Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution
Menu

Contact Us
If you have any questions or feedback please contact us.

Matthew G Frank

TitleSr Research Associate
InstitutionUniversity of Colorado Boulder
DepartmentIntegrative Physiology

    Collapse Research 
    Collapse research activities and funding
    R21MH116263     (LOWRY, CHRISTOPHER A)May 4, 2018 - Jan 31, 2021
    NIH
    Mycobacterium vaccae and stress resilience: Neural mechanisms
    Role: Co-Principal Investigator
    F32DA015591     (FRANK, MATTHEW G)Sep 1, 2003 - Aug 31, 2006
    NIH
    Nicotine Modulation of Gene Expression in Mice
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Frank MG, Baratta MV. Use of an immunocapture device to detect cytokine release in discrete brain regions. Neural Regen Res. 2024 Apr; 19(4):703-704. PMID: 37843193.
      View in: PubMed
    2. Desmond LW, Holbrook EM, Wright CTO, Zambrano CA, Stamper CE, Bohr AD, Frank MG, Podell BK, Moreno JA, MacDonald AS, Reber SO, Hern?ndez-Pando R, Lowry CA. Effects of Mycobacterium vaccae NCTC 11659 and Lipopolysaccharide Challenge on Polarization of Murine BV-2 Microglial Cells. Int J Mol Sci. 2023 Dec 29; 25(1). PMID: 38203645.
      View in: PubMed
    3. Coleman PT, Costanza-Chavez GW, Martin HN, Amat J, Frank MG, Sanchez RJ, Potter GJ, Mellert SM, Carter RK, Bonnici GN, Maier SF, Baratta MV. Prior experience with behavioral control over stress facilitates social dominance. Neurobiol Stress. 2024 Jan; 28:100597. PMID: 38213318.
      View in: PubMed
    4. Green-Fulgham SM, Ball JB, Kwilasz AJ, Harland ME, Frank MG, Dragavon JM, Grace PM, Watkins LR. Interleukin-1beta and inflammasome expression in spinal cord following chronic constriction injury in male and female rats. Brain Behav Immun. 2024 01; 115:157-168. PMID: 37838078.
      View in: PubMed
    5. Coleman PT, Costanza-Chavez GW, Martin HN, Amat J, Frank MG, Sanchez RJ, Potter GJ, Mellert SM, Carter RK, Bonnici GN, Maier SF, Baratta MV. Prior experience with behavioral control over stress facilitates social dominance. bioRxiv. 2023 Jun 07. PMID: 37333397.
      View in: PubMed
    6. Frank MG, Fleshner M, Maier SF. Exploring the immunogenic properties of SARS-CoV-2 structural proteins: PAMP:TLR signaling in the mediation of the neuroinflammatory and neurologic sequelae of COVID-19. Brain Behav Immun. 2023 07; 111:259-269. PMID: 37116592.
      View in: PubMed
    7. Holbrook EM, Zambrano CA, Wright CTO, Dub? EM, Stewart JR, Sanders WJ, Frank MG, MacDonald AS, Reber SO, Lowry CA. Mycobacterium vaccae NCTC 11659, a Soil-Derived Bacterium with Stress Resilience Properties, Modulates the Proinflammatory Effects of LPS in Macrophages. Int J Mol Sci. 2023 Mar 08; 24(6). PMID: 36982250.
      View in: PubMed
    8. Hassell JE, Baratta MV, Fallon IP, Siebler PH, Karns BL, Nguyen KT, Gates CA, Fonken LK, Frank MG, Maier SF, Lowry CA. Immunization with a heat-killed preparation of Mycobacterium vaccae NCTC 11659 enhances auditory-cued fear extinction in a stress-dependent manner. Brain Behav Immun. 2023 01; 107:1-15. PMID: 36108946.
      View in: PubMed
    9. Frank MG, Nguyen KH, Ball JB, Hopkins S, Kelley T, Baratta MV, Fleshner M, Maier SF. SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties. Brain Behav Immun. 2022 02; 100:267-277. PMID: 34915155.
