA SIMPLEX
    Role: Principal Investigator

    U01CA105491     (ROOP, DENNIS)Sep 30, 2004 - Mar 31, 2010
    NIH/NCI
    INDUCIBLE MOUSE MODELS FOR SKIN AND HEAD AND NECK CANCER
    Role: Principal Investigator

    R03HL096382     (ROOP, DENNIS)Dec 1, 2008 - May 31, 2009
    NIH/NHLBI
    The Denver Network of the NHLBI Progenitor Cell Biology Consortium
    Role: Principal Investigator

    R01AR060388     (ROOP, DENNIS)Sep 1, 2011 - Jun 30, 2016
    NIH/NIAMS
    The consequences of loricrin deficiency on epidermal barrier function
    Role: Principal Investigator

    R01AR059947     (ROOP, DENNIS)Sep 17, 2012 - Aug 31, 2017
    NIH/NIAMS
    Testing the Therapeutic Potential of iPS Cells for Inherited Skin Diseases
    Role: Principal Investigator

    R13AR068231     (ROOP, DENNIS)May 11, 2015 - Apr 30, 2016
    NIH/NIAMS
    2015 Barrier Function of Mammalian Skin Gordon Research Conference
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yang N, Leung EL, Liu C, Li L, Eguether T, Jun Yao XJ, Jones EC, Norris DA, Liu A, Clark RA, Roop DR, Pazour GJ, Shroyer KR, Chen J. INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma. Oncogene. 2017 May 01. PMID: 28459465.
      View in: PubMed
    2. Birlea SA, Costin GE, Roop DR, Norris DA. Trends in Regenerative Medicine: Repigmentation in Vitiligo Through Melanocyte Stem Cell Mobilization. Med Res Rev. 2017 Jul; 37(4):907-935. PMID: 28029168.
      View in: PubMed
    3. Gaskill C, Marriott S, Pratap S, Menon S, Hedges LK, Fessel JP, Kropski JA, Ames D, Wheeler L, Loyd JE, Hemnes AR, Roop DR, Klemm DJ, Austin ED, Majka SM. Shared gene expression patterns in mesenchymal progenitors derived from lung and epidermis in pulmonary arterial hypertension: identifying key pathways in pulmonary vascular disease. Pulm Circ. 2016 Dec; 6(4):483-497. PMID: 28090290.
      View in: PubMed
    4. Goldstein NB, Koster MI, Hoaglin LG, Wright MJ, Robinson SE, Robinson WA, Roop DR, Norris DA, Birlea SA. Isolating RNA from precursor and mature melanocytes from human vitiligo and normal skin using laser capture microdissection. Exp Dermatol. 2016 Oct; 25(10):805-11. PMID: 27193292.
      View in: PubMed
    5. Keysar SB, Le PN, Miller B, Jackson BC, Eagles JR, Nieto C, Kim J, Tang B, Glogowska MJ, Morton JJ, Padilla-Just N, Gomez K, Warnock E, Reisinger J, Arcaroli JJ, Messersmith WA, Wakefield LM, Gao D, Tan AC, Serracino H, Vasiliou V, Roop DR, Wang XJ, Jimeno A. Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2. J Natl Cancer Inst. 2017 01; 109(1). PMID: 27634934.
      View in: PubMed
    6. Zhang L, Ferreyros M, Feng W, Hupe M, Crumrine DA, Chen J, Elias PM, Holleran WM, Niswander L, Hohl D, Williams T, Torchia EC, Roop DR. Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis. PLoS One. 2016; 11(8):e0161465. PMID: 27551807; PMCID: PMC4994956.
    7. Rice RH, Durbin-Johnson BP, Ishitsuka Y, Salemi M, Phinney BS, Rocke DM, Roop DR. Proteomic Analysis of Loricrin Knockout Mouse Epidermis. J Proteome Res. 2016 Aug 05; 15(8):2560-6. PMID: 27418529.
      View in: PubMed
    8. Ishitsuka Y, Huebner AJ, Rice RH, Koch PJ, Speransky VV, Steven AC, Roop DR. Lce1 Family Members Are Nrf2-Target Genes that Are Induced to Compensate for the Loss of Loricrin. J Invest Dermatol. 2016 Aug; 136(8):1656-63. PMID: 27167730.
      View in: PubMed
    9. Kumar V, Bouameur JE, Bär J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj P, Brazel CB, Heller S, Binder H, Löffler-Wirth H, Seibel P, Magin TM. Correction: A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. J Cell Biol. 2016 Mar 28; 212(7):877. PMID: 27002167; PMCID: PMC4810296.
    10. Liu Y, Snedecor ER, Zhang X, Xu Y, Huang L, Jones EC, Zhang L, Clark RA, Roop DR, Qin C, Chen J. Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75. J Invest Dermatol. 2016 Jan; 136(1):45-51. PMID: 26763422; PMCID: PMC4764097.
    11. Bowles DW, Keysar SB, Eagles JR, Wang G, Glogowska MJ, McDermott JD, Le PN, Gao D, Ray CE, Rochon PJ, Roop DR, Tan AC, Serracino HS, Jimeno A. A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma. Oral Oncol. 2016 Feb; 53:74-9. PMID: 26705064.
      View in: PubMed
    12. Kumar V, Bouameur JE, Bär J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj P, Brazel CB, Heller S, Binder H, Löffler-Wirth H, Seibel P, Magin TM. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. J Cell Biol. 2015 Dec 07; 211(5):1057-75. PMID: 26644517; PMCID: PMC4674273.
    13. Riemondy K, Wang XJ, Torchia EC, Roop DR, Yi R. MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells. Elife. 2015 Jul 23; 4. PMID: 26203562; PMCID: PMC4536367.
    14. Morton JJ, Bird G, Keysar SB, Astling DP, Lyons TR, Anderson RT, Glogowska MJ, Estes P, Eagles JR, Le PN, Gan G, McGettigan B, Fernandez P, Padilla-Just N, Varella-Garcia M, Song JI, Bowles DW, Schedin P, Tan AC, Roop DR, Wang XJ, Refaeli Y, Jimeno A. XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer. Oncogene. 2016 Jan 21; 35(3):290-300. PMID: 25893296; PMCID: PMC4613815.
    15. Goldstein NB, Koster MI, Hoaglin LG, Spoelstra NS, Kechris KJ, Robinson SE, Robinson WA, Roop DR, Norris DA, Birlea SA. Narrow Band Ultraviolet B Treatment for Human Vitiligo Is Associated with Proliferation, Migration, and Differentiation of Melanocyte Precursors. J Invest Dermatol. 2015 Aug; 135(8):2068-76. PMID: 25822579.
      View in: PubMed
    16. Bilousova G, Roop DR. Induced pluripotent stem cells in dermatology: potentials, advances, and limitations. Cold Spring Harb Perspect Med. 2014 Nov 03; 4(11):a015164. PMID: 25368014; PMCID: PMC4208713.
    17. Rorke EA, Adhikary G, Young CA, Roop DR, Eckert RL. Suppressing AP1 factor signaling in the suprabasal epidermis produces a keratoderma phenotype. J Invest Dermatol. 2015 Jan; 135(1):170-80. PMID: 25050598; PMCID: PMC4268309.
    18. van Steensel MA, Coulombe PA, Kaspar RL, Milstone LM, McLean IW, Roop DR, Smith FJ, Sprecher E, Schwartz ME. Report of the 10th Annual International Pachyonychia Congenita Consortium Meeting. J Invest Dermatol. 2014 Mar; 134(3):588-91. PMID: 24518109; PMCID: PMC3930927.
    19. Schäfer M, Willrodt AH, Kurinna S, Link AS, Farwanah H, Geusau A, Gruber F, Sorg O, Huebner AJ, Roop DR, Sandhoff K, Saurat JH, Tschachler E, Schneider MR, Langbein L, Bloch W, Beer HD, Werner S. Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice. EMBO Mol Med. 2014 04; 6(4):442-57. PMID: 24503019; PMCID: PMC3992072.
    20. Kogut I, Roop DR, Bilousova G. Differentiation of human induced pluripotent stem cells into a keratinocyte lineage. Methods Mol Biol. 2014; 1195:1-12. PMID: 24510784; PMCID: PMC4096605.
    21. Dallaglio K, Petrachi T, Marconi A, Truzzi F, Lotti R, Saltari A, Morandi P, Puviani M, Maiorana A, Roop DR, Pincelli C. Isolation and characterization of squamous cell carcinoma-derived stem-like cells: role in tumor formation. Int J Mol Sci. 2013 Sep 26; 14(10):19540-55. PMID: 24077125; PMCID: PMC3821572.
    22. White RA, Neiman JM, Reddi A, Han G, Birlea S, Mitra D, Dionne L, Fernandez P, Murao K, Bian L, Keysar SB, Goldstein NB, Song N, Bornstein S, Han Z, Lu X, Wisell J, Li F, Song J, Lu SL, Jimeno A, Roop DR, Wang XJ. Epithelial stem cell mutations that promote squamous cell carcinoma metastasis. J Clin Invest. 2013 Oct; 123(10):4390-404. PMID: 23999427; PMCID: PMC3784525.
    23. Chari NS, Romano RA, Koster MI, Jaks V, Roop D, Flores ER, Teglund S, Sinha S, Gruber W, Aberger F, Medeiros LJ, Toftgard R, McDonnell TJ. Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis. Cell Death Differ. 2013 Aug; 20(8):1080-8. PMID: 23686138; PMCID: PMC3705600.
    24. Yasuda M, Claypool DJ, Guevara E, Roop DR, Chen J. Genetic manipulation of keratinocyte stem cells with lentiviral vectors. Methods Mol Biol. 2013; 989:143-51. PMID: 23483393.
      View in: PubMed
    25. Bilousova G, Roop DR. Generation of functional multipotent keratinocytes from mouse induced pluripotent stem cells. Methods Mol Biol. 2013; 961:337-50. PMID: 23325655.
