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Sandra L Martin

InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Cell and Devopmental Bio

    Collapse Research 
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    R29GM040367     (MARTIN, SANDRA L)Jul 1, 1988 - Jun 30, 1994
    Role: Principal Investigator

    R01GM040367     (MARTIN, SANDRA L)Jul 1, 1988 - Jun 30, 2012
    Genetics and Biochemistry of a Murine Retroposon
    Role: Principal Investigator

    R29MH056540     (MARTIN, SANDRA L.)Feb 1, 1997 - Jan 31, 2003
    Role: Principal Investigator

    R01HL089049     (MARTIN, SANDRA L)Mar 15, 2008 - Feb 28, 2014
    Biomarkers for the two phase switches of mammalian hibernation
    Role: Principal Investigator

    R13HG005181     (MARTIN, SANDRA L)Jul 2, 2009 - Jun 30, 2010
    Mobile Elements in Mammalian Genomes
    Role: Principal Investigator

    R21DK095180     (MARTIN, SANDRA L)Apr 1, 2012 - Mar 31, 2014
    Brown fat dynamics: elucidation of molecular drivers using hibernation as a model
    Role: Principal Investigator

    R21NS088315     (MARTIN, SANDRA L)Apr 1, 2015 - Mar 31, 2017
    Examining the hibernating brain for temperature-sensitive RNA editing
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Riemondy KA, Gillen AE, White EA, Bogren LK, Hesselberth JR, Martin SL. Dynamic temperature-sensitive A-to-I RNA editing in the brain of a heterothermic mammal during hibernation. RNA. 2018 11; 24(11):1481-1495. PMID: 30065024.
      View in: PubMed
    2. Martin SL. On the move. Elife. 2018 Feb 21; 7. PMID: 29465398.
      View in: PubMed
    3. Bogren LK, Grabek KR, Barsh GS, Martin SL. Comparative tissue transcriptomics highlights dynamic differences among tissues but conserved metabolic transcript prioritization in preparation for arousal from torpor. J Comp Physiol B. 2017 Jul; 187(5-6):735-748. PMID: 28332019.
      View in: PubMed
    4. D'Alessandro A, Nemkov T, Bogren LK, Martin SL, Hansen KC. Comfortably Numb and Back: Plasma Metabolomics Reveals Biochemical Adaptations in the Hibernating 13-Lined Ground Squirrel. J Proteome Res. 2017 02 03; 16(2):958-969. PMID: 27991798.
      View in: PubMed
    5. Jain S, Keys D, Martin S, Edelstein CL, Jani A. Protection From Apoptotic Cell Death During Cold Storage Followed by Rewarming in 13-Lined Ground Squirrel Tubular Cells: The Role of Prosurvival Factors X-Linked Inhibitor of Apoptosis and PhosphoAkt. Transplantation. 2016 Mar; 100(3):538-45. PMID: 26457601; PMCID: PMC4764458 [Available on 03/01/17].
    6. van Breukelen F, Martin SL. The Hibernation Continuum: Physiological and Molecular Aspects of Metabolic Plasticity in Mammals. Physiology (Bethesda). 2015 Jul; 30(4):273-81. PMID: 26136541.
      View in: PubMed
    7. Grabek KR, Martin SL, Hindle AG. Proteomics approaches shed new light on hibernation physiology. J Comp Physiol B. 2015 Aug; 185(6):607-27. PMID: 25976608.
      View in: PubMed
    8. Lanaspa MA, Epperson LE, Li N, Cicerchi C, Garcia GE, Roncal-Jimenez CA, Trostel J, Jain S, Mant CT, Rivard CJ, Ishimoto T, Shimada M, Sanchez-Lozada LG, Nakagawa T, Jani A, Stenvinkel P, Martin SL, Johnson RJ. Opposing activity changes in AMP deaminase and AMP-activated protein kinase in the hibernating ground squirrel. PLoS One. 2015; 10(4):e0123509. PMID: 25856396; PMCID: PMC4391924.
    9. Grabek KR, Diniz Behn C, Barsh GS, Hesselberth JR, Martin SL. Enhanced stability and polyadenylation of select mRNAs support rapid thermogenesis in the brown fat of a hibernator. Elife. 2015 Jan 27; 4. PMID: 25626169; PMCID: PMC4383249.
    10. Hindle AG, Otis JP, Epperson LE, Hornberger TA, Goodman CA, Carey HV, Martin SL. Prioritization of skeletal muscle growth for emergence from hibernation. J Exp Biol. 2015 Jan 15; 218(Pt 2):276-84. PMID: 25452506; PMCID: PMC4302166.
