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Christopher A DeSouza

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentIntegrative Physiology
Phone303/492-2988

    Collapse Research 
    Collapse research activities and funding
    R01HL135598     (DESOUZA, CHRISTOPHER A)Dec 20, 2016 - Nov 30, 2021
    NIH
    Sleep and Blood Pressure-Related Endothelial Abnormalities
    Role: Principal Investigator
    R01HL131458     (DESOUZA, CHRISTOPHER A)Jan 15, 2016 - Dec 31, 2020
    NIH
    HIV-1, Insufficient Sleep and Vascular Endothelial Dysfunction
    Role: Co-Principal Investigator
    R01HL098052     (DESOUZA, CHRISTOPHER A)Sep 30, 2011 - Jun 30, 2016
    NIH
    HIV-1, Exercise and Endothelial Function
    Role: Principal Investigator
    R21HL088911     (DESOUZA, CHRISTOPHER A)Jun 7, 2007 - May 31, 2010
    NIH
    HIV-1 Infection and Endothelial t-PA Release
    Role: Principal Investigator
    R01HL077450     (DESOUZA, CHRISTOPHER A)Jul 1, 2004 - Jun 30, 2009
    NIH
    Aging, Exercise and Endothelin-1 Vasoconstrictor Tone
    Role: Principal Investigator
    R01HL076434     (DESOUZA, CHRISTOPHER A)Jun 1, 2004 - May 31, 2010
    NIH
    Obesity/Insulin Resistance, Vitamin C and Endothelin-1
    Role: Principal Investigator
    R03DK062061     (DESOUZA, CHRISTOPHER A)Aug 15, 2002 - Jun 30, 2004
    NIH
    Obesity/Insulin Resistance and Endothelial t-PA Release
    Role: Principal Investigator
    R01HL068030     (DESOUZA, CHRISTOPHER A)Aug 1, 2002 - Jan 31, 2007
    NIH
    Endothelial Abnormalities in Obesity/Insulin Resistance
    Role: Principal Investigator
    K01HL003840     (DESOUZA, CHRISTOPHER A)Aug 1, 1998 - Jul 31, 2003
    NIH
    AGING, EXERCISE AND ENDOTHELIAL FUNCTION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Barranco-Gil D, Muriel X, Lucia A, Joyner MJ, DeSouza CA, Valenzuela PL. The Tour de France, also possible for mortals? A comparison of a recreational and a World Tour cyclist. J Appl Physiol (1985). 2024 Feb 01; 136(2):432-436. PMID: 38174376.
      View in: PubMed
    2. Garcia VP, Fandl HK, Hijmans JG, Berry AR, Cardenas HL, Stockelman KA, DeSouza NM, Treuth JW, Greiner JJ, Park AJ, Stauffer BL, DeSouza CA. Effects of circulating endothelial microvesicles isolated from adults with obesity on endothelial cell inflammation, apoptosis, and nitric oxide production. Am J Physiol Endocrinol Metab. 2024 01 01; 326(1):E38-E49. PMID: 37991453.
      View in: PubMed
    3. Parikh K, Shepley BR, Tymko MM, Hijmans JG, Hoiland RL, Desouza CA, Sekhon MS, Ainslie PN, Bain AR. Cerebral uptake of microvesicles occurs in normocapnic but not hypocapnic passive hyperthermia in young healthy male adults. J Physiol. 2023 Dec; 601(24):5601-5616. PMID: 37975212.
      View in: PubMed
    4. Park AJ, Garcia VP, Greiner JJ, Berry AR, Cardenas HL, Wegerson KN, Stauffer B, DeSouza CA. Development of a Hypercoagulable-Hypofibrinolytic State Early After Spinal Cord Injury. Arch Phys Med Rehabil. 2023 Nov 15. PMID: 37977547.