      View in: PubMed
    26. Huebner AJ, Dai D, Morasso M, Schmidt EE, Schäfer M, Werner S, Roop DR. Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero. Dev Cell. 2012 Dec 11; 23(6):1238-46. PMID: 23237955; PMCID: PMC3710685.
    27. Tao J, Koster MI, Harrison W, Moran JL, Beier DR, Roop DR, Overbeek PA. A spontaneous Fatp4/Scl27a4 splice site mutation in a new murine model for congenital ichthyosis. PLoS One. 2012; 7(11):e50634. PMID: 23226340; PMCID: PMC3511458.
    28. Luo Y, Dallaglio K, Chen Y, Robinson WA, Robinson SE, McCarter MD, Wang J, Gonzalez R, Thompson DC, Norris DA, Roop DR, Vasiliou V, Fujita M. ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets. Stem Cells. 2012 Oct; 30(10):2100-13. PMID: 22887839; PMCID: PMC3448863.
    29. Chen J, Roop DR. Mimicking hair disorders by genetic manipulation of organ-cultured human hair follicles. J Invest Dermatol. 2012 Oct; 132(10):2312-4. PMID: 22971919; PMCID: PMC3708693.
    30. Torchia EC, Zhang L, Huebner AJ, Sen S, Roop DR. Aurora kinase-A deficiency during skin development impairs cell division and stratification. J Invest Dermatol. 2013 Jan; 133(1):78-86. PMID: 22832491; PMCID: PMC3494779.
    31. Luo Y, Ellis LZ, Dallaglio K, Takeda M, Robinson WA, Robinson SE, Liu W, Lewis KD, McCarter MD, Gonzalez R, Norris DA, Roop DR, Spritz RA, Ahn NG, Fujita M. Side population cells from human melanoma tumors reveal diverse mechanisms for chemoresistance. J Invest Dermatol. 2012 Oct; 132(10):2440-50. PMID: 22622430; PMCID: PMC3434242.
    32. Yuspa SH, Kraemer KH, Dlugosz AA, Roop DR, Kulesz-Martin M, Bickenbach JR. Montagna Symposium 2011: 60th Anniversary--Advances in Science and Medicine Catalyzed by Pioneering Skin Research. J Invest Dermatol. 2012 May; 132(5):1317-20. PMID: 22499034; PMCID: PMC3480207.
    33. Schäfer M, Farwanah H, Willrodt AH, Huebner AJ, Sandhoff K, Roop D, Hohl D, Bloch W, Werner S. Nrf2 links epidermal barrier function with antioxidant defense. EMBO Mol Med. 2012 May; 4(5):364-79. PMID: 22383093; PMCID: PMC3403295.
    34. Torchia EC, Caulin C, Acin S, Terzian T, Kubick BJ, Box NF, Roop DR. Myc, Aurora Kinase A, and mutant p53(R172H) co-operate in a mouse model of metastatic skin carcinoma. Oncogene. 2012 May 24; 31(21):2680-90. PMID: 21963848; PMCID: PMC4576849.
    35. Acin S, Li Z, Mejia O, Roop DR, El-Naggar AK, Caulin C. Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras. J Pathol. 2011 Dec; 225(4):479-89. PMID: 21952947; PMCID: PMC4302750.
    36. Terzian T, Dumble M, Arbab F, Thaller C, Donehower LA, Lozano G, Justice MJ, Roop DR, Box NF. Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug; 224(4):540-52. PMID: 21674502; PMCID: PMC3632393.
    37. Kubick BJ, Roop DR. A fitness model for melanoma-initiating cells. Pigment Cell Melanoma Res. 2011 Jun; 24(3):396-7. PMID: 22489315.
      View in: PubMed
    38. Bu W, Chen J, Morrison GD, Huang S, Creighton CJ, Huang J, Chamness GC, Hilsenbeck SG, Roop DR, Leavitt AD, Li Y. Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer. Oncogene. 2011 Oct 27; 30(43):4399-409. PMID: 21532625; PMCID: PMC3156856.
    39. Bilousova G, Jun du H, King KB, De Langhe S, Chick WS, Torchia EC, Chow KS, Klemm DJ, Roop DR, Majka SM. Osteoblasts derived from induced pluripotent stem cells form calcified structures in scaffolds both in vitro and in vivo. Stem Cells. 2011 Feb; 29(2):206-16. PMID: 21732479; PMCID: PMC3321731.
    40. Franco HL, Dai D, Lee KY, Rubel CA, Roop D, Boerboom D, Jeong JW, Lydon JP, Bagchi IC, Bagchi MK, DeMayo FJ. WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse. FASEB J. 2011 Apr; 25(4):1176-87. PMID: 21163860; PMCID: PMC3058697.
    41. Bilousova G, Chen J, Roop DR. Differentiation of mouse induced pluripotent stem cells into a multipotent keratinocyte lineage. J Invest Dermatol. 2011 Apr; 131(4):857-64. PMID: 21150926.
      View in: PubMed
    42. Terzian T, Torchia EC, Dai D, Robinson SE, Murao K, Stiegmann RA, Gonzalez V, Boyle GM, Powell MB, Pollock PM, Lozano G, Robinson WA, Roop DR, Box NF. p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation. Pigment Cell Melanoma Res. 2010 Dec; 23(6):781-94. PMID: 20849464; PMCID: PMC3137930.
    43. Dai D, Zhu H, Wlodarczyk B, Zhang L, Li L, Li AG, Finnell RH, Roop DR, Chen J. Fuz controls the morphogenesis and differentiation of hair follicles through the formation of primary cilia. J Invest Dermatol. 2011 Feb; 131(2):302-10. PMID: 20962855.
      View in: PubMed
    44. Bilousova G, Roop DR. Altering cell fate: from thymus epithelium to skin stem cells. Cell Stem Cell. 2010 Oct 08; 7(4):419-20. PMID: 20887943.
      View in: PubMed
    45. Box NF, Torchia EC, Roop DR. Are stem cell niches shared for skin cancers? Pigment Cell Melanoma Res. 2010 Aug; 23(4):517-20. PMID: 20546533; PMCID: PMC3137929.
    46. Honeycutt KA, Waikel RL, Koster MI, Wang XJ, Roop DR. The effect of c-myc on stem cell fate influences skin tumor phenotype. Mol Carcinog. 2010 Apr; 49(4):315-9. PMID: 20146250.
      View in: PubMed
    47. Li F, Huang Q, Chen J, Peng Y, Roop DR, Bedford JS, Li CY. Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration. Sci Signal. 2010 Feb 23; 3(110):ra13. PMID: 20179271; PMCID: PMC2905599.
    48. Mikkola ML, Costanzo A, Thesleff I, Roop DR, Koster MI. Treasure or artifact: a decade of p63 research speaks for itself. Cell Death Differ. 2010 Jan; 17(1):180-3; author reply 184-6. PMID: 19876067; PMCID: PMC2795030.
    49. Chen D, Lin Q, Box N, Roop D, Ishii S, Matsuzaki K, Fan T, Hornyak TJ, Reed JA, Stavnezer E, Timchenko NA, Medrano EE. SKI knockdown inhibits human melanoma tumor growth in vivo. Pigment Cell Melanoma Res. 2009 Dec; 22(6):761-72. PMID: 19845874.
      View in: PubMed
    50. Kim S, Choi IF, Quante JR, Zhang L, Roop DR, Koster MI. p63 directly induces expression of Alox12, a regulator of epidermal barrier formation. Exp Dermatol. 2009 Dec; 18(12):1016-21. PMID: 19555433; PMCID: PMC2857403.
    51. Torchia EC, Chen Y, Sheng H, Katayama H, Fitzpatrick J, Brinkley WR, Caulin C, Sen S, Roop DR. A genetic variant of Aurora kinase A promotes genomic instability leading to highly malignant skin tumors. Cancer Res. 2009 Sep 15; 69(18):7207-15. PMID: 19738056; PMCID: PMC2745523.
    52. Koster MI, Marinari B, Payne AS, Kantaputra PN, Costanzo A, Roop DR. DeltaNp63 knockdown mice: A mouse model for AEC syndrome. Am J Med Genet A. 2009 Sep; 149A(9):1942-7. PMID: 19681108; PMCID: PMC2753548.
    53. Fete M, vanBokhoven H, Clements SE, McKeon F, Roop DR, Koster MI, Missero C, Attardi LD, Lombillo VA, Ratovitski E, Julapalli M, Ruths D, Sybert VP, Siegfried EC, Bree AF. International Research Symposium on Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate (AEC) syndrome. Am J Med Genet A. 2009 Sep; 149A(9):1885-93. PMID: 19353643; PMCID: PMC2736474.
    54. Refaeli Y, Bhoumik A, Roop DR, Ronai ZA. Melanoma-initiating cells: a compass needed. EMBO Rep. 2009 Sep; 10(9):965-72. PMID: 19680286; PMCID: PMC2750051.
    55. Roop D, Toftgård R. Hedgehog in Wnterland. Nat Genet. 2008 Sep; 40(9):1040-1. PMID: 19165916.
      View in: PubMed
    56. Marinari B, Ballaro C, Koster MI, Giustizieri ML, Moretti F, Crosti F, Papoutsaki M, Karin M, Alema S, Chimenti S, Roop DR, Costanzo A. IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias. J Invest Dermatol. 2009 Jan; 129(1):60-9. PMID: 18633439.
      View in: PubMed
    57. Koster MI, Roop DR. Sorting out the p63 signaling network. J Invest Dermatol. 2008 Jul; 128(7):1617-9. PMID: 18548078; PMCID: PMC2854628.
    58. Chen J, Roop DR. Genetically engineered mouse models for skin research: taking the next step. J Dermatol Sci. 2008 Oct; 52(1):1-12. PMID: 18511240; PMCID: PMC3701407.
