Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Kenneth L Tyler

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-NEUR General Operations
Phone303/724-4327

    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MAB.A.History
    Johns Hopkins, Baltimore, MDM.D.Medicine
    Brigham & Womens Hospital, Boston, MAInternal Medicine
    MGH, Boston, MANeurology
    Harvard Medical School, Boston, MAMicrobiology & Molecular Genetics
    Collapse awards and honors
    1997Elected Member, American Society Clinical Investigation
    2000Lawrence McHenry Jr. Award, American Academy of Neurology
    20025th Landau Lecturer, Wasington University, St. Louis
    2004Connell Memorial Professor, Queens University, Ontario
    2004Inaugural Friedlander Lecturer, University of Nebraska
    2006 - 2008Chair, CNBT Study Section, NIH
    2007Elected Member, Association American Physicians
    2007Elected Fellow, American Association Advancement of Science
    201025th Lippard Lecturer, Columbia
    201240th Aird Professor, UCSF
    2012Elected Fellow, American Society Microbiology
    2014Elected Member, Henry Kunkel Society, Rockefeller University
    2014 - 2018Treasurer, Board of Directors, American Neurological Association
    2015 - 2017Director, Association University Professors Neurology
    20174th Visiting Professor, UTMB Galveston, Dept. Neurology
    2017 - 2017Chair, Zika R21 SEP NIH Study Section
    2018Richard Paine Lecturer, Children's National Medical Center, Washington DC
    2018Inaugural H Richard Tyler lecturer, Brigham & Womens Hospital, Dept. Neurology

    Collapse Research 
    Collapse research activities and funding
    R01NS101208     (TYLER, KENNETH L.)Sep 1, 2018 - Aug 31, 2022
    NIH
    EV-D68-induced CNS disease: pathogenic mechanisms and identification of therapeutic targets.
    Role: Principal Investigator

    R21NS103186     (TYLER, KENNETH L.)Jul 1, 2017 - Jun 30, 2019
    NIH
    Identification and evaluation of novel therapeutic strategies for Zika virus-induced CNS disease
    Role: Principal Investigator

    R56NS101208     (TYLER, KENNETH L.)Apr 1, 2017 - Mar 31, 2018
    NIH
    EV-D68-induced CNS disease: pathogenic mechanisms and identification of therapeutic targets.
    Role: Principal Investigator

    R33AI101064     (TYLER, KENNETH L.)Jun 1, 2012 - May 31, 2018
    NIH
    Identification and evaluation of novel therapeutic targets for virus-induced neuronal disease
    Role: Principal Investigator

    R21AI101064     (TYLER, KENNETH L.)Jun 1, 2012 - May 31, 2014
    NIH
    Identification and evaluation of novel therapeutic targets for virus-induced neuronal disease
    Role: Principal Investigator

    I01BX000963     (TYLER, KENNETH L.)Oct 1, 2011 - Dec 31, 2020
    NIH
    Mechanisms of Virus-induced Injury in the Brain and Spinal Cord
    Role: Principal Investigator

    R01NS076512     (TYLER, KENNETH L.)Sep 15, 2011 - Nov 30, 2016
    NIH
    Cellular genes and signaling pathways as therapeutic targets for virus-induced CN
    Role: Principal Investigator

    R01NS051403     (TYLER, KENNETH L.)Feb 7, 2006 - Dec 31, 2012
    NIH
    Mechanisms of virus-induced apoptosis in neurons and CNS
    Role: Principal Investigator

    R01NS050138     (TYLER, KENNETH L.)Jan 1, 2005 - Dec 31, 2010
    NIH
    Mechanisms of apoptosis in the central nervous system
    Role: Principal Investigator

    R01AG014071     (TYLER, KENNETH L.)Aug 15, 1997 - May 31, 2002
    NIH
    MECHANISM OF VIRUS INDUCED CNS APOPTOSIS
    Role: Principal Investigator

    K11AI000610     (TYLER, KENNETH L.)Jul 1, 1984 - Jun 30, 1989
    NIH
    GENETIC BASIS OF VIRAL NEUROVIRULENCE AND NEURAL SPREAD
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Rudy MJ, Frost J, Clarke P, Tyler KL. Neutralizing Antibody Given after Paralysis Onset Reduces the Severity of Paralysis Compared to Nonspecific Antibody-Treated Controls in a Mouse Model of EV-D68-Associated Acute Flaccid Myelitis. Antimicrob Agents Chemother. 2022 Jul 27; e0022722. PMID: 35894595.
      View in: PubMed
    2. Tyler KL. The enigmatic links between Epstein-Barr virus infection and multiple sclerosis. J Clin Invest. 2022 May 02; 132(9). PMID: 35499072.
      View in: PubMed
    3. Stonedahl S, Leser JS, Clarke P, Tyler KL. Depletion of Microglia in an Ex Vivo Brain Slice Culture Model of West Nile Virus Infection Leads to Increased Viral Titers and Cell Death. Microbiol Spectr. 2022 04 27; 10(2):e0068522. PMID: 35412380.
      View in: PubMed
    4. Matthews E, Chauhan L, Piquet AL, Tyler KL, Pastula DM. An Overview of La Crosse Virus Disease. Neurohospitalist. 2022 Jul; 12(3):587-588. PMID: 35755222.
      View in: PubMed
    5. Messacar K, Palmer C, Gregoire L, Elliott A, Ackley E, Perraillon MC, Tyler KL, Dominguez SR. Clinical and Financial Impact of a Diagnostic Stewardship Program for Children with Suspected Central Nervous System Infection. J Pediatr. 2022 05; 244:161-168.e1. PMID: 35150729.
      View in: PubMed
    6. Potter H, Kendall L, Boyd T, Sillau S, Bosco-Lauth A, Markham N, Fong D, Clarke P, Tyler K. GM-CSF Promotes Immune Response and Survival in a Mouse Model of COVID-19. Res Sq. 2022 Jan 26. PMID: 35118463.
      View in: PubMed
    7. Tyler KL. A Message from the Editor-in-Chief. Ann Neurol. 2022 01; 91(1):1-3. PMID: 34820891.
      View in: PubMed
    8. Tyler KL. The Link Between Alzheimer Disease and Herpes Simplex Virus Infection: Better Late Than Never, or Better Never Than Late? Neurotherapeutics. 2021 10; 18(4):2421-2424. PMID: 34480291.
      View in: PubMed
    9. Clarke P, Leser JS, Tyler KL. Intrinsic Innate Immune Responses Control Viral Growth and Protect against Neuronal Death in an Ex Vivo Model of West Nile Virus-Induced Central Nervous System Disease. J Virol. 2021 08 25; 95(18):e0083521. PMID: 34190599.