      View in: PubMed
    10. Loupy KM, Cler KE, Marquart BM, Yifru TW, D'Angelo HM, Arnold MR, Elsayed AI, Gebert MJ, Fierer N, Fonken LK, Frank MG, Zambrano CA, Maier SF, Lowry CA. Comparing the effects of two different strains of mycobacteria, Mycobacterium vaccae NCTC 11659 and M. vaccae ATCC 15483, on stress-resilient behaviors and lipid-immune signaling in rats. Brain Behav Immun. 2021 01; 91:212-229. PMID: 33011306.
      View in: PubMed
    11. Frank MG, Baratta MV, Zhang K, Fallon IP, Pearson MA, Liu G, Hutchinson MR, Watkins LR, Goldys EM, Maier SF. Acute stress induces the rapid and transient induction of caspase-1, gasdermin D and release of constitutive IL-1? protein in dorsal hippocampus. Brain Behav Immun. 2020 11; 90:70-80. PMID: 32750541.
      View in: PubMed
    12. Frank MG, Fonken LK, Watkins LR, Maier SF. Acute stress induces chronic neuroinflammatory, microglial and behavioral priming: A role for potentiated NLRP3 inflammasome activation. Brain Behav Immun. 2020 10; 89:32-42. PMID: 32485293.
      View in: PubMed
    13. Loupy KM, Lee T, Zambrano CA, Elsayed AI, D'Angelo HM, Fonken LK, Frank MG, Maier SF, Lowry CA. Alzheimer's Disease: Protective Effects of Mycobacterium vaccae, a Soil-Derived Mycobacterium with Anti-Inflammatory and Anti-Tubercular Properties, on the Proteomic Profiles of Plasma and Cerebrospinal Fluid in Rats. J Alzheimers Dis. 2020; 78(3):965-987. PMID: 33074227.
      View in: PubMed
    14. Frank MG, Annis JL, Watkins LR, Maier SF. Glucocorticoids mediate stress induction of the alarmin HMGB1 and reduction of the microglia checkpoint receptor CD200R1 in limbic brain structures. Brain Behav Immun. 2019 08; 80:678-687. PMID: 31078691.
      View in: PubMed
    15. Frank MG, Fonken LK, Watkins LR, Maier SF. Microglia: Neuroimmune-sensors of stress. Semin Cell Dev Biol. 2019 10; 94:176-185. PMID: 30638704.
      View in: PubMed
    16. Frank MG, Fonken LK, Watkins LR, Maier SF, Lowry CA. Could Probiotics Be Used to Mitigate Neuroinflammation? ACS Chem Neurosci. 2019 01 16; 10(1):13-15. PMID: 30109920.
      View in: PubMed
    17. Fonken LK, Frank MG, D'Angelo HM, Heinze JD, Watkins LR, Lowry CA, Maier SF. Mycobacterium vaccae immunization protects aged rats from surgery-elicited neuroinflammation and cognitive dysfunction. Neurobiol Aging. 2018 11; 71:105-114. PMID: 30118926.
      View in: PubMed
    18. Fonken LK, Frank MG, Gaudet AD, Maier SF. Stress and aging act through common mechanisms to elicit neuroinflammatory priming. Brain Behav Immun. 2018 10; 73:133-148. PMID: 30009999.
      View in: PubMed
    19. Frank MG, Fonken LK, Dolzani SD, Annis JL, Siebler PH, Schmidt D, Watkins LR, Maier SF, Lowry CA. Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: Attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior. Brain Behav Immun. 2018 10; 73:352-363. PMID: 29807129.
      View in: PubMed
    20. Schindler SM, Frank MG, Annis JL, Maier SF, Klegeris A. Pattern recognition receptors mediate pro-inflammatory effects of extracellular mitochondrial transcription factor A (TFAM). Mol Cell Neurosci. 2018 06; 89:71-79. PMID: 29678518.
      View in: PubMed
    21. Zhang K, Baratta MV, Liu G, Frank MG, Leslie NR, Watkins LR, Maier SF, Hutchinson MR, Goldys EM. A novel platform for in vivo detection of cytokine release within discrete brain regions. Brain Behav Immun. 2018 07; 71:18-22. PMID: 29678795.
