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Laurent Camille Gapin

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER
Phone303/724-8667

    Collapse Research 
    Collapse research activities and funding
    R01AI057485     (GAPIN, LAURENT)Mar 1, 2004 - Feb 28, 2010
    NIH/NIAID
    Homeostasis of Valpha14i Natural Killer T Cells
    Role: Principal Investigator
    R21AI076463     (GAPIN, LAURENT)Jul 1, 2008 - Jun 30, 2011
    NIH/NIAID
    Visualization of Va14i NKT cells in vivo
    Role: Principal Investigator
    R56AI078246     (GAPIN, LAURENT)May 22, 2009 - Apr 30, 2011
    NIH/NIAID
    Structural Requirements of glycolipid/CD1d Recognition by NKT Cells
    Role: Principal Investigator
    R21AI090450     (GAPIN, LAURENT)Jun 1, 2010 - May 31, 2013
    NIH/NIAID
    CD1d2-Selected iNKT Cells
    Role: Principal Investigator
    R01AI092108     (GAPIN, LAURENT)Aug 4, 2011 - Jul 31, 2015
    NIH/NIAID
    iNKT Cell Recognition of Endogenous Lipid Antigens
    Role: Principal Investigator
    R21AI121761     (GAPIN, LAURENT)Jan 1, 2016 - Dec 31, 2017
    NIH/NIAID
    Inherent reactivity of T cell antigen receptors for MHC molecules
    Role: Principal Investigator
    R21AI124076     (GAPIN, LAURENT)Aug 1, 2016 - Jul 31, 2018
    NIH/NIAID
    Regulation of Natural Killer T cell lineage diversification by the Src-like Adaptor protein 2
    Role: Principal Investigator
    R21AI135339     (GAPIN, LAURENT)May 7, 2018 - Apr 30, 2020
    NIH/NIAID
    Role of mCD1D2 in iNKT cell development and functions
    Role: Principal Investigator
    R01AI130198     (GAPIN, LAURENT)Aug 10, 2018 - Jul 31, 2023
    NIH/NIAID
    TCR signal strength and iNKT cell subset development
    Role: Principal Investigator
    R21CA245432     (MCCARTER, MARTIN)Mar 1, 2020 - Jan 31, 2022
    NIH/NCI
    Improving immunotherapies to melanoma through modulation of MAIT cell activation by the microbiome
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gray JI, Al-Khabouri S, Morton F, Clambey ET, Gapin L, Matsuda JL, Kappler JW, Marrack P, Garside P, Otto TD, MacLeod MKL. Tolerance induction in memory CD4 T cells is partial and reversible. Immunology. 2020 Sep 15. PMID: 32931017.
      View in: PubMed
    2. Perroteau J, Navet B, Devilder MC, Hesnard L, Scotet E, Gapin L, Saulquin X, Gautreau-Rolland L. Contribution of the SYK Tyrosine kinase expression to human iNKT self-reactivity. Eur J Immunol. 2020 Oct; 50(10):1454-1467. PMID: 32460359.
      View in: PubMed
    3. Krovi SH, Kappler JW, Marrack P, Gapin L. Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules. Proc Natl Acad Sci U S A. 2019 10 29; 116(44):22252-22261. PMID: 31570608.
      View in: PubMed
    4. Wang Y, Sosinowski T, Novikov A, Crawford F, White J, Jin N, Liu Z, Zou J, Neau D, Davidson HW, Nakayama M, Kwok WW, Gapin L, Marrack P, Kappler JW, Dai S. How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes. Sci Immunol. 2019 04 05; 4(34). PMID: 30952805.
      View in: PubMed
    5. Williams T, Krovi HS, Landry LG, Crawford F, Jin N, Hohenstein A, DeNicola ME, Michels AW, Davidson HW, Kent SC, Gapin L, Kappler JW, Nakayama M. Development of T cell lines sensitive to antigen stimulation. J Immunol Methods. 2018 11; 462:65-73. PMID: 30165064.