      View in: PubMed
    10. High B, Hixon AM, Tyler KL, Piquet AL, Pelak VS. Neurology and the COVID-19 Pandemic: Gathering Data for an Informed Response. Neurol Clin Pract. 2021 Apr; 11(2):e48-e63. PMID: 33842072.
      View in: PubMed
    11. Rozental AJ, McGrath S, Mooney AP, Hinson SR, McKeon A, Pittock SJ, Gross CC, Tyler KL. Evaluation of cell-based and tissue-based immunofluorescent assays for detection of glial fibrillary acidic protein autoantibodies in the cerebrospinal fluid of dogs with meningoencephalitis of unknown origin and other central nervous system disorders. Am J Vet Res. 2021 Feb; 82(2):132-137. PMID: 33480282.
      View in: PubMed
    12. Dionne KR, Tyler KL, Clarke P. Slice Culture Modeling of CNS Viral Infection. Methods Mol Biol. 2021; 2311:109-130. PMID: 34033080.
      View in: PubMed
    13. Stonedahl S, Clarke P, Tyler KL. The Role of Microglia during West Nile Virus Infection of the Central Nervous System. Vaccines (Basel). 2020 Aug 28; 8(3). PMID: 32872152.
      View in: PubMed
    14. Koralnik IJ, Tyler KL. COVID-19: A Global Threat to the Nervous System. Ann Neurol. 2020 07; 88(1):1-11. PMID: 32506549.
      View in: PubMed
    15. Messacar K, Gaensbauer JT, Birkholz M, Palmer C, Todd JK, Tyler KL, Dominguez SR. Impact of FilmArray meningitis encephalitis panel on HSV testing and empiric acyclovir use in children beyond the neonatal period. Diagn Microbiol Infect Dis. 2020 Aug; 97(4):115085. PMID: 32559588.
      View in: PubMed
    16. Kuczynski AM, Wallace CJ, Wada R, Tyler KL, Kapadia RK. Crossed Zoster Syndrome: A Rare Clinical Presentation Following Herpes Zoster Ophthalmicus. Can J Neurol Sci. 2020 09; 47(5):711-713. PMID: 32389129.
      View in: PubMed
    17. Kapadia RK, Chauhan L, Piquet AL, Tyler KL, Pastula DM. An Overview of Eastern Equine Encephalitis (EEE). Neurohospitalist. 2020 Jul; 10(3):161-162. PMID: 32549937.
      View in: PubMed
    18. Tyler KL, Rüegg S. The neuromythology of Hashimoto encephalopathy: The emperor has no clothes. Neurology. 2020 01 14; 94(2):55-56. PMID: 31882524.
      View in: PubMed
    19. Messacar K, Spence-Davizon E, Osborne C, Press C, Schreiner TL, Martin J, Messer R, Maloney J, Burakoff A, Barnes M, Rogers S, Lopez AS, Routh J, Gerber SI, Oberste MS, Nix WA, Abzug MJ, Tyler KL, Herlihy R, Dominguez SR. Clinical characteristics of enterovirus A71 neurological disease during an outbreak in children in Colorado, USA, in 2018: an observational cohort study. Lancet Infect Dis. 2020 02; 20(2):230-239. PMID: 31859216.
      View in: PubMed
    20. Gnann JW, Agrawal A, Hart J, Buitrago M, Carson P, Hanfelt-Goade D, Tyler K, Spotkov J, Freifeld A, Moore T, Reyno J, Masur H, Jester P, Dale I, Li Y, Aban I, Lakeman FD, Whitley RJ. Lack of Efficacy of High-Titered Immunoglobulin in Patients with West Nile Virus Central Nervous System Disease. Emerg Infect Dis. 2019 11; 25(11):2064-2073. PMID: 31625835.
      View in: PubMed
    21. Gill CM, Beckham JD, Piquet AL, Tyler KL, Pastula DM. Five Emerging Neuroinvasive Arboviral Diseases: Cache Valley, Eastern Equine Encephalitis, Jamestown Canyon, Powassan, and Usutu. Semin Neurol. 2019 08; 39(4):419-427. PMID: 31533182.
      View in: PubMed
    22. Hixon AM, Frost J, Rudy MJ, Messacar K, Clarke P, Tyler KL. Understanding Enterovirus D68-Induced Neurologic Disease: A Basic Science Review. Viruses. 2019 09 04; 11(9). PMID: 31487952.
      View in: PubMed
    23. Hixon AM, Clarke P, Tyler KL. Contemporary Circulating Enterovirus D68 Strains Infect and Undergo Retrograde Axonal Transport in Spinal Motor Neurons Independent of Sialic Acid. J Virol. 2019 08 15; 93(16). PMID: 31167912.
      View in: PubMed
    24. Khan M, Beckham JD, Piquet AL, Tyler KL, Pastula DM. An Overview of Powassan Virus Disease. Neurohospitalist. 2019 Oct; 9(4):181-182. PMID: 31534605.
      View in: PubMed
    25. Messacar K, Tyler KL. Enterovirus D68-Associated Acute Flaccid Myelitis: Rising to the Clinical and Research Challenges. JAMA. 2019 03 05; 321(9):831-832. PMID: 30768149.
      View in: PubMed
    26. Dubey D, Pittock SJ, Krecke KN, Morris PP, Sechi E, Zalewski NL, Weinshenker BG, Shosha E, Lucchinetti CF, Fryer JP, Lopez-Chiriboga AS, Chen JC, Jitprapaikulsan J, McKeon A, Gadoth A, Keegan BM, Tillema JM, Naddaf E, Patterson MC, Messacar K, Tyler KL, Flanagan EP. Clinical, Radiologic, and Prognostic Features of Myelitis Associated With Myelin Oligodendrocyte Glycoprotein Autoantibody. JAMA Neurol. 2019 03 01; 76(3):301-309. PMID: 30575890.
      View in: PubMed
    27. Messacar K, Sillau S, Hopkins SE, Otten C, Wilson-Murphy M, Wong B, Santoro JD, Treister A, Bains HK, Torres A, Zabrocki L, Glanternik JR, Hurst AL, Martin JA, Schreiner T, Makhani N, DeBiasi RL, Kruer MC, Tremoulet AH, Van Haren K, Desai J, Benson LA, Gorman MP, Abzug MJ, Tyler KL, Dominguez SR. Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis. Neurology. 2019 04 30; 92(18):e2118-e2126. PMID: 30413631.
      View in: PubMed
    28. Tyler KL. Acute Viral Encephalitis. N Engl J Med. 2018 Aug 09; 379(6):557-566. PMID: 30089069.
      View in: PubMed
    29. Tyler KL. What's Next (Generation) for the Diagnosis of Chronic Meningitis? JAMA Neurol. 2018 08 01; 75(8):915-917. PMID: 29710076.
      View in: PubMed
    30. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 29899084.
      View in: PubMed
    31. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 29482893.
      View in: PubMed
    32. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 30327438.