      View in: PubMed
    5. Stephenson KE, Marcelin JR, Pettifor AE, Janes H, Brown E, Neradilek M, Yen C, Andriesen J, Grunenberg N, Espy N, Trahey M, Fischer RSB, DeSouza CA, Shisler JL, Connick E, Houpt ER, Chu HY, McCulloh RJ, Becker-Dreps S, Vielot NA, Kalbaugh CA, Cherabuddi K, Krueger KM, Rosenberg M, Greenberg RN, Joaquin A, Immergluck LC, Corey L, Kublin JG. Efficacy of Messenger RNA-1273 Against Severe Acute Respiratory Syndrome Coronavirus 2 Acquisition in Young Adults From March to December 2021. Open Forum Infect Dis. 2023 Nov; 10(11):ofad511. PMID: 38023544.
      View in: PubMed
    6. Cardenas HL, Evanoff NG, Fandl HK, Berry AR, Wegerson KN, Ostrander EI, Greiner JJ, Dufresne SR, Kotlyar M, Dengel DR, DeSouza CA, Garcia VP. Endothelial-derived extracellular vesicles associated with electronic cigarette use impair cerebral microvascular cell function. J Appl Physiol (1985). 2023 08 01; 135(2):271-278. PMID: 37348012.
      View in: PubMed
    7. Park AJ, Fandl HK, Garcia VP, Coombs GB, DeSouza NM, Greiner JJ, Barak OF, Mijacika T, Dujic Z, Ainslie PN, DeSouza CA. Differential Expression of Vascular-Related MicroRNA in Circulating Endothelial Microvesicles in Adults With Spinal Cord Injury: A Pilot Study. Top Spinal Cord Inj Rehabil. 2023; 29(2):34-42. PMID: 37235195.
      View in: PubMed
    8. Wenner MM, Welti LM, Dow CA, Greiner JJ, Stauffer BL, DeSouza CA. Aerobic exercise training reduces ET-1-mediated vasoconstriction and improves endothelium-dependent vasodilation in postmenopausal women. Am J Physiol Heart Circ Physiol. 2023 06 01; 324(6):H732-H738. PMID: 36961490.
      View in: PubMed
    9. Fandl HK, Garcia VP, Treuth JW, Brewster LM, Greiner JJ, Davy KP, Stauffer BL, Desouza CA. Endothelial-derived extracellular vesicles from obese/hypertensive adults increase factors associated with hypertrophy and fibrosis in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2023 05 01; 324(5):H675-H685. PMID: 36930654.
      View in: PubMed
    10. Stone RM, Ainslie PN, Tremblay JC, Akins JD, MacLeod DB, Tymko MM, DeSouza CA, Bain AR. GLOBAL REACH 2018: intra-arterial vitamin C improves endothelial-dependent vasodilatory function in humans at high altitude. J Physiol. 2022 03; 600(6):1373-1383. PMID: 34743333.
      View in: PubMed
    11. Stockelman KA, Bain AR, Goulding A, DeSouza NM, Rahaman C, Maly L, Greiner JJ, Stauffer BL, DeSouza CA. Negative Influence of Insufficient Sleep on Endothelial Vasodilator and Fibrinolytic Function in Hypertensive Adults. Hypertension. 2021 12; 78(6):1829-1840. PMID: 34488434.
      View in: PubMed
    12. Craighead DH, Heinbockel TC, Freeberg KA, Rossman MJ, Jackman RA, Jankowski LR, Hamilton MN, Ziemba BP, Reisz JA, D'Alessandro A, Brewster LM, DeSouza CA, You Z, Chonchol M, Bailey EF, Seals DR. Time-Efficient Inspiratory Muscle Strength Training Lowers Blood Pressure and Improves Endothelial Function, NO Bioavailability, and Oxidative Stress in Midlife/Older Adults With Above-Normal Blood Pressure. J Am Heart Assoc. 2021 07 06; 10(13):e020980. PMID: 34184544.
      View in: PubMed
    13. DeSouza NM, Brewster LM, Bain AR, Garcia VP, Stone R, Stockelman KA, Greiner JJ, Tymko MM, Vizcardo-Galindo G, Figueroa-Mujica RJ, Villafuerte FC, Ainslie PN, DeSouza CA. Global REACH 2018: Influence of excessive erythrocytosis on coagulation and fibrinolytic factors in Andean highlanders. Exp Physiol. 2021 06; 106(6):1335-1342. PMID: 33745204.