    59. Leachman SA, Hickerson RP, Hull PR, Smith FJ, Milstone LM, Lane EB, Bale SJ, Roop DR, McLean WH, Kaspar RL. Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenita. J Dermatol Sci. 2008 Sep; 51(3):151-7. PMID: 18495438; PMCID: PMC2587483.
    60. Iwai N, Zhou Z, Roop DR, Behringer RR. Horizontal basal cells are multipotent progenitors in normal and injured adult olfactory epithelium. Stem Cells. 2008 May; 26(5):1298-306. PMID: 18308944; PMCID: PMC4091843.
    61. Guttormsen J, Koster MI, Stevens JR, Roop DR, Williams T, Winger QA. Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice. Dev Biol. 2008 May 01; 317(1):187-95. PMID: 18353300; PMCID: PMC2435508.
    62. Lee S, Chari NS, Kim HW, Wang X, Roop DR, Cho SH, DiGiovanni J, McDonnell TJ. Cooperation of Ha-ras and Bcl-2 during multistep skin carcinogenesis. Mol Carcinog. 2007 Dec; 46(12):949-57. PMID: 17538944.
      View in: PubMed
    63. Chen J, Jaeger K, Den Z, Koch PJ, Sundberg JP, Roop DR. Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita. J Invest Dermatol. 2008 Feb; 128(2):270-9. PMID: 17851587.
      View in: PubMed
    64. Caulin C, Nguyen T, Lang GA, Goepfert TM, Brinkley BR, Cai WW, Lozano G, Roop DR. An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations. J Clin Invest. 2007 Jul; 117(7):1893-901. PMID: 17607363; PMCID: PMC1904325.
    65. Shah VR, Koster MI, Roop DR, Spencer DM, Wei L, Li Q, Schwartz RJ, Chang J. Double-inducible gene activation system for caspase 3 and 9 in epidermis. Genesis. 2007 Apr; 45(4):194-9. PMID: 17417788; PMCID: PMC2566959.
    66. Koster MI, Dai D, Marinari B, Sano Y, Costanzo A, Karin M, Roop DR. p63 induces key target genes required for epidermal morphogenesis. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3255-60. PMID: 17360634; PMCID: PMC1805532.
    67. Koster MI, Dai D, Roop DR. Conflicting roles for p63 in skin development and carcinogenesis. Cell Cycle. 2007 Feb 01; 6(3):269-73. PMID: 17224652.
      View in: PubMed
    68. Buitrago W, Roop DR. Oct-4: the almighty POUripotent regulator? J Invest Dermatol. 2007 Feb; 127(2):260-2. PMID: 17228302.
      View in: PubMed
    69. Prigozhina NL, Zhong L, Hunter EA, Mikic I, Callaway S, Roop DR, Mancini MA, Zacharias DA, Price JH, McDonough PM. Plasma membrane assays and three-compartment image cytometry for high content screening. Assay Drug Dev Technol. 2007 Feb; 5(1):29-48. PMID: 17355198.
      View in: PubMed
    70. Koster MI, Roop DR. Mechanisms regulating epithelial stratification. Annu Rev Cell Dev Biol. 2007; 23:93-113. PMID: 17489688.
      View in: PubMed
    71. Chen J, Cheng X, Merched-Sauvage M, Caulin C, Roop DR, Koch PJ. An unexpected role for keratin 10 end domains in susceptibility to skin cancer. J Cell Sci. 2006 Dec 15; 119(Pt 24):5067-76. PMID: 17118961.
      View in: PubMed
    72. Geng S, Mezentsev A, Kalachikov S, Raith K, Roop DR, Panteleyev AA. Targeted ablation of Arnt in mouse epidermis results in profound defects in desquamation and epidermal barrier function. J Cell Sci. 2006 Dec 01; 119(Pt 23):4901-12. PMID: 17105764.
      View in: PubMed
    73. Yu Z, Lin KK, Bhandari A, Spencer JA, Xu X, Wang N, Lu Z, Gill GN, Roop DR, Wertz P, Andersen B. The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Dev Biol. 2006 Nov 01; 299(1):122-36. PMID: 16949565.
      View in: PubMed
    74. Grimm SL, Bu W, Longley MA, Roop DR, Li Y, Rosen JM. Keratin 6 is not essential for mammary gland development. Breast Cancer Res. 2006; 8(3):R29. PMID: 16790075; PMCID: PMC1557733.
    75. Keyes WM, Vogel H, Koster MI, Guo X, Qi Y, Petherbridge KM, Roop DR, Bradley A, Mills AA. p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors. Proc Natl Acad Sci U S A. 2006 May 30; 103(22):8435-40. PMID: 16714381; PMCID: PMC1482510.
    76. Koster MI, Lu SL, White LD, Wang XJ, Roop DR. Reactivation of developmentally expressed p63 isoforms predisposes to tumor development and progression. Cancer Res. 2006 Apr 15; 66(8):3981-6. PMID: 16618715.
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    77. Nguyen BC, Lefort K, Mandinova A, Antonini D, Devgan V, Della Gatta G, Koster MI, Zhang Z, Wang J, Tommasi di Vignano A, Kitajewski J, Chiorino G, Roop DR, Missero C, Dotto GP. Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev. 2006 Apr 15; 20(8):1028-42. PMID: 16618808; PMCID: PMC1472299.
    78. Honeycutt KA, Chen Z, Koster MI, Miers M, Nuchtern J, Hicks J, Roop DR, Shohet JM. Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis. Oncogene. 2006 Jul 06; 25(29):4027-32. PMID: 16518415.
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    79. Koster MI, Kim S, Huang J, Williams T, Roop DR. TAp63alpha induces AP-2gamma as an early event in epidermal morphogenesis. Dev Biol. 2006 Jan 01; 289(1):253-61. PMID: 16324689.
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    80. Koster MI, Kim S, Roop DR. P63 deficiency: a failure of lineage commitment or stem cell maintenance? J Investig Dermatol Symp Proc. 2005 Nov; 10(2):118-23. PMID: 16363063.
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    81. Koster MI, Roop DR. Asymmetric cell division in skin development: a new look at an old observation. Dev Cell. 2005 Oct; 9(4):444-6. PMID: 16198286.
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    82. Chen J, Roop DR. Mouse models in preclinical studies for pachyonychia congenita. J Investig Dermatol Symp Proc. 2005 Oct; 10(1):37-46. PMID: 16250208.
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    83. Mammucari C, Tommasi di Vignano A, Sharov AA, Neilson J, Havrda MC, Roop DR, Botchkarev VA, Crabtree GR, Dotto GP. Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. Dev Cell. 2005 May; 8(5):665-76. PMID: 15866158.
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    84. Koster MI, Roop DR. Genetic pathways required for epidermal morphogenesis. Eur J Cell Biol. 2004 Dec; 83(11-12):625-9. PMID: 15679107.
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    85. Xu X, Kawachi Y, Nakamura Y, Sakurai H, Hirota A, Banno T, Takahashi T, Roop DR, Otsuka F. Yin-yang 1 negatively regulates the differentiation-specific transcription of mouse loricrin gene in undifferentiated keratinocytes. J Invest Dermatol. 2004 Dec; 123(6):1120-6. PMID: 15610523.
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    86. Koch PJ, Roop DR. The role of keratins in epidermal development and homeostasis--going beyond the obvious. J Invest Dermatol. 2004 Nov; 123(5):x-xi. PMID: 15482464.
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    87. Koster MI, Roop DR. p63 and epithelial appendage development. Differentiation. 2004 Oct; 72(8):364-70. PMID: 15606495.
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    88. Honeycutt KA, Koster MI, Roop DR. Genes involved in stem cell fate decisions and commitment to differentiation play a role in skin disease. J Investig Dermatol Symp Proc. 2004 Sep; 9(3):261-8. PMID: 15369222.
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    89. Matsumoto T, Kiguchi K, Jiang J, Carbajal S, Ruffino L, Beltrán L, Wang XJ, Roop DR, DiGiovanni J. Development of transgenic mice that inducibly express an active form of c-Src in the epidermis. Mol Carcinog. 2004 Aug; 40(4):189-200. PMID: 15264211.
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    90. Caulin C, Nguyen T, Longley MA, Zhou Z, Wang XJ, Roop DR. Inducible activation of oncogenic K-ras results in tumor formation in the oral cavity. Cancer Res. 2004 Aug 01; 64(15):5054-8. PMID: 15289303.
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    91. Honeycutt KA, Roop DR. c-Myc and epidermal stem cell fate determination. J Dermatol. 2004 May; 31(5):368-75. PMID: 15187303.
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    92. Sil AK, Maeda S, Sano Y, Roop DR, Karin M. IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature. 2004 Apr 08; 428(6983):660-4. PMID: 15071597.
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    93. Koster MI, Roop DR. Transgenic mouse models provide new insights into the role of p63 in epidermal development. Cell Cycle. 2004 Apr; 3(4):411-3. PMID: 14976425.
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    94. Koster MI, Roop DR. The role of p63 in development and differentiation of the epidermis. J Dermatol Sci. 2004 Feb; 34(1):3-9. PMID: 14757276.
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    95. Koster MI, Kim S, Mills AA, DeMayo FJ, Roop DR. p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev. 2004 Jan 15; 18(2):126-31. PMID: 14729569; PMCID: PMC324418.
    96. Arin MJ, Roop DR. Inducible mouse models for inherited skin diseases: implications for skin gene therapy. Cells Tissues Organs. 2004; 177(3):160-8. PMID: 15388990.
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    97. Bigelow RL, Chari NS, Unden AB, Spurgers KB, Lee S, Roop DR, Toftgard R, McDonnell TJ. Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1. J Biol Chem. 2004 Jan 09; 279(2):1197-205. PMID: 14555646.
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    98. Wakabayashi N, Itoh K, Wakabayashi J, Motohashi H, Noda S, Takahashi S, Imakado S, Kotsuji T, Otsuka F, Roop DR, Harada T, Engel JD, Yamamoto M. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet. 2003 Nov; 35(3):238-45. PMID: 14517554.