      View in: PubMed
    22. Fonken LK, Frank MG, Gaudet AD, D'Angelo HM, Daut RA, Hampson EC, Ayala MT, Watkins LR, Maier SF. Neuroinflammatory priming to stress is differentially regulated in male and female rats. Brain Behav Immun. 2018 05; 70:257-267. PMID: 29524458.
      View in: PubMed
    23. Frank MG, Fonken LK, Annis JL, Watkins LR, Maier SF. Stress disinhibits microglia via down-regulation of CD200R: A mechanism of neuroinflammatory priming. Brain Behav Immun. 2018 03; 69:62-73. PMID: 29104062.
      View in: PubMed
    24. Sobesky JL, D'Angelo HM, Weber MD, Anderson ND, Frank MG, Watkins LR, Maier SF, Barrientos RM. Glucocorticoids Mediate Short-Term High-Fat Diet Induction of Neuroinflammatory Priming, the NLRP3 Inflammasome, and the Danger Signal HMGB1. eNeuro. 2016 Jul-Aug; 3(4). PMID: 27595136.
      View in: PubMed
    25. Fonken LK, Frank MG, Kitt MM, D'Angelo HM, Norden DM, Weber MD, Barrientos RM, Godbout JP, Watkins LR, Maier SF. The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming. J Neurosci. 2016 07 27; 36(30):7946-56. PMID: 27466339.
      View in: PubMed
    26. Fonken LK, Weber MD, Daut RA, Kitt MM, Frank MG, Watkins LR, Maier SF. Stress-induced neuroinflammatory priming is time of day dependent. Psychoneuroendocrinology. 2016 Apr; 66:82-90. PMID: 26799851.
      View in: PubMed
    27. Frank MG, Weber MD, Watkins LR, Maier SF. Stress-induced neuroinflammatory priming: A liability factor in the etiology of psychiatric disorders. Neurobiol Stress. 2016 Oct; 4:62-70. PMID: 27981190.
      View in: PubMed
    28. Frank MG, Weber MD, Fonken LK, Hershman SA, Watkins LR, Maier SF. The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome. Brain Behav Immun. 2016 07; 55:215-224. PMID: 26482581.
      View in: PubMed
    29. Frank MG, Adhikary S, Sobesky JL, Weber MD, Watkins LR, Maier SF. The danger-associated molecular pattern HMGB1 mediates the neuroinflammatory effects of methamphetamine. Brain Behav Immun. 2016 Jan; 51:99-108. PMID: 26254235.
      View in: PubMed
    30. Frank MG, Watkins LR, Maier SF. The permissive role of glucocorticoids in neuroinflammatory priming: mechanisms and insights. Curr Opin Endocrinol Diabetes Obes. 2015 Aug; 22(4):300-5. PMID: 26087336.
      View in: PubMed
    31. Frank MG, Weber MD, Watkins LR, Maier SF. Stress sounds the alarmin: The role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming. Brain Behav Immun. 2015 Aug; 48:1-7. PMID: 25816800.
      View in: PubMed
    32. Weber MD, Frank MG, Tracey KJ, Watkins LR, Maier SF. Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome. J Neurosci. 2015 Jan 07; 35(1):316-24. PMID: 25568124.
      View in: PubMed
    33. Barrientos RM, Thompson VM, Kitt MM, Amat J, Hale MW, Frank MG, Crysdale NY, Stamper CE, Hennessey PA, Watkins LR, Spencer RL, Lowry CA, Maier SF. Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia. Neurobiol Aging. 2015 Mar; 36(3):1483-95. PMID: 25559333.
      View in: PubMed
    34. Fonken LK, Frank MG, Kitt MM, Barrientos RM, Watkins LR, Maier SF. Microglia inflammatory responses are controlled by an intrinsic circadian clock. Brain Behav Immun. 2015 Mar; 45:171-9. PMID: 25433170.
      View in: PubMed
    35. Barrientos RM, Thompson VM, Arnold TH, Frank MG, Watkins LR, Maier SF. The role of hepatic and splenic macrophages in E. coli-induced memory impairments in aged rats. Brain Behav Immun. 2015 Jan; 43:60-7. PMID: 25043992.
      View in: PubMed
    36. Frank MG, Hershman SA, Weber MD, Watkins LR, Maier SF. Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus. Psychoneuroendocrinology. 2014 Feb; 40:191-200. PMID: 24485491.