      View in: PubMed
    33. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 28291542.
      View in: PubMed
    34. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 7636650.
      View in: PubMed
    35. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 28878079.
      View in: PubMed
    36. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 28968718.
      View in: PubMed
    37. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 29197179.
      View in: PubMed
    38. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 25956893.
      View in: PubMed
    39. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 26633778.
      View in: PubMed
    40. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 26501778.
      View in: PubMed
    41. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 27183312.
      View in: PubMed
    42. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 27307572.
      View in: PubMed
    43. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 27422805.
      View in: PubMed
    44. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 27820625.
      View in: PubMed
    45. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12885910.
      View in: PubMed
    46. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 3322182.
      View in: PubMed
    47. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 6336831.
      View in: PubMed
    48. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 23732875.
      View in: PubMed
    49. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 24722324.
      View in: PubMed
    50. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 25420159.
      View in: PubMed
    51. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 31858483.
      View in: PubMed
    52. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 30814290.
      View in: PubMed
    53. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 31387911.
      View in: PubMed
    54. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 31515289.
      View in: PubMed
    55. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 32704352.
      View in: PubMed
    56. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 32778604.
      View in: PubMed
    57. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 34214953.
      View in: PubMed
    58. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 34163560.
      View in: PubMed
    59. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 35170992.
      View in: PubMed
    60. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18195672.
      View in: PubMed
    61. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 22939285.
      View in: PubMed
    62. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2460637.
      View in: PubMed
    63. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8892922.
      View in: PubMed
    64. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 3528529.
      View in: PubMed
    65. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19279118.
      View in: PubMed
    66. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 15607987.
      View in: PubMed
    67. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2554768.
      View in: PubMed
    68. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12388702.
      View in: PubMed
    69. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 6848089.
      View in: PubMed
    70. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 15319091.
      View in: PubMed
    71. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 16819421.
      View in: PubMed
    72. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9599934.
      View in: PubMed
    73. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18418317.
      View in: PubMed
    74. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 6341874.
      View in: PubMed
    75. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 10472489.
      View in: PubMed
    76. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12402163.
      View in: PubMed
    77. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 3010183.
      View in: PubMed
    78. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 1719233.
      View in: PubMed
    79. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19892131.
      View in: PubMed
    80. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12402250.
      View in: PubMed
    81. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18305310.
      View in: PubMed
    82. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19321603.
      View in: PubMed
    83. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2536101.
      View in: PubMed
    84. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 1654436.
      View in: PubMed
    85. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8396673.
      View in: PubMed
    86. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 15452224.
      View in: PubMed
    87. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2465596.
      View in: PubMed
    88. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 23302889.
      View in: PubMed
    89. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 15116303.
      View in: PubMed
    90. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12020250.
      View in: PubMed
    91. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18657724.
      View in: PubMed
    92. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 15947079.
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    93. Messacar K, Fischer M, Dominguez SR, Tyler KL, Abzug MJ. Encephalitis in US Children. Infect Dis Clin North Am. 2018 03; 32(1):145-162. PMID: 29224854.
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    94. Tyler KL, Roos KL. The Expanding Spectrum of Zika Virus Infections of the Nervous System. JAMA Neurol. 2017 10 01; 74(10):1169-1171. PMID: 28806454.
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    95. Martin JA, Messacar K, Yang ML, Maloney JA, Lindwall J, Carry T, Kenyon P, Sillau SH, Oleszek J, Tyler KL, Dominguez SR, Schreiner TL. Outcomes of Colorado children with acute flaccid myelitis at 1 year. Neurology. 2017 Jul 11; 89(2):129-137. PMID: 28615421.
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    96. Pastula DM, Durrant JC, Smith DE, Beckham JD, Tyler KL. Zika Virus Disease for the Neurointensivist. Neurocrit Care. 2017 Jun; 26(3):457-463. PMID: 27995511.
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    97. McGuinness I, Beckham JD, Tyler KL, Pastula DM. An Overview of Yellow Fever Virus Disease. Neurohospitalist. 2017 Oct; 7(4):157-158. PMID: 28974992.
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    98. Hixon AM, Yu G, Leser JS, Yagi S, Clarke P, Chiu CY, Tyler KL. A mouse model of paralytic myelitis caused by enterovirus D68. PLoS Pathog. 2017 02; 13(2):e1006199. PMID: 28231269.
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    99. Tyler KL, Vollmer TL. To PLEX or not to PLEX in natalizumab-associated PML. Neurology. 2017 03 21; 88(12):1108-1109. PMID: 28228561.
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    100. Duca LM, Beckham JD, Tyler KL, Pastula DM. Zika Virus Disease and Associated Neurologic Complications. Curr Infect Dis Rep. 2017 Jan; 19(1):4. PMID: 28220392.
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    101. Smith DE, Beckham JD, Tyler KL, Pastula DM. Zika virus disease for neurologists. Neurol Clin Pract. 2016 Dec; 6(6):515-522. PMID: 28058206.
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    102. Wilson M, Tyler KL. Emerging Diagnostic and Therapeutic Tools for Central Nervous System Infections. JAMA Neurol. 2016 12 01; 73(12):1389-1390. PMID: 27695862.
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    103. Lipton HL, Tyler K. In memoriam: Donald H. Gilden, M.D. J Neurovirol. 2016 10; 22(5):551-552. PMID: 27683234.
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    104. White MK, Wollebo HS, David Beckham J, Tyler KL, Khalili K. Zika virus: An emergent neuropathological agent. Ann Neurol. 2016 Oct; 80(4):479-89. PMID: 27464346.
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    105. Vasek MJ, Garber C, Dorsey D, Durrant DM, Bollman B, Soung A, Yu J, Perez-Torres C, Frouin A, Wilton DK, Funk K, DeMasters BK, Jiang X, Bowen JR, Mennerick S, Robinson JK, Garbow JR, Tyler KL, Suthar MS, Schmidt RE, Stevens B, Klein RS. A complement-microglial axis drives synapse loss during virus-induced memory impairment. Nature. 2016 06 23; 534(7608):538-43. PMID: 27337340.
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    106. Pastula DM, Smith DE, Beckham JD, Tyler KL. An Overview of Zika Virus Disease. Neurohospitalist. 2016 Jul; 6(3):93-4. PMID: 27366289.
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    107. Pastula DM, Smith DE, Beckham JD, Tyler KL. Four emerging arboviral diseases in North America: Jamestown Canyon, Powassan, chikungunya, and Zika virus diseases. J Neurovirol. 2016 06; 22(3):257-60. PMID: 26903031.
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    108. Tyler KL. Rationale for the evaluation of fluoxetine in the treatment of enterovirus D68-associated acute flaccid myelitis. JAMA Neurol. 2015 May; 72(5):493-4. PMID: 25775436.
