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Edith T Zemanick

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone720/777-6181

    Collapse Research 
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    K23HL114883     (ZEMANICK, EDITH TOWLER)Jan 1, 2014 - Dec 31, 2017
    NIH
    Airway Microbiome in Cystic Fibrosis Pulmonary Exacerbations
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lenhart-Pendergrass PM, Anthony M, Sariyska S, Andrews A, Scavezze H, Towler E, Martiniano SL, Hoppe JE, Zemanick ET. Detection of Bacterial Pathogens Using Home Oropharyngeal Swab Collection in Children with Cystic Fibrosis. Pediatr Pulmonol. 2021 Apr 13. PMID: 33847465.
      View in: PubMed
    2. Khalaf RT, Furuta GT, Wagner BD, Robertson CE, Andrews R, Stevens MJ, Fillon SA, Zemanick ET, Harris JK. Influence of Acid Blockade on the Aerodigestive Tract Microbiome in Children With Cystic Fibrosis. J Pediatr Gastroenterol Nutr. 2021 Apr 01; 72(4):520-527. PMID: 33394582.
      View in: PubMed
    3. Zemanick ET, Taylor-Cousar JL, Davies J, Gibson RL, Mall MA, McKone EF, McNally P, Ramsey BW, Rayment JH, Rowe SM, Tullis E, Ahluwalia N, Chu C, Ho T, Moskowitz SM, Noel S, Tian S, Waltz D, Weinstock TG, Xuan F, Wainwright CE, McColley SA. A Phase 3 Open-Label Study of ELX/TEZ/IVA in Children 6 Through 11 Years of Age With CF and at Least One F508del Allele. Am J Respir Crit Care Med. 2021 Mar 18. PMID: 33734030.
      View in: PubMed
    4. Wagner BD, Berkalieva A, Borges M, Fleming G, Graham N, Peterson E, Jin X, Zemanick ET. Change in circulating proteins during treatment of pulmonary exacerbation in patients with cystic fibrosis. Health Sci Rep. 2021 Mar; 4(1):e246. PMID: 33614983.
      View in: PubMed
    5. Zemanick ET, Konstan MW, VanDevanter DR, Rowe SM, Clancy JP, Odem-Davis K, Skalland M, Mayer-Hamblett N. Measuring the impact of CFTR modulation on sweat chloride in cystic fibrosis: Rationale and design of the CHEC-SC study. J Cyst Fibros. 2021 Feb 08. PMID: 33573995.
      View in: PubMed
    6. Drake MG, Shah NG, Lee M, Brady A, Connors GR, Clark BJ, Kritek PA, McCallister JW, Burkart KM, Pedraza I, Jamieson D, Ingram JL, Lynch L, Makani SS, Siegel-Gasiewski J, Larsson EM, Zemanick ET, Liptzin DR, Good R, Crotty Alexander LE. Development of a National Academic Boot Camp to Improve Fellowship Readiness. ATS Sch. 2020 Dec 22; 2(1):49-65. PMID: 33870323.
      View in: PubMed
    7. Hoppe JE, Hinds DM, Colborg A, Wagner BD, Morgan WJ, Rosenfeld M, Zemanick ET, Sanders DB. Oral antibiotic prescribing patterns for treatment of pulmonary exacerbations in two large pediatric CF centers. Pediatr Pulmonol. 2020 12; 55(12):3400-3406. PMID: 32970375.
      View in: PubMed
    8. Hahn A, Burrell A, Ansusinha E, Peng D, Chaney H, Sami I, Perez GF, Koumbourlis AC, McCarter R, Freishtat RJ, Crandall KA, Zemanick ET. Airway microbial diversity is decreased in young children with cystic fibrosis compared to healthy controls but improved with CFTR modulation. Heliyon. 2020 Jun; 6(6):e04104. PMID: 32514485.
      View in: PubMed
    9. Jewell MP, Saccomano SC, David AA, Harris JK, Zemanick ET, Cash KJ. Nanodiagnostics to monitor biofilm oxygen metabolism for antibiotic susceptibility testing. Analyst. 2020 Jun 07; 145(11):3996-4003. PMID: 32342070.