      View in: PubMed
    37. Weber MD, Frank MG, Sobesky JL, Watkins LR, Maier SF. Blocking toll-like receptor 2 and 4 signaling during a stressor prevents stress-induced priming of neuroinflammatory responses to a subsequent immune challenge. Brain Behav Immun. 2013 Aug; 32:112-21. PMID: 23500798.
      View in: PubMed
    38. Frank MG, Watkins LR, Maier SF. Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger. Brain Behav Immun. 2013 Oct; 33:1-6. PMID: 23459026.
      View in: PubMed
    39. Barrientos RM, Hein AM, Frank MG, Watkins LR, Maier SF. Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats. J Neurosci. 2012 Oct 17; 32(42):14641-8. PMID: 23077050.
      View in: PubMed
    40. Frank MG, Barrientos RM, Thompson BM, Weber MD, Watkins LR, Maier SF. IL-1RA injected intra-cisterna magna confers extended prophylaxis against lipopolysaccharide-induced neuroinflammatory and sickness responses. J Neuroimmunol. 2012 Nov 15; 252(1-2):33-9. PMID: 22871632.
      View in: PubMed
    41. Barrientos RM, Frank MG, Watkins LR, Maier SF. Aging-related changes in neuroimmune-endocrine function: implications for hippocampal-dependent cognition. Horm Behav. 2012 Aug; 62(3):219-27. PMID: 22370243.
      View in: PubMed
    42. Frank MG, Thompson BM, Watkins LR, Maier SF. Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses. Brain Behav Immun. 2012 Feb; 26(2):337-45. PMID: 22041296.
      View in: PubMed
    43. Rozeske RR, Evans AK, Frank MG, Watkins LR, Lowry CA, Maier SF. Uncontrollable, but not controllable, stress desensitizes 5-HT1A receptors in the dorsal raphe nucleus. J Neurosci. 2011 Oct 05; 31(40):14107-15. PMID: 21976495.
      View in: PubMed
    44. Hains LE, Loram LC, Taylor FR, Strand KA, Wieseler JL, Barrientos RM, Young JJ, Frank MG, Sobesky J, Martin TJ, Eisenach JC, Maier SF, Johnson JD, Fleshner M, Watkins LR. Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors. J Neuroimmunol. 2011 Oct 28; 239(1-2):53-60. PMID: 21907418.
      View in: PubMed
    45. Barrientos RM, Frank MG, Crysdale NY, Chapman TR, Ahrendsen JT, Day HE, Campeau S, Watkins LR, Patterson SL, Maier SF. Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes. J Neurosci. 2011 Aug 10; 31(32):11578-86. PMID: 21832188.
      View in: PubMed
    46. Loram LC, Taylor FR, Strand KA, Frank MG, Sholar P, Harrison JA, Maier SF, Watkins LR. Prior exposure to glucocorticoids potentiates lipopolysaccharide induced mechanical allodynia and spinal neuroinflammation. Brain Behav Immun. 2011 Oct; 25(7):1408-15. PMID: 21536123.
      View in: PubMed
    47. Frank MG, Watkins LR, Maier SF. Stress- and glucocorticoid-induced priming of neuroinflammatory responses: potential mechanisms of stress-induced vulnerability to drugs of abuse. Brain Behav Immun. 2011 Jun; 25 Suppl 1:S21-8. PMID: 21256955.
      View in: PubMed
    48. Hains LE, Loram LC, Weiseler JL, Frank MG, Bloss EB, Sholar P, Taylor FR, Harrison JA, Martin TJ, Eisenach JC, Maier SF, Watkins LR. Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming. J Pain. 2010 Oct; 11(10):1004-14. PMID: 20434956.
      View in: PubMed
    49. Frank MG, Barrientos RM, Watkins LR, Maier SF. Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo. J Neuroimmunol. 2010 Sep 14; 226(1-2):181-4. PMID: 20537730.
      View in: PubMed
    50. Soderquist RG, Sloane EM, Loram LC, Harrison JA, Dengler EC, Johnson SM, Amer LD, Young CS, Lewis MT, Poole S, Frank MG, Watkins LR, Milligan ED, Mahoney MJ. Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration. Pharm Res. 2010 May; 27(5):841-54. PMID: 20224990.