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    109. Steiner I, Tyler KL. The toll (like receptor 3) to the pathogenesis of herpes simplex encephalitis. Neurology. 2014 Nov 18; 83(21):1882-3. PMID: 25339218.
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    110. Quick ED, Leser JS, Clarke P, Tyler KL. Activation of intrinsic immune responses and microglial phagocytosis in an ex vivo spinal cord slice culture model of West Nile virus infection. J Virol. 2014 Nov; 88(22):13005-14. PMID: 25165111.
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    111. Clarke P, Leser JS, Bowen RA, Tyler KL. Virus-induced transcriptional changes in the brain include the differential expression of genes associated with interferon, apoptosis, interleukin 17 receptor A, and glutamate signaling as well as flavivirus-specific upregulation of tRNA synthetases. mBio. 2014 Mar 11; 5(2):e00902-14. PMID: 24618253.
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    112. Oyer RJ, David Beckham J, Tyler KL. West Nile and St. Louis encephalitis viruses. Handb Clin Neurol. 2014; 123:433-47. PMID: 25015498.
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    113. Clarke P, Leser JS, Quick ED, Dionne KR, Beckham JD, Tyler KL. Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response. J Virol. 2014 Jan; 88(2):1080-9. PMID: 24198425.
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    114. Nath A, Tyler KL. Novel approaches and challenges to treatment of central nervous system viral infections. Ann Neurol. 2013 Sep; 74(3):412-22. PMID: 23913580.
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    115. Tyler KL. PML therapy: "It's Déjà vu all over again". J Neurovirol. 2013 Aug; 19(4):311-3. PMID: 23913113.
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    116. Tyler KL, Johnson EC, Cantu DS, Haller BL. A 20-year-old woman with headache and transient numbness. Neurohospitalist. 2013 Apr; 3(2):101-10. PMID: 23983894.
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    117. Dionne KR, Tyler KL. Slice culture modeling of central nervous system (CNS) viral infection. Methods Mol Biol. 2013; 1078:97-117. PMID: 23975824.
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    118. Schittone SA, Dionne KR, Tyler KL, Clarke P. Activation of innate immune responses in the central nervous system during reovirus myelitis. J Virol. 2012 Aug; 86(15):8107-18. PMID: 22623770.
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    119. Stankiewicz TR, Loucks FA, Schroeder EK, Nevalainen MT, Tyler KL, Aktories K, Bouchard RJ, Linseman DA. Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity. J Biol Chem. 2012 May 11; 287(20):16835-48. PMID: 22378792.
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    120. Beckham JD, Tyler KL. Neuro-intensive care of patients with acute CNS infections. Neurotherapeutics. 2012 Jan; 9(1):124-38. PMID: 22102180.
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    121. Wilson MR, Tyler KL. Issues and updates in emerging neurologic viral infections. Semin Neurol. 2011 Jul; 31(3):245-53. PMID: 21964843.
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    122. Dionne KR, Galvin JM, Schittone SA, Clarke P, Tyler KL. Type I interferon signaling limits reoviral tropism within the brain and prevents lethal systemic infection. J Neurovirol. 2011 Aug; 17(4):314-26. PMID: 21671121.
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    123. Clifford DB, Ances B, Costello C, Rosen-Schmidt S, Andersson M, Parks D, Perry A, Yerra R, Schmidt R, Alvarez E, Tyler KL. Rituximab-associated progressive multifocal leukoencephalopathy in rheumatoid arthritis. Arch Neurol. 2011 Sep; 68(9):1156-64. PMID: 21555606.
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    124. Berens HM, Tyler KL. The proapoptotic Bcl-2 protein Bax plays an important role in the pathogenesis of reovirus encephalitis. J Virol. 2011 Apr; 85(8):3858-71. PMID: 21307199.
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    125. Dionne KR, Leser JS, Lorenzen KA, Beckham JD, Tyler KL. A brain slice culture model of viral encephalitis reveals an innate CNS cytokine response profile and the therapeutic potential of caspase inhibition. Exp Neurol. 2011 Apr; 228(2):222-31. PMID: 21241693.
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    126. Tyler KL. Progressive multifocal leukoencephalopathy: can we reduce risk in patients receiving biological immunomodulatory therapies? Ann Neurol. 2010 Sep; 68(3):271-4. PMID: 20818784.
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    127. Beckham JD, Tuttle KD, Tyler KL. Caspase-3 activation is required for reovirus-induced encephalitis in vivo. J Neurovirol. 2010 Jul; 16(4):306-17. PMID: 20626234.
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    128. Tyler KL, Leser JS, Phang TL, Clarke P. Gene expression in the brain during reovirus encephalitis. J Neurovirol. 2010 Feb; 16(1):56-71. PMID: 20158406.
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    129. Blakely PK, Kleinschmidt-DeMasters BK, Tyler KL, Irani DN. Disrupted glutamate transporter expression in the spinal cord with acute flaccid paralysis caused by West Nile virus infection. J Neuropathol Exp Neurol. 2009 Oct; 68(10):1061-72. PMID: 19918118.
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    130. Tyler KL. Emerging viral infections of the central nervous system: part 2. Arch Neurol. 2009 Sep; 66(9):1065-74. PMID: 19752295.
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    131. Levi ME, Quan D, Ho JT, Kleinschmidt-Demasters BK, Tyler KL, Grazia TJ. Impact of rituximab-associated B-cell defects on West Nile virus meningoencephalitis in solid organ transplant recipients. Clin Transplant. 2010 Mar-Apr; 24(2):223-8. PMID: 19659514.
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    132. Korman BD, Tyler KL, Korman NJ. Progressive multifocal leukoencephalopathy, efalizumab, and immunosuppression: a cautionary tale for dermatologists. Arch Dermatol. 2009 Aug; 145(8):937-42. PMID: 19687432.
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    133. Tyler KL. Emerging viral infections of the central nervous system: part 1. Arch Neurol. 2009 Aug; 66(8):939-48. PMID: 19667214.
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    134. Boster A, Hreha S, Berger JR, Bao F, Penmesta R, Tselis A, Endress C, Zak I, Perumal J, Caon C, Vazquez J, Tyler KL, Racke MK, Millis S, Khan O. Progressive multifocal leukoencephalopathy and relapsing-remitting multiple sclerosis: a comparative study. Arch Neurol. 2009 May; 66(5):593-9. PMID: 19433659.
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    135. Miyamoto SD, Brown RD, Robinson BA, Tyler KL, Long CS, Debiasi RL. Cardiac cell-specific apoptotic and cytokine responses to reovirus infection: determinants of myocarditic phenotype. J Card Fail. 2009 Aug; 15(6):529-39. PMID: 19643365.
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    136. Clarke P, Tyler KL. Apoptosis in animal models of virus-induced disease. Nat Rev Microbiol. 2009 Feb; 7(2):144-55. PMID: 19148180.