      View in: PubMed
    10. Harris JK, Wagner BD, Zemanick ET, Robertson CE, Stevens MJ, Heltshe SL, Rowe SM, Sagel SD. Changes in Airway Microbiome and Inflammation with Ivacaftor Treatment in Patients with Cystic Fibrosis and the G551D Mutation. Ann Am Thorac Soc. 2020 02; 17(2):212-220. PMID: 31604026.
      View in: PubMed
    11. Martiniano SL, Esther CR, Haworth CS, Kasperbauer SH, Zemanick ET, Caverly LJ. Challenging scenarios in nontuberculous mycobacterial infection in cystic fibrosis. Pediatr Pulmonol. 2020 02; 55(2):521-525. PMID: 31821718.
      View in: PubMed
    12. Hahn A, Zemanick ET. Bacterial Community Variability: Outliers May Be Leading Us Astray. Ann Am Thorac Soc. 2019 12; 16(12):1499-1501. PMID: 31774321.
      View in: PubMed
    13. Zemanick ET, Bell SC. Prevention of chronic infection with Pseudomonas aeruginosa infection in cystic fibrosis. Curr Opin Pulm Med. 2019 11; 25(6):636-645. PMID: 31397692.
      View in: PubMed
    14. Zemanick E, Burgel PR, Taccetti G, Holmes A, Ratjen F, Byrnes CA, Waters VJ, Bell SC, VanDevanter DR, Stuart Elborn J, Flume PA. Antimicrobial resistance in cystic fibrosis: A Delphi approach to defining best practices. J Cyst Fibros. 2020 05; 19(3):370-375. PMID: 31680041.
      View in: PubMed
    15. Zemanick ET, Accurso FJ. Entering the era of highly effective CFTR modulator therapy. Lancet. 2019 11 23; 394(10212):1886-1888. PMID: 31679947.
      View in: PubMed
    16. Jewell MP, Galyean AA, Kirk Harris J, Zemanick ET, Cash KJ. Luminescent Nanosensors for Ratiometric Monitoring of Three-Dimensional Oxygen Gradients in Laboratory and Clinical Pseudomonas aeruginosa Biofilms. Appl Environ Microbiol. 2019 10 15; 85(20). PMID: 31420335.
      View in: PubMed
    17. Theprungsirikul J, Skopelja-Gardner S, Meagher RE, Clancy JP, Zemanick ET, Ashare A, Rigby WFC. Dissociation of systemic and mucosal autoimmunity in cystic fibrosis. J Cyst Fibros. 2020 03; 19(2):196-202. PMID: 31262645.
      View in: PubMed
    18. Martiniano SL, Daines CL, Dellon EP, Esther CR, Muhlebach MS, Ong T, Rabinowitz EC, Toprak D, Zemanick ET. Highlights from the 2018 North American cystic fibrosis conference. Pediatr Pulmonol. 2019 07; 54(7):941-948. PMID: 31091021.
      View in: PubMed
    19. Zemanick ET, Polineni D. Unraveling the CFTR Function-Phenotype Connection for Precision Treatment in Cystic Fibrosis. Am J Respir Crit Care Med. 2019 May 01; 199(9):1053-1054. PMID: 30939246.
      View in: PubMed
    20. Hahn A, Fanous H, Jensen C, Chaney H, Sami I, Perez GF, Koumbourlis AC, Louie S, Bost JE, van den Anker JN, Freishtat RJ, Zemanick ET, Crandall KA. Changes in microbiome diversity following beta-lactam antibiotic treatment are associated with therapeutic versus subtherapeutic antibiotic exposure in cystic fibrosis. Sci Rep. 2019 02 22; 9(1):2534. PMID: 30796252.
      View in: PubMed
    21. Juarez-Colunga E, Rosenfeld M, Zemanick ET, Wagner B. Application of multiple event analysis as an alternative approach to studying pulmonary exacerbations as an outcome measure. J Cyst Fibros. 2020 01; 19(1):114-118. PMID: 30642785.
