Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Luisa Mestroni

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-0577
ORCID ORCID Icon0000-0003-1116-2286 Additional info

    Collapse Overview 
    Collapse overview
    We are interested in the genetic basis, pathogenic mechanisms and phenotype correlations of cardiomyopathies, in particular arrhythmogenic forms (ACM, ARVC, LVNC). Our Familial Cardiomyopathy Registry biobank includes >2000 subjects. Our tools include clinical genetics, bioinformatics, outcome studies, induced pluripotent stem cell models, -omics, cell biomechanics and tissue engineering. I serve as a cardiology mentor.

    Collapse Research 
    Collapse research activities and funding
    R01HL164634     (MESTRONI, LUISA)Apr 5, 2023 - Feb 29, 2028
    NIH
    Elucidating the Origin of Sudden Cardiac Death in Dilated Cardiomyopathy: from Phenotype Predictors to Therapeutic Targets
    Role: Principal Investigator
    R01HL147064     (MESTRONI, LUISA)Jan 1, 2020 - Dec 31, 2024
    NIH
    Cardiomyocyte phenotype and mechanotransduction in Filamin C gene variants causing arrhythmogenic cardiomyopathy
    Role: Principal Investigator
    R01HL116906     (TOWBIN, JEFFREY ALLEN)Aug 23, 2013 - Jun 30, 2019
    NIH
    Genetics, Mechanisms and Clinical Phenotypes of Arrhythmogenic Cardiomyopathy
    Role: Co-Principal Investigator
    R01HL069071     (MESTRONI, LUISA)Jan 1, 2002 - Dec 31, 2005
    NIH
    Molecular Epidemiology of Dilated Cardiomyopath
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Cannie DE, Syrris P, Protonotarios A, Bakalakos A, Pruny JF, Ditaranto R, Martinez-Veira C, Larra?aga-Moreira JM, Medo K, Berm?dez-Jim?nez FJ, Ben Yaou R, Leturcq F, Mezcua AR, Marini-Bettolo C, Cabrera E, Reuter C, Limeres Freire J, Rodr?guez-Palomares JF, Mestroni L, Taylor MRG, Parikh VN, Ashley EA, Barriales-Villa R, Jim?nez-J?imez J, Garcia-Pavia P, Charron P, Biagini E, Garc?a Pinilla JM, Bourke J, Savvatis K, Wahbi K, Elliott PM. Emery-Dreifuss muscular dystrophy Type 1 is associated with a high risk of malignant ventricular arrhythmias and end-stage heart failure. Eur Heart J. 2023 Dec 21; 44(48):5064-5073. PMID: 37639473.
      View in: PubMed
    2. Namasivayam M, Bertrand PB, Bernard S, Churchill TW, Khurshid S, Marcus FI, Mestroni L, Saffitz JE, Towbin JA, Zareba W, Picard MH, Sanborn DY. Utility of Left and Right Ventricular Strain in Arrhythmogenic Right Ventricular Cardiomyopathy: A Prospective Multicenter Registry. Circ Cardiovasc Imaging. 2023 12; 16(12):e015671. PMID: 38113321.
      View in: PubMed
    3. Tu C, Caudal A, Liu Y, Gorgodze N, Zhang H, Lam CK, Dai Y, Zhang A, Wnorowski A, Wu MA, Yang H, Abilez OJ, Lyu X, Narayan SM, Mestroni L, Taylor MRG, Recchia FA, Wu JC. Tachycardia-induced metabolic rewiring as a driver of contractile dysfunction. Nat Biomed Eng. 2024 Apr; 8(4):479-494. PMID: 38012305.
      View in: PubMed
    4. Vissing CR, Axelsson Raja A, Day SM, Russell MW, Zahka K, Lever HM, Pereira AC, Colan SD, Margossian R, Murphy AM, Canter C, Bach RG, Wheeler MT, Rossano JW, Owens AT, Benson L, Mestroni L, Taylor MRG, Patel AR, Wilmot I, Thrush P, Soslow JH, Becker JR, Seidman CE, Lakdawala NK, Cirino AL, McMurray JJV, MacRae CA, Solomon SD, Bundgaard H, Orav EJ, Ho CY. Cardiac Remodeling in Subclinical Hypertrophic Cardiomyopathy: The VANISH Randomized Clinical Trial. JAMA Cardiol. 2023 11 01; 8(11):1083-1088. PMID: 37672268.