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    137. Tyler KL. Prednisolone--but not antiviral drugs--improves outcome in patients with Bell's palsy. Nat Clin Pract Neurol. 2009 Feb; 5(2):74-5. PMID: 19139743.
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    138. Tyler KL. Neurological infections: advances in therapy, outcome, and prediction. Lancet Neurol. 2009 Jan; 8(1):19-21. PMID: 19081508.
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    139. Tyler KL. The 50th birthday of progressive multifocal leukoencephalopathy: New insights into pathogenesis. Ann Neurol. 2008 Oct; 64(4):359-61. PMID: 18991349.
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    140. Bosque PJ, Tyler KL. Prions' travels--feces and transmission of prion diseases. J Infect Dis. 2008 Jul 01; 198(1):8-9. PMID: 18505382.
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    141. Tyler KL. Bacterial meningitis: an urgent need for further progress to reduce mortality and morbidity. Neurology. 2008 May 27; 70(22 Pt 2):2095-6. PMID: 18505990.
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    142. Goody RJ, Schittone SA, Tyler KL. Experimental reovirus-induced acute flaccid paralysis and spinal motor neuron cell death. J Neuropathol Exp Neurol. 2008 Mar; 67(3):231-9. PMID: 18344914.
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    143. Hudson LA, Rollins YD, Anderson CA, Johnston-Brooks C, Tyler KL, Filley CM. Reduplicative paramnesia in Morvan's syndrome. J Neurol Sci. 2008 Apr 15; 267(1-2):154-7. PMID: 17928004.
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    144. Gilden DH, Tyler KL. Bell's palsy--is glucocorticoid treatment enough? N Engl J Med. 2007 Oct 18; 357(16):1653-5. PMID: 17942879.
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    145. Zimmermann AK, Loucks FA, Schroeder EK, Bouchard RJ, Tyler KL, Linseman DA. Glutathione binding to the Bcl-2 homology-3 domain groove: a molecular basis for Bcl-2 antioxidant function at mitochondria. J Biol Chem. 2007 Oct 05; 282(40):29296-304. PMID: 17690097.
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    146. Goody RJ, Beckham JD, Rubtsova K, Tyler KL. JAK-STAT signaling pathways are activated in the brain following reovirus infection. J Neurovirol. 2007 Aug; 13(4):373-83. PMID: 17849321.
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    147. Beckham JD, Goody RJ, Clarke P, Bonny C, Tyler KL. Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase. J Virol. 2007 Jul; 81(13):6984-92. PMID: 17475657.
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    148. Anderson CA, Bosque P, Filley CM, Arciniegas DB, Kleinschmidt-Demasters BK, Pape WJ, Tyler KL. Colorado surveillance program for chronic wasting disease transmission to humans: lessons from 2 highly suspicious but negative cases. Arch Neurol. 2007 Mar; 64(3):439-41. PMID: 17353391.
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    149. Tyler KL, Aksamit AJ, Keegan BM, Parisi JE. An 85-year-old man with chronic lymphocytic leukemia and altered mental status. Neurology. 2007 Feb 06; 68(6):460-7. PMID: 17283324.
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    150. Gilden DH, Mahalingam R, Cohrs RJ, Tyler KL. Herpesvirus infections of the nervous system. Nat Clin Pract Neurol. 2007 Feb; 3(2):82-94. PMID: 17279082.
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    151. Clarke P, Tyler KL. Down-regulation of cFLIP following reovirus infection sensitizes human ovarian cancer cells to TRAIL-induced apoptosis. Apoptosis. 2007 Jan; 12(1):211-23. PMID: 17136319.
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    152. Beckham JD, Tyler KL. Infectious disease - developments in the field of Creutzfeldt-Jakob disease. Rev Neurol Dis. 2007; 4(3):168-72. PMID: 17943072.
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    153. Davis LE, DeBiasi R, Goade DE, Haaland KY, Harrington JA, Harnar JB, Pergam SA, King MK, DeMasters BK, Tyler KL. West Nile virus neuroinvasive disease. Ann Neurol. 2006 Sep; 60(3):286-300. PMID: 16983682.
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    154. Debiasi RL, Tyler KL. West Nile virus meningoencephalitis. Nat Clin Pract Neurol. 2006 May; 2(5):264-75. PMID: 16932563.
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    155. Tyler KL, Pape J, Goody RJ, Corkill M, Kleinschmidt-DeMasters BK. CSF findings in 250 patients with serologically confirmed West Nile virus meningitis and encephalitis. Neurology. 2006 Feb 14; 66(3):361-5. PMID: 16382032.
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    156. Goody RJ, Hoyt CC, Tyler KL. Reovirus infection of the CNS enhances iNOS expression in areas of virus-induced injury. Exp Neurol. 2005 Oct; 195(2):379-90. PMID: 16004984.
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    157. Le SS, Loucks FA, Udo H, Richardson-Burns S, Phelps RA, Bouchard RJ, Barth H, Aktories K, Tyler KL, Kandel ER, Heidenreich KA, Linseman DA. Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons. J Neurochem. 2005 Aug; 94(4):1025-39. PMID: 16092944.
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    158. Clarke P, Debiasi RL, Meintzer SM, Robinson BA, Tyler KL. Inhibition of NF-kappa B activity and cFLIP expression contribute to viral-induced apoptosis. Apoptosis. 2005 May; 10(3):513-24. PMID: 15909114.
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    159. Richardson-Burns SM, Tyler KL. Minocycline delays disease onset and mortality in reovirus encephalitis. Exp Neurol. 2005 Apr; 192(2):331-9. PMID: 15755550.
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    160. Hoyt CC, Richardson-Burns SM, Goody RJ, Robinson BA, Debiasi RL, Tyler KL. Nonstructural protein sigma1s is a determinant of reovirus virulence and influences the kinetics and severity of apoptosis induction in the heart and central nervous system. J Virol. 2005 Mar; 79(5):2743-53. PMID: 15708993.
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    161. Clarke P, Richardson-Burns SM, DeBiasi RL, Tyler KL. Mechanisms of apoptosis during reovirus infection. Curr Top Microbiol Immunol. 2005; 289:1-24. PMID: 15791949.
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    162. Clarke P, Debiasi RL, Goody R, Hoyt CC, Richardson-Burns S, Tyler KL. Mechanisms of reovirus-induced cell death and tissue injury: role of apoptosis and virus-induced perturbation of host-cell signaling and transcription factor activation. Viral Immunol. 2005; 18(1):89-115. PMID: 15802955.
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    163. Tyler KL, Khalili K. Natalizumab and progressive multifocal leukoencephalopathy: highlights of the International Workshop on JC Virus/PML and Multiple Sclerosis, June 3-4, 2005, Philadelphia PA. Rev Neurol Dis. 2005; 2(3):144-9. PMID: 16400315.
