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Colin Thomas Mant

TitleLecturer
InstitutionUniversity of Colorado Denver - Denver Campus
DepartmentCLAS-Chemistry
Phone303/724-3250

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Nichols PJ, Falconer I, Griffin A, Mant C, Hodges R, McKnight CJ, V?geli B, Vugmeyster L. Deuteration of nonexchangeable protons on proteins affects their thermal stability, side-chain dynamics, and hydrophobicity. Protein Sci. 2020 07; 29(7):1641-1654. PMID: 32356390.
      View in: PubMed
    2. Mant CT, Jiang Z, Gera L, Davis T, Hodges RS. Design of Novel Amphipathic a-Helical Antimicrobial Peptides with No Toxicity as Therapeutics against the Antibiotic-Resistant Gram-Negative Bacterial Pathogen, Acinetobacter Baumannii. J Med Chem Drug Des. 2019; 2(2). PMID: 34377965.
      View in: PubMed
    3. Mant CT, Jiang Z, Gera L, Davis T, Nelson KL, Bevers S, Hodges RS. De Novo Designed Amphipathic a-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii. J Med Chem. 2019 04 11; 62(7):3354-3366. PMID: 30848594.
      View in: PubMed
    4. Mant CT, Byars A, Ankarlo S, Jiang Z, Hodges RS. Separation of highly charged (+5 to +10) amphipathic a-helical peptide standards by cation-exchange and reversed-phase high-performance liquid chromatography. J Chromatogr A. 2018 Nov 02; 1574:60-70. PMID: 30220427.
      View in: PubMed
    5. Falconer IB, Mant CT, McKnight CJ, Vugmeyster L, Hodges R. Optimized purification of a fusion protein by reversed-phase high performance liquid chromatography informed by the linear solvent strength model. J Chromatogr A. 2017 Oct 27; 1521:44-52. PMID: 28942999.
      View in: PubMed
    6. Jiang Z, Mant CT, Vasil M, Hodges RS. Role of positively charged residues on the polar and non-polar faces of amphipathic a-helical antimicrobial peptides on specificity and selectivity for Gram-negative pathogens. Chem Biol Drug Des. 2018 01; 91(1):75-92. PMID: 28636788.
      View in: PubMed
    7. Mant CT, Hodges RS. Separation of Peptides on HALO 2-Micron Particles. Curr Protoc Protein Sci. 2016 08 01; 85:11.6.1-11.6.16. PMID: 27479502.
      View in: PubMed
    8. Jiang Z, Gera L, Mant CT, Hirsch B, Yan Z, Shortt JA, Pollock DD, Qian Z, Holmes KV, Hodges RS. Platform technology to generate broadly cross-reactive antibodies to a-helical epitopes in hemagglutinin proteins from influenza A viruses. Biopolymers. 2016 Mar; 106(2):144-159. PMID: 26799790.
      View in: PubMed
    9. Lanaspa MA, Epperson LE, Li N, Cicerchi C, Garcia GE, Roncal-Jimenez CA, Trostel J, Jain S, Mant CT, Rivard CJ, Ishimoto T, Shimada M, Sanchez-Lozada LG, Nakagawa T, Jani A, Stenvinkel P, Martin SL, Johnson RJ. Opposing activity changes in AMP deaminase and AMP-activated protein kinase in the hibernating ground squirrel. PLoS One. 2015; 10(4):e0123509. PMID: 25856396.
      View in: PubMed
    10. Abraham T, Prenner EJ, Lewis RN, Mant CT, Keller S, Hodges RS, McElhaney RN. Structure-activity relationships of the antimicrobial peptide gramicidin S and its analogs: aqueous solubility, self-association, conformation, antimicrobial activity and interaction with model lipid membranes. Biochim Biophys Acta. 2014 May; 1838(5):1420-9. PMID: 24388950.
      View in: PubMed
    11. Huang Y, Pan L, Zhao L, Mant CT, Hodges RS, Chen Y. Structure-guided RP-HPLC chromatography of diastereomeric a-helical peptide analogs substituted with single amino acid stereoisomers. Biomed Chromatogr. 2014 Apr; 28(4):511-7. PMID: 24127254.
      View in: PubMed
    12. Mant CT, Jiang Z, Boyes BE, Hodges RS. An improved approach to hydrophilic interaction chromatography of peptides: salt gradients in the presence of high isocratic acetonitrile concentrations. J Chromatogr A. 2013 Feb 15; 1277:15-25. PMID: 23332786.