      View in: PubMed
    5. Slaven S, Raymer DS, Mestroni L. The electrocardiographic signature of variant transthyretin amyloidosis. Int J Cardiol. 2024 Mar 01; 398:131442. PMID: 37852541.
      View in: PubMed
    6. Liu D, Wang M, Murthy V, McNamara DM, Nguyen TTL, Philips TJ, Vyas H, Gao H, Sahni J, Starling RC, Cooper LT, Skime MK, Batzler A, Jenkins GD, Barlera S, Pileggi S, Mestroni L, Merlo M, Sinagra G, Pinet F, Krejc? J, Chaloupka A, Miller JD, de Groote P, Tschumperlin DJ, Weinshilboum RM, Pereira NL. Myocardial Recovery in Recent Onset Dilated Cardiomyopathy: Role of CDCP1 and Cardiac Fibrosis. Circ Res. 2023 10 27; 133(10):810-825. PMID: 37800334.
      View in: PubMed
    7. Eldemire R, Mestroni L, Taylor MRG. Genetics of Dilated Cardiomyopathy. Annu Rev Med. 2024 Jan 29; 75:417-426. PMID: 37788487.
      View in: PubMed
    8. Bueno-Beti C, Tafuni A, Chelko SP, Sheppard MN, Field E, Tollit J, Heenan IK, Barnes A, Taylor MR, Mestroni L, Kaski JP, Saffitz JE, Asimaki A. Innate immune signaling in hearts and buccal mucosa cells of patients with arrhythmogenic cardiomyopathy. Heart Rhythm O2. 2023 Oct; 4(10):650-659. PMID: 37936669.
      View in: PubMed
    9. Cannie DE, Protonotarios A, Bakalakos A, Syrris P, Lorenzini M, De Stavola B, Bjerregaard L, Dybro AM, Hey TM, Hansen FG, Navarro Pe?alver M, Crespo-Leiro MG, Larra?aga-Moreira JM, de Frutos F, Johnson R, Slater TA, Monserrat L, Sengupta A, Mestroni L, Taylor MRG, Sinagra G, Bilinska Z, Solla-Ruiz I, Arana Achaga X, Barriales-Villa R, Garcia-Pavia P, Gimeno JR, Dal Ferro M, Merlo M, Wahbi K, Fatkin D, Mogensen J, Rasmussen TB, Elliott PM. Risks of Ventricular Arrhythmia and Heart Failure in Carriers of RBM20 Variants. Circ Genom Precis Med. 2023 10; 16(5):434-441. PMID: 37593875.
      View in: PubMed
    10. Bueto-Beni C, Tafuni A, Chelko SP, Sheppard MN, Field E, Tollit J, Heenan IK, Barnes A, Taylor MR, Mestroni L, Kaski JP, Saffitz JE, Asimaki A. Innate Immune Signaling in Hearts and Buccal Mucosa Cells of Patients with Arrhythmogenic Cardiomyopathy. bioRxiv. 2023 Jul 27. PMID: 37649905.
      View in: PubMed
    11. Nagyova E, Hoorntje ET, Te Rijdt WP, Bosman LP, Syrris P, Protonotarios A, Elliott PM, Tsatsopoulou A, Mestroni L, Taylor MRG, Sinagra G, Merlo M, Wada Y, Horie M, Mogensen J, Christensen AH, Gerull B, Song L, Yao Y, Fan S, Saguner AM, Duru F, Koskenvuo JW, Cruz Marino T, Tichnell C, Judge DP, Dooijes D, Lekanne Deprez RH, Basso C, Pilichou K, Bauce B, Wilde AAM, Charron P, Fressart V, van der Heijden JF, van den Berg MP, Asselbergs FW, James CA, Jongbloed JDH, Harakalova M, van Tintelen JP. A Systematic Analysis of the Clinical Outcome Associated with Multiple Reclassified Desmosomal Gene Variants in Arrhythmogenic Right Ventricular Cardiomyopathy Patients. J Cardiovasc Transl Res. 2023 12; 16(6):1276-1286. PMID: 37418234.