      View in: PubMed
    6. Tuttle KD, Krovi SH, Zhang J, Bedel R, Harmacek L, Peterson LK, Dragone LL, Lefferts A, Halluszczak C, Riemondy K, Hesselberth JR, Rao A, O'Connor BP, Marrack P, Scott-Browne J, Gapin L. TCR signal strength controls thymic differentiation of iNKT cell subsets. Nat Commun. 2018 07 09; 9(1):2650. PMID: 29985393.
      View in: PubMed
    7. Krovi SH, Gapin L. Invariant Natural Killer T Cell Subsets-More Than Just Developmental Intermediates. Front Immunol. 2018; 9:1393. PMID: 29973936.
      View in: PubMed
    8. Sundararaj S, Zhang J, Krovi SH, Bedel R, Tuttle KD, Veerapen N, Besra GS, Khandokar Y, Praveena T, Le Nours J, Matsuda JL, Rossjohn J, Gapin L. Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function. Proc Natl Acad Sci U S A. 2018 02 06; 115(6):E1204-E1213. PMID: 29351991.
      View in: PubMed
    9. Tuttle KD, Gapin L. Characterization of Thymic Development of Natural Killer T Cell Subsets by Multiparameter Flow Cytometry. Methods Mol Biol. 2018; 1799:121-133. PMID: 29956149.
      View in: PubMed
    10. Marrack P, Krovi SH, Silberman D, White J, Kushnir E, Nakayama M, Crooks J, Danhorn T, Leach S, Anselment R, Scott-Browne J, Gapin L, Kappler J. The somatically generated portion of T cell receptor CDR3a contributes to the MHC allele specificity of the T cell receptor. Elife. 2017 11 17; 6. PMID: 29148973.
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    11. Van Rhijn I, Iwany SK, Fodran P, Cheng TY, Gapin L, Minnaard AJ, Moody DB. CD1b-mycolic acid tetramers demonstrate T-cell fine specificity for mycobacterial lipid tails. Eur J Immunol. 2017 09; 47(9):1525-1534. PMID: 28665555.
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    12. Krovi SH, Gapin L. iNKT cells need UTX-tra demethylation. Nat Immunol. 2017 01 19; 18(2):148-150. PMID: 28102220.
      View in: PubMed
    13. Gras S, Van Rhijn I, Shahine A, Cheng TY, Bhati M, Tan LL, Halim H, Tuttle KD, Gapin L, Le Nours J, Moody DB, Rossjohn J. T cell receptor recognition of CD1b presenting a mycobacterial glycolipid. Nat Commun. 2016 10 27; 7:13257. PMID: 27807341.
      View in: PubMed
    14. Silberman D, Krovi SH, Tuttle KD, Crooks J, Reisdorph R, White J, Gross J, Matsuda JL, Gapin L, Marrack P, Kappler JW. Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptors. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):E5608-17. PMID: 27588903.
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    15. Krovi SH, Gapin L. Structure and function of the non-classical major histocompatibility complex molecule MR1. Immunogenetics. 2016 08; 68(8):549-59. PMID: 27448212.
      View in: PubMed
    16. Zhang J, Bedel R, Krovi SH, Tuttle KD, Zhang B, Gross J, Gapin L, Matsuda JL. Mutation of the Traj18 gene segment using TALENs to generate Natural Killer T cell deficient mice. Sci Rep. 2016 06 03; 6:27375. PMID: 27256918.
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    17. Krovi SH, Gapin L. Revealing the TCR bias for MHC molecules. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):2809-11. PMID: 26933216.
      View in: PubMed
    18. Gapin L. Development of invariant natural killer T cells. Curr Opin Immunol. 2016 Apr; 39:68-74. PMID: 26802287.
      View in: PubMed
    19. Krovi SH, Gapin L. It is time to beelieve the CD1a hype! Eur J Immunol. 2016 Jan; 46(1):56-9. PMID: 26617406.
      View in: PubMed
    20. Pennock ND, Gapin L, Kedl RM. IL-27 is required for shaping the magnitude, affinity distribution, and memory of T cells responding to subunit immunization. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16472-7. PMID: 25267651.