      View in: PubMed
    14. Brewster LM, Bain AR, Garcia VP, Fandl HK, Stone R, DeSouza NM, Greiner JJ, Tymko MM, Vizcardo-Galindo GA, Figueroa-Mujica RJ, Villafuerte FC, Ainslie PN, DeSouza CA. Global REACH 2018: dysfunctional extracellular microvesicles in Andean highlander males with excessive erythrocytosis. Am J Physiol Heart Circ Physiol. 2021 05 01; 320(5):H1851-H1861. PMID: 33710927.
      View in: PubMed
    15. Stockelman KA, Bain AR, Dow CA, Diehl KJ, Greiner JJ, Stauffer BL, DeSouza CA. Regular aerobic exercise counteracts endothelial vasomotor dysfunction associated with insufficient sleep. Am J Physiol Heart Circ Physiol. 2021 03 01; 320(3):H1080-H1088. PMID: 33416458.
      View in: PubMed
    16. Brewster LM, Garcia VP, Levy MV, Stockelman KA, Goulding A, DeSouza NM, Greiner JJ, Hijmans JG, DeSouza CA. Endothelin-1-induced endothelial microvesicles impair endothelial cell function. J Appl Physiol (1985). 2020 06 01; 128(6):1497-1505. PMID: 32324474.
      View in: PubMed
    17. Brewster LM, Coombs GB, Garcia VP, Hijmans JG, DeSouza NM, Stockelman KA, Barak OF, Mijacika T, Dujic Z, Greiner JJ, Phillips AA, Ainslie PN, DeSouza CA. Effects of circulating extracellular microvesicles from spinal cord-injured adults on endothelial cell function. Clin Sci (Lond). 2020 04 17; 134(7):777-789. PMID: 32219341.
      View in: PubMed
    18. Stockelman KA, Hijmans JG, Bammert TD, Greiner JJ, Stauffer BL, DeSouza CA. Circulating endothelial cell derived microvesicles are elevated with hypertension and associated with endothelial dysfunction. Can J Physiol Pharmacol. 2020 Aug; 98(8):557-561. PMID: 32268071.
      View in: PubMed
    19. Bain AR, Hoiland RL, Donnelly J, Nowak-Fl?ck D, Sekhon M, Tymko MM, Greiner JJ, DeSouza CA, Ainslie PN. Cerebral metabolism, oxidation and inflammation in severe passive hyperthermia with and without respiratory alkalosis. J Physiol. 2020 03; 598(5):943-954. PMID: 31900940.
      View in: PubMed
    20. Davidson JA, Desouza C, Fonseca V, Frias JP, Van Gaal L, Giorgino F, Chao J, Dex TA, Roberts M, Saremi A, Leiter LA. Glycaemic target attainment in people with Type 2 diabetes treated with insulin glargine/lixisenatide fixed-ratio combination: a post hoc analysis of the LixiLan-O and LixiLan-L trials. Diabet Med. 2020 02; 37(2):256-266. PMID: 31365765.
      View in: PubMed
    21. Hijmans JG, Levy M, Garcia V, Lincenberg GM, Diehl KJ, Greiner JJ, Stauffer BL, DeSouza CA. Insufficient sleep is associated with a pro-atherogenic circulating microRNA signature. Exp Physiol. 2019 06; 104(6):975-982. PMID: 31016755.
      View in: PubMed
    22. Hijmans JG, Stockelman K, Levy M, Brewster LM, Bammert TD, Greiner JJ, Connick E, DeSouza CA. Effects of HIV-1 gp120 and TAT-derived microvesicles on endothelial cell function. J Appl Physiol (1985). 2019 05 01; 126(5):1242-1249. PMID: 30789287.