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    99. Koster MI, Huntzinger KA, Roop DR. Epidermal differentiation: transgenic/knockout mouse models reveal genes involved in stem cell fate decisions and commitment to differentiation. J Investig Dermatol Symp Proc. 2002 Dec; 7(1):41-5. PMID: 12518791.
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    100. Long DJ, Iskander K, Gaikwad A, Arin M, Roop DR, Knox R, Barrios R, Jaiswal AK. Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity. J Biol Chem. 2002 Nov 29; 277(48):46131-9. PMID: 12351651.
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    101. Cao T, Tsai SY, O'Malley BW, Wang XJ, Roop DR. The epidermis as a bioreactor: topically regulated cutaneous delivery into the circulation. Hum Gene Ther. 2002 Jun 10; 13(9):1075-80. PMID: 12067440.
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    102. Cao T, He W, Roop DR, Wang XJ. K14-GLp65 transactivator induces transgene expression in embryonic epidermis. Genesis. 2002 Feb; 32(2):189-90. PMID: 11857818.
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    103. Zhou Z, Wang D, Wang XJ, Roop DR. In utero activation of K5.CrePR1 induces gene deletion. Genesis. 2002 Feb; 32(2):191-2. PMID: 11857819.
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    104. Arin MJ, Roop DR. Use of laser capture microscopy in the analysis of mouse models of human diseases. Methods Enzymol. 2002; 356:207-15. PMID: 12418199.
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    105. Jarnik M, de Viragh PA, Schärer E, Bundman D, Simon MN, Roop DR, Steven AC. Quasi-normal cornified cell envelopes in loricrin knockout mice imply the existence of a loricrin backup system. J Invest Dermatol. 2002 Jan; 118(1):102-9. PMID: 11851882.
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    106. Arin MJ, Roop DR. Disease model: heritable skin blistering. Trends Mol Med. 2001 Sep; 7(9):422-4. PMID: 11530338.
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    107. Wojcik SM, Longley MA, Roop DR. Discovery of a novel murine keratin 6 (K6) isoform explains the absence of hair and nail defects in mice deficient for K6a and K6b. J Cell Biol. 2001 Aug 06; 154(3):619-30. PMID: 11489919; PMCID: PMC2196416.
    108. Long DJ, Waikel RL, Wang XJ, Roop DR, Jaiswal AK. NAD(P)H:quinone oxidoreductase 1 deficiency and increased susceptibility to 7,12-dimethylbenz[a]-anthracene-induced carcinogenesis in mouse skin. J Natl Cancer Inst. 2001 Aug 01; 93(15):1166-70. PMID: 11481389.
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    109. Waikel RL, Kawachi Y, Waikel PA, Wang XJ, Roop DR. Deregulated expression of c-Myc depletes epidermal stem cells. Nat Genet. 2001 Jun; 28(2):165-8. PMID: 11381265.
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    110. Arin MJ, Longley MA, Wang XJ, Roop DR. Focal activation of a mutant allele defines the role of stem cells in mosaic skin disorders. J Cell Biol. 2001 Feb 05; 152(3):645-9. PMID: 11157989; PMCID: PMC2195990.
    111. Cao T, Longley MA, Wang XJ, Roop DR. An inducible mouse model for epidermolysis bullosa simplex: implications for gene therapy. J Cell Biol. 2001 Feb 05; 152(3):651-6. PMID: 11157990; PMCID: PMC2195993.
    112. Long DJ, Waikel RL, Wang XJ, Perlaky L, Roop DR, Jaiswal AK. NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis. Cancer Res. 2000 Nov 01; 60(21):5913-5. PMID: 11085502.
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    113. Cao T, Wang XJ, Roop DR. Regulated cutaneous gene delivery: the skin as a bioreactor. Hum Gene Ther. 2000 Nov 01; 11(16):2297-300. PMID: 11084689.
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    114. Suga Y, Jarnik M, Attar PS, Longley MA, Bundman D, Steven AC, Koch PJ, Roop DR. Transgenic mice expressing a mutant form of loricrin reveal the molecular basis of the skin diseases, Vohwinkel syndrome and progressive symmetric erythrokeratoderma. J Cell Biol. 2000 Oct 16; 151(2):401-12. PMID: 11038186; PMCID: PMC2192631.
    115. Koch PJ, de Viragh PA, Scharer E, Bundman D, Longley MA, Bickenbach J, Kawachi Y, Suga Y, Zhou Z, Huber M, Hohl D, Kartasova T, Jarnik M, Steven AC, Roop DR. Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein. J Cell Biol. 2000 Oct 16; 151(2):389-400. PMID: 11038185; PMCID: PMC2192642.
    116. Wang XJ, Greenhalgh DA, Donehower LA, Roop DR. Cooperation between Ha-ras and fos or transforming growth factor alpha overcomes a paradoxic tumor-inhibitory effect of p53 loss in transgenic mouse epidermis. Mol Carcinog. 2000 Oct; 29(2):67-75. PMID: 11074603.
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    117. Liefer KM, Koster MI, Wang XJ, Yang A, McKeon F, Roop DR. Down-regulation of p63 is required for epidermal UV-B-induced apoptosis. Cancer Res. 2000 Aug 01; 60(15):4016-20. PMID: 10945600.
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    118. Wojcik SM, Bundman DS, Roop DR. Delayed wound healing in keratin 6a knockout mice. Mol Cell Biol. 2000 Jul; 20(14):5248-55. PMID: 10866680; PMCID: PMC85973.
    119. Wang XJ, Greenhalgh DA, Roop DR. Transgenic coexpression of v-Ha-ras and transforming growth factor alpha increases epidermal hyperproliferation and tumorigenesis and predisposes to malignant conversion via endogenous c-Ha-ras activation. Mol Carcinog. 2000 Mar; 27(3):200-9. PMID: 10708482.
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    120. Berton TR, Wang XJ, Zhou Z, Kellendonk C, Schütz G, Tsai S, Roop DR. Characterization of an inducible, epidermal-specific knockout system: differential expression of lacZ in different Cre reporter mouse strains. Genesis. 2000 Feb; 26(2):160-1. PMID: 10686618.
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    121. Suga Y, Arin MJ, Scott G, Goldsmith LA, Magro CM, Baden LA, Baden HP, Roop DR. Hot spot mutations in keratin 2e suggest a correlation between genotype and phenotype in patients with ichthyosis bullosa of Siemens. Exp Dermatol. 2000 Feb; 9(1):11-5. PMID: 10688369.
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    122. Arin MJ, Longley MA, Epstein EH, Rothnagel JA, Roop DR. Identification of a novel mutation in keratin 1 in a family with epidermolytic hyperkeratosis. Exp Dermatol. 2000 Feb; 9(1):16-9. PMID: 10688370.
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    123. Wang XJ, Liefer KM, Greenhalgh DA, Roop DR. 12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mouse epidermis coexpressing transforming growth factor-alpha and v-fos: acceleration of autonomous papilloma formation and malignant conversion via c-Ha-ras activation. Mol Carcinog. 1999 Dec; 26(4):305-11. PMID: 10569807.
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    124. Rothnagel JA, Seki T, Ogo M, Longley MA, Wojcik SM, Bundman DS, Bickenbach JR, Roop DR. The mouse keratin 6 isoforms are differentially expressed in the hair follicle, footpad, tongue and activated epidermis. Differentiation. 1999 Oct; 65(2):119-30. PMID: 10550545.
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    125. Wojcik SM, Imakado S, Seki T, Longley MA, Petherbridge L, Bundman DS, Bickenbach JR, Rothnagel JA, Roop DR. Expression of MK6a dominant-negative and C-terminal mutant transgenes in mice has distinct phenotypic consequences in the epidermis and hair follicle. Differentiation. 1999 Oct; 65(2):97-112. PMID: 10550543.
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    126. Waikel RL, Wang XJ, Roop DR. Targeted expression of c-Myc in the epidermis alters normal proliferation, differentiation and UV-B induced apoptosis. Oncogene. 1999 Aug 26; 18(34):4870-8. PMID: 10490820.
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    127. Wang XJ, Liefer KM, Tsai S, O'Malley BW, Roop DR. Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis. Proc Natl Acad Sci U S A. 1999 Jul 20; 96(15):8483-8. PMID: 10411901; PMCID: PMC17542.
    128. Bickenbach JR, Roop DR. Transduction of a preselected population of human epidermal stem cells: consequences for gene therapy. Proc Assoc Am Physicians. 1999 May-Jun; 111(3):184-9. PMID: 10354357.
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    129. DiSepio D, Bickenbach JR, Longley MA, Bundman DS, Rothnagel JA, Roop DR. Characterization of loricrin regulation in vitro and in transgenic mice. Differentiation. 1999 May; 64(4):225-35. PMID: 10365440.
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    130. Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature. 1999 Apr 22; 398(6729):708-13. PMID: 10227293.
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    131. Lin MT, Levy ML, Bowden PE, Magro C, Baden L, Baden HP, Roop DR. Identification of sporadic mutations in the helix initiation motif of keratin 6 in two pachyonychia congenita patients: further evidence for a mutational hot spot. Exp Dermatol. 1999 Apr; 8(2):115-9. PMID: 10232401.
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    132. Arin MJ, Longley MA, Küster W, Huber M, Hohl D, Rothnagel JA, Roop DR. An asparagine to threonine substitution in the 1A domain of keratin 1: a novel mutation that causes epidermolytic hyperkeratosis. Exp Dermatol. 1999 Apr; 8(2):124-7. PMID: 10232403.
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    133. Arin MJ, Longley MA, Anton-Lamprecht I, Kurze G, Huber M, Hohl D, Rothnagel JA, Roop DR. A novel substitution in keratin 10 in epidermolytic hyperkeratosis. J Invest Dermatol. 1999 Apr; 112(4):506-8. PMID: 10201536.