    11. Martin SL. Intrinsic circannual rhythm controls protein dynamics in a hibernator to support rapid heat production. Temperature (Austin). 2014 Jul-Sep; 1(2):80-1. PMID: 27581746; PMCID: PMC4977172.
    12. Martin SL, Yoder AD. Theme and variations: heterothermy in mammals. Integr Comp Biol. 2014 Sep; 54(3):439-42. PMID: 24948136.
      View in: PubMed
    13. Malki S, van der Heijden GW, O'Donnell KA, Martin SL, Bortvin A. A role for retrotransposon LINE-1 in fetal oocyte attrition in mice. Dev Cell. 2014 Jun 09; 29(5):521-533. PMID: 24882376; PMCID: PMC4056315.
    14. Hindle AG, Grabek KR, Epperson LE, Karimpour-Fard A, Martin SL. Metabolic changes associated with the long winter fast dominate the liver proteome in 13-lined ground squirrels. Physiol Genomics. 2014 May 15; 46(10):348-61. PMID: 24642758; PMCID: PMC4042184.
    15. Hindle AG, Martin SL. Intrinsic circannual regulation of brown adipose tissue form and function in tune with hibernation. Am J Physiol Endocrinol Metab. 2014 Feb; 306(3):E284-99. PMID: 24326419; PMCID: PMC3920013.
    16. Jani A, Martin SL, Jain S, Keys D, Edelstein CL. Renal adaptation during hibernation. Am J Physiol Renal Physiol. 2013 Dec 01; 305(11):F1521-32. PMID: 24049148; PMCID: PMC4073900.
    17. Hindle AG, Martin SL. Cytoskeletal regulation dominates temperature-sensitive proteomic changes of hibernation in forebrain of 13-lined ground squirrels. PLoS One. 2013; 8(8):e71627. PMID: 23951209; PMCID: PMC3739743.
    18. Johnson RJ, Stenvinkel P, Martin SL, Jani A, Sánchez-Lozada LG, Hill JO, Lanaspa MA. Redefining metabolic syndrome as a fat storage condition based on studies of comparative physiology. Obesity (Silver Spring). 2013 Apr; 21(4):659-64. PMID: 23401356.
      View in: PubMed
    19. Xie Y, Mates L, Ivics Z, Izsvák Z, Martin SL, An W. Cell division promotes efficient retrotransposition in a stable L1 reporter cell line. Mob DNA. 2013 Mar 06; 4(1):10. PMID: 23497436; PMCID: PMC3607998.
    20. Peddigari S, Li PW, Rabe JL, Martin SL. hnRNPL and nucleolin bind LINE-1 RNA and function as host factors to modulate retrotransposition. Nucleic Acids Res. 2013 Jan 07; 41(1):575-85. PMID: 23161687; PMCID: PMC3592465.
    21. Jani A, Orlicky DJ, Karimpour-Fard A, Epperson LE, Russell RL, Hunter LE, Martin SL. Kidney proteome changes provide evidence for a dynamic metabolism and regional redistribution of plasma proteins during torpor-arousal cycles of hibernation. Physiol Genomics. 2012 Jul 15; 44(14):717-27. PMID: 22643061; PMCID: PMC3426438.
    22. Carey HV, Martin SL, Horwitz BA, Yan L, Bailey SM, Podrabsky J, Storz JF, Ortiz RM, Wong RP, Lathrop DA. Elucidating nature's solutions to heart, lung, and blood diseases and sleep disorders. Circ Res. 2012 Mar 30; 110(7):915-21. PMID: 22461362.
      View in: PubMed
    23. Jani A, Epperson E, Martin J, Pacic A, Ljubanovic D, Martin SL, Edelstein CL. Renal protection from prolonged cold ischemia and warm reperfusion in hibernating squirrels. Transplantation. 2011 Dec 15; 92(11):1215-21. PMID: 22082817.
      View in: PubMed
    24. Grabek KR, Karimpour-Fard A, Epperson LE, Hindle A, Hunter LE, Martin SL. Multistate proteomics analysis reveals novel strategies used by a hibernator to precondition the heart and conserve ATP for winter heterothermy. Physiol Genomics. 2011 Nov 21; 43(22):1263-75. PMID: 21914784; PMCID: PMC3217319.
    25. Hindle AG, Karimpour-Fard A, Epperson LE, Hunter LE, Martin SL. Skeletal muscle proteomics: carbohydrate metabolism oscillates with seasonal and torpor-arousal physiology of hibernation. Am J Physiol Regul Integr Comp Physiol. 2011 Nov; 301(5):R1440-52. PMID: 21865542; PMCID: PMC3213940.
    26. Januszyk K, Fleissner MR, Atchabahian L, Shieh FK, Altenbach C, Martin SL, Guo F, Hubbell WL, Clubb RT. Site-directed spin labeling electron paramagnetic resonance study of the ORF1 protein from a mouse L1 retrotransposon. Protein Sci. 2011 Jul; 20(7):1231-43. PMID: 21563223; PMCID: PMC3149196.