      View in: PubMed
    51. Barrientos RM, Frank MG, Watkins LR, Maier SF. Memory impairments in healthy aging: Role of aging-induced microglial sensitization. Aging Dis. 2010 Jan 01; 1(3):212-231. PMID: 21132050.
      View in: PubMed
    52. Frank MG, Barrientos RM, Hein AM, Biedenkapp JC, Watkins LR, Maier SF. IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344xBN F1 rats. Brain Behav Immun. 2010 Feb; 24(2):254-62. PMID: 19822205.
      View in: PubMed
    53. Frank MG, Miguel ZD, Watkins LR, Maier SF. Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide. Brain Behav Immun. 2010 Jan; 24(1):19-30. PMID: 19647070.
      View in: PubMed
    54. Barrientos RM, Frank MG, Hein AM, Higgins EA, Watkins LR, Rudy JW, Maier SF. Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection. Brain Behav Immun. 2009 Jan; 23(1):46-54. PMID: 18664380.
      View in: PubMed
    55. Frank MG, Der-Avakian A, Bland ST, Watkins LR, Maier SF. Stress-induced glucocorticoids suppress the antisense molecular regulation of FGF-2 expression. Psychoneuroendocrinology. 2007 May; 32(4):376-84. PMID: 17383826.
      View in: PubMed
    56. Holguin A, Frank MG, Biedenkapp JC, Nelson K, Lippert D, Watkins LR, Rudy JW, Maier SF. Characterization of the temporo-spatial effects of chronic bilateral intrahippocampal cannulae on interleukin-1beta. J Neurosci Methods. 2007 Apr 15; 161(2):265-72. PMID: 17241670.
      View in: PubMed
    57. Schoeniger-Skinner DK, Ledeboer A, Frank MG, Milligan ED, Poole S, Martin D, Maier SF, Watkins LR. Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120. Brain Behav Immun. 2007 Jul; 21(5):660-7. PMID: 17204394.
      View in: PubMed
    58. Milligan ED, Sloane EM, Langer SJ, Hughes TS, Jekich BM, Frank MG, Mahoney JH, Levkoff LH, Maier SF, Cruz PE, Flotte TR, Johnson KW, Mahoney MM, Chavez RA, Leinwand LA, Watkins LR. Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain. Pain. 2006 Dec 15; 126(1-3):294-308. PMID: 16949747.
      View in: PubMed
    59. Frank MG, Baratta MV, Sprunger DB, Watkins LR, Maier SF. Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behav Immun. 2007 Jan; 21(1):47-59. PMID: 16647243.
      View in: PubMed
    60. Frank MG, Barrientos RM, Biedenkapp JC, Rudy JW, Watkins LR, Maier SF. mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging. Neurobiol Aging. 2006 May; 27(5):717-22. PMID: 15890435.
      View in: PubMed
    61. Frank MG, Wieseler-Frank JL, Watkins LR, Maier SF. Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics. J Neurosci Methods. 2006 Mar 15; 151(2):121-30. PMID: 16125247.
      View in: PubMed
    62. Ledeboer A, Sloane EM, Milligan ED, Frank MG, Mahony JH, Maier SF, Watkins LR. Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain. 2005 May; 115(1-2):71-83. PMID: 15836971.
      View in: PubMed
    63. Johnston IN, Milligan ED, Wieseler-Frank J, Frank MG, Zapata V, Campisi J, Langer S, Martin D, Green P, Fleshner M, Leinwand L, Maier SF, Watkins LR. A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. J Neurosci. 2004 Aug 18; 24(33):7353-65. PMID: 15317861.
      View in: PubMed
    64. Frank MG, Wieseler Frank JL, Hendricks SE, Burke WJ, Johnson DR. Age at onset of major depressive disorder predicts reductions in NK cell number and activity. J Affect Disord. 2002 Sep; 71(1-3):159-67. PMID: 12167512.
      View in: PubMed
    Frank's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (237) concept(s)
    _
    Co-Authors Expand Description
    See all (13) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department

    Copyright © 2025 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)