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    164. Lapadat R, Debiasi RL, Johnson GL, Tyler KL, Shah I. Genes Induced by Reovirus Infection Have a Distinct Modular Cis-Regulatory Architecture. Curr Genomics. 2005; 6:501-513. PMID: 23335855.
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    165. Weinberg A, Bloch KC, Li S, Tang YW, Palmer M, Tyler KL. Dual infections of the central nervous system with Epstein-Barr virus. J Infect Dis. 2005 Jan 15; 191(2):234-7. PMID: 15609233.
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    166. Clarke P, Meintzer SM, Wang Y, Moffitt LA, Richardson-Burns SM, Johnson GL, Tyler KL. JNK regulates the release of proapoptotic mitochondrial factors in reovirus-infected cells. J Virol. 2004 Dec; 78(23):13132-8. PMID: 15542665.
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    167. Debiasi RL, Tyler KL. Molecular methods for diagnosis of viral encephalitis. Clin Microbiol Rev. 2004 Oct; 17(4):903-25, table of contents. PMID: 15489354.
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    168. Kleinschmidt-DeMasters BK, Marder BA, Levi ME, Laird SP, McNutt JT, Escott EJ, Everson GT, Tyler KL. Naturally acquired West Nile virus encephalomyelitis in transplant recipients: clinical, laboratory, diagnostic, and neuropathological features. Arch Neurol. 2004 Aug; 61(8):1210-20. PMID: 15313837.
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    169. Tyler KL. COMMENTARY: Gibbs CJ Jr, Amyx HL, Bacote A, Masters CL, Gajdusek DC. Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to nonhuman primates. J Infect Dis 1980; 142:205-208. J Infect Dis. 2004 Aug 01; 190(3):653-60. PMID: 15243947.
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    170. Tyler KL. West Nile virus infection in the United States. Arch Neurol. 2004 Aug; 61(8):1190-5. PMID: 15313835.
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    171. Hoyt CC, Bouchard RJ, Tyler KL. Novel nuclear herniations induced by nuclear localization of a viral protein. J Virol. 2004 Jun; 78(12):6360-9. PMID: 15163729.
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    172. Richardson-Burns SM, Tyler KL. Regional differences in viral growth and central nervous system injury correlate with apoptosis. J Virol. 2004 May; 78(10):5466-75. PMID: 15113925.
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    173. Edelmann KH, Richardson-Burns S, Alexopoulou L, Tyler KL, Flavell RA, Oldstone MB. Does Toll-like receptor 3 play a biological role in virus infections? Virology. 2004 May 01; 322(2):231-8. PMID: 15110521.
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    174. Tyler KL. Update on herpes simplex encephalitis. Rev Neurol Dis. 2004; 1(4):169-78. PMID: 16400278.
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    175. McCabe K, Tyler K, Tanabe J. Diffusion-weighted MRI abnormalities as a clue to the diagnosis of herpes simplex encephalitis. Neurology. 2003 Oct 14; 61(7):1015-6. PMID: 14557588.
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    176. Tyler KL. Origins and early descriptions of "Duchenne muscular dystrophy". Muscle Nerve. 2003 Oct; 28(4):402-22. PMID: 14506712.
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    177. Tyler KL. The uninvited guest: JC virus infection of neurons in PML. Neurology. 2003 Sep 23; 61(6):734-5. PMID: 14504312.
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    178. Tyler KL. William Richard Gowers (1845-1915). J Neurol. 2003 Aug; 250(8):1012-3. PMID: 12928929.
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    179. Cuevas BD, Abell AN, Witowsky JA, Yujiri T, Johnson NL, Kesavan K, Ware M, Jones PL, Weed SA, DeBiasi RL, Oka Y, Tyler KL, Johnson GL. MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts. EMBO J. 2003 Jul 01; 22(13):3346-55. PMID: 12839996.
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    180. Gonzales N, Tyler KL, Gilden DH. Recurrent dermatomal vesicular skin lesions: a clue to diagnosis of herpes simplex virus 2 meningitis. Arch Neurol. 2003 Jun; 60(6):868-9. PMID: 12810492.
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    181. Tyler KL. Human herpesvirus 6 and multiple sclerosis: the continuing conundrum. J Infect Dis. 2003 May 01; 187(9):1360-4. PMID: 12717616.
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    182. Clarke P, Meintzer SM, Moffitt LA, Tyler KL. Two distinct phases of virus-induced nuclear factor kappa B regulation enhance tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in virus-infected cells. J Biol Chem. 2003 May 16; 278(20):18092-100. PMID: 12637521.
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    183. Clarke P, Tyler KL. Reovirus-induced apoptosis: A minireview. Apoptosis. 2003 Mar; 8(2):141-50. PMID: 12766474.
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    184. Tyler KL. Creutzfeldt-Jakob disease. N Engl J Med. 2003 Feb 20; 348(8):681-2. PMID: 12594311.
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    185. Tyler K, York GK, Steinberg DA, Okun MS, Steinbach M, Satran R, Fine EJ, Manteghi T, Bleck TP, Swanson JW, Mishra S, Meador KJ, Clifford DB, Toole JF, Melson L. Part 2: history of 20th century neurology: decade by decade. Ann Neurol. 2003; 53 Suppl 4:S27-45. PMID: 12722088.
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    186. Richardson-Burns SM, Kleinschmidt-DeMasters BK, DeBiasi RL, Tyler KL. Progressive multifocal leukoencephalopathy and apoptosis of infected oligodendrocytes in the central nervous system of patients with and without AIDS. Arch Neurol. 2002 Dec; 59(12):1930-6. PMID: 12470182.
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    187. Mann MA, Tyler KL, Knipe DM, Fields BN. Type 3 reovirus neuroinvasion after intramuscular inoculation: viral genetic determinants of lethality and spinal cord infection. Virology. 2002 Nov 25; 303(2):213-21. PMID: 12490384.
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    188. DeBiasi RL, Kleinschmidt-DeMasters BK, Richardson-Burns S, Tyler KL. Central nervous system apoptosis in human herpes simplex virus and cytomegalovirus encephalitis. J Infect Dis. 2002 Dec 01; 186(11):1547-57. PMID: 12447729.
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    189. Kominsky DJ, Bickel RJ, Tyler KL. Reovirus-induced apoptosis requires both death receptor- and mitochondrial-mediated caspase-dependent pathways of cell death. Cell Death Differ. 2002 Sep; 9(9):926-33. PMID: 12181743.
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    190. DeBiasi RL, Kleinschmidt-DeMasters BK, Weinberg A, Tyler KL. Use of PCR for the diagnosis of herpesvirus infections of the central nervous system. J Clin Virol. 2002 Jul; 25 Suppl 1:S5-11. PMID: 12091076.