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    134. Arin MJ, Longley MA, Epstein EH, Scott G, Goldsmith LA, Rothnagel JA, Roop DR. A novel mutation in the 1A domain of keratin 2e in ichthyosis bullosa of Siemens. J Invest Dermatol. 1999 Mar; 112(3):380-2. PMID: 10084318.
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    135. Suga Y, Duncan KO, Heald PW, Roop DR. A novel helix termination mutation in keratin 10 in annular epidermolytic ichthyosis, a variant of bullous congenital ichthyosiform erythroderma. J Invest Dermatol. 1998 Dec; 111(6):1220-3. PMID: 9856845.
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    136. Wang XJ, Greenhalgh DA, Jiang A, He D, Zhong L, Brinkley BR, Roop DR. Analysis of centrosome abnormalities and angiogenesis in epidermal-targeted p53172H mutant and p53-knockout mice after chemical carcinogenesis: evidence for a gain of function. Mol Carcinog. 1998 Nov; 23(3):185-92. PMID: 9833779.
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    137. Klug DB, Carter C, Crouch E, Roop D, Conti CJ, Richie ER. Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11822-7. PMID: 9751749; PMCID: PMC21724.
    138. Rothnagel JA, Lin MT, Longley MA, Holder RA, Hazen PG, Levy ML, Roop DR. Prenatal diagnosis for keratin mutations to exclude transmission of epidermolytic hyperkeratosis. Prenat Diagn. 1998 Aug; 18(8):826-30. PMID: 9742571.
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    139. Wang XJ, Greenhalgh DA, Jiang A, He D, Zhong L, Medina D, Brinkley BR, Roop DR. Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis. Oncogene. 1998 Jul 09; 17(1):35-45. PMID: 9671312.
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    140. Bonnekoh B, Greenhalgh DA, Chen SH, Block A, Rich SS, Krieg T, Woo SL, Roop DR. Ex vivo and in vivo adenovirus-mediated gene therapy strategies induce a systemic anti-tumor immune defence in the B16 melanoma model. J Invest Dermatol. 1998 Jun; 110(6):867-71. PMID: 9620291.
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    141. Rodríguez-Villanueva J, Greenhalgh D, Wang XJ, Bundman D, Cho S, Delehedde M, Roop D, McDonnell TJ. Human keratin-1.bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation. Oncogene. 1998 Feb 19; 16(7):853-63. PMID: 9484776.
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    142. Bonnekoh B, Greenhalgh DA, Chen SH, Bickenbach J, Block A, Rich SS, Krieg T, Woo SL, Roop DR. Adenovirus-mediated ex vivo immunogene and in vivo combination gene therapy strategies induce a systemic anti-tumor immune defense in the mouse B16 melanoma model. Adv Exp Med Biol. 1998; 451:335-43. PMID: 10026893.
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    143. Borkowski TA, Letterio JJ, Mackall CL, Saitoh A, Wang XJ, Roop DR, Gress RE, Udey MC. A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice. J Clin Invest. 1997 Aug 01; 100(3):575-81. PMID: 9239404; PMCID: PMC508224.
    144. Attar PS, Wertz PW, McArthur M, Imakado S, Bickenbach JR, Roop DR. Inhibition of retinoid signaling in transgenic mice alters lipid processing and disrupts epidermal barrier function. Mol Endocrinol. 1997 Jun; 11(6):792-800. PMID: 9171242.
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    145. Wang XJ, Greenhalgh DA, Bickenbach JR, Jiang A, Bundman DS, Krieg T, Derynck R, Roop DR. Expression of a dominant-negative type II transforming growth factor beta (TGF-beta) receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition. Proc Natl Acad Sci U S A. 1997 Mar 18; 94(6):2386-91. PMID: 9122204; PMCID: PMC20097.
    146. Joh GY, Traupe H, Metze D, Nashan D, Huber M, Hohl D, Longley MA, Rothnagel JA, Roop DR. A novel dinucleotide mutation in keratin 10 in the annular epidermolytic ichthyosis variant of bullous congenital ichthyosiform erythroderma. J Invest Dermatol. 1997 Mar; 108(3):357-61. PMID: 9036939.
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    147. Borkowski TA, Letterio JJ, Mackall CL, Saitoh A, Farr AG, Wang XJ, Roop DR, Gress RE, Udey MC. Langerhans cells in the TGF beta 1 null mouse. Adv Exp Med Biol. 1997; 417:307-10. PMID: 9286378.
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    148. Bonnekoh B, Bickenbach JR, Roop DR. Immunological gene therapy approaches for malignant melanoma. 2. Preclinical studies and clinical strategies. Skin Pharmacol. 1997; 10(3):105-25. PMID: 9287392.
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    149. Bonnekoh B, Bickenbach JR, Roop DR. Immunological gene therapy approaches for malignant melanoma. 1. Tumor-immunological background. Skin Pharmacol. 1997; 10(2):49-62. PMID: 9257373.
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    150. Bickenbach JR, Longley MA, Bundman DS, Dominey AM, Bowden PE, Rothnagel JA, Roop DR. A transgenic mouse model that recapitulates the clinical features of both neonatal and adult forms of the skin disease epidermolytic hyperkeratosis. Differentiation. 1996 Dec; 61(2):129-39. PMID: 8983179.
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    151. Greenhalgh DA, Wang XJ, Donehower LA, Roop DR. Paradoxical tumor inhibitory effect of p53 loss in transgenic mice expressing epidermal-targeted v-rasHa, v-fos, or human transforming growth factor alpha. Cancer Res. 1996 Oct 01; 56(19):4413-23. PMID: 8813135.
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    152. Greenhalgh DA, Wang XJ, Roop DR. Multistage epidermal carcinogenesis in transgenic mice: cooperativity and paradox. J Investig Dermatol Symp Proc. 1996 Apr; 1(2):162-76. PMID: 9627712.
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    153. Ishida-Yamamoto A, Eady RA, Watt FM, Roop DR, Hohl D, Iizuka H. Immunoelectron microscopic analysis of cornified cell envelope formation in normal and psoriatic epidermis. J Histochem Cytochem. 1996 Feb; 44(2):167-75. PMID: 8609373.
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    154. Greenhalgh DA, Wang XJ, Roop DR. Multistage skin carcinogenesis in transgenic mice. Proc Assoc Am Physicians. 1995 Jul; 107(2):258-75. PMID: 8624862.
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    155. DiSepio D, Jones A, Longley MA, Bundman D, Rothnagel JA, Roop DR. The proximal promoter of the mouse loricrin gene contains a functional AP-1 element and directs keratinocyte-specific but not differentiation-specific expression. J Biol Chem. 1995 May 05; 270(18):10792-9. PMID: 7738016.
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    156. Rothnagel JA, Roop DR. Hair follicle companion layer: reacquainting an old friend. J Invest Dermatol. 1995 May; 104(5 Suppl):42S-43S. PMID: 7537786.
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    157. Greenhalgh DA, Wang XJ, Eckhardt JN, Roop DR. 12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mice expressing epidermal-targeted v-fos induces rasHA-activated papillomas and carcinomas without p53 mutation: association of v-fos expression with promotion and tumor autonomy. Cell Growth Differ. 1995 May; 6(5):579-86. PMID: 7544154.
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    158. Matzuk MM, Kumar TR, Vassalli A, Bickenbach JR, Roop DR, Jaenisch R, Bradley A. Functional analysis of activins during mammalian development. Nature. 1995 Mar 23; 374(6520):354-6. PMID: 7885473.
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    159. Matzuk MM, Lu N, Vogel H, Sellheyer K, Roop DR, Bradley A. Multiple defects and perinatal death in mice deficient in follistatin. Nature. 1995 Mar 23; 374(6520):360-3. PMID: 7885475.
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    160. Rothnagel JA, Wojcik S, Liefer KM, Dominey AM, Huber M, Hohl D, Roop DR. Mutations in the 1A domain of keratin 9 in patients with epidermolytic palmoplantar keratoderma. J Invest Dermatol. 1995 Mar; 104(3):430-3. PMID: 7532199.
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    161. Bickenbach JR, Greer JM, Bundman DS, Rothnagel JA, Roop DR. Loricrin expression is coordinated with other epidermal proteins and the appearance of lipid lamellar granules in development. J Invest Dermatol. 1995 Mar; 104(3):405-10. PMID: 7861010.
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    162. Bonnekoh B, Greenhalgh DA, Bundman DS, Eckhardt JN, Longley MA, Chen SH, Woo SL, Roop DR. Inhibition of melanoma growth by adenoviral-mediated HSV thymidine kinase gene transfer in vivo. J Invest Dermatol. 1995 Mar; 104(3):313-7. PMID: 7860993.
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    163. Roop D. Defects in the barrier. Science. 1995 Jan 27; 267(5197):474-5. PMID: 7529942.
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    164. Wang XJ, Greenhalgh DA, Lu XR, Bickenbach JR, Roop DR. TGF alpha and v-fos cooperation in transgenic mouse epidermis induces aberrant keratinocyte differentiation and stable, autonomous papillomas. Oncogene. 1995 Jan 19; 10(2):279-89. PMID: 7530825.
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    165. Ishida-Yamamoto A, Iizuka H, Manabe M, O'Guin WM, Hohl D, Kartasova T, Kuroki T, Roop DR, Eady RA. Altered distribution of keratinization markers in epidermolytic hyperkeratosis. Arch Dermatol Res. 1995; 287(8):705-11. PMID: 8554380.
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    166. Kulesz-Martin MF, Lisafeld B, Paterson J, Driscoll D, Shudo K, Roop DR, Kisiel ND. Differentiation and tumor response to retinobenzoic acid RE-80 in a malignant conversion model. Cancer Detect Prev. 1995; 19(4):355-66. PMID: 7553678.
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    167. Greenhalgh DA, Rothnagel JA, Roop DR. Epidermis: an attractive target tissue for gene therapy. J Invest Dermatol. 1994 Nov; 103(5 Suppl):63S-69S. PMID: 7963687.