      View in: PubMed
    13. Lanaspa MA, Cicerchi C, Garcia G, Li N, Roncal-Jimenez CA, Rivard CJ, Hunter B, Andr?s-Hernando A, Ishimoto T, S?nchez-Lozada LG, Thomas J, Hodges RS, Mant CT, Johnson RJ. Counteracting roles of AMP deaminase and AMP kinase in the development of fatty liver. PLoS One. 2012; 7(11):e48801. PMID: 23152807.
      View in: PubMed
    14. Zajdowicz S, Haller JC, Krafft AE, Hunsucker SW, Mant CT, Duncan MW, Hodges RS, Jones DN, Holmes RK. Purification and structural characterization of siderophore (corynebactin) from Corynebacterium diphtheriae. PLoS One. 2012; 7(4):e34591. PMID: 22514641.
      View in: PubMed
    15. Mant CT, Hodges RS. Design of peptide standards with the same composition and minimal sequence variation to monitor performance/selectivity of reversed-phase matrices. J Chromatogr A. 2012 Mar 23; 1230:30-40. PMID: 22326185.
      View in: PubMed
    16. Mant CT, Cepeniene D, Hodges RS. Reversed-phase HPLC of peptides: Assessing column and solvent selectivity on standard, polar-embedded and polar endcapped columns. J Sep Sci. 2010 Oct; 33(19):3005-21. PMID: 21038458.
      View in: PubMed
    17. Mant CT, Kovacs JM, Kim HM, Pollock DD, Hodges RS. Intrinsic amino acid side-chain hydrophilicity/hydrophobicity coefficients determined by reversed-phase high-performance liquid chromatography of model peptides: comparison with other hydrophilicity/hydrophobicity scales. Biopolymers. 2009; 92(6):573-95. PMID: 19795449.
      View in: PubMed
    18. Jiang Z, Kullberg BJ, van der Lee H, Vasil AI, Hale JD, Mant CT, Hancock RE, Vasil ML, Netea MG, Hodges RS. Effects of hydrophobicity on the antifungal activity of alpha-helical antimicrobial peptides. Chem Biol Drug Des. 2008 Dec; 72(6):483-95. PMID: 19090916.
      View in: PubMed
    19. Mant CT, Hodges RS. Mixed-mode hydrophilic interaction/cation-exchange chromatography (HILIC/CEX) of peptides and proteins. J Sep Sci. 2008 Aug; 31(15):2754-73. PMID: 18668504.
      View in: PubMed
    20. Mant CT, Hodges RS. Mixed-mode hydrophilic interaction/cation-exchange chromatography: separation of complex mixtures of peptides of varying charge and hydrophobicity. J Sep Sci. 2008 May; 31(9):1573-84. PMID: 18461566.
      View in: PubMed
    21. Popa TV, Mant CT, Hodges RS. Ion-interaction CZE: the presence of high concentrations of ion-pairing reagents demonstrates the complex mechanisms involved in peptide separations. Electrophoresis. 2007 Jul; 28(13):2181-90. PMID: 17557361.
      View in: PubMed
    22. Mant CT, Chen Y, Yan Z, Popa TV, Kovacs JM, Mills JB, Tripet BP, Hodges RS. HPLC analysis and purification of peptides. Methods Mol Biol. 2007; 386:3-55. PMID: 18604941.
      View in: PubMed
    23. Tripet B, Cepeniene D, Kovacs JM, Mant CT, Krokhin OV, Hodges RS. Requirements for prediction of peptide retention time in reversed-phase high-performance liquid chromatography: hydrophilicity/hydrophobicity of side-chains at the N- and C-termini of peptides are dramatically affected by the end-groups and location. J Chromatogr A. 2007 Feb 09; 1141(2):212-25. PMID: 17187811.
      View in: PubMed
    24. Chen Y, Guarnieri MT, Vasil AI, Vasil ML, Mant CT, Hodges RS. Role of peptide hydrophobicity in the mechanism of action of alpha-helical antimicrobial peptides. Antimicrob Agents Chemother. 2007 Apr; 51(4):1398-406. PMID: 17158938.
      View in: PubMed
    25. Chen Y, Mant CT, Hodges RS. Preparative reversed-phase high-performance liquid chromatography collection efficiency for an antimicrobial peptide on columns of varying diameters (1mm to 9.4mm I.D.). J Chromatogr A. 2007 Jan 26; 1140(1-2):112-20. PMID: 17156789.
      View in: PubMed
    26. Mills JB, Mant CT, Hodges RS. One-step purification of a recombinant protein from a whole cell extract by reversed-phase high-performance liquid chromatography. J Chromatogr A. 2006 Nov 10; 1133(1-2):248-53. PMID: 16945380.
