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Alkesh Jani

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-4819

    Collapse Research 
    Collapse research activities and funding
    K08DK069512     (JANI, ALKESH HARIHAR)Sep 15, 2006 - Aug 31, 2012
    NIH/NIDDK
    The Role of Caspases in Warm and Cold Ischemia
    Role: Principal Investigator

    R03DK096151     (JANI, ALKESH HARIHAR)Jul 1, 2012 - Jun 30, 2014
    NIH/NIDDK
    The role of XIAP during cold ischemia and kidney transplantation.
    Role: Principal Investigator

    I01BX002798     (JANI, ALKESH HARIHAR)Apr 1, 2016 - Mar 31, 2020
    VA
    The Pathophysiology of Delayed Graft Function
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Jain S, Keys D, Martin S, Edelstein CL, Jani A. Protection From Apoptotic Cell Death During Cold Storage Followed by Rewarming in 13-Lined Ground Squirrel Tubular Cells: The Role of Prosurvival Factors X-Linked Inhibitor of Apoptosis and PhosphoAkt. Transplantation. 2016 Mar; 100(3):538-45. PMID: 26457601; PMCID: PMC4764458 [Available on 03/01/17].
    2. Ravichandran K, Wang Q, Ozkok A, Jani A, Li H, He Z, Ljubanovic D, Weiser-Evans MC, Nemenoff RA, Edelstein CL. CD4 T cell knockout does not protect against kidney injury and worsens cancer. J Mol Med (Berl). 2016 Apr; 94(4):443-55. PMID: 26620676.
      View in: PubMed
    3. Jain S, Keys D, Ljubanovic D, Edelstein CL, Jani A. Protection Against Cold Storage-Induced Renal Tubular Cell Apoptosis. Transplantation. 2015 Nov; 99(11):2311-6. PMID: 26177086; PMCID: PMC4618769 [Available on 11/01/16].
    4. Plenter R, Jain S, Ruller CM, Nydam TL, Jani AH. Murine Kidney Transplant Technique. J Vis Exp. 2015 Oct 20; (105):e52848. PMID: 26555373.
      View in: PubMed
    5. Plenter RJ, Jain S, Nydam TL, Jani AH. Revised Arterial Anastomosis for Improving Murine Kidney Transplant Outcomes. J Invest Surg. 2015; 28(4):208-14. PMID: 26087146.
      View in: PubMed
    6. Lanaspa MA, Epperson LE, Li N, Cicerchi C, Garcia GE, Roncal-Jimenez CA, Trostel J, Jain S, Mant CT, Rivard CJ, Ishimoto T, Shimada M, Sanchez-Lozada LG, Nakagawa T, Jani A, Stenvinkel P, Martin SL, Johnson RJ. Opposing activity changes in AMP deaminase and AMP-activated protein kinase in the hibernating ground squirrel. PLoS One. 2015; 10(4):e0123509. PMID: 25856396; PMCID: PMC4391924.
    7. Jain S, Keys D, Nydam T, Plenter RJ, Edelstein CL, Jani A. Inhibition of autophagy increases apoptosis during re-warming after cold storage in renal tubular epithelial cells. Transpl Int. 2015 Feb; 28(2):214-23. PMID: 25270002.
      View in: PubMed
    8. Kim HJ, Ravichandran K, Ozkok A, Wang Q, He Z, Jani A, Ljubanovic D, Douglas IS, Edelstein CL. The water-soluble triptolide derivative PG490-88 protects against cisplatin-induced acute kidney injury. J Pharmacol Exp Ther. 2014 Jun; 349(3):518-25. PMID: 24727856.
      View in: PubMed
    9. Jani A, Martin SL, Jain S, Keys D, Edelstein CL. Renal adaptation during hibernation. Am J Physiol Renal Physiol. 2013 Dec 01; 305(11):F1521-32. PMID: 24049148; PMCID: PMC4073900.
    10. Kim HJ, Lee DW, Ravichandran K, O Keys D, Akcay A, Nguyen Q, He Z, Jani A, Ljubanovic D, Edelstein CL. NLRP3 inflammasome knockout mice are protected against ischemic but not cisplatin-induced acute kidney injury. J Pharmacol Exp Ther. 2013 Sep; 346(3):465-72. PMID: 23833276; PMCID: PMC3876780.
    11. Johnson RJ, Stenvinkel P, Martin SL, Jani A, Sánchez-Lozada LG, Hill JO, Lanaspa MA. Redefining metabolic syndrome as a fat storage condition based on studies of comparative physiology. Obesity (Silver Spring). 2013 Apr; 21(4):659-64. PMID: 23401356; PMCID: PMC3660463.
    12. Sirota JC, Walcher A, Faubel S, Jani A, McFann K, Devarajan P, Davis CL, Edelstein CL. Urine IL-18, NGAL, IL-8 and serum IL-8 are biomarkers of acute kidney injury following liver transplantation. BMC Nephrol. 2013 Jan 17; 14:17. PMID: 23327592; PMCID: PMC3562144.
    13. Stenvinkel P, Jani AH, Johnson RJ. Hibernating bears (Ursidae): metabolic magicians of definite interest for the nephrologist. Kidney Int. 2013 Feb; 83(2):207-12. PMID: 23254895.
      View in: PubMed