      View in: PubMed
    12. O'Neill MJ, Chen SN, Rumping L, Johnson R, van Slegtenhorst M, Glazer AM, Yang T, Solus JF, Laudeman J, Mitchell DW, Vanags LR, Kroncke BM, Anderson K, Gao S, Verdonschot JAJ, Brunner H, Hellebrekers D, Taylor MRG, Roden DM, Wessels MW, Lekanne Dit Deprez RH, Fatkin D, Mestroni L, Shoemaker MB. Multicenter clinical and functional evidence reclassifies a recurrent noncanonical filamin C splice-altering variant. Heart Rhythm. 2023 08; 20(8):1158-1166. PMID: 37164047.
      View in: PubMed
    13. Kim Y, Mastali M, Van Eyk JE, Orav EJ, Vissing CR, Day SM, Axelsson Raja A, Russell MW, Zahka K, Lever HM, Pereira AC, Murphy AM, Canter C, Bach RG, Wheeler MT, Rossano JW, Owens AT, Bundgaard H, Benson L, Mestroni L, Taylor MRG, Patel AR, Wilmot I, Thrush P, Soslow JH, Becker JR, Seidman CE, Ho CY. Transforming Growth Factor-? Analysis of the VANISH Trial Cohort. Circ Heart Fail. 2023 04; 16(4):e010314. PMID: 36999957.
      View in: PubMed
    14. MacRae CA, Taylor MR, Mestroni L, Moses J, Ashley EA, Wheeler MT, Lakdawala NK, Hershberger RE, Sandor V, Saunders ME, Oliver C, Lee PA, Judge DP. Plain Language Summary of Publication of the safety and efficacy of ARRY-371797 in people with dilated cardiomyopathy and a faulty LMNA gene. Future Cardiol. 2023 02; 19(2):55-63. PMID: 36718638.
      View in: PubMed
    15. MacRae CA, Taylor MRG, Mestroni L, Moses J, Ashley EA, Wheeler MT, Lakdawala NK, Hershberger RE, Sandor V, Saunders ME, Oliver C, Lee PA, Judge DP. Efficacy and Safety of ARRY-371797 in LMNA-Related Dilated Cardiomyopathy: A Phase 2 Study. Circ Genom Precis Med. 2023 02; 16(1):e003730. PMID: 36515663.
      View in: PubMed
    16. Pe?a B, Gao S, Borin D, Del Favero G, Abdel-Hafiz M, Farahzad N, Lorenzon P, Sinagra G, Taylor MRG, Mestroni L, Sbaizero O. Cellular Biomechanic Impairment in Cardiomyocytes Carrying the Progeria Mutation: An Atomic Force Microscopy Investigation. Langmuir. 2022 12 06; 38(48):14928-14940. PMID: 36420863.
      View in: PubMed
    17. Paldino A, Dal Ferro M, Stolfo D, Gandin I, Medo K, Graw S, Gigli M, Gagno G, Zaffalon D, Castrichini M, Mas? M, Cannat? A, Brun F, Storm G, Severini GM, Lenarduzzi S, Girotto G, Gasparini P, Bortolotti F, Giacca M, Zacchigna S, Merlo M, Taylor MRG, Mestroni L, Sinagra G. Prognostic Prediction of Genotype vs Phenotype in Genetic Cardiomyopathies. J Am Coll Cardiol. 2022 11 22; 80(21):1981-1994. PMID: 36396199.
      View in: PubMed
    18. Altman NL, Berning AA, Saxon CE, Adamek KE, Wagner JA, Slavov D, Quaife RA, Gill EA, Minobe WA, Jonas ER, Carroll IA, Huebler SP, Raines J, Messenger JC, Ambardekar AV, Mestroni L, Rosenberg RM, Rove J, Campbell TB, Bristow MR. Myocardial Injury and Altered Gene Expression Associated With SARS-CoV-2 Infection or mRNA Vaccination. JACC Basic Transl Sci. 2023 Feb; 8(2):124-137. PMID: 36281440.