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    168. Rothnagel JA, Longley MA, Bundman DS, Naylor SL, Lalley PA, Jenkins NA, Gilbert DJ, Copeland NG, Roop DR. Characterization of the mouse loricrin gene: linkage with profilaggrin and the flaky tail and soft coat mutant loci on chromosome 3. Genomics. 1994 Sep 15; 23(2):450-6. PMID: 7835895.
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    169. Heyden A, Lützow-Holm C, Clausen OP, Thrane EV, Brandtzaeg P, Roop DR, Yuspa SH, Huitfeldt HS. Application of cantharidin or 12-O-tetradecanoylphorbol-13-acetate on mouse epidermis induces a cell population shift that causes altered keratin distribution. Differentiation. 1994 Sep; 57(3):187-93. PMID: 7527355.
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    170. Rothnagel JA, Traupe H, Wojcik S, Huber M, Hohl D, Pittelkow MR, Saeki H, Ishibashi Y, Roop DR. Mutations in the rod domain of keratin 2e in patients with ichthyosis bullosa of Siemens. Nat Genet. 1994 Aug; 7(4):485-90. PMID: 7524919.
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    171. Rothnagel JA, Longley MA, Holder RA, Bundman DS, Seki T, Bickenbach JR, Roop DR. Genetic disorders of keratin: are scarring alopecias a sub-set? J Dermatol Sci. 1994 Jul; 7 Suppl:S164-9. PMID: 7528048.
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    172. Brown LJ, Geesin JC, Rothnagel JA, Roop DR, Gordon JS. Retinoic acid suppression of loricrin expression in reconstituted human skin cultured at the liquid-air interface. J Invest Dermatol. 1994 Jun; 102(6):886-90. PMID: 7516397.
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    173. Greenhalgh DA, Wang XJ, Rothnagel JA, Eckhardt JN, Quintanilla MI, Barber JL, Bundman DS, Longley MA, Schlegel R, Roop DR. Transgenic mice expressing targeted HPV-18 E6 and E7 oncogenes in the epidermis develop verrucous lesions and spontaneous, rasHa-activated papillomas. Cell Growth Differ. 1994 Jun; 5(6):667-75. PMID: 7522035.
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    174. Wang XJ, Greenhalgh DA, Eckhardt JN, Rothnagel JA, Roop DR. Epidermal expression of transforming growth factor-alpha in transgenic mice: induction of spontaneous and 12-O-tetradecanoylphorbol-13-acetate-induced papillomas via a mechanism independent of Ha-ras activation or overexpression. Mol Carcinog. 1994 May; 10(1):15-22. PMID: 8185825.
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    175. Sundberg JP, Dunstan RW, Roop DR, Beamer WG. Full-thickness skin grafts from flaky skin mice to nude mice: maintenance of the psoriasiform phenotype. J Invest Dermatol. 1994 May; 102(5):781-8. PMID: 8176263.
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    176. Gimenez-Conti IB, Lynch M, Roop D, Bhowmik S, Majeski P, Conti CJ. Expression of keratins in mouse vaginal epithelium. Differentiation. 1994 May; 56(3):143-51. PMID: 7518402.
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    177. Huber M, Scaletta C, Benathan M, Frenk E, Greenhalgh DA, Rothnagel JA, Roop DR, Hohl D. Abnormal keratin 1 and 10 cytoskeleton in cultured keratinocytes from epidermolytic hyperkeratosis caused by keratin 10 mutations. J Invest Dermatol. 1994 May; 102(5):691-4. PMID: 7513736.
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    178. Lu B, Rothnagel JA, Longley MA, Tsai SY, Roop DR. Differentiation-specific expression of human keratin 1 is mediated by a composite AP-1/steroid hormone element. J Biol Chem. 1994 Mar 11; 269(10):7443-9. PMID: 7510286.
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    179. Sundberg JP, Erickson AA, Roop DR, Binder RL. Ornithine decarboxylase expression in cutaneous papillomas in SENCAR mice is associated with altered expression of keratins 1 and 10. Cancer Res. 1994 Mar 01; 54(5):1344-51. PMID: 7509717.
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    180. Greenhalgh DA, Roop DR. Dissecting molecular carcinogenesis: development of transgenic mouse models by epidermal gene targeting. Adv Cancer Res. 1994; 64:247-96. PMID: 7879660.
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    181. Greenhalgh DA, Wang XJ, Dominey AM, Rothnagel JA, Roop DR. Development of transgenic mouse models of skin carcinogenesis: potential applications. Prog Clin Biol Res. 1994; 387:75-94. PMID: 7526406.
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    182. Rothnagel JA, Longley MA, Holder RA, Küster W, Roop DR. Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing. J Invest Dermatol. 1994 Jan; 102(1):13-6. PMID: 7507150.
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    183. Rothnagel JA, Fisher MP, Axtell SM, Pittelkow MR, Anton-Lamprecht I, Huber M, Hohl D, Roop DR. A mutational hot spot in keratin 10 (KRT 10) in patients with epidermolytic hyperkeratosis. Hum Mol Genet. 1993 Dec; 2(12):2147-50. PMID: 7509230.
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    184. Rothnagel JA, Greenhalgh DA, Wang XJ, Sellheyer K, Bickenbach JR, Dominey AM, Roop DR. Transgenic models of skin diseases. Arch Dermatol. 1993 Nov; 129(11):1430-6. PMID: 7694550.
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    185. Greenhalgh DA, Quintanilla MI, Orengo CC, Barber JL, Eckhardt JN, Rothnagel JA, Roop DR. Cooperation between v-fos and v-rasHA induces autonomous papillomas in transgenic epidermis but not malignant conversion. Cancer Res. 1993 Nov 01; 53(21):5071-5. PMID: 7693330.
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    186. Rothnagel JA, Greenhalgh DA, Gagne TA, Longley MA, Roop DR. Identification of a calcium-inducible, epidermal-specific regulatory element in the 3'-flanking region of the human keratin 1 gene. J Invest Dermatol. 1993 Oct; 101(4):506-13. PMID: 7691971.
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    187. Greenhalgh DA, Rothnagel JA, Wang XJ, Quintanilla MI, Orengo CC, Gagne TA, Bundman DS, Longley MA, Fisher C, Roop DR. Hyperplasia, hyperkeratosis and benign tumor production in transgenic mice by a targeted v-fos oncogene suggest a role for fos in epidermal differentiation and neoplasia. Oncogene. 1993 Aug; 8(8):2145-57. PMID: 7687760.
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    188. Hohl D, Ruf Olano B, de Viragh PA, Huber M, Detrisac CJ, Schnyder UW, Roop DR. Expression patterns of loricrin in various species and tissues. Differentiation. 1993 Aug; 54(1):25-34. PMID: 8405772.
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    189. Sellheyer K, Bickenbach JR, Rothnagel JA, Bundman D, Longley MA, Krieg T, Roche NS, Roberts AB, Roop DR. Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice. Proc Natl Acad Sci U S A. 1993 Jun 01; 90(11):5237-41. PMID: 7685120; PMCID: PMC46691.
    190. Kartasova T, Roop DR, Holbrook KA, Yuspa SH. Mouse differentiation-specific keratins 1 and 10 require a preexisting keratin scaffold to form a filament network. J Cell Biol. 1993 Mar; 120(5):1251-61. PMID: 7679677; PMCID: PMC2119738.
    191. Ishida-Yamamoto A, Hohl D, Roop DR, Iizuka H, Eady RA. Loricrin immunoreactivity in human skin: localization to specific granules (L-granules) in acrosyringia. Arch Dermatol Res. 1993; 285(8):491-8. PMID: 8274037.
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    192. Greenhalgh DA, Rothnagel JA, Quintanilla MI, Orengo CC, Gagne TA, Bundman DS, Longley MA, Roop DR. Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v-Ha-ras oncogene. Mol Carcinog. 1993; 7(2):99-110. PMID: 7681293.
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    193. Robles AI, Gimenez-Conti IB, Roop D, Slaga TJ, Conti CJ. Low frequency of codon 61 Ha-ras mutations and lack of keratin 13 expression in 7,12-dimethylbenz[a]-anthracene-induced hamster skin tumors. Mol Carcinog. 1993; 7(2):94-8. PMID: 7681292.
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    194. Blouin R, Blouin MJ, Royal I, Grenier A, Roop DR, Loranger A, Marceau N. Cytokeratin 14 expression in rat liver cells in culture and localization in vivo. Differentiation. 1992 Dec; 52(1):45-54. PMID: 1283740.
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    195. Rothnagel JA, Dominey AM, Dempsey LD, Longley MA, Greenhalgh DA, Gagne TA, Huber M, Frenk E, Hohl D, Roop DR. Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis. Science. 1992 Aug 21; 257(5073):1128-30. PMID: 1380725.
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    196. Rosenthal DS, Griffiths CE, Yuspa SH, Roop DR, Voorhees JJ. Acute or chronic topical retinoic acid treatment of human skin in vivo alters the expression of epidermal transglutaminase, loricrin, involucrin, filaggrin, and keratins 6 and 13 but not keratins 1, 10, and 14. J Invest Dermatol. 1992 Mar; 98(3):343-50. PMID: 1372028.
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    197. Kartasova T, Roop DR, Yuspa SH. Relationship between the expression of differentiation-specific keratins 1 and 10 and cell proliferation in epidermal tumors. Mol Carcinog. 1992; 6(1):18-25. PMID: 1380247.
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    198. Sundberg JP, Roop DR, Dunstan R, Lavker R, Sun TT. Interaction between dermal papilla and bulge: the rhino mouse mutation as a model system. Ann N Y Acad Sci. 1991 Dec 26; 642:496-9. PMID: 1725585.