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    21. Gapin L. Check MAIT. J Immunol. 2014 May 15; 192(10):4475-80. PMID: 24795465.
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    22. Bedel R, Berry R, Mallevaey T, Matsuda JL, Zhang J, Godfrey DI, Rossjohn J, Kappler JW, Marrack P, Gapin L. Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):E119-28. PMID: 24344267.
      View in: PubMed
    23. Gapin L, Godfrey DI, Rossjohn J. Natural Killer T cell obsession with self-antigens. Curr Opin Immunol. 2013 Apr; 25(2):168-73. PMID: 23384972.
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    24. Sosinowski T, White JT, Cross EW, Haluszczak C, Marrack P, Gapin L, Kedl RM. CD8a+ dendritic cell trans presentation of IL-15 to naive CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function. J Immunol. 2013 Mar 01; 190(5):1936-47. PMID: 23355737.
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    25. Young MH, U'Ren L, Huang S, Mallevaey T, Scott-Browne J, Crawford F, Lantz O, Hansen TH, Kappler J, Marrack P, Gapin L. MAIT cell recognition of MR1 on bacterially infected and uninfected cells. PLoS One. 2013; 8(1):e53789. PMID: 23342002.
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    26. Young MH, Gapin L. Mucosal associated invariant T cells: don't forget your vitamins. Cell Res. 2013 Apr; 23(4):460-2. PMID: 23208418.
      View in: PubMed
    27. Rossjohn J, Pellicci DG, Patel O, Gapin L, Godfrey DI. Recognition of CD1d-restricted antigens by natural killer T cells. Nat Rev Immunol. 2012 Dec; 12(12):845-57. PMID: 23154222.
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    28. Yin L, Scott-Browne J, Kappler JW, Gapin L, Marrack P. T cells and their eons-old obsession with MHC. Immunol Rev. 2012 Nov; 250(1):49-60. PMID: 23046122.
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    29. Bjordahl RL, Gapin L, Marrack P, Refaeli Y. iNKT cells suppress the CD8+ T cell response to a murine Burkitt's-like B cell lymphoma. PLoS One. 2012; 7(8):e42635. PMID: 22880059.
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    30. Patel O, Pellicci DG, Gras S, Sandoval-Romero ML, Uldrich AP, Mallevaey T, Clarke AJ, Le Nours J, Theodossis A, Cardell SL, Gapin L, Godfrey DI, Rossjohn J. Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor. Nat Immunol. 2012 Sep; 13(9):857-63. PMID: 22820603.
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    31. Bedel R, Matsuda JL, Brigl M, White J, Kappler J, Marrack P, Gapin L. Lower TCR repertoire diversity in Traj18-deficient mice. Nat Immunol. 2012 Jul 19; 13(8):705-6. PMID: 22814339.
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    32. Garcia KC, Gapin L, Adams JJ, Birnbaum ME, Scott-Browne JP, Kappler JW, Marrack P. A closer look at TCR germline recognition. Immunity. 2012 Jun 29; 36(6):887-8. PMID: 22705103.
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    33. Baker RL, Mallevaey T, Gapin L, Haskins K. T cells interact with T cells via CD40-CD154 to promote autoimmunity in type 1 diabetes. Eur J Immunol. 2012 Mar; 42(3):672-80. PMID: 22488364.
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    34. Nakayama M, Castoe T, Sosinowski T, He X, Johnson K, Haskins K, Vignali DA, Gapin L, Pollock D, Eisenbarth GS. Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice. Diabetes. 2012 Apr; 61(4):857-65. PMID: 22315318.