      View in: PubMed
    19. Escobar-Lopez L, Ochoa JP, Royuela A, Verdonschot JAJ, Dal Ferro M, Espinosa MA, Sabater-Molina M, Gallego-Delgado M, Larra?aga-Moreira JM, Garcia-Pinilla JM, Basurte-Elorz MT, Rodr?guez-Palomares JF, Climent V, Bermudez-Jimenez FJ, Mogoll?n-Jim?nez MV, Lopez J, Pe?a-Pe?a ML, Garcia-Alvarez A, L?pez-Abel B, Ripoll-Vera T, Palomino-Doza J, Bayes-Genis A, Brugada R, Idiazabal U, Mirelis JG, Dominguez F, Henkens MTHM, Krapels IPC, Brunner HG, Paldino A, Zaffalon D, Mestroni L, Sinagra G, Heymans SRB, Merlo M, Garcia-Pavia P. Clinical Risk Score to Predict Pathogenic?Genotypes in Patients With?Dilated Cardiomyopathy. J Am Coll Cardiol. 2022 09 20; 80(12):1115-1126. PMID: 36109106.
      View in: PubMed
    20. Judge DP, Lakdawala NK, Taylor MRG, Mestroni L, Li H, Oliver C, Angeli FS, Lee PA, MacRae CA. Long-Term Efficacy and Safety of ARRY-371797 (PF-07265803) in Patients With Lamin A/C-Related Dilated Cardiomyopathy. Am J Cardiol. 2022 11 15; 183:93-98. PMID: 36114020.
      View in: PubMed
    21. Alegret N, Dominguez-Alfaro A, Mecerreyes D, Prato M, Mestroni L, Pe?a B. Neonatal rat ventricular myocytes interfacing conductive polymers and carbon nanotubes. Cell Biol Toxicol. 2023 08; 39(4):1627-1639. PMID: 36029423.
      View in: PubMed
    22. Castrichini M, Porcari A, Baggio C, Gagno G, Maione D, Barbati G, Medo K, Mestroni L, Merlo M, Sinagra G. Sex differences in natural history of cardiovascular magnetic resonance- and biopsy-proven lymphocytic myocarditis. ESC Heart Fail. 2022 12; 9(6):4010-4019. PMID: 36000547.
      View in: PubMed
    23. Gao S, Taylor MRG, Mestroni L. Hidden Risk: Arrhythmogenic Genes in the General Population. Circ Genom Precis Med. 2022 10; 15(5):e003869. PMID: 35980659.
      View in: PubMed
    24. Kuwabara JT, Hara A, Heckl JR, Pe?a B, Bhutada S, DeMaris R, Ivey MJ, DeAngelo LP, Liu X, Park J, Jahansooz JR, Mestroni L, McKinsey TA, Apte SS, Tallquist MD. Regulation of extracellular matrix composition by fibroblasts during perinatal cardiac maturation. J Mol Cell Cardiol. 2022 08; 169:84-95. PMID: 35569524.
      View in: PubMed
    25. Cannat? A, Merlo M, Dal Ferro M, Barbati G, Manca P, Paldino A, Graw S, Gigli M, Stolfo D, Johnson R, Roy D, Tharratt K, Bromage DI, Jirikowic J, Abbate A, Goodwin A, Rao K, Marawan A, Carr-White G, Robert L, Parikh V, Ashley E, McDonagh T, Lakdawala NK, Fatkin D, Taylor MRG, Mestroni L, Sinagra G. Association of Titin Variations With Late-Onset Dilated Cardiomyopathy. JAMA Cardiol. 2022 04 01; 7(4):371-377. PMID: 35138330.
      View in: PubMed
    26. Pe?a B, Adbel-Hafiz M, Cavasin M, Mestroni L, Sbaizero O. Atomic Force Microscopy (AFM) Applications in Arrhythmogenic Cardiomyopathy. Int J Mol Sci. 2022 Mar 28; 23(7). PMID: 35409059.
      View in: PubMed
    27. Sidhu K, Castrini AI, Parikh V, Reza N, Owens A, Tremblay-Gravel M, Wheeler MT, Mestroni L, Taylor M, Graw S, Gigli M, Merlo M, Paldino A, Sinagra G, Judge DP, Ramos H, Mesubi O, Brown E, Turnbull S, Kumar S, Roy D, Tedrow UB, Ngo L, Haugaa K, Lakdawala NK. The response to cardiac resynchronization therapy in LMNA cardiomyopathy. Eur J Heart Fail. 2022 04; 24(4):685-693. PMID: 35229420.