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    199. Huitfeldt HS, Heyden A, Clausen OP, Thrane EV, Roop D, Yuspa SH. Altered regulation of growth and expression of differentiation-associated keratins in benign mouse skin tumors. Carcinogenesis. 1991 Nov; 12(11):2063-7. PMID: 1718620.
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    200. Breitkreutz D, Boukamp P, Ryle CM, Stark HJ, Roop DR, Fusenig NE. Epidermal morphogenesis and keratin expression in c-Ha-ras-transfected tumorigenic clones of the human HaCaT cell line. Cancer Res. 1991 Aug 15; 51(16):4402-9. PMID: 1714343.
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    201. Sundberg JP, Hanson CA, Roop DR, Brown KS, Bedigian HG. Myoepitheliomas in inbred laboratory mice. Vet Pathol. 1991 Jul; 28(4):313-23. PMID: 1719689.
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    202. Yuspa SH, Kilkenny A, Cheng C, Roop D, Hennings H, Kruszewski F, Lee E, Strickland J, Greenhalgh DA. Alterations in epidermal biochemistry as a consequence of stage-specific genetic changes in skin carcinogenesis. Environ Health Perspect. 1991 Jun; 93:3-10. PMID: 1773799; PMCID: PMC1568044.
    203. Hohl D, Mehrel T, Lichti U, Turner ML, Roop DR, Steinert PM. Characterization of human loricrin. Structure and function of a new class of epidermal cell envelope proteins. J Biol Chem. 1991 Apr 05; 266(10):6626-36. PMID: 2007607.
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    204. Hohl D, Lichti U, Breitkreutz D, Steinert PM, Roop DR. Transcription of the human loricrin gene in vitro is induced by calcium and cell density and suppressed by retinoic acid. J Invest Dermatol. 1991 Apr; 96(4):414-8. PMID: 2007780.
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    205. Rosenthal DS, Steinert PM, Chung S, Huff CA, Johnson J, Yuspa SH, Roop DR. A human epidermal differentiation-specific keratin gene is regulated by calcium but not negative modulators of differentiation in transgenic mouse keratinocytes. Cell Growth Differ. 1991 Feb; 2(2):107-13. PMID: 1712625.
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    206. Rosenthal DS, Roop DR, Huff CA, Weiss JS, Ellis CN, Hamilton T, Voorhees JJ, Yuspa SH. Changes in photo-aged human skin following topical application of all-trans retinoic acid. J Invest Dermatol. 1990 Nov; 95(5):510-5. PMID: 1700022.
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    207. Rothnagel JA, Longley MA, Bundman D, Greenhalgh DA, Dominey AM, Roop DR. Targeting gene expression to the epidermis of transgenic mice: potential applications to genetic skin disorders. J Invest Dermatol. 1990 Nov; 95(5 Suppl):59S-61S. PMID: 16788636.
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    208. Gimenez-Conti I, Aldaz CM, Bianchi AB, Roop DR, Slaga TJ, Conti CJ. Early expression of type I K13 keratin in the progression of mouse skin papillomas. Carcinogenesis. 1990 Nov; 11(11):1995-9. PMID: 1699681.
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    209. Rothnagel JA, Longley MA, Bundman D, Greenhalgh DA, Dominey AM, Roop DR. Targeting gene expression to the epidermis of transgenic mice: potential applications to genetic skin disorders. J Invest Dermatol. 1990 Nov; 95(5):59S-61S. PMID: 2230223.
      View in: PubMed
    210. Yuspa SH, Hennings H, Roop D, Strickland J, Greenhalgh DA. The malignant conversion step of mouse skin carcinogenesis. Environ Health Perspect. 1990 Aug; 88:193-5. PMID: 2272314; PMCID: PMC1568012.
    211. Stark HJ, Breitkreutz D, Limat A, Ryle CM, Roop D, Leigh I, Fusenig N. Keratins 1 and 10 or homologues as regular constituents of inner root sheath and cuticle cells in the human hair follicle. Eur J Cell Biol. 1990 Aug; 52(2):359-72. PMID: 1706998.
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    212. Gimenez-Conti IB, Shin DM, Bianchi AB, Roop DR, Hong WK, Conti CJ, Slaga TJ. Changes in keratin expression during 7,12-dimethylbenz[a]anthracene-induced hamster cheek pouch carcinogenesis. Cancer Res. 1990 Jul 15; 50(14):4441-5. PMID: 1694722.
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    213. Steven AC, Bisher ME, Roop DR, Steinert PM. Biosynthetic pathways of filaggrin and loricrin--two major proteins expressed by terminally differentiated epidermal keratinocytes. J Struct Biol. 1990 Jul-Sep; 104(1-3):150-62. PMID: 2088443.
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    214. Smith GH, Mehrel T, Roop DR. Differential keratin gene expression in developing, differentiating, preneoplastic, and neoplastic mouse mammary epithelium. Cell Growth Differ. 1990 Apr; 1(4):161-70. PMID: 1707299.
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    215. Cheng C, Kilkenny AE, Roop D, Yuspa SH. The v-ras oncogene inhibits the expression of differentiation markers and facilitates expression of cytokeratins 8 and 18 in mouse keratinocytes. Mol Carcinog. 1990; 3(6):363-73. PMID: 1703765.
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    216. Thrane PS, Roop DR, Sollid LM, Huitfeldt HS, Brandtzaeg P. Two-colour immunofluorescence marker study of pleomorphic adenomas. Histochemistry. 1990; 93(5):459-68. PMID: 2158957.
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    217. De Luca LM, Huang FL, Roop DR. Retinoids and control of epithelial differentiation and keratin biosynthesis in hamster trachea. Methods Enzymol. 1990; 190:91-100. PMID: 1708082.
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    218. Yuspa SH, Kilkenny AE, Steinert PM, Roop DR. Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro. J Cell Biol. 1989 Sep; 109(3):1207-17. PMID: 2475508; PMCID: PMC2115750.
    219. Ryle CM, Breitkreutz D, Stark HJ, Leigh IM, Steinert PM, Roop D, Fusenig NE. Density-dependent modulation of synthesis of keratins 1 and 10 in the human keratinocyte line HACAT and in ras-transfected tumorigenic clones. Differentiation. 1989 Mar; 40(1):42-54. PMID: 2472990.
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    220. Yuspa SH, Kilkenny AE, Roop DR, Strickland JE, Tucker R, Hennings H, Jaken S. Consequences of exposure to initiating levels of carcinogens in vitro and in vivo: altered differentiation and growth, mutations, and transformation. Prog Clin Biol Res. 1989; 298:127-35. PMID: 2664806.
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    221. Roop DR, Mehrel T, Krieg TM, Nakazawa H, Cheng CK, Yuspa SH. Keratin expression in mouse epidermal tumors. Carcinog Compr Surv. 1989; 11:257-71. PMID: 2465821.
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    222. Stanley JR, Tanaka T, Mueller S, Klaus-Kovtun V, Roop D. Isolation of complementary DNA for bullous pemphigoid antigen by use of patients' autoantibodies. J Clin Invest. 1988 Dec; 82(6):1864-70. PMID: 2461961; PMCID: PMC442765.
    223. Luo W, Roop DR, Lau EC, Melrose RJ, Mostofi R, Stenman G, Snead ML. In situ hybridization analysis of keratin gene expression in human ameloblastomas. J Oral Pathol. 1988 Nov; 17(9-10):534-40. PMID: 2470885.
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    224. Zhou XM, Idler WW, Steven AC, Roop DR, Steinert PM. The complete sequence of the human intermediate filament chain keratin 10. Subdomainal divisions and model for folding of end domain sequences. J Biol Chem. 1988 Oct 25; 263(30):15584-9. PMID: 2459124.
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    225. Rogers GE, Martinet N, Steinert P, Wynn P, Roop D, Kilkenny A, Morgan D, Yuspa SH. A procedure for the culture of hair follicles as functionally intact organoids. Clin Dermatol. 1988 Oct-Dec; 6(4):36-41. PMID: 2463868.
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    226. Aldaz CM, Conti CJ, Larcher F, Trono D, Roop DR, Chesner J, Whitehead T, Slaga TJ. Sequential development of aneuploidy, keratin modifications, and gamma-glutamyltransferase expression in mouse skin papillomas. Cancer Res. 1988 Jun 01; 48(11):3253-7. PMID: 2452689.
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    227. Roop DR, Krieg TM, Mehrel T, Cheng CK, Yuspa SH. Transcriptional control of high molecular weight keratin gene expression in multistage mouse skin carcinogenesis. Cancer Res. 1988 Jun 01; 48(11):3245-52. PMID: 2452688.
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    228. Ansel JC, Luger TA, Lowry D, Perry P, Roop DR, Mountz JD. The expression and modulation of IL-1 alpha in murine keratinocytes. J Immunol. 1988 Apr 01; 140(7):2274-8. PMID: 3258334.
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    229. Steinert PM, Roop DR. Molecular and cellular biology of intermediate filaments. Annu Rev Biochem. 1988; 57:593-625. PMID: 3052284.
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    230. Yuspa SH, Kilkenny A, Roop DR. Aberrant differentiation in mouse skin carcinogenesis. IARC Sci Publ. 1988; (92):3-10. PMID: 2466787.
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    231. Nischt R, Roop DR, Mehrel T, Yuspa SH, Rentrop M, Winter H, Schweizer J. Aberrant expression during two-stage mouse skin carcinogenesis of a type I 47-kDa keratin, K13, normally associated with terminal differentiation of internal stratified epithelia. Mol Carcinog. 1988; 1(2):96-108. PMID: 3076454.
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    232. Hawley-Nelson P, Roop DR, Cheng CK, Krieg TM, Yuspa SH. Molecular cloning of mouse epidermal cystatin A and detection of regulated expression in differentiation and tumorigenesis. Mol Carcinog. 1988; 1(3):202-11. PMID: 2471537.
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    233. Yuspa SH, Hennings H, Tucker RW, Jaken S, Kilkenny AE, Roop DR. Signal transduction for proliferation and differentiation in keratinocytes. Ann N Y Acad Sci. 1988; 548:191-6. PMID: 2470295.