      View in: PubMed
    23. Hijmans JG, Stockelman KA, Garcia V, Levy MV, Brewster LM, Bammert TD, Greiner JJ, Stauffer BL, Connick E, DeSouza CA. Circulating Microparticles Are Elevated in Treated HIV -1 Infection and Are Deleterious to Endothelial Cell Function. J Am Heart Assoc. 2019 02 19; 8(4):e011134. PMID: 30779672.
      View in: PubMed
    24. Coombs GB, Barak OF, Phillips AA, Mijacika T, Sarafis ZK, Lee AHX, Squair JW, Bammert TD, DeSouza NM, Gagnon D, Krassioukov AV, Dujic Z, DeSouza CA, Ainslie PN. Acute heat stress reduces biomarkers of endothelial activation but not macro- or microvascular dysfunction in cervical spinal cord injury. Am J Physiol Heart Circ Physiol. 2019 03 01; 316(3):H722-H733. PMID: 30575438.
      View in: PubMed
    25. Myette-C?t? ?, Durrer C, Neudorf H, Bammert TD, Botezelli JD, Johnson JD, DeSouza CA, Little JP. The effect of a short-term low-carbohydrate, high-fat diet with or without postmeal walks on glycemic control and inflammation in type 2 diabetes: a randomized trial. Am J Physiol Regul Integr Comp Physiol. 2018 12 01; 315(6):R1210-R1219. PMID: 30303707.
      View in: PubMed
    26. Hijmans JG, Bammert TD, Stockelman KA, Reiakvam WR, Greiner JJ, DeSouza CA. High glucose-induced endothelial microparticles increase adhesion molecule expression on endothelial cells. Diabetol Int. 2019 Apr; 10(2):143-147. PMID: 31139533.
      View in: PubMed
    27. Hijmans JG, Diehl KJ, Bammert TD, Kavlich PJ, Lincenberg GM, Greiner JJ, Stauffer BL, DeSouza CA. Association between hypertension and circulating vascular-related microRNAs. J Hum Hypertens. 2018 06; 32(6):440-447. PMID: 29615793.
      View in: PubMed
    28. Hijmans JG, Stockleman K, Reiakvam W, Levy MV, Brewster LM, Bammert TD, Greiner JJ, Connick E, DeSouza CA. Effects of HIV-1 gp120 and tat on endothelial cell sensescence and senescence-associated microRNAs. Physiol Rep. 2018 03; 6(6):e13647. PMID: 29595877.
      View in: PubMed
    29. Hijmans JG, Diehl KJ, Bammert TD, Kavlich PJ, Lincenberg GM, Greiner JJ, Stauffer BL, DeSouza CA. Influence of Overweight and Obesity on Circulating Inflammation-Related microRNA. Microrna. 2018; 7(2):148-154. PMID: 29607782.
      View in: PubMed
    30. Stauffer BL, Dow CA, Diehl KJ, Bammert TD, Greiner JJ, DeSouza CA. Nebivolol, But Not Metoprolol, Treatment Improves Endothelial Fibrinolytic Capacity in Adults With Elevated Blood Pressure. J Am Heart Assoc. 2017 Nov 09; 6(11). PMID: 29122812.
      View in: PubMed
    31. Francois ME, Myette-Cote E, Bammert TD, Durrer C, Neudorf H, DeSouza CA, Little JP. Carbohydrate restriction with postmeal walking effectively mitigates postprandial hyperglycemia and improves endothelial function in type 2 diabetes. Am J Physiol Heart Circ Physiol. 2018 01 01; 314(1):H105-H113. PMID: 29030343.
      View in: PubMed
    32. Bammert TD, Hijmans JG, Reiakvam WR, Levy MV, Brewster LM, Goldthwaite ZA, Greiner JJ, Stockelman KA, DeSouza CA. High glucose derived endothelial microparticles increase active caspase-3 and reduce microRNA-Let-7a expression in endothelial cells. Biochem Biophys Res Commun. 2017 11 18; 493(2):1026-1029. PMID: 28942148.
      View in: PubMed
    33. Bain AR, Weil BR, Diehl KJ, Greiner JJ, Stauffer BL, DeSouza CA. Insufficient sleep is associated with impaired nitric oxide-mediated endothelium-dependent vasodilation. Atherosclerosis. 2017 Oct; 265:41-46. PMID: 28846879.