      View in: PubMed
    28. Chen SN, Lam CK, Wan YW, Gao S, Malak OA, Zhao SR, Lombardi R, Ambardekar AV, Bristow MR, Cleveland J, Gigli M, Sinagra G, Graw S, Taylor MRG, Wu JC, Mestroni L. Activation of PDGFRA signaling contributes to filamin C-related arrhythmogenic cardiomyopathy. Sci Adv. 2022 Feb 25; 8(8):eabk0052. PMID: 35196083.
      View in: PubMed
    29. Bui QM, Hong KN, Kraushaar M, Ma GS, Brambatti M, Kahn AM, Battiha CE, Boynton K, Storm G, Mestroni L, Taylor MRG, DeMaria AN, Adler EA. Myocardial Strain and Association With Clinical Outcomes in Danon Disease: A Model for Monitoring Progression of Genetic Cardiomyopathies. J Am Heart Assoc. 2021 12 07; 10(23):e022544. PMID: 34845930.
      View in: PubMed
    30. Castrichini M, Eldemire R, Groves DW, Taylor MR, Miyamoto S, Mestroni L. Clinical and genetic features of arrhythmogenic cardiomyopathy: diagnosis, management and the heart failure perspective. Prog Pediatr Cardiol. 2021 Dec; 63. PMID: 34970070.
      View in: PubMed
    31. Chadalawada S, Rassi A, Samara O, Monzon A, Gudapati D, Vargas Barahona L, Hyson P, Sillau S, Mestroni L, Taylor M, da Consola??o Vieira Moreira M, DeSanto K, Agudelo Higuita NI, Franco-Paredes C, Henao-Mart?nez AF. Mortality risk in chronic Chagas cardiomyopathy: a systematic review and meta-analysis. ESC Heart Fail. 2021 12; 8(6):5466-5481. PMID: 34716744.
      View in: PubMed
    32. Merlo M, Grilli G, Cappelletto C, Mas? M, Porcari A, Ferro MD, Gigli M, Stolfo D, Zecchin M, De Luca A, Mestroni L, Sinagra G. The Arrhythmic Phenotype in Cardiomyopathy. Heart Fail Clin. 2022 Jan; 18(1):101-113. PMID: 34776072.
      View in: PubMed
    33. Gao S, Mumme-Monheit A, Chen SN, Spector EB, Slavov D, Baralle FE, Bristow MR, Mestroni L, Taylor MRG. An LMNA synonymous variant associated with severe dilated cardiomyopathy: Case report. Am J Med Genet A. 2022 02; 188(2):600-605. PMID: 34652067.
      View in: PubMed
    34. Dries AM, Kirillova A, Reuter CM, Garcia J, Zouk H, Hawley M, Murray B, Tichnell C, Pilichou K, Protonotarios A, Medeiros-Domingo A, Kelly MA, Baras A, Ingles J, Semsarian C, Bauce B, Celeghin R, Basso C, Jongbloed JDH, Nussbaum RL, Funke B, Cerrone M, Mestroni L, Taylor MRG, Sinagra G, Merlo M, Saguner AM, Elliott PM, Syrris P, van Tintelen JP, James CA, Haggerty CM, Parikh VN. Correction to: The genetic architecture of Plakophilin 2 cardiomyopathy. Genet Med. 2021 Oct; 23(10):2014. PMID: 34408292.
      View in: PubMed
    35. Gigli M, Stolfo D, Graw SL, Merlo M, Gregorio C, Nee Chen S, Dal Ferro M, PaldinoMD A, De Angelis G, Brun F, Jirikowic J, Salcedo EE, Turja S, Fatkin D, Johnson R, van Tintelen JP, Te Riele ASJM, Wilde AAM, Lakdawala NK, Picard K, Miani D, Muser D, Maria Severini G, Calkins H, James CA, Murray B, Tichnell C, Parikh VN, Ashley EA, Reuter C, Song J, Judge DP, McKenna WJ, Taylor MRG, Sinagra G, Mestroni L. Phenotypic Expression, Natural History, and Risk Stratification of Cardiomyopathy Caused by Filamin C Truncating Variants. Circulation. 2021 11 16; 144(20):1600-1611. PMID: 34587765.
