Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Last Name

Contact Us
If you have any questions or feedback please contact us.

Mary Heather Knowles

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Biography 
    Collapse awards and honors
    2017Award for Excellence, Division of Hematology, University of Colorado SOM
    2020Inpatient APP of the Year, Division of Hematology, University of Colorado SOM

    Collapse Overview 
    Collapse overview
    I’m a Physician Assistant (PA) and Assistant Professor at the University of Colorado School of Medicine. I began my career as a research immunologist studying the pathophysiology of autoimmune disorders and infections. I left the laboratory after many years to pursue a clinical career as a PA, treating patients with blood cancers. My research and clinical focus are to reduce the impact that treatment-related complications from chimeric antigen receptor (CAR)-T cell therapy or stem cell transplant have on the patient’s experience during their journey for a cure.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Knowles H, Li Y, Perraud AL. The TRPM2 ion channel, an oxidative stress and metabolic sensor regulating innate immunity and inflammation. Immunol Res. 2013 Mar; 55(1-3):241-8. PMID: 22975787.
      View in: PubMed
    2. Jin L, Getahun A, Knowles HM, Mogan J, Akerlund LJ, Packard TA, Perraud AL, Cambier JC. STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration. J Immunol. 2013 Mar 15; 190(6):2835-43. PMID: 23378430.
      View in: PubMed
    3. Jin L, Hill KK, Filak H, Mogan J, Knowles H, Zhang B, Perraud AL, Cambier JC, Lenz LL. MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J Immunol. 2011 Sep 01; 187(5):2595-601. PMID: 21813776.
      View in: PubMed
    4. Knowles H, Heizer JW, Li Y, Chapman K, Ogden CA, Andreasen K, Shapland E, Kucera G, Mogan J, Humann J, Lenz LL, Morrison AD, Perraud AL. Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11578-83. PMID: 21709234.
      View in: PubMed
    5. Perraud AL, Takanishi CL, Shen B, Kang S, Smith MK, Schmitz C, Knowles HM, Ferraris D, Li W, Zhang J, Stoddard BL, Scharenberg AM. Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. J Biol Chem. 2005 Feb 18; 280(7):6138-48. PMID: 15561722.
      View in: PubMed
    6. Perraud AL, Knowles HM, Schmitz C. Novel aspects of signaling and ion-homeostasis regulation in immunocytes. The TRPM ion channels and their potential role in modulating the immune response. Mol Immunol. 2004 Jul; 41(6-7):657-73. PMID: 15220002.
      View in: PubMed
    7. Cipriani B, Chen L, Hiromatsu K, Knowles H, Raine CS, Battistini L, Porcelli SA, Brosnan CF. Upregulation of group 1 CD1 antigen presenting molecules in guinea pigs with experimental autoimmune encephalomyelitis: an immunohistochemical study. Brain Pathol. 2003 Jan; 13(1):1-9. PMID: 12580540.
      View in: PubMed
    8. Cipriani B, Knowles H, Chen L, Battistini L, Brosnan CF. Involvement of classical and novel protein kinase C isoforms in the response of human V gamma 9V delta 2 T cells to phosphate antigens. J Immunol. 2002 Nov 15; 169(10):5761-70. PMID: 12421956.
      View in: PubMed
    9. Cipriani B, Borsellino G, Knowles H, Tramonti D, Cavaliere F, Bernardi G, Battistini L, Brosnan CF. Curcumin inhibits activation of Vgamma9Vdelta2 T cells by phosphoantigens and induces apoptosis involving apoptosis-inducing factor and large scale DNA fragmentation. J Immunol. 2001 Sep 15; 167(6):3454-62. PMID: 11544338.
      View in: PubMed
    10. Downen M, Belkowski S, Knowles H, Cardillo M, Prystowsky MB. Developmental expression of voltage-gated potassium channel beta subunits. Brain Res Dev Brain Res. 1999 Oct 20; 117(1):71-80. PMID: 10536234.
      View in: PubMed
    Knowles's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    Co-Authors Expand Description
    Similar People Expand Description
    Same Department Expand Description

    Copyright © 2024 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)