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    234. Rothnagel JA, Mehrel T, Idler WW, Roop DR, Steinert PM. The gene for mouse epidermal filaggrin precursor. Its partial characterization, expression, and sequence of a repeating filaggrin unit. J Biol Chem. 1987 Nov 15; 262(32):15643-8. PMID: 3680218.
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    235. Fisher C, Jones A, Roop DR. Abnormal expression and processing of keratins in pupoid fetus (pf/pf) and repeated epilation (Er/Er) mutant mice. J Cell Biol. 1987 Oct; 105(4):1807-19. PMID: 2444602; PMCID: PMC2114667.
    236. Rogers G, Martinet N, Steinert P, Wynn P, Roop D, Kilkenny A, Morgan D, Yuspa SH. Cultivation of murine hair follicles as organoids in a collagen matrix. J Invest Dermatol. 1987 Oct; 89(4):369-79. PMID: 2822817.
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    237. Roop DR, Huitfeldt H, Kilkenny A, Yuspa SH. Regulated expression of differentiation-associated keratins in cultured epidermal cells detected by monospecific antibodies to unique peptides of mouse epidermal keratins. Differentiation. 1987; 35(2):143-50. PMID: 2450799.
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    238. Meruelo D, Rossomando A, Scandalis S, D'Eustachio P, Fournier RE, Roop DR, Saxe D, Blatt C, Nesbitt MN. Assignment of the Ly-6--Ril-1--Sis--H-30--Pol-5/Xmmv-72--Ins-3--Krt-1--Int-1 --Gdc-1 region to mouse chromosome 15. Immunogenetics. 1987; 25(6):361-72. PMID: 2885263.
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    239. Roop DR. Regulation of keratin gene expression during differentiation of epidermal and vaginal epithelial cells. Curr Top Dev Biol. 1987; 22:195-207. PMID: 2443311.
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    240. Roop DR, Lowy DR, Tambourin PE, Strickland J, Harper JR, Balaschak M, Spangler EF, Yuspa SH. An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue. Nature. 1986 Oct 30-Nov 5; 323(6091):822-4. PMID: 2430189.
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    241. Hawley-Nelson P, Roop DR, Cheng CK, Yuspa SH. Regulated synthesis of low-molecular-weight antigens in keratinocyte cell cultures. J Invest Dermatol. 1986 Oct; 87(4):454-9. PMID: 3531354.
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    242. Harper JR, Roop DR, Yuspa SH. Transfection of the EJ rasHa gene into keratinocytes derived from carcinogen-induced mouse papillomas causes malignant progression. Mol Cell Biol. 1986 Sep; 6(9):3144-9. PMID: 2431297; PMCID: PMC367049.
    243. Huang FL, Roop DR, De Luca LM. Vitamin A deficiency and keratin biosynthesis in cultured hamster trachea. In Vitro Cell Dev Biol. 1986 Apr; 22(4):223-30. PMID: 2422152.
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    244. Toftgard R, Yuspa SH, Roop DR. Keratin gene expression in mouse skin tumors and in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 1985 Nov; 45(11 Pt 2):5845-50. PMID: 2414001.
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    245. Steinert PM, Steven AC, Roop DR. The molecular biology of intermediate filaments. Cell. 1985 Sep; 42(2):411-20. PMID: 2411418.
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    246. Steinert PM, Parry DA, Idler WW, Johnson LD, Steven AC, Roop DR. Amino acid sequences of mouse and human epidermal type II keratins of Mr 67,000 provide a systematic basis for the structural and functional diversity of the end domains of keratin intermediate filament subunits. J Biol Chem. 1985 Jun 10; 260(11):7142-9. PMID: 2581964.
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    247. Krieg TM, Schafer MP, Cheng CK, Filpula D, Flaherty P, Steinert PM, Roop DR. Organization of a type I keratin gene. Evidence for evolution of intermediate filaments from a common ancestral gene. J Biol Chem. 1985 May 25; 260(10):5867-70. PMID: 2581944.
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    248. Toftgard R, Roop DR, Yuspa SH. Proto-oncogene expression during two-stage carcinogenesis in mouse skin. Carcinogenesis. 1985 Apr; 6(4):655-7. PMID: 3921276.
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    249. Johnson LD, Idler WW, Zhou XM, Roop DR, Steinert PM. Structure of a gene for the human epidermal 67-kDa keratin. Proc Natl Acad Sci U S A. 1985 Apr; 82(7):1896-900. PMID: 2580302; PMCID: PMC397440.
    250. Steinert PM, Idler WW, Zhou XM, Johnson LD, Parry DA, Steven AC, Roop DR. Structural and functional implications of amino acid sequences of keratin intermediate filament subunits. Ann N Y Acad Sci. 1985; 455:451-61. PMID: 2417526.
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    251. Roop DR, Cheng CK, Toftgard R, Stanley JR, Steinert PM, Yuspa SH. The use of cDNA clones and monospecific antibodies as probes to monitor keratin gene expression. Ann N Y Acad Sci. 1985; 455:426-35. PMID: 2417524.
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    252. De Luca LM, Roop D, Huang FL. Vitamin A: a key nutrient for the maintenance of epithelial differentiation. Acta Vitaminol Enzymol. 1985; 7 Suppl:13-20. PMID: 2430438.
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    253. Steinert PM, Parry DA, Racoosin EL, Idler WW, Steven AC, Trus BL, Roop DR. The complete cDNA and deduced amino acid sequence of a type II mouse epidermal keratin of 60,000 Da: analysis of sequence differences between type I and type II keratins. Proc Natl Acad Sci U S A. 1984 Sep; 81(18):5709-13. PMID: 6207530; PMCID: PMC391780.
    254. Roop DR, Cheng CK, Titterington L, Meyers CA, Stanley JR, Steinert PM, Yuspa SH. Synthetic peptides corresponding to keratin subunits elicit highly specific antibodies. J Biol Chem. 1984 Jul 10; 259(13):8037-40. PMID: 6203901.
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    255. Steinert PM, Steven AC, Roop DR. Structural features of epidermal keratin filaments reassembled in vitro. J Invest Dermatol. 1983 Jul; 81(1 Suppl):86s-90s. PMID: 6190964.
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    256. Roop DR, Hawley-Nelson P, Cheng CK, Yuspa SH. Expression of keratin genes in mouse epidermis and normal and malignantly transformed epidermal cells in culture. J Invest Dermatol. 1983 Jul; 81(1 Suppl):144s-9s. PMID: 6190960.
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    257. Steinert PM, Rice RH, Roop DR, Trus BL, Steven AC. Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature. 1983 Apr 28; 302(5911):794-800. PMID: 6188955.
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    258. Roop DR, Hawley-Nelson P, Cheng CK, Yuspa SH. Keratin gene expression in mouse epidermis and cultured epidermal cells. Proc Natl Acad Sci U S A. 1983 Feb; 80(3):716-20. PMID: 6187003; PMCID: PMC393450.
    259. Lai EC, Roop DR, Tsai MJ, Woo SL, O'Malley BW. Heterogeneous initiation regions for transcription of the chicken ovomucoid gene. Nucleic Acids Res. 1982 Sep 25; 10(18):5553-67. PMID: 6128724; PMCID: PMC320906.
    260. Roop DR, Kristo P, Stumph WE, Tsai MJ, O'Malley BW. Structure and expression of a chicken gene coding for U1 RNA. Cell. 1981 Mar; 23(3):671-80. PMID: 6164492.
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    261. Roop DR, Tsai SY, Tsai MJ, O'Malley BW. Definition of the transcription unit of the natural ovalbumin gene. Prog Clin Biol Res. 1981; 66 Pt B:381-92. PMID: 6273930.
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    262. Tsai SY, Roop DR, Stumph WE, Tsai MJ, O'Malley BW. Evidence that deoxyribonucleic acid sequences flanking the ovalbumin gene are not transcribed. Biochemistry. 1980 Apr 29; 19(9):1755-61. PMID: 6246933.
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    263. Roop DR, Tsai MJ, O'Malley BW. Definition of the 5' and 3' ends of transcripts of the ovalbumin gene. Cell. 1980 Jan; 19(1):63-8. PMID: 7357607.
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    264. Nordstrom JL, Roop DR, Tsai MJ, O'Malley BW. Identification of potential ovomucoid mRNA precursors in chick oviduct nuclei. Nature. 1979 Mar 22; 278(5702):328-31. PMID: 423986.
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    265. O'Malley BW, Roop DR, Lai EC, Nordstrom JL, Catterall JF, Swaneck GE, Colbert DA, Tsai MJ, Dugaiczyk A, Woo SL. The ovalbumin gene: organization, structure, transcription, and regulation. Recent Prog Horm Res. 1979; 35:1-46. PMID: 229523.
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    266. Swaneck GE, Tsai SY, Tsai MJ, Nordstrom JL, Roop DR, O'Malley BW. The ovalbumin gene: transcriptional regulation by estrogen. Adv Exp Med Biol. 1979; 117:461-85. PMID: 474290.
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    267. Tsai SY, Roop DR, Tsai MJ, Stein JP, Means AR, O'Malley BW. Effect of estrogen on gene expression in the chick oviduct. Regulation of the ovomucoid gene. Biochemistry. 1978 Dec 26; 17(26):5773-80. PMID: 728435.
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    268. Roop DR, Nordstrom JL, Tsai SY, Tsai MJ, O'Malley BW. Transcription of structural and intervening sequences in the ovalbumin gene and identification of potential ovalbumin mRNA precursors. Cell. 1978 Oct; 15(2):671-85. PMID: 719758.
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    269. Roop DR, Riggsby WS. Choice of labeled precursors in synthesis of DNA for molecular hybridization. Biochem Biophys Res Commun. 1978 Apr 14; 81(3):764-71. PMID: 666789.
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