    27. Epperson LE, Karimpour-Fard A, Hunter LE, Martin SL. Metabolic cycles in a circannual hibernator. Physiol Genomics. 2011 Jul 14; 43(13):799-807. PMID: 21540299; PMCID: PMC3132838.
    28. Evans JD, Peddigari S, Chaurasiya KR, Williams MC, Martin SL. Paired mutations abolish and restore the balanced annealing and melting activities of ORF1p that are required for LINE-1 retrotransposition. Nucleic Acids Res. 2011 Jul; 39(13):5611-21. PMID: 21441536; PMCID: PMC3141268.
    29. Rose JC, Epperson LE, Carey HV, Martin SL. Seasonal liver protein differences in a hibernator revealed by quantitative proteomics using whole animal isotopic labeling. Comp Biochem Physiol Part D Genomics Proteomics. 2011 Jun; 6(2):163-70. PMID: 21481655; PMCID: PMC3183095.
    30. Martin SL. Nucleic acid chaperone properties of ORF1p from the non-LTR retrotransposon, LINE-1. RNA Biol. 2010 Nov-Dec; 7(6):706-11. PMID: 21045547; PMCID: PMC3073329.
    31. Russell RL, O'Neill PH, Epperson LE, Martin SL. Extensive use of torpor in 13-lined ground squirrels in the fall prior to cold exposure. J Comp Physiol B. 2010 Nov; 180(8):1165-72. PMID: 20556614; PMCID: PMC3116921.
    32. Epperson LE, Rose JC, Russell RL, Nikrad MP, Carey HV, Martin SL. Seasonal protein changes support rapid energy production in hibernator brainstem. J Comp Physiol B. 2010 Apr; 180(4):599-617. PMID: 19967378; PMCID: PMC3116658.
    33. Shoji M, Tanaka T, Hosokawa M, Reuter M, Stark A, Kato Y, Kondoh G, Okawa K, Chujo T, Suzuki T, Hata K, Martin SL, Noce T, Kuramochi-Miyagawa S, Nakano T, Sasaki H, Pillai RS, Nakatsuji N, Chuma S. The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev Cell. 2009 Dec; 17(6):775-87. PMID: 20059948.
      View in: PubMed
    34. Epperson LE, Rose JC, Carey HV, Martin SL. Seasonal proteomic changes reveal molecular adaptations to preserve and replenish liver proteins during ground squirrel hibernation. Am J Physiol Regul Integr Comp Physiol. 2010 Feb; 298(2):R329-40. PMID: 19923364; PMCID: PMC2828287.
    35. Nelson CJ, Otis JP, Martin SL, Carey HV. Analysis of the hibernation cycle using LC-MS-based metabolomics in ground squirrel liver. Physiol Genomics. 2009 Mar 03; 37(1):43-51. PMID: 19106184.
      View in: PubMed
    36. Martin SL, Bushman D, Wang F, Li PW, Walker A, Cummiskey J, Branciforte D, Williams MC. A single amino acid substitution in ORF1 dramatically decreases L1 retrotransposition and provides insight into nucleic acid chaperone activity. Nucleic Acids Res. 2008 Oct; 36(18):5845-54. PMID: 18790804; PMCID: PMC2566875.
    37. Soper SF, van der Heijden GW, Hardiman TC, Goodheart M, Martin SL, de Boer P, Bortvin A. Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis. Dev Cell. 2008 Aug; 15(2):285-97. PMID: 18694567; PMCID: PMC2546488.
    38. Martin SL. Mammalian hibernation: a naturally reversible model for insulin resistance in man? Diab Vasc Dis Res. 2008 Jun; 5(2):76-81. PMID: 18537093.
      View in: PubMed
    39. Martin SL, Epperson LE, Rose JC, Kurtz CC, Ané C, Carey HV. Proteomic analysis of the winter-protected phenotype of hibernating ground squirrel intestine. Am J Physiol Regul Integr Comp Physiol. 2008 Jul; 295(1):R316-28. PMID: 18434441.
      View in: PubMed
    40. Januszyk K, Li PW, Villareal V, Branciforte D, Wu H, Xie Y, Feigon J, Loo JA, Martin SL, Clubb RT. Identification and solution structure of a highly conserved C-terminal domain within ORF1p required for retrotransposition of long interspersed nuclear element-1. J Biol Chem. 2007 Aug 24; 282(34):24893-904. PMID: 17569664.
      View in: PubMed
