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Genevieve C Sparagna

TitleAsst Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-8714

    Collapse Research 
    Collapse research activities and funding
    F32HL010019     (SPARAGNA, GENEVIEVE C)Dec 31, 1998
    NIH/NHLBI
    MITOCHONDRIAS ROLE IN CARDIAC APOPTOSIS
    Role: Principal Investigator

    R21HL084129     (SPARAGNA, GENEVIEVE C)May 15, 2007 - Apr 30, 2010
    NIH/NHLBI
    Influence of Diet on Mitochondria &Cardiolipin During Heart Failure in SHHF Rats
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Cole LK, Mejia EM, Vandel M, Sparagna GC, Claypool SM, Dyck-Chan L, Klein J, Hatch GM. Erratum. Impaired Cardiolipin Biosynthesis Prevents Hepatic Steatosis and Diet-Induced Obesity. Diabetes 2016;65:3289-3300. Diabetes. 2017 Jan; 66(1):231. PMID: 27856607.
      View in: PubMed
    2. Cole LK, Mejia EM, Vandel M, Sparagna GC, Claypool SM, Dyck-Chan L, Klein J, Hatch GM. Impaired Cardiolipin Biosynthesis Prevents Hepatic Steatosis and Diet-Induced Obesity. Diabetes. 2016 Nov; 65(11):3289-3300. PMID: 27495222.
      View in: PubMed
    3. Dolinsky VW, Cole LK, Sparagna GC, Hatch GM. Cardiac mitochondrial energy metabolism in heart failure: Role of cardiolipin and sirtuins. Biochim Biophys Acta. 2016 Oct; 1860(10):1544-54. PMID: 26972373.
      View in: PubMed
    4. Mejia EM, Chau S, Sparagna GC, Sipione S, Hatch GM. Reduced Mitochondrial Function in Human Huntington Disease Lymphoblasts is Not Due to Alterations in Cardiolipin Metabolism or Mitochondrial Supercomplex Assembly. Lipids. 2016 May; 51(5):561-9. PMID: 26846325.
      View in: PubMed
    5. Mejia EM, Ibdah JA, Sparagna GC, Hatch GM. Differential reduction in cardiac and liver monolysocardiolipin acyltransferase-1 and reduction in cardiac and liver tetralinoleoyl-cardiolipin in the a-subunit of trifunctional protein heterozygous knockout mice. Biochem J. 2015 Oct 01; 471(1):123-9. PMID: 26251360.
      View in: PubMed
    6. Chatfield KC, Sparagna GC, Sucharov CC, Miyamoto SD, Grudis JE, Sobus RD, Hijmans J, Stauffer BL. Dysregulation of cardiolipin biosynthesis in pediatric heart failure. J Mol Cell Cardiol. 2014 Sep; 74:251-9. PMID: 24937604.
      View in: PubMed
    7. Le CH, Mulligan CM, Routh MA, Bouma GJ, Frye MA, Jeckel KM, Sparagna GC, Lynch JM, Moore RL, McCune SA, Bristow M, Zarini S, Murphy RC, Chicco AJ. Delta-6-desaturase links polyunsaturated fatty acid metabolism with phospholipid remodeling and disease progression in heart failure. Circ Heart Fail. 2014 Jan; 7(1):172-83. PMID: 24284026.
      View in: PubMed
    8. Huang JV, Lu L, Ye S, Bergman BC, Sparagna GC, Sarraf M, Reusch JE, Greyson CR, Schwartz GG. Impaired contractile recovery after low-flow myocardial ischemia in a porcine model of metabolic syndrome. Am J Physiol Heart Circ Physiol. 2013 Mar 15; 304(6):H861-73. PMID: 23335793.
      View in: PubMed
    9. Rees ML, Gioscia-Ryan RA, McCune SA, Browder JC, Zachman DK, Chicco AJ, Johnson CA, Murphy RC, Moore RL, Sparagna GC. The AIN-76A defined rodent diet accelerates the development of heart failure in SHHF rats: a cautionary note on its use in cardiac studies. J Anim Physiol Anim Nutr (Berl). 2014 Feb; 98(1):56-64. PMID: 23298172.
      View in: PubMed
    10. Bazán S, Mileykovskaya E, Mallampalli VK, Heacock P, Sparagna GC, Dowhan W. Cardiolipin-dependent reconstitution of respiratory supercomplexes from purified Saccharomyces cerevisiae complexes III and IV. J Biol Chem. 2013 Jan 04; 288(1):401-11. PMID: 23172229.
      View in: PubMed
    11. Taylor WA, Mejia EM, Mitchell RW, Choy PC, Sparagna GC, Hatch GM. Human trifunctional protein alpha links cardiolipin remodeling to beta-oxidation. PLoS One. 2012; 7(11):e48628. PMID: 23152787.
      View in: PubMed
    12. Mileykovskaya E, Penczek PA, Fang J, Mallampalli VK, Sparagna GC, Dowhan W. Arrangement of the respiratory chain complexes in Saccharomyces cerevisiae supercomplex III2IV2 revealed by single particle cryo-electron microscopy. J Biol Chem. 2012 Jun 29; 287(27):23095-103. PMID: 22573332.