      View in: PubMed
    35. Patel O, Pellicci DG, Uldrich AP, Sullivan LC, Bhati M, McKnight M, Richardson SK, Howell AR, Mallevaey T, Zhang J, Bedel R, Besra GS, Brooks AG, Kjer-Nielsen L, McCluskey J, Porcelli SA, Gapin L, Rossjohn J, Godfrey DI. Vß2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen. Proc Natl Acad Sci U S A. 2011 Nov 22; 108(47):19007-12. PMID: 22065767.
      View in: PubMed
    36. Scott-Browne JP, Crawford F, Young MH, Kappler JW, Marrack P, Gapin L. Evolutionarily conserved features contribute to aß T cell receptor specificity. Immunity. 2011 Oct 28; 35(4):526-35. PMID: 21962492.
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    37. Pellicci DG, Clarke AJ, Patel O, Mallevaey T, Beddoe T, Le Nours J, Uldrich AP, McCluskey J, Besra GS, Porcelli SA, Gapin L, Godfrey DI, Rossjohn J. Recognition of ß-linked self glycolipids mediated by natural killer T cell antigen receptors. Nat Immunol. 2011 Jul 31; 12(9):827-33. PMID: 21804559.
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    38. Mallevaey T, Clarke AJ, Scott-Browne JP, Young MH, Roisman LC, Pellicci DG, Patel O, Vivian JP, Matsuda JL, McCluskey J, Godfrey DI, Marrack P, Rossjohn J, Gapin L. A molecular basis for NKT cell recognition of CD1d-self-antigen. Immunity. 2011 Mar 25; 34(3):315-26. PMID: 21376640.
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    39. Wun KS, Cameron G, Patel O, Pang SS, Pellicci DG, Sullivan LC, Keshipeddy S, Young MH, Uldrich AP, Thakur MS, Richardson SK, Howell AR, Illarionov PA, Brooks AG, Besra GS, McCluskey J, Gapin L, Porcelli SA, Godfrey DI, Rossjohn J. A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells. Immunity. 2011 Mar 25; 34(3):327-39. PMID: 21376639.
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    40. Young MH, Gapin L. Group 1 CD1-restricted T cells take center stage. Eur J Immunol. 2011 Mar; 41(3):592-4. PMID: 21341260.
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    41. Matsuda H, Takeda K, Koya T, Okamoto M, Shiraishi Y, Miyahara N, Dakhama A, Matsuda JL, Gapin L, Gelfand EW. Plasticity of invariant NKT cell regulation of allergic airway disease is dependent on IFN-gamma production. J Immunol. 2010 Jul 01; 185(1):253-62. PMID: 20525882.
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    42. Gapin L. iNKT cell autoreactivity: what is 'self' and how is it recognized? Nat Rev Immunol. 2010 Apr; 10(4):272-7. PMID: 20224567.
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    43. McWilliams JA, Sanchez PJ, Haluszczak C, Gapin L, Kedl RM. Multiple innate signaling pathways cooperate with CD40 to induce potent, CD70-dependent cellular immunity. Vaccine. 2010 Feb 10; 28(6):1468-76. PMID: 19995538.
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    44. Florence WC, Xia C, Gordy LE, Chen W, Zhang Y, Scott-Browne J, Kinjo Y, Yu KO, Keshipeddy S, Pellicci DG, Patel O, Kjer-Nielsen L, McCluskey J, Godfrey DI, Rossjohn J, Richardson SK, Porcelli SA, Howell AR, Hayakawa K, Gapin L, Zajonc DM, Wang PG, Joyce S. Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands. EMBO J. 2009 Dec 02; 28(23):3781. PMID: 19953109.
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    45. Florence WC, Xia C, Gordy LE, Chen W, Zhang Y, Scott-Browne J, Kinjo Y, Yu KO, Keshipeddy S, Pellicci DG, Patel O, Kjer-Nielsen L, McCluskey J, Godfrey DI, Rossjohn J, Richardson SK, Porcelli SA, Howell AR, Hayakawa K, Gapin L, Zajonc DM, Wang PG, Joyce S. Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands. EMBO J. 2009 Nov 18; 28(22):3579-90. PMID: 19816402.