    14. Andres-Hernando A, Dursun B, Altmann C, Ahuja N, He Z, Bhargava R, Edelstein CE, Jani A, Hoke TS, Klein C, Faubel S. Cytokine production increases and cytokine clearance decreases in mice with bilateral nephrectomy. Nephrol Dial Transplant. 2012 Dec; 27(12):4339-47. PMID: 22778179; PMCID: PMC3520082.
    15. Jani A, Orlicky DJ, Karimpour-Fard A, Epperson LE, Russell RL, Hunter LE, Martin SL. Kidney proteome changes provide evidence for a dynamic metabolism and regional redistribution of plasma proteins during torpor-arousal cycles of hibernation. Physiol Genomics. 2012 Jul 15; 44(14):717-27. PMID: 22643061; PMCID: PMC3426438.
    16. Lu L, Faubel S, He Z, Andres Hernando A, Jani A, Kedl R, Edelstein CL. Depletion of macrophages and dendritic cells in ischemic acute kidney injury. Am J Nephrol. 2012; 35(2):181-90. PMID: 22286667; PMCID: PMC3326279.
    17. Jani A, Epperson E, Martin J, Pacic A, Ljubanovic D, Martin SL, Edelstein CL. Renal protection from prolonged cold ischemia and warm reperfusion in hibernating squirrels. Transplantation. 2011 Dec 15; 92(11):1215-21. PMID: 22082817.
      View in: PubMed
    18. Akcay A, Nguyen Q, He Z, Turkmen K, Won Lee D, Hernando AA, Altmann C, Toker A, Pacic A, Ljubanovic DG, Jani A, Faubel S, Edelstein CL. IL-33 exacerbates acute kidney injury. J Am Soc Nephrol. 2011 Nov; 22(11):2057-67. PMID: 21949094; PMCID: PMC3279998.
    19. Turkmen K, Martin J, Akcay A, Nguyen Q, Ravichandran K, Faubel S, Pacic A, Ljubanovic D, Edelstein CL, Jani A. Apoptosis and autophagy in cold preservation ischemia. Transplantation. 2011 Jun 15; 91(11):1192-7. PMID: 21577181.
      View in: PubMed
    20. Jani A, Zimmerman M, Martin J, Lu L, Turkmen K, Ravichandran K, Pacic A, Ljubanovic D, Edelstein CL. Perfusion storage reduces apoptosis in a porcine kidney model of donation after cardiac death. Transplantation. 2011 Jan 27; 91(2):169-75. PMID: 21200363.
      View in: PubMed
    21. Belibi F, Zafar I, Ravichandran K, Segvic AB, Jani A, Ljubanovic DG, Edelstein CL. Hypoxia-inducible factor-1a (HIF-1a) and autophagy in polycystic kidney disease (PKD). Am J Physiol Renal Physiol. 2011 May; 300(5):F1235-43. PMID: 21270095; PMCID: PMC3094047.
    22. He Z, Lu L, Altmann C, Hoke TS, Ljubanovic D, Jani A, Dinarello CA, Faubel S, Edelstein CL. Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury. Am J Physiol Renal Physiol. 2008 Nov; 295(5):F1414-21. PMID: 18753296; PMCID: PMC2584896.
    23. Yarlagadda SG, Klein CL, Jani A. Long-term renal outcomes after delayed graft function. Adv Chronic Kidney Dis. 2008 Jul; 15(3):248-56. PMID: 18565476.
      View in: PubMed
    24. Amura CR, Brodsky KS, Gitomer B, McFann K, Lazennec G, Nichols MT, Jani A, Schrier RW, Doctor RB. CXCR2 agonists in ADPKD liver cyst fluids promote cell proliferation. Am J Physiol Cell Physiol. 2008 Mar; 294(3):C786-96. PMID: 18199703; PMCID: PMC2956747.
    25. Jani A, Wang W, Faubel S, Falk S, Ljubanovic D, Dursun B, Edelstein CL. Ischemic acute renal failure following nephrectomy impairs long-term renal function. Transplantation. 2006 Mar 15; 81(5):800-3. PMID: 16534486.
      View in: PubMed
    26. Gibney EM, Parikh CR, Jani A, Fischer MJ, Collier D, Wiseman AC. Kidney transplantation for systemic sclerosis improves survival and may modulate disease activity. Am J Transplant. 2004 Dec; 4(12):2027-31. PMID: 15575905.
      View in: PubMed
    27. Jani A, Ljubanovic D, Faubel S, Kim J, Mischak R, Edelstein CL. Caspase inhibition prevents the increase in caspase-3, -2, -8 and -9 activity and apoptosis in the cold ischemic mouse kidney. Am J Transplant. 2004 Aug; 4(8):1246-54. PMID: 15268725.
      View in: PubMed
    28. Parikh CR, Jani A, Melnikov VY, Faubel S, Edelstein CL. Urinary interleukin-18 is a marker of human acute tubular necrosis. Am J Kidney Dis. 2004 Mar; 43(3):405-14. PMID: 14981598.
      View in: PubMed
    29. Wiseman AC, Kam I, Christians U, Jani A, Bak T, Wachs M, Chan L. Fixed-dose sirolimus with reduced dose calcineurin inhibitor: the University of Colorado experience. Transplant Proc. 2003 May; 35(3 Suppl):122S-124S. PMID: 12742482.
      View in: PubMed
    30. Jani A, Polhemus C, Corrigan G, Kwon O, Myers BD, Pavlakis M. Determinants of hypofiltration during acute renal allograft rejection. J Am Soc Nephrol. 2002 Mar; 13(3):773-8. PMID: 11856784.
      View in: PubMed
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