      View in: PubMed
    34. Dow CA, Stauffer BL, Brunjes DL, Greiner JJ, DeSouza CA. Regular aerobic exercise reduces endothelin-1-mediated vasoconstrictor tone in overweight and obese adults. Exp Physiol. 2017 09 01; 102(9):1133-1142. PMID: 28635124.
      View in: PubMed
    35. Bammert TD, Hijmans JG, Kavlich PJ, Lincenberg GM, Reiakvam WR, Fay RT, Greiner JJ, Stauffer BL, DeSouza CA. Influence of sex on the number of circulating endothelial microparticles and microRNA expression in middle-aged adults. Exp Physiol. 2017 08 01; 102(8):894-900. PMID: 28568648.
      View in: PubMed
    36. Bain AR, Ainslie PN, Bammert TD, Hijmans JG, Sekhon M, Hoiland RL, Fl?ck D, Donnelly J, DeSouza CA. Passive heat stress reduces circulating endothelial and platelet microparticles. Exp Physiol. 2017 06 01; 102(6):663-669. PMID: 28397383.
      View in: PubMed
    37. Dow CA, Lincenberg GM, Greiner JJ, Stauffer BL, DeSouza CA. Endothelial vasodilator function in normal-weight adults with metabolic syndrome. Appl Physiol Nutr Metab. 2016 Oct; 41(10):1013-1017. PMID: 27643673.
      View in: PubMed
    38. Diehl KJ, Stauffer BL, Dow CA, Bammert TD, Brunjes DL, Greiner JJ, DeSouza CA. Chronic Nebivolol Treatment Suppresses Endothelin-1-Mediated Vasoconstrictor Tone in Adults With Elevated Blood Pressure. Hypertension. 2016 06; 67(6):1196-204. PMID: 27113048.
      View in: PubMed
    39. Dow CA, Templeton DL, Lincenberg GM, Greiner JJ, Stauffer BL, DeSouza CA. Elevations in C-reactive protein and endothelin-1 system activity in humans. Life Sci. 2016 Aug 15; 159:66-70. PMID: 26685760.
      View in: PubMed
    40. Dow CA, Stauffer BL, Greiner JJ, DeSouza CA. Influence of habitual high dietary fat intake on endothelium-dependent vasodilation. Appl Physiol Nutr Metab. 2015 Jul; 40(7):711-5. PMID: 26058441.
      View in: PubMed
    41. Wright KP, Drake AL, Frey DJ, Fleshner M, Desouza CA, Gronfier C, Czeisler CA. Influence of sleep deprivation and circadian misalignment on cortisol, inflammatory markers, and cytokine balance. Brain Behav Immun. 2015 Jul; 47:24-34. PMID: 25640603.
      View in: PubMed
    42. Diehl KJ, Weil BR, Greiner JJ, Wright KP, Stauffer BL, DeSouza CA. Impaired endogenous fibrinolytic capacity in prehypertensive men. J Hum Hypertens. 2015 Aug; 29(8):468-72. PMID: 25566873.
      View in: PubMed
    43. Diehl KJ, Stauffer BL, Greiner JJ, DeSouza CA. ENDOTHELIN-1 SYTEM ACTIVITY IN ADULTS WITH BORDERLINE HIGH LDL-CHOLESTEROL. Artery Res. 2014 Sep 01; 8(3):115-118. PMID: 25267931.
      View in: PubMed
    44. Dow CA, Stauffer BL, Greiner JJ, DeSouza CA. Influence of dietary saturated fat intake on endothelial fibrinolytic capacity in adults. Am J Cardiol. 2014 Sep 01; 114(5):783-8. PMID: 25052545.
      View in: PubMed
    45. Rocha NG, Templeton DL, Greiner JJ, Stauffer BL, DeSouza CA. Metabolic syndrome and endothelin-1 mediated vasoconstrictor tone in overweight/obese adults. Metabolism. 2014 Jul; 63(7):951-6. PMID: 24856242.