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    191. Tyler KL, McArthur JC. Through a glass, darkly: cerebrospinal fluid viral load measurements and the pathogenesis of human immunodeficiency virus infection of the central nervous system. Arch Neurol. 2002 Jun; 59(6):909-12. PMID: 12056925.
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    192. Poggioli GJ, DeBiasi RL, Bickel R, Jotte R, Spalding A, Johnson GL, Tyler KL. Reovirus-induced alterations in gene expression related to cell cycle regulation. J Virol. 2002 Mar; 76(6):2585-94. PMID: 11861824.
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    193. Spalding AC, Jotte RM, Scheinman RI, Geraci MW, Clarke P, Tyler KL, Johnson GL. TRAIL and inhibitors of apoptosis are opposing determinants for NF-kappaB-dependent, genotoxin-induced apoptosis of cancer cells. Oncogene. 2002 Jan 10; 21(2):260-71. PMID: 11803469.
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    194. Clarke P, Meintzer SM, Widmann C, Johnson GL, Tyler KL. Reovirus infection activates JNK and the JNK-dependent transcription factor c-Jun. J Virol. 2001 Dec; 75(23):11275-83. PMID: 11689607.
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    195. Tyler KL, Clarke P, DeBiasi RL, Kominsky D, Poggioli GJ. Reoviruses and the host cell. Trends Microbiol. 2001 Nov; 9(11):560-4. PMID: 11825717.
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    196. Clarke P, Meintzer SM, Spalding AC, Johnson GL, Tyler KL. Caspase 8-dependent sensitization of cancer cells to TRAIL-induced apoptosis following reovirus-infection. Oncogene. 2001 Oct 18; 20(47):6910-9. PMID: 11687970.
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    197. Kleinschmidt-DeMasters BK, DeBiasi RL, Tyler KL. Polymerase chain reaction as a diagnostic adjunct in herpesvirus infections of the nervous system. Brain Pathol. 2001 Oct; 11(4):452-64. PMID: 11556691.
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    198. Poggioli GJ, Dermody TS, Tyler KL. Reovirus-induced sigma1s-dependent G(2)/M phase cell cycle arrest is associated with inhibition of p34(cdc2). J Virol. 2001 Aug; 75(16):7429-34. PMID: 11462015.
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    199. Tyler KL. West Nile virus encephalitis in America. N Engl J Med. 2001 Jun 14; 344(24):1858-9. PMID: 11407349.
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    200. DeBiasi RL, Edelstein CL, Sherry B, Tyler KL. Calpain inhibition protects against virus-induced apoptotic myocardial injury. J Virol. 2001 Jan; 75(1):351-61. PMID: 11119604.
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    201. Tyler KL, Malessa R. The Goltz-Ferrier debates and the triumph of cerebral localizationalist theory. Neurology. 2000 Oct 10; 55(7):1015-24. PMID: 11061261.
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    202. Poggioli GJ, Keefer C, Connolly JL, Dermody TS, Tyler KL. Reovirus-induced G(2)/M cell cycle arrest requires sigma1s and occurs in the absence of apoptosis. J Virol. 2000 Oct; 74(20):9562-70. PMID: 11000227.
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    203. Clarke P, Meintzer SM, Gibson S, Widmann C, Garrington TP, Johnson GL, Tyler KL. Reovirus-induced apoptosis is mediated by TRAIL. J Virol. 2000 Sep; 74(17):8135-9. PMID: 10933724.
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    204. Tyler KL. Positive CSF HSV PCR in patients with GBM: a note of caution. Neurology. 2000 Aug 22; 55(4):604. PMID: 10953212.
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    205. Tyler KL, Roberts D, Tyler HR. The shorthand publications of Sir William Richard Gowers. Neurology. 2000 Jul 25; 55(2):289-93. PMID: 10908908.
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    206. Yujiri T, Ware M, Widmann C, Oyer R, Russell D, Chan E, Zaitsu Y, Clarke P, Tyler K, Oka Y, Fanger GR, Henson P, Johnson GL. MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7272-7. PMID: 10852963.
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    207. Connolly JL, Rodgers SE, Clarke P, Ballard DW, Kerr LD, Tyler KL, Dermody TS. Reovirus-induced apoptosis requires activation of transcription factor NF-kappaB. J Virol. 2000 Apr; 74(7):2981-9. PMID: 10708412.
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    208. Anderson CA, Sandberg E, Filley CM, Harris SL, Tyler KL. One and one-half syndrome with supranuclear facial weakness: magnetic resonance imaging localization. Arch Neurol. 1999 Dec; 56(12):1509-11. PMID: 10593308.
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    209. DeBiasi RL, Tyler KL. Polymerase chain reaction in the diagnosis and management of central nervous system infections. Arch Neurol. 1999 Oct; 56(10):1215-9. PMID: 10520937.
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    210. Clifford DB, Yiannoutsos C, Glicksman M, Simpson DM, Singer EJ, Piliero PJ, Marra CM, Francis GS, McArthur JC, Tyler KL, Tselis AC, Hyslop NE. HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy. Neurology. 1999 Feb; 52(3):623-5. PMID: 10025799.
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    211. Greenwood-Van Meerveld B, Tyler K, Kuge T, Ogata N. Anti-diarrhoeal effects of seirogan in the rat small intestine and colon examined in vitro. Aliment Pharmacol Ther. 1999 Jan; 13(1):97-102. PMID: 9892885.
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    212. Debiasi RL, Squier MK, Pike B, Wynes M, Dermody TS, Cohen JJ, Tyler KL. Reovirus-induced apoptosis is preceded by increased cellular calpain activity and is blocked by calpain inhibitors. J Virol. 1999 Jan; 73(1):695-701. PMID: 9847375.
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    213. Pelosi E, Rozenberg F, Coen DM, Tyler KL. A herpes simplex virus DNA polymerase mutation that specifically attenuates neurovirulence in mice. Virology. 1998 Dec 20; 252(2):364-72. PMID: 9878615.
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    214. Kleinschmidt-DeMasters BK, Mahalingam R, Shimek C, Marcoux HL, Wellish M, Tyler KL, Gilden DH. Profound cerebrospinal fluid pleocytosis and Froin's Syndrome secondary to widespread necrotizing vasculitis in an HIV-positive patient with varicella zoster virus encephalomyelitis. J Neurol Sci. 1998 Aug 14; 159(2):213-8. PMID: 9741410.
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    215. Fodor PA, Levin MJ, Weinberg A, Sandberg E, Sylman J, Tyler KL. Atypical herpes simplex virus encephalitis diagnosed by PCR amplification of viral DNA from CSF. Neurology. 1998 Aug; 51(2):554-9. PMID: 9710034.
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    216. Tyler KL. Serious methodological failures concerning presence of HSV DNA in surgical tissue from human epileptic seizure foci detected by PCR. Arch Neurol. 1998 Jul; 55(7):1031-2. PMID: 9678323.