      View in: PubMed
    22. DeBoer EM, Wagner BD, Popler J, Harris JK, Zemanick ET, Accurso FJ, Sagel SD, Deterding RR. Novel Application of Aptamer Proteomic Analysis in Cystic Fibrosis Bronchoalveolar Lavage Fluid. Proteomics Clin Appl. 2019 05; 13(3):e1800085. PMID: 30431231.
      View in: PubMed
    23. Li A, Vigers T, Pyle L, Zemanick E, Nadeau K, Sagel SD, Chan CL. Continuous glucose monitoring in youth with cystic fibrosis treated with lumacaftor-ivacaftor. J Cyst Fibros. 2019 01; 18(1):144-149. PMID: 30104123.
      View in: PubMed
    24. Hoppe JE, Wagner BD, Accurso FJ, Zemanick ET, Sagel SD. Characteristics and outcomes of oral antibiotic treated pulmonary exacerbations in children with cystic fibrosis. J Cyst Fibros. 2018 11; 17(6):760-768. PMID: 29921503.
      View in: PubMed
    25. Wagner BD, Grunwald GK, Zerbe GO, Mikulich-Gilbertson SK, Robertson CE, Zemanick ET, Harris JK. On the Use of Diversity Measures in Longitudinal Sequencing Studies of Microbial Communities. Front Microbiol. 2018; 9:1037. PMID: 29872428.
      View in: PubMed
    26. Martiniano SL, Toprak D, Ong T, Zemanick ET, Daines CL, Muhlebach MS, Esther CR, Dellon EP. Highlights from the 2017 North American Cystic Fibrosis Conference. Pediatr Pulmonol. 2018 07; 53(7):979-986. PMID: 29660839.
      View in: PubMed
    27. Nasir M, Bean HD, Smolinska A, Rees CA, Zemanick ET, Hill JE. Volatile molecules from bronchoalveolar lavage fluid can 'rule-in' Pseudomonas aeruginosa and 'rule-out' Staphylococcus aureus infections in cystic fibrosis patients. Sci Rep. 2018 01 16; 8(1):826. PMID: 29339749.
      View in: PubMed
    28. Hoppe JE, Wagner BD, Sagel SD, Accurso FJ, Zemanick ET. Pulmonary exacerbations and clinical outcomes in a longitudinal cohort of infants and preschool children with cystic fibrosis. BMC Pulm Med. 2017 Dec 11; 17(1):188. PMID: 29228933.
      View in: PubMed
    29. Zemanick ET, Wagner BD, Robertson CE, Ahrens RC, Chmiel JF, Clancy JP, Gibson RL, Harris WT, Kurland G, Laguna TA, McColley SA, McCoy K, Retsch-Bogart G, Sobush KT, Zeitlin PL, Stevens MJ, Accurso FJ, Sagel SD, Harris JK. Airway microbiota across age and disease spectrum in cystic fibrosis. Eur Respir J. 2017 11; 50(5). PMID: 29146601.
      View in: PubMed
    30. Zemanick ET, Daines CL, Dellon EP, Esther CR, Kinghorn B, Ong T, Muhlebach MS. Highlights from the 2016 North American Cystic Fibrosis Conference. Pediatr Pulmonol. 2017 08; 52(8):1103-1110. PMID: 28696526.
      View in: PubMed
    31. Williamson KM, Wagner BD, Robertson CE, Johnson EJ, Zemanick ET, Harris JK. Impact of enzymatic digestion on bacterial community composition in CF airway samples. PeerJ. 2017; 5:e3362. PMID: 28584706.
      View in: PubMed
    32. Hoppe JE, Zemanick ET. Lessons from the lower airway microbiome in early CF. Thorax. 2017 12; 72(12):1063-1064. PMID: 28450530.
      View in: PubMed
    33. Donaldson SH, Solomon GM, Zeitlin PL, Flume PA, Casey A, McCoy K, Zemanick ET, Mandagere A, Troha JM, Shoemaker SA, Chmiel JF, Taylor-Cousar JL. Pharmacokinetics and safety of cavosonstat (N91115) in healthy and cystic fibrosis adults homozygous for F508DEL-CFTR. J Cyst Fibros. 2017 May; 16(3):371-379. PMID: 28209466.