      View in: PubMed
    27. Kovacs JM, Mant CT, Kwok SC, Osguthorpe DJ, Hodges RS. Quantitation of the nearest-neighbour effects of amino acid side-chains that restrict conformational freedom of the polypeptide chain using reversed-phase liquid chromatography of synthetic model peptides with L- and D-amino acid substitutions. J Chromatogr A. 2006 Aug 11; 1123(2):212-24. PMID: 16712857.
      View in: PubMed
    28. Chen Y, Vasil AI, Rehaume L, Mant CT, Burns JL, Vasil ML, Hancock RE, Hodges RS. Comparison of biophysical and biologic properties of alpha-helical enantiomeric antimicrobial peptides. Chem Biol Drug Des. 2006 Feb; 67(2):162-73. PMID: 16492164.
      View in: PubMed
    29. Kovacs JM, Mant CT, Hodges RS. Determination of intrinsic hydrophilicity/hydrophobicity of amino acid side chains in peptides in the absence of nearest-neighbor or conformational effects. Biopolymers. 2006; 84(3):283-97. PMID: 16315143.
      View in: PubMed
    30. Popa TV, Mant CT, Hodges RS. Ion-interaction-capillary zone electrophoresis of cationic proteomic peptide standards. J Chromatogr A. 2006 Apr 14; 1111(2):192-9. PMID: 16569578.
      View in: PubMed
    31. Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS. Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index. J Biol Chem. 2005 Apr 01; 280(13):12316-29. PMID: 15677462.
      View in: PubMed
    32. Popa TV, Mant CT, Chen Y, Hodges RS. Capillary zone electrophoresis of alpha-helical diastereomeric peptide pairs with anionic ion-pairing reagents. J Chromatogr A. 2004 Jul 16; 1043(1):113-22. PMID: 15317419.
      View in: PubMed
    33. Popa TV, Mant CT, Hodges RS. Capillary electrophoresis of cationic random coil peptide standards: effect of anionic ion-pairing reagents and comparison with reversed-phase chromatography. Electrophoresis. 2004 May; 25(9):1219-29. PMID: 15174041.
      View in: PubMed
    34. Popa TV, Mant CT, Hodges RS. Capillary electrophoresis of amphipathic alpha-helical peptide diastereomers. Electrophoresis. 2004 Jan; 25(1):94-107. PMID: 14730573.
      View in: PubMed
    35. Popa TV, Mant CT, Hodges RS. Capillary electrophoresis of synthetic peptide standards varying in charge and hydrophobicity. Electrophoresis. 2003 Dec; 24(24):4197-208. PMID: 14679567.
      View in: PubMed
    36. Chen Y, Mant CT, Hodges RS. Temperature selectivity effects in reversed-phase liquid chromatography due to conformation differences between helical and non-helical peptides. J Chromatogr A. 2003 Aug 22; 1010(1):45-61. PMID: 14503815.
      View in: PubMed
    37. Mant CT, Chen Y, Hodges RS. Temperature profiling of polypeptides in reversed-phase liquid chromatography. I. Monitoring of dimerization and unfolding of amphipathic alpha-helical peptides. J Chromatogr A. 2003 Aug 15; 1009(1-2):29-43. PMID: 13677643.
      View in: PubMed
    38. Mant CT, Tripet B, Hodges RS. Temperature profiling of polypeptides in reversed-phase liquid chromatography. II. Monitoring of folding and stability of two-stranded alpha-helical coiled-coils. J Chromatogr A. 2003 Aug 15; 1009(1-2):45-59. PMID: 13677644.
      View in: PubMed
    39. Hartmann E, Chen Y, Mant CT, Jungbauer A, Hodges RS. Comparison of reversed-phase liquid chromatography and hydrophilic interaction/cation-exchange chromatography for the separation of amphipathic alpha-helical peptides with L- and D-amino acid substitutions in the hydrophilic face. J Chromatogr A. 2003 Aug 15; 1009(1-2):61-71. PMID: 13677645.
      View in: PubMed
    40. Lee DL, Mant CT, Hodges RS. A novel method to measure self-association of small amphipathic molecules: temperature profiling in reversed-phase chromatography. J Biol Chem. 2003 Jun 20; 278(25):22918-27. PMID: 12686558.
      View in: PubMed
    41. Kwok SC, Mant CT, Hodges RS. Importance of secondary structural specificity determinants in protein folding: insertion of a native beta-sheet sequence into an alpha-helical coiled-coil. Protein Sci. 2002 Jun; 11(6):1519-31. PMID: 12021450.
      View in: PubMed
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