      View in: PubMed
    36. Ho CY, Day SM, Axelsson A, Russell MW, Zahka K, Lever HM, Pereira AC, Colan SD, Margossian R, Murphy AM, Canter C, Bach RG, Wheeler MT, Rossano JW, Owens AT, Bundgaard H, Benson L, Mestroni L, Taylor MRG, Patel AR, Wilmot I, Thrush P, Vargas JD, Soslow JH, Becker JR, Seidman CE, Lakdawala NK, Cirino AL, Burns KM, McMurray JJV, MacRae CA, Solomon SD, Orav EJ, Braunwald E. Valsartan in early-stage hypertrophic cardiomyopathy: a randomized phase 2 trial. Nat Med. 2021 10; 27(10):1818-1824. PMID: 34556856.
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    37. Fraley C, Milgrom SA, Kondapalli L, Taylor MRG, Mestroni L, Miyamoto SD. Mechanisms and Insights for the Development of Heart Failure Associated with Cancer Therapy. Children (Basel). 2021 Sep 21; 8(9). PMID: 34572260.
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    38. Lachaize V, Pe?a B, Ciubotaru C, Cojoc D, Chen SN, Taylor MRG, Mestroni L, Sbaizero O. Compromised Biomechanical Properties, Cell-Cell Adhesion and Nanotubes Communication in Cardiac Fibroblasts Carrying the Lamin A/C D192G Mutation. Int J Mol Sci. 2021 Aug 25; 22(17). PMID: 34502098.
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    39. Zanetti M, Chen SN, Conti M, Taylor MRG, Sbaizero O, Mestroni L, Lazzarino M. Microfabricated cantilevers for parallelized cell-cell adhesion measurements. Eur Biophys J. 2022 Mar; 51(2):147-156. PMID: 34304293.
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    40. Eldemire R, Tharp CA, Taylor MRG, Sbaizero O, Mestroni L. The Sarcomeric Spring Protein Titin: Biophysical Properties, Molecular Mechanisms, and Genetic Mutations Associated with Heart Failure and Cardiomyopathy. Curr Cardiol Rep. 2021 07 16; 23(9):121. PMID: 34269900.
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    41. Manca P, Cannat? A, Nuzzi V, Bromage DI, Varr? GG, Rossi M, Dal Ferro M, Paldino A, Gigli M, Barbati G, Ramani F, Pinamonti B, Stolfo D, Porcu M, Mestroni L, Merlo M, Sinagra G. Prevalence and Evolution of Right Ventricular Dysfunction Among Different Genetic Backgrounds in Dilated Cardiomyopathy. Can J Cardiol. 2021 11; 37(11):1743-1750. PMID: 34273475.
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    42. Dries AM, Kirillova A, Reuter CM, Garcia J, Zouk H, Hawley M, Murray B, Tichnell C, Pilichou K, Protonotarios A, Medeiros-Domingo A, Kelly MA, Baras A, Ingles J, Semsarian C, Bauce B, Celeghin R, Basso C, Jongbloed JDH, Nussbaum RL, Funke B, Cerrone M, Mestroni L, Taylor MRG, Sinagra G, Merlo M, Saguner AM, Elliott PM, Syrris P, van Tintelen JP, James CA, Haggerty CM, Parikh VN. The genetic architecture of Plakophilin 2 cardiomyopathy. Genet Med. 2021 10; 23(10):1961-1968. PMID: 34120153.
      View in: PubMed
    43. Hyson P, Barahona LV, Pedraza-Ar?valo LC, Schultz J, Mestroni L, da Consola??o Moreira M, Taylor M, Franco-Paredes C, Benamu E, Ramanan P, Rassi A, Hawkins K, Henao-Mart?nez AF. Experiences with Diagnosis and Treatment of Chagas Disease at a United States Teaching Hospital-Clinical Features of Patients with Positive Screening Serologic Testing. Trop Med Infect Dis. 2021 May 31; 6(2). PMID: 34072787.
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    44. Cappelletto C, Gregorio C, Barbati G, Romani S, De Luca A, Merlo M, Mestroni L, Stolfo D, Sinagra G. Antiarrhythmic therapy and risk of cumulative ventricular arrhythmias in arrhythmogenic right ventricle cardiomyopathy. Int J Cardiol. 2021 Jul 01; 334:58-64. PMID: 33961942.
      View in: PubMed
    45. Chen SN, Mestroni L, Taylor MRG. Genetics of dilated cardiomyopathy. Curr Opin Cardiol. 2021 05 01; 36(3):288-294. PMID: 33769382.