      View in: PubMed
    34. Laguna TA, Wagner BD, Williams CB, Stevens MJ, Robertson CE, Welchlin CW, Moen CE, Zemanick ET, Harris JK. Airway Microbiota in Bronchoalveolar Lavage Fluid from Clinically Well Infants with Cystic Fibrosis. PLoS One. 2016; 11(12):e0167649. PMID: 27930727.
      View in: PubMed
    35. Muhlebach MS, Beckett V, Popowitch E, Miller MB, Baines A, Mayer-Hamblett N, Zemanick ET, Hoover WC, VanDalfsen JM, Campbell P, Goss CH. Microbiological efficacy of early MRSA treatment in cystic fibrosis in a randomised controlled trial. Thorax. 2017 Apr; 72(4):318-326. PMID: 27852955.
      View in: PubMed
    36. Zemanick ET, Hoffman LR. Cystic Fibrosis: Microbiology and Host Response. Pediatr Clin North Am. 2016 08; 63(4):617-36. PMID: 27469179.
      View in: PubMed
    37. Martiniano SL, Sagel SD, Zemanick ET. Cystic fibrosis: a model system for precision medicine. Curr Opin Pediatr. 2016 06; 28(3):312-7. PMID: 27031658.
      View in: PubMed
    38. Zemanick ET, Ong T, Daines CL, Dellon EP, Muhlebach MS, Esther CR. Highlights from the 2015 North American Cystic Fibrosis Conference. Pediatr Pulmonol. 2016 Jun; 51(6):650-7. PMID: 27074261.
      View in: PubMed
    39. Lahiri T, Hempstead SE, Brady C, Cannon CL, Clark K, Condren ME, Guill MF, Guillerman RP, Leone CG, Maguiness K, Monchil L, Powers SW, Rosenfeld M, Schwarzenberg SJ, Tompkins CL, Zemanick ET, Davis SD. Clinical Practice Guidelines From the Cystic Fibrosis Foundation for Preschoolers With Cystic Fibrosis. Pediatrics. 2016 Apr; 137(4). PMID: 27009033.
      View in: PubMed
    40. Zemanick ET, Wainwright C. Alterations of the Nasopharyngeal Microbiota in Infants with Cystic Fibrosis. Cystic Fibrosis Transmembrane Conductance Regulator and Antibiotic Effects. Am J Respir Crit Care Med. 2016 Mar 01; 193(5):473-4. PMID: 26930426.
      View in: PubMed
    41. Johnson EJ, Zemanick ET, Accurso FJ, Wagner BD, Robertson CE, Harris JK. Molecular Identification of Staphylococcus aureus in Airway Samples from Children with Cystic Fibrosis. PLoS One. 2016; 11(1):e0147643. PMID: 26808658.
      View in: PubMed
    42. Zemanick ET, Laguna TA. Editorial Commentary: Pseudomonas aeruginosa Eradication: How Do We Measure Success? Clin Infect Dis. 2015 Sep 01; 61(5):716-8. PMID: 25972023.
      View in: PubMed
    43. Ma DC, Yoon AJ, Faull KF, Desharnais R, Zemanick ET, Porter E. Cholesteryl esters are elevated in the lipid fraction of bronchoalveolar lavage fluid collected from pediatric cystic fibrosis patients. PLoS One. 2015; 10(4):e0125326. PMID: 25919295.
      View in: PubMed
    44. Flass T, Tong S, Frank DN, Wagner BD, Robertson CE, Kotter CV, Sokol RJ, Zemanick E, Accurso F, Hoffenberg EJ, Narkewicz MR. Intestinal lesions are associated with altered intestinal microbiome and are more frequent in children and young adults with cystic fibrosis and cirrhosis. PLoS One. 2015; 10(2):e0116967. PMID: 25658710.
      View in: PubMed
    45. Zemanick ET, Wagner BD, Robertson CE, Stevens MJ, Szefler SJ, Accurso FJ, Sagel SD, Harris JK. Assessment of airway microbiota and inflammation in cystic fibrosis using multiple sampling methods. Ann Am Thorac Soc. 2015 Feb; 12(2):221-9. PMID: 25474078.