      View in: PubMed
    46. Fasing KA, Nissan BJ, Greiner JJ, Stauffer BL, DeSouza CA. Influence of elevated levels of C-reactive protein on circulating endothelial progenitor cell function. Clin Transl Sci. 2014 Apr; 7(2):137-40. PMID: 24422709.
      View in: PubMed
    47. Diehl KJ, Templeton DL, Ma J, Weil BR, Greiner JJ, Stauffer BL, DeSouza CA. Impaired fasting blood glucose is associated with increased endothelin-1 vasoconstrictor tone. Atherosclerosis. 2013 Jul; 229(1):130-3. PMID: 23643051.
      View in: PubMed
    48. Weil BR, Greiner JJ, Stauffer BL, Desouza CA. Self-reported habitual short sleep duration is associated with endothelial fibrinolytic dysfunction in men: a preliminary report. Sleep. 2013 Feb 01; 36(2):183-8. PMID: 23372265.
      View in: PubMed
    49. Diehl KJ, Weil BR, Greiner JJ, Stauffer BL, Desouza CA. White blood cell count and endothelin-1 vasoconstrictor tone in middle-aged and older adults. Artery Res. 2012 Jun 01; 6(2):65-70. PMID: 23908675.
      View in: PubMed
    50. Diehl KJ, Stauffer BL, Greiner JJ, Weil BR, DeSouza CA. Nitric oxide-mediated endothlium-dependent vasodilation is impaired with borderline high-LDL cholesterol. Clin Transl Sci. 2012 Feb; 5(1):21-6. PMID: 22376252.
      View in: PubMed
    51. Diehl KJ, Weil BR, Westby CM, MacEneaney OJ, Kushner EJ, Greiner JJ, DeSouza CA. Effects of endothelin-1 on endothelial progenitor cell function. Clin Chem Lab Med. 2012 Feb 01; 50(6):1121-4. PMID: 22706256.
      View in: PubMed
    52. Weil BR, Westby CM, Greiner JJ, Stauffer BL, DeSouza CA. Elevated endothelin-1 vasoconstrictor tone in prehypertensive adults. Can J Cardiol. 2012 May; 28(3):347-53. PMID: 22244775.
      View in: PubMed
    53. Weil BR, Greiner JJ, DeSouza CA, Stauffer BL. Relation of C-reactive protein to endothelial fibrinolytic function in healthy adults. Am J Cardiol. 2011 Dec 01; 108(11):1675-9. PMID: 21890088.
      View in: PubMed
    54. Weil BR, Kushner EJ, Diehl KJ, Greiner JJ, Stauffer BL, Desouza CA. CD31+ T cells, endothelial function and cardiovascular risk. Heart Lung Circ. 2011 Oct; 20(10):659-62. PMID: 21767986.
      View in: PubMed
    55. Weil BR, Stauffer BL, Mestek ML, DeSouza CA. Influence of abdominal obesity on vascular endothelial function in overweight/obese adult men. Obesity (Silver Spring). 2011 Sep; 19(9):1742-6. PMID: 21738236.
      View in: PubMed
    56. Weil BR, Westby CM, Van Guilder GP, Greiner JJ, Stauffer BL, DeSouza CA. Enhanced endothelin-1 system activity with overweight and obesity. Am J Physiol Heart Circ Physiol. 2011 Sep; 301(3):H689-95. PMID: 21666117.
      View in: PubMed
    57. Weil BR, Stauffer BL, Greiner JJ, DeSouza CA. Prehypertension is associated with impaired nitric oxide-mediated endothelium-dependent vasodilation in sedentary adults. Am J Hypertens. 2011 Sep; 24(9):976-81. PMID: 21633396.
      View in: PubMed
    58. Westby CM, Weil BR, Greiner JJ, Stauffer BL, DeSouza CA. Endothelin-1 vasoconstriction and the age-related decline in endothelium-dependent vasodilatation in men. Clin Sci (Lond). 2011 Jun; 120(11):485-91. PMID: 21143196.