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    46. Travers JG, Wennersten SA, Pe?a B, Bagchi RA, Smith HE, Hirsch RA, Vanderlinden LA, Lin YH, Dobrinskikh E, Demos-Davies KM, Cavasin MA, Mestroni L, Steink?hler C, Lin CY, Houser SR, Woulfe KC, Lam MPY, McKinsey TA. HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling. Circulation. 2021 05 11; 143(19):1874-1890. PMID: 33682427.
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    47. Mueller AC, Piper M, Goodspeed A, Bhuvane S, Williams JS, Bhatia S, Phan AV, Van Court B, Zolman KL, Pe?a B, Oweida AJ, Zakem S, Meguid C, Knitz MW, Darragh L, Bickett TE, Gadwa J, Mestroni L, Taylor MRG, Jordan KR, Dempsey P, Lucia MS, McCarter MD, Del Chiaro M, Messersmith WA, Schulick RD, Goodman KA, Gough MJ, Greene CS, Costello JC, Neto AG, Lagares D, Hansen KC, Van Bokhoven A, Karam SD. Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer. Cancer Res. 2021 06 15; 81(12):3255-3269. PMID: 33526513.
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    48. Sanchez F, Weitz C, Gutierrez JM, Mestroni L, Hanneman K, Vargas D. Cardiac MR Imaging of Muscular Dystrophies. Curr Probl Diagn Radiol. 2022 Mar-Apr; 51(2):225-234. PMID: 33551194.
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    49. Merlo M, Cappelletto C, De Angelis G, Porcari A, Caiffa T, Lardieri G, Pagnan L, Severini GM, Dal Ferro M, Stolfo D, Vitrella G, De Luca A, Korkova R, Massa L, Tavc?ar I, Aleksova A, Barbati G, Zanchi C, Ramani F, Di Lenarda A, Perkan A, Mestroni L, Zecchin M, Pinamonti B, Bussani R, Sinagra G. [Diagnostic work-up and clinical management of cardiomyopathies: the operative protocol from the Cardiothoracovascular Department of Trieste, Italy]. G Ital Cardiol (Rome). 2020 Dec; 21(12):935-953. PMID: 33231213.
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    50. R Amin D, Sink E, Narayan SP, Abdel-Hafiz M, Mestroni L, Pe?a B. Nanomaterials for Cardiac Tissue Engineering. Molecules. 2020 Nov 07; 25(21). PMID: 33171802.
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    51. Eldemire R, Taylor MRG, Mestroni L. Precision medicine in laminopathies: insights from the REDLAMINA registry. Rev Esp Cardiol (Engl Ed). 2021 03; 74(3):208-209. PMID: 33162390.
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    52. Tharp C, Mestroni L, Taylor M. Modifications of Titin Contribute to the Progression of Cardiomyopathy and Represent a Therapeutic Target for Treatment of Heart Failure. J Clin Med. 2020 Aug 26; 9(9). PMID: 32859027.
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    53. Pecorari I, Mestroni L, Sbaizero O. Current Understanding of the Role of Cytoskeletal Cross-Linkers in the Onset and Development of Cardiomyopathies. Int J Mol Sci. 2020 Aug 15; 21(16). PMID: 32824180.
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    54. Del Favero G, Bonifacio A, Rowland TJ, Gao S, Song K, Sergo V, Adler ED, Mestroni L, Sbaizero O, Taylor MRG. Danon Disease-Associated LAMP-2 Deficiency Drives Metabolic Signature Indicative of Mitochondrial Aging and Fibrosis in Cardiac Tissue and hiPSC-Derived Cardiomyocytes. J Clin Med. 2020 Jul 31; 9(8). PMID: 32751926.
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    55. Bui QM, Hong KN, Kraushaar M, Ma GS, Brambatti M, Kahn AM, Bougault C, Boynton K, Mestroni L, Taylor MRG, Adler E. Apical Sparing Strain Pattern in Danon Disease: Insights From a Global Registry. JACC Cardiovasc Imaging. 2020 12; 13(12):2689-2691. PMID: 32739374.
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    56. Eldemire R, Taylor MRG, Mestroni L. Understanding the role of titin in dilated cardiomyopathy. Int J Cardiol. 2020 10 01; 316:186-187. PMID: 32634495.