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    217. Tyler KL, Sokol RJ, Oberhaus SM, Le M, Karrer FM, Narkewicz MR, Tyson RW, Murphy JR, Low R, Brown WR. Detection of reovirus RNA in hepatobiliary tissues from patients with extrahepatic biliary atresia and choledochal cysts. Hepatology. 1998 Jun; 27(6):1475-82. PMID: 9620316.
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    218. Oberhaus SM, Dermody TS, Tyler KL. Apoptosis and the cytopathic effects of reovirus. Curr Top Microbiol Immunol. 1998; 233(Pt 2):23-49. PMID: 9599930.
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    219. Virgin HW, Dermody TS, Tyler KL. Cellular and humoral immunity to reovirus infection. Curr Top Microbiol Immunol. 1998; 233(Pt 2):147-61. PMID: 9599936.
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    220. Rodgers SE, Barton ES, Oberhaus SM, Pike B, Gibson CA, Tyler KL, Dermody TS. Reovirus-induced apoptosis of MDCK cells is not linked to viral yield and is blocked by Bcl-2. J Virol. 1997 Mar; 71(3):2540-6. PMID: 9032397.
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    221. Oberhaus SM, Smith RL, Clayton GH, Dermody TS, Tyler KL. Reovirus infection and tissue injury in the mouse central nervous system are associated with apoptosis. J Virol. 1997 Mar; 71(3):2100-6. PMID: 9032342.
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    222. Tyler KL, Tedder DG, Yamamoto LJ, Klapper JA, Ashley R, Lichtenstein KA, Levin MJ. Recurrent brainstem encephalitis associated with herpes simplex virus type 1 DNA in cerebrospinal fluid. Neurology. 1995 Dec; 45(12):2246-50. PMID: 8848201.
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    223. Almond JW, Brown P, Gore SM, Hofman A, Wientjens PW, Ridley RM, Baker HF, Roberts GW, Tyler KL. Creutzfeldt-Jakob disease and bovine spongiform encephalopathy: any connection? BMJ. 1995 Nov 25; 311(7017):1415-21. PMID: 8520279.
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    224. Tyler KL, Squier MK, Rodgers SE, Schneider BE, Oberhaus SM, Grdina TA, Cohen JJ, Dermody TS. Differences in the capacity of reovirus strains to induce apoptosis are determined by the viral attachment protein sigma 1. J Virol. 1995 Nov; 69(11):6972-9. PMID: 7474116.
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    225. Dermody TS, Chappell JD, Hofler JG, Kramp W, Tyler KL. Eradication of persistent reovirus infection from a B-cell hybridoma. Virology. 1995 Sep 10; 212(1):272-6. PMID: 7676645.
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    226. Paskavitz JF, Anderson CA, Filley CM, Kleinschmidt-DeMasters BK, Tyler KL. Acute arcuate fiber demyelinating encephalopathy following Epstein-Barr virus infection. Ann Neurol. 1995 Jul; 38(1):127-31. PMID: 7611716.
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    227. Tyler KL, Sandberg E, Baum KF. Medical medullary syndrome and meningovascular syphilis: a case report in an HIV-infected man and a review of the literature. Neurology. 1994 Dec; 44(12):2231-5. PMID: 7991103.
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    228. Tyler KL. Polymerase chain reaction and the diagnosis of viral central nervous system diseases. Ann Neurol. 1994 Dec; 36(6):809-11. PMID: 7998764.
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    229. Virgin HW, Mann MA, Tyler KL. Protective antibodies inhibit reovirus internalization and uncoating by intracellular proteases. J Virol. 1994 Oct; 68(10):6719-29. PMID: 8084004.
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    230. Tedder DG, Ashley R, Tyler KL, Levin MJ. Herpes simplex virus infection as a cause of benign recurrent lymphocytic meningitis. Ann Intern Med. 1994 Sep 01; 121(5):334-8. PMID: 8042822.
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    231. Tyler KL, Mann MA, Fields BN, Virgin HW. Protective anti-reovirus monoclonal antibodies and their effects on viral pathogenesis. J Virol. 1993 Jun; 67(6):3446-53. PMID: 8388508.
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    232. Ravilochan K, Tyler KL. Human transmissible neurodegenerative diseases (prion diseases). Semin Neurol. 1992 Sep; 12(3):178-92. PMID: 1455105.
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    233. Bia MJ, Tyler K. Evidence that calcium channel blockade prevents cyclosporine-induced exacerbation of renal ischemic injury. Transplantation. 1991 Feb; 51(2):293-5. PMID: 1847248.
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    234. Tyler KL, Virgin HW, Bassel-Duby R, Fields BN. Antibody inhibits defined stages in the pathogenesis of reovirus serotype 3 infection of the central nervous system. J Exp Med. 1989 Sep 01; 170(3):887-900. PMID: 2549167.
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    235. Coen DM, Kosz-Vnenchak M, Jacobson JG, Leib DA, Bogard CL, Schaffer PA, Tyler KL, Knipe DM. Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate. Proc Natl Acad Sci U S A. 1989 Jun; 86(12):4736-40. PMID: 2543985.
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    236. Tyler KL, McPhee DA. Molecular and genetic aspects of the pathogenesis of viral infections of the central nervous system. Crit Rev Neurobiol. 1987; 3(3):221-43. PMID: 3315238.
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    237. Tyler KL, McPhee DA, Fields BN. Distinct pathways of viral spread in the host determined by reovirus S1 gene segment. Science. 1986 Aug 15; 233(4765):770-4. PMID: 3016895.
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    238. Kaye KM, Spriggs DR, Bassel-Duby R, Fields BN, Tyler KL. Genetic basis for altered pathogenesis of an immune-selected antigenic variant of reovirus type 3 (Dearing). J Virol. 1986 Jul; 59(1):90-7. PMID: 3012122.
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    239. Tyler KL, Tyler HR. The secret life of James Parkinson (1755-1824): the writings of Old Hubert. Neurology. 1986 Feb; 36(2):222-4. PMID: 3511403.
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    240. Tyler KL. Lawrence Chester McHenry, Jr, MD (1929-1985). Arch Neurol. 1985 Dec; 42(12):1202-3. PMID: 3904680.
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    241. Tyler KL, Bronson RT, Byers KB, Fields B. Molecular basis of viral neurotropism: experimental reovirus infection. Neurology. 1985 Jan; 35(1):88-92. PMID: 2981418.
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    242. Tyler HR, Tyler KL. Charles Edouard Brown-Séquard: professor of physiology and pathology of the nervous system at Harvard Medical School. Neurology. 1984 Sep; 34(9):1231-6. PMID: 6379508.
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    243. Tyler KL. Classics in neurology. Fragments of neurologic history: "Tetanoid Chorea" and progressive lenticular degeneration. Neurology. 1983 Apr; 33(4):461-2. PMID: 6339984.
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