      View in: PubMed
    46. Mallevaey T, Scott-Browne JP, Matsuda JL, Young MH, Pellicci DG, Patel O, Thakur M, Kjer-Nielsen L, Richardson SK, Cerundolo V, Howell AR, McCluskey J, Godfrey DI, Rossjohn J, Marrack P, Gapin L. T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire. Immunity. 2009 Jul 17; 31(1):60-71. PMID: 19592274.
      View in: PubMed
    47. Pellicci DG, Patel O, Kjer-Nielsen L, Pang SS, Sullivan LC, Kyparissoudis K, Brooks AG, Reid HH, Gras S, Lucet IS, Koh R, Smyth MJ, Mallevaey T, Matsuda JL, Gapin L, McCluskey J, Godfrey DI, Rossjohn J. Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptors. Immunity. 2009 Jul 17; 31(1):47-59. PMID: 19592275.
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    48. Gapin L. Where do MAIT cells fit in the family of unconventional T cells? PLoS Biol. 2009 Mar 31; 7(3):e70. PMID: 19338386.
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    49. Scott-Browne JP, White J, Kappler JW, Gapin L, Marrack P. Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection. Nature. 2009 Apr 23; 458(7241):1043-6. PMID: 19262510.
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    50. Gapin L. The making of NKT cells. Nat Immunol. 2008 Sep; 9(9):1009-11. PMID: 18711440.
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    51. Matsuda JL, Mallevaey T, Scott-Browne J, Gapin L. CD1d-restricted iNKT cells, the 'Swiss-Army knife' of the immune system. Curr Opin Immunol. 2008 Jun; 20(3):358-68. PMID: 18501573.
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    52. Wun KS, Borg NA, Kjer-Nielsen L, Beddoe T, Koh R, Richardson SK, Thakur M, Howell AR, Scott-Browne JP, Gapin L, Godfrey DI, McCluskey J, Rossjohn J. A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR. J Exp Med. 2008 Apr 14; 205(4):939-49. PMID: 18378792.
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    53. Chung Y, Nurieva R, Esashi E, Wang YH, Zhou D, Gapin L, Dong C. A critical role of costimulation during intrathymic development of invariant NK T cells. J Immunol. 2008 Feb 15; 180(4):2276-83. PMID: 18250436.
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    54. Marrack P, Scott-Browne JP, Dai S, Gapin L, Kappler JW. Evolutionarily conserved amino acids that control TCR-MHC interaction. Annu Rev Immunol. 2008; 26:171-203. PMID: 18304006.
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    55. Scott-Browne JP, Matsuda JL, Mallevaey T, White J, Borg NA, McCluskey J, Rossjohn J, Kappler J, Marrack P, Gapin L. Germline-encoded recognition of diverse glycolipids by natural killer T cells. Nat Immunol. 2007 Oct; 8(10):1105-13. PMID: 17828267.
      View in: PubMed
    56. Jin N, Miyahara N, Roark CL, French JD, Aydintug MK, Matsuda JL, Gapin L, O'Brien RL, Gelfand EW, Born WK. Airway hyperresponsiveness through synergy of gammadelta} T cells and NKT cells. J Immunol. 2007 Sep 01; 179(5):2961-8. PMID: 17709511.
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    57. Hager E, Hawwari A, Matsuda JL, Krangel MS, Gapin L. Multiple constraints at the level of TCRalpha rearrangement impact Valpha14i NKT cell development. J Immunol. 2007 Aug 15; 179(4):2228-34. PMID: 17675483.
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    58. Joshi NS, Cui W, Chandele A, Lee HK, Urso DR, Hagman J, Gapin L, Kaech SM. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity. 2007 Aug; 27(2):281-95. PMID: 17723218.
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    59. Kronenberg M, Gapin L. Natural killer T cells: know thyself. Proc Natl Acad Sci U S A. 2007 Apr 03; 104(14):5713-4. PMID: 17389403.