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    142. Herman DS, Lam L, Taylor MR, Wang L, Teekakirikul P, Christodoulou D, Conner L, DePalma SR, McDonough B, Sparks E, Teodorescu DL, Cirino AL, Banner NR, Pennell DJ, Graw S, Merlo M, Di Lenarda A, Sinagra G, Bos JM, Ackerman MJ, Mitchell RN, Murry CE, Lakdawala NK, Ho CY, Barton PJ, Cook SA, Mestroni L, Seidman JG, Seidman CE. Truncations of titin causing dilated cardiomyopathy. N Engl J Med. 2012 Feb 16; 366(7):619-28. PMID: 22335739.
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    143. Miani D, Taylor M, Mestroni L, D'Aurizio F, Finato N, Fanin M, Brigido S, Proclemer A. Sudden death associated with danon disease in women. Am J Cardiol. 2012 Feb 01; 109(3):406-11. PMID: 22074992.
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    154. Taylor MR, Slavov D, Humphrey K, Zhao L, Cockroft J, Zhu X, Lavori P, Bristow MR, Mestroni L, Lazzeroni LC. Pharmacogenetic effect of an endothelin-1 haplotype on response to bucindolol therapy in chronic heart failure. Pharmacogenet Genomics. 2009 Jan; 19(1):35-43. PMID: 18953265.
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    155. Mestroni L, Taylor MR. Lamin A/C gene and the heart: how genetics may impact clinical care. J Am Coll Cardiol. 2008 Oct 07; 52(15):1261-2. PMID: 18926330.
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    157. Amat di San Filippo C, Taylor MR, Mestroni L, Botto LD, Longo N. Cardiomyopathy and carnitine deficiency. Mol Genet Metab. 2008 Jun; 94(2):162-6. PMID: 18337137.
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    158. Zecchin M, Di Lenarda A, Gregori D, Merlo M, Pivetta A, Vitrella G, Sabbadini G, Mestroni L, Sinagra G. Are nonsustained ventricular tachycardias predictive of major arrhythmias in patients with dilated cardiomyopathy on optimal medical treatment? Pacing Clin Electrophysiol. 2008 Mar; 31(3):290-9. PMID: 18307623.
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    159. Taylor MR, Slavov D, Ku L, Di Lenarda A, Sinagra G, Carniel E, Haubold K, Boucek MM, Ferguson D, Graw SL, Zhu X, Cavanaugh J, Sucharov CC, Long CS, Bristow MR, Lavori P, Mestroni L. Prevalence of desmin mutations in dilated cardiomyopathy. Circulation. 2007 Mar 13; 115(10):1244-51. PMID: 17325244.
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    163. Taylor MR, Slavov D, Gajewski A, Vlcek S, Ku L, Fain PR, Carniel E, Di Lenarda A, Sinagra G, Boucek MM, Cavanaugh J, Graw SL, Ruegg P, Feiger J, Zhu X, Ferguson DA, Bristow MR, Gotzmann J, Foisner R, Mestroni L. Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy. Hum Mutat. 2005 Dec; 26(6):566-74. PMID: 16247757.
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    165. Lindenfeld J, Miller GG, Shakar SF, Zolty R, Lowes BD, Wolfel EE, Mestroni L, Page RL, Kobashigawa J. Drug therapy in the heart transplant recipient: part II: immunosuppressive drugs. Circulation. 2004 Dec 21; 110(25):3858-65. PMID: 15611389.
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    221. Campello C, Dal Molin G, Gasparini V, Mestroni L, Salvi A, Camerini F, Majori L. [Retrospective study of coxsackie B virus infections and congestive cardiomyopathy]. Boll Ist Sieroter Milan. 1984 Sep; 63(4):325-30. PMID: 6097290.
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    222. Camerini F, Mestroni L, Neri R, Humar F. Vasodilators in left ventricular failure. G Ital Cardiol. 1984 Sep; 14(9):685-93. PMID: 6510623.
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    223. Mestroni L, Fonda F, Camerini F. Ventricular arrhythmias in congestive cardiomyopathy. N Engl J Med. 1983 Aug 11; 309(6):377-8. PMID: 6866073.
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    224. Morgera T, Humar F, Mestroni L, Maras P, Camerini F. [Captopril therapy in chronic congestive heart failure]. G Ital Cardiol. 1983; 13(1):39-46. PMID: 6347789.
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