      View in: PubMed
    13. Mulligan CM, Sparagna GC, Le CH, De Mooy AB, Routh MA, Holmes MG, Hickson-Bick DL, Zarini S, Murphy RC, Xu FY, Hatch GM, McCune SA, Moore RL, Chicco AJ. Dietary linoleate preserves cardiolipin and attenuates mitochondrial dysfunction in the failing rat heart. Cardiovasc Res. 2012 Jun 01; 94(3):460-8. PMID: 22411972.
      View in: PubMed
    14. Saini-Chohan HK, Dakshinamurti S, Taylor WA, Shen GX, Murphy R, Sparagna GC, Hatch GM. Persistent pulmonary hypertension results in reduced tetralinoleoyl-cardiolipin and mitochondrial complex II + III during the development of right ventricular hypertrophy in the neonatal pig heart. Am J Physiol Heart Circ Physiol. 2011 Oct; 301(4):H1415-24. PMID: 21841017.
      View in: PubMed
    15. Khairallah RJ, Sparagna GC, Khanna N, O'Shea KM, Hecker PA, Kristian T, Fiskum G, Des Rosiers C, Polster BM, Stanley WC. Dietary supplementation with docosahexaenoic acid, but not eicosapentaenoic acid, dramatically alters cardiac mitochondrial phospholipid fatty acid composition and prevents permeability transition. Biochim Biophys Acta. 2010 Aug; 1797(8):1555-62. PMID: 20471951.
      View in: PubMed
    16. Zachman DK, Chicco AJ, McCune SA, Murphy RC, Moore RL, Sparagna GC. The role of calcium-independent phospholipase A2 in cardiolipin remodeling in the spontaneously hypertensive heart failure rat heart. J Lipid Res. 2010 Mar; 51(3):525-34. PMID: 19741254.
      View in: PubMed
    17. O'Shea KM, Khairallah RJ, Sparagna GC, Xu W, Hecker PA, Robillard-Frayne I, Des Rosiers C, Kristian T, Murphy RC, Fiskum G, Stanley WC. Dietary omega-3 fatty acids alter cardiac mitochondrial phospholipid composition and delay Ca2+-induced permeability transition. J Mol Cell Cardiol. 2009 Dec; 47(6):819-27. PMID: 19703463.
      View in: PubMed
    18. Shah KB, Duda MK, O'Shea KM, Sparagna GC, Chess DJ, Khairallah RJ, Robillard-Frayne I, Xu W, Murphy RC, Des Rosiers C, Stanley WC. The cardioprotective effects of fish oil during pressure overload are blocked by high fat intake: role of cardiac phospholipid remodeling. Hypertension. 2009 Sep; 54(3):605-11. PMID: 19597033.
      View in: PubMed
    19. Sparagna GC, Lesnefsky EJ. Cardiolipin remodeling in the heart. J Cardiovasc Pharmacol. 2009 Apr; 53(4):290-301. PMID: 19276988.
      View in: PubMed
    20. Saini-Chohan HK, Holmes MG, Chicco AJ, Taylor WA, Moore RL, McCune SA, Hickson-Bick DL, Hatch GM, Sparagna GC. Cardiolipin biosynthesis and remodeling enzymes are altered during development of heart failure. J Lipid Res. 2009 Aug; 50(8):1600-8. PMID: 19001357.
      View in: PubMed
    21. Gumpricht E, Devereaux MW, Dahl R, Soden JS, Sparagna GC, Leonard SW, Traber MG, Sokol RJ. Resistance of young rat hepatic mitochondria to bile acid-induced permeability transition: potential role of alpha-tocopherol. Pediatr Res. 2008 Nov; 64(5):498-504. PMID: 18596569.
      View in: PubMed
    22. Chicco AJ, Sparagna GC, McCune SA, Johnson CA, Murphy RC, Bolden DA, Rees ML, Gardner RT, Moore RL. Linoleate-rich high-fat diet decreases mortality in hypertensive heart failure rats compared with lard and low-fat diets. Hypertension. 2008 Sep; 52(3):549-55. PMID: 18663155.
      View in: PubMed
    23. Chicco AJ, McCune SA, Emter CA, Sparagna GC, Rees ML, Bolden DA, Marshall KD, Murphy RC, Moore RL. Low-intensity exercise training delays heart failure and improves survival in female hypertensive heart failure rats. Hypertension. 2008 Apr; 51(4):1096-102. PMID: 18259016.
      View in: PubMed
    24. Sparagna GC, Chicco AJ, Murphy RC, Bristow MR, Johnson CA, Rees ML, Maxey ML, McCune SA, Moore RL. Loss of cardiac tetralinoleoyl cardiolipin in human and experimental heart failure. J Lipid Res. 2007 Jul; 48(7):1559-70. PMID: 17426348.