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    60. Matsuda JL, George TC, Hagman J, Gapin L. Temporal dissection of T-bet functions. J Immunol. 2007 Mar 15; 178(6):3457-65. PMID: 17339440.
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    61. Matsuda JL, Gapin L. Does the developmental status of Valpha14i NKT cells play a role in disease? Int Rev Immunol. 2007 Jan-Apr; 26(1-2):5-29. PMID: 17454262.
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    62. Matsuda JL, Zhang Q, Ndonye R, Richardson SK, Howell AR, Gapin L. T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells. Blood. 2006 Apr 01; 107(7):2797-805. PMID: 16357323.
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    63. Intlekofer AM, Takemoto N, Wherry EJ, Longworth SA, Northrup JT, Palanivel VR, Mullen AC, Gasink CR, Kaech SM, Miller JD, Gapin L, Ryan K, Russ AP, Lindsten T, Orange JS, Goldrath AW, Ahmed R, Reiner SL. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol. 2005 Dec; 6(12):1236-44. PMID: 16273099.
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    64. Matsuda JL, Gapin L. Developmental program of mouse Valpha14i NKT cells. Curr Opin Immunol. 2005 Apr; 17(2):122-30. PMID: 15766670.
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    65. Faure M, Gapin L, Viret C. Stressing the virtues of the immune system. Microbes Infect. 2004 Aug; 6(10):960-4. PMID: 15332301.
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    66. Townsend MJ, Weinmann AS, Matsuda JL, Salomon R, Farnham PJ, Biron CA, Gapin L, Glimcher LH. T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity. 2004 Apr; 20(4):477-94. PMID: 15084276.
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    67. Stetson DB, Mohrs M, Reinhardt RL, Baron JL, Wang ZE, Gapin L, Kronenberg M, Locksley RM. Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J Exp Med. 2003 Oct 06; 198(7):1069-76. PMID: 14530376.
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    68. Matsuda JL, Gapin L, Baron JL, Sidobre S, Stetson DB, Mohrs M, Locksley RM, Kronenberg M. Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8395-400. PMID: 12829795.
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    69. Chun T, Page MJ, Gapin L, Matsuda JL, Xu H, Nguyen H, Kang HS, Stanic AK, Joyce S, Koltun WA, Chorney MJ, Kronenberg M, Wang CR. CD1d-expressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cells. J Exp Med. 2003 Apr 07; 197(7):907-18. PMID: 12682110.
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    70. Matsuda JL, Gapin L, Sidobre S, Kieper WC, Tan JT, Ceredig R, Surh CD, Kronenberg M. Homeostasis of V alpha 14i NKT cells. Nat Immunol. 2002 Oct; 3(10):966-74. PMID: 12244311.
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    71. Kronenberg M, Gapin L. The unconventional lifestyle of NKT cells. Nat Rev Immunol. 2002 Aug; 2(8):557-68. PMID: 12154375.
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    72. Kieper WC, Tan JT, Bondi-Boyd B, Gapin L, Sprent J, Ceredig R, Surh CD. Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells. J Exp Med. 2002 Jun 17; 195(12):1533-9. PMID: 12070281.
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    73. Takahashi I, Matsuda J, Gapin L, DeWinter H, Kai Y, Tamagawa H, Kronenberg M, Kiyono H. Colitis-related public T cells are selected in the colonic lamina propria of IL-10-deficient mice. Clin Immunol. 2002 Mar; 102(3):237-48. PMID: 11890710.
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    74. Leishman AJ, Gapin L, Capone M, Palmer E, MacDonald HR, Kronenberg M, Cheroutre H. Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) T cells are positively selected in the thymus by agonist self-peptides. Immunity. 2002 Mar; 16(3):355-64. PMID: 11911821.