      View in: PubMed
    46. Hoppe JE, Towler E, Wagner BD, Accurso FJ, Sagel SD, Zemanick ET. Sputum induction improves detection of pathogens in children with cystic fibrosis. Pediatr Pulmonol. 2015 Jul; 50(7):638-46. PMID: 25565628.
      View in: PubMed
    47. Zemanick ET, Hoffman L, Rosenfeld M. Narrowing in on early cystic fibrosis lung disease. Am J Respir Crit Care Med. 2014 Nov 15; 190(10):1082-4. PMID: 25398104.
      View in: PubMed
    48. Martiniano SL, Hoppe JE, Sagel SD, Zemanick ET. Advances in the diagnosis and treatment of cystic fibrosis. Adv Pediatr. 2014 Aug; 61(1):225-43. PMID: 25037130.
      View in: PubMed
    49. Zemanick ET, Accurso FJ. Cystic fibrosis transmembrane conductance regulator and pseudomonas. Am J Respir Crit Care Med. 2014 Apr 01; 189(7):763-5. PMID: 24684355.
      View in: PubMed
    50. Zemanick ET, Emerson J, Thompson V, McNamara S, Morgan W, Gibson RL, Rosenfeld M. Clinical outcomes after initial pseudomonas acquisition in cystic fibrosis. Pediatr Pulmonol. 2015 Jan; 50(1):42-8. PMID: 24644274.
      View in: PubMed
    51. Harris JK, Zemanick ET. Microbes in bronchiectasis: the forest or the trees? Am J Respir Crit Care Med. 2013 May 15; 187(10):1044-5. PMID: 23675713.
      View in: PubMed
    52. Zemanick ET, Harris JK, Wagner BD, Robertson CE, Sagel SD, Stevens MJ, Accurso FJ, Laguna TA. Inflammation and airway microbiota during cystic fibrosis pulmonary exacerbations. PLoS One. 2013; 8(4):e62917. PMID: 23646159.
      View in: PubMed
    53. Sagel SD, Wagner BD, Anthony MM, Emmett P, Zemanick ET. Sputum biomarkers of inflammation and lung function decline in children with cystic fibrosis. Am J Respir Crit Care Med. 2012 Nov 01; 186(9):857-65. PMID: 22904182.
      View in: PubMed
    54. Wagener JS, Zemanick ET, Sontag MK. Newborn screening for cystic fibrosis. Curr Opin Pediatr. 2012 Jun; 24(3):329-35. PMID: 22491493.
      View in: PubMed
    55. Zemanick ET, Sagel SD, Harris JK. The airway microbiome in cystic fibrosis and implications for treatment. Curr Opin Pediatr. 2011 Jun; 23(3):319-24. PMID: 21494150.
      View in: PubMed
    56. Zemanick ET, Wagner BD, Sagel SD, Stevens MJ, Accurso FJ, Harris JK. Reliability of quantitative real-time PCR for bacterial detection in cystic fibrosis airway specimens. PLoS One. 2010 Nov 30; 5(11):e15101. PMID: 21152087.
      View in: PubMed
    57. Zemanick ET, Wagner BD, Harris JK, Wagener JS, Accurso FJ, Sagel SD. Pulmonary exacerbations in cystic fibrosis with negative bacterial cultures. Pediatr Pulmonol. 2010 Jun; 45(6):569-77. PMID: 20503282.
      View in: PubMed
    58. Zemanick ET, Harris JK, Conway S, Konstan MW, Marshall B, Quittner AL, Retsch-Bogart G, Saiman L, Accurso FJ. Measuring and improving respiratory outcomes in cystic fibrosis lung disease: opportunities and challenges to therapy. J Cyst Fibros. 2010 Jan; 9(1):1-16. PMID: 19833563.
      View in: PubMed
    59. Harris JK, De Groote MA, Sagel SD, Zemanick ET, Kapsner R, Penvari C, Kaess H, Deterding RR, Accurso FJ, Pace NR. Molecular identification of bacteria in bronchoalveolar lavage fluid from children with cystic fibrosis. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20529-33. PMID: 18077362.
      View in: PubMed
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