    41. Serkova NJ, Rose JC, Epperson LE, Carey HV, Martin SL. Quantitative analysis of liver metabolites in three stages of the circannual hibernation cycle in 13-lined ground squirrels by NMR. Physiol Genomics. 2007 Sep 19; 31(1):15-24. PMID: 17536023.
      View in: PubMed
    42. Li PW, Li J, Timmerman SL, Krushel LA, Martin SL. The dicistronic RNA from the mouse LINE-1 retrotransposon contains an internal ribosome entry site upstream of each ORF: implications for retrotransposition. Nucleic Acids Res. 2006; 34(3):853-64. PMID: 16464823; PMCID: PMC1361618.
    43. Basame S, Wai-lun Li P, Howard G, Branciforte D, Keller D, Martin SL. Spatial assembly and RNA binding stoichiometry of a LINE-1 protein essential for retrotransposition. J Mol Biol. 2006 Mar 24; 357(2):351-7. PMID: 16434051.
      View in: PubMed
    44. Martin SL. The ORF1 protein encoded by LINE-1: structure and function during L1 retrotransposition. J Biomed Biotechnol. 2006; 2006(1):45621. PMID: 16877816; PMCID: PMC1510943.
    45. Heras SR, López MC, García-Pérez JL, Martin SL, Thomas MC. The L1Tc C-terminal domain from Trypanosoma cruzi non-long terminal repeat retrotransposon codes for a protein that bears two C2H2 zinc finger motifs and is endowed with nucleic acid chaperone activity. Mol Cell Biol. 2005 Nov; 25(21):9209-20. PMID: 16227574; PMCID: PMC1265797.
    46. Williams DR, Epperson LE, Li W, Hughes MA, Taylor R, Rogers J, Martin SL, Cossins AR, Gracey AY. Seasonally hibernating phenotype assessed through transcript screening. Physiol Genomics. 2005 Dec 14; 24(1):13-22. PMID: 16249311.
      View in: PubMed
    47. Martin SL, Cruceanu M, Branciforte D, Wai-Lun Li P, Kwok SC, Hodges RS, Williams MC. LINE-1 retrotransposition requires the nucleic acid chaperone activity of the ORF1 protein. J Mol Biol. 2005 May 06; 348(3):549-61. PMID: 15826653.
      View in: PubMed
    48. Goldstein KM, Martin SL. Intimate partner physical assault before and during pregnancy: how does it relate to women's psychological vulnerability? Violence Vict. 2004 Aug; 19(4):387-98. PMID: 15726934.
      View in: PubMed
    49. Epperson LE, Dahl TA, Martin SL. Quantitative analysis of liver protein expression during hibernation in the golden-mantled ground squirrel. Mol Cell Proteomics. 2004 Sep; 3(9):920-33. PMID: 15266006.
      View in: PubMed
    50. van Breukelen F, Sonenberg N, Martin SL. Seasonal and state-dependent changes of eIF4E and 4E-BP1 during mammalian hibernation: implications for the control of translation during torpor. Am J Physiol Regul Integr Comp Physiol. 2004 Aug; 287(2):R349-53. PMID: 15059792.
      View in: PubMed
    51. Martin SL, Branciforte D, Keller D, Bain DL. Trimeric structure for an essential protein in L1 retrotransposition. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):13815-20. PMID: 14615577; PMCID: PMC283504.
    52. Carey HV, Andrews MT, Martin SL. Mammalian hibernation: cellular and molecular responses to depressed metabolism and low temperature. Physiol Rev. 2003 Oct; 83(4):1153-81. PMID: 14506303.
      View in: PubMed
    53. Martin SL, Garfinkel DJ. Survival strategies for transposons and genomes. Genome Biol. 2003; 4(4):313. PMID: 12702203; PMCID: PMC154573.
    54. Kolosha VO, Martin SL. High-affinity, non-sequence-specific RNA binding by the open reading frame 1 (ORF1) protein from long interspersed nuclear element 1 (LINE-1). J Biol Chem. 2003 Mar 07; 278(10):8112-7. PMID: 12506113.
      View in: PubMed
    55. Epperson LE, Martin SL. Quantitative assessment of ground squirrel mRNA levels in multiple stages of hibernation. Physiol Genomics. 2002 Aug 14; 10(2):93-102. PMID: 12181366.
      View in: PubMed
    56. Van Breukelen F, Martin SL. Invited review: molecular adaptations in mammalian hibernators: unique adaptations or generalized responses? J Appl Physiol (1985). 2002 Jun; 92(6):2640-7. PMID: 12015384.
      View in: PubMed
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