      View in: PubMed
    25. Watson PA, Reusch JE, McCune SA, Leinwand LA, Luckey SW, Konhilas JP, Brown DA, Chicco AJ, Sparagna GC, Long CS, Moore RL. Restoration of CREB function is linked to completion and stabilization of adaptive cardiac hypertrophy in response to exercise. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H246-59. PMID: 17337597.
      View in: PubMed
    26. Chicco AJ, Sparagna GC. Role of cardiolipin alterations in mitochondrial dysfunction and disease. Am J Physiol Cell Physiol. 2007 Jan; 292(1):C33-44. PMID: 16899548.
      View in: PubMed
    27. Emter CA, McCune SA, Sparagna GC, Radin MJ, Moore RL. Low-intensity exercise training delays onset of decompensated heart failure in spontaneously hypertensive heart failure rats. Am J Physiol Heart Circ Physiol. 2005 Nov; 289(5):H2030-8. PMID: 15994855.
      View in: PubMed
    28. Sparagna GC, Johnson CA, McCune SA, Moore RL, Murphy RC. Quantitation of cardiolipin molecular species in spontaneously hypertensive heart failure rats using electrospray ionization mass spectrometry. J Lipid Res. 2005 Jun; 46(6):1196-204. PMID: 15772420.
      View in: PubMed
    29. Sparagna GC, Jones CE, Hickson-Bick DL. Attenuation of fatty acid-induced apoptosis by low-dose alcohol in neonatal rat cardiomyocytes. Am J Physiol Heart Circ Physiol. 2004 Nov; 287(5):H2209-15. PMID: 15217794.
      View in: PubMed
    30. Brown DA, Jew KN, Sparagna GC, Musch TI, Moore RL. Exercise training preserves coronary flow and reduces infarct size after ischemia-reperfusion in rat heart. J Appl Physiol (1985). 2003 Dec; 95(6):2510-8. PMID: 12937028.
      View in: PubMed
    31. Hickson-Bick DL, Sparagna GC, Buja LM, McMillin JB. Palmitate-induced apoptosis in neonatal cardiomyocytes is not dependent on the generation of ROS. Am J Physiol Heart Circ Physiol. 2002 Feb; 282(2):H656-64. PMID: 11788415.
      View in: PubMed
    32. Ostrander DB, Sparagna GC, Amoscato AA, McMillin JB, Dowhan W. Decreased cardiolipin synthesis corresponds with cytochrome c release in palmitate-induced cardiomyocyte apoptosis. J Biol Chem. 2001 Oct 12; 276(41):38061-7. PMID: 11500520.
      View in: PubMed
    33. Buntinas L, Gunter KK, Sparagna GC, Gunter TE. The rapid mode of calcium uptake into heart mitochondria (RaM): comparison to RaM in liver mitochondria. Biochim Biophys Acta. 2001 Apr 02; 1504(2-3):248-61. PMID: 11245789.
      View in: PubMed
    34. Sparagna GC, Hickson-Bick DL, Buja LM, McMillin JB. Fatty acid-induced apoptosis in neonatal cardiomyocytes: redox signaling. Antioxid Redox Signal. 2001 Feb; 3(1):71-9. PMID: 11291600.
      View in: PubMed
    35. Sparagna GC, Hickson-Bick DL, Buja LM, McMillin JB. A metabolic role for mitochondria in palmitate-induced cardiac myocyte apoptosis. Am J Physiol Heart Circ Physiol. 2000 Nov; 279(5):H2124-32. PMID: 11045945.
      View in: PubMed
    36. Gunter TE, Buntinas L, Sparagna G, Eliseev R, Gunter K. Mitochondrial calcium transport: mechanisms and functions. Cell Calcium. 2000 Nov-Dec; 28(5-6):285-96. PMID: 11115368.
      View in: PubMed
    37. Sparagna GC, Hickson-Bick DL. Cardiac fatty acid metabolism and the induction of apoptosis. Am J Med Sci. 1999 Jul; 318(1):15-21. PMID: 10408756.
      View in: PubMed
    38. Gunter TE, Buntinas L, Sparagna GC, Gunter KK. The Ca2+ transport mechanisms of mitochondria and Ca2+ uptake from physiological-type Ca2+ transients. Biochim Biophys Acta. 1998 Aug 10; 1366(1-2):5-15. PMID: 9714709.
      View in: PubMed
    39. Gunter TE, Buntinas L, Sparagna GC, Gunter KK. The interaction of mitochondria with pulses of calcium. Biofactors. 1998; 8(3-4):205-7. PMID: 9914820.
      View in: PubMed
    40. Sparagna GC, Gunter KK, Sheu SS, Gunter TE. Mitochondrial calcium uptake from physiological-type pulses of calcium. A description of the rapid uptake mode. J Biol Chem. 1995 Nov 17; 270(46):27510-5. PMID: 7499209.
      View in: PubMed
    41. Sparagna GC, Gunter KK, Gunter TE. A system for producing and monitoring in vitro calcium pulses similar to those observed in vivo. Anal Biochem. 1994 May 15; 219(1):96-103. PMID: 8059961.
      View in: PubMed
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