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    75. Ebhardt MB, Shive CL, Guardia R, Gapin L, Boehm BO, Forsthuber TG. Immunological adjuvants efficiently induce antigen-specific T cell responses in old mice: implications for vaccine adjuvant development in aged individuals. Cell Immunol. 2002 Jan; 215(1):87-97. PMID: 12142040.
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    76. Matsuda JL, Gapin L, Fazilleau N, Warren K, Naidenko OV, Kronenberg M. Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor beta repertoire and small clone size. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12636-41. PMID: 11592984.
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    77. Gapin L, Matsuda JL, Surh CD, Kronenberg M. NKT cells derive from double-positive thymocytes that are positively selected by CD1d. Nat Immunol. 2001 Oct; 2(10):971-8. PMID: 11550008.
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    78. Matsuda JL, Naidenko OV, Gapin L, Nakayama T, Taniguchi M, Wang CR, Koezuka Y, Kronenberg M. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J Exp Med. 2000 Sep 04; 192(5):741-54. PMID: 10974039.
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    79. Matsuda JL, Gapin L, Sydora BC, Byrne F, Binder S, Kronenberg M, Aranda R. Systemic activation and antigen-driven oligoclonal expansion of T cells in a mouse model of colitis. J Immunol. 2000 Mar 01; 164(5):2797-806. PMID: 10679123.
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    80. Foucras G, Gapin L, Coureau C, Kanellopoulos JM, Guéry JC. Interleukin 4-producing CD4 T cells arise from different precursors depending on the conditions of antigen exposure in vivo. J Exp Med. 2000 Feb 21; 191(4):683-94. PMID: 10684860.
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    81. Gapin L, Cheroutre H, Kronenberg M. Cutting edge: TCR alpha beta+ CD8 alpha alpha+ T cells are found in intestinal intraepithelial lymphocytes of mice that lack classical MHC class I molecules. J Immunol. 1999 Oct 15; 163(8):4100-4. PMID: 10510343.
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    82. Gapin L, Fukui Y, Kanellopoulos J, Sano T, Casrouge A, Malier V, Beaudoing E, Gautheret D, Claverie JM, Sasazuki T, Kourilsky P. Quantitative analysis of the T cell repertoire selected by a single peptide-major histocompatibility complex. J Exp Med. 1998 Jun 01; 187(11):1871-83. PMID: 9607927.
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    83. Amigorena S, Lankar D, Briken V, Gapin L, Viguier M, Bonnerot C. Type II and III receptors for immunoglobulin G (IgG) control the presentation of different T cell epitopes from single IgG-complexed antigens. J Exp Med. 1998 Feb 16; 187(4):505-15. PMID: 9463401.
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    84. Gapin L, Bravo de Alba Y, Casrouge A, Cabaniols JP, Kourilsky P, Kanellopoulos J. Antigen presentation by dendritic cells focuses T cell responses against immunodominant peptides: studies in the hen egg-white lysozyme (HEL) model. J Immunol. 1998 Feb 15; 160(4):1555-64. PMID: 9469410.
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    85. Kourilsky P, Bousso P, Calbo S, Gapin L. Immunological issues in vaccine trials: T-cell responses. Dev Biol Stand. 1998; 95:117-24. PMID: 9855421.
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    86. Gapin L, Cabaniols JP, Cibotti R, Ojcius DM, Kourilsky P, Kanellopoulos JM. Determinant selection for T-cell tolerance in HEL-transgenic mice: dissociation between immunogenicity and tolerogenicity. Cell Immunol. 1997 Apr 10; 177(1):77-85. PMID: 9140098.
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    87. Ojcius DM, Gapin L, Kanellopoulos JM, Kourilsky P. Is antigen processing guided by major histocompatibility complex molecules? FASEB J. 1994 Sep; 8(12):974-8. PMID: 8088463.
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    88. Ojcius DM, Gapin L, Kourilsky P. Dissociation of the peptide/MHC class I complex: pH dependence and effect of endogenous peptides on the activation energy. Biochem Biophys Res Commun. 1993 Dec 30; 197(3):1216-22. PMID: 8280136.
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