      View in: PubMed
    59. Kushner EJ, MacEneaney OJ, Weil BR, Greiner JJ, Stauffer BL, DeSouza CA. Aging is associated with a proapoptotic endothelial progenitor cell phenotype. J Vasc Res. 2011; 48(5):408-14. PMID: 21625174.
      View in: PubMed
    60. Weil BR, Maceneaney OJ, Stauffer BL, Desouza CA. Habitual short sleep duration and circulating endothelial progenitor cells. J Cardiovasc Dis Res. 2011 Apr; 2(2):110-4. PMID: 21814415.
      View in: PubMed
    61. MacEneaney OJ, Connick E, DeSouza CA. Effects of HIV-1 gp120 and protease inhibitors on apoptotic susceptibility of CD34+ hematopoietic progenitor cells. J Acquir Immune Defic Syndr. 2011 Feb 01; 56(2):e49-50. PMID: 21233630.
      View in: PubMed
    62. Kushner EJ, Weil BR, MacEneaney OJ, Morgan RG, Mestek ML, Van Guilder GP, Diehl KJ, Stauffer BL, DeSouza CA. Human aging and CD31+ T-cell number, migration, apoptotic susceptibility, and telomere length. J Appl Physiol (1985). 2010 Dec; 109(6):1756-61. PMID: 20864561.
      View in: PubMed
    63. Weil BR, Mestek ML, Westby CM, Van Guilder GP, Greiner JJ, Stauffer BL, DeSouza CA. Short sleep duration is associated with enhanced endothelin-1 vasoconstrictor tone. Can J Physiol Pharmacol. 2010 Aug; 88(8):777-81. PMID: 20725134.
      View in: PubMed
    64. Mestek ML, Weil BR, Greiner JJ, Westby CM, DeSouza CA, Stauffer BL. Osteopenia and endothelin-1-mediated vasconstrictor tone in postmenopausal women. Bone. 2010 Sep; 47(3):542-5. PMID: 20685405.
      View in: PubMed
    65. Stauffer BL, DeSouza CA. Epigenetics: an emerging player in health and disease. J Appl Physiol (1985). 2010 Jul; 109(1):230-1. PMID: 20489037.
      View in: PubMed
    66. MacEneaney OJ, DeSouza CA, Weil BR, Kushner EJ, Van Guilder GP, Mestek ML, Greiner JJ, Stauffer BL. Prehypertension and endothelial progenitor cell function. J Hum Hypertens. 2011 Jan; 25(1):57-62. PMID: 20336149.
      View in: PubMed
    67. MacEneaney OJ, Kushner EJ, Westby CM, Cech JN, Greiner JJ, Stauffer BL, DeSouza CA. Endothelial progenitor cell function, apoptosis, and telomere length in overweight/obese humans. Obesity (Silver Spring). 2010 Sep; 18(9):1677-82. PMID: 20057362.
      View in: PubMed
    68. Mestek ML, Westby CM, Van Guilder GP, Greiner JJ, Stauffer BL, DeSouza CA. Regular aerobic exercise, without weight loss, improves endothelium-dependent vasodilation in overweight and obese adults. Obesity (Silver Spring). 2010 Aug; 18(8):1667-9. PMID: 20057377.
      View in: PubMed
    69. Kushner E, Van Guilder G, MacEneaney O, Greiner J, Cech J, Stauffer B, Desouza C. Ageing and endothelial progenitor cell release of proangiogenic cytokines. Age Ageing. 2010 Mar; 39(2):268-72. PMID: 20040613.
      View in: PubMed
    70. Stauffer BL, Westby CM, Greiner JJ, Van Guilder GP, Desouza CA. Sex differences in endothelin-1-mediated vasoconstrictor tone in middle-aged and older adults. Am J Physiol Regul Integr Comp Physiol. 2010 Feb; 298(2):R261-5. PMID: 19939973.
      View in: PubMed
    71. Kushner EJ, MacEneaney OJ, Morgan RG, Van Engelenburg AM, Van Guilder GP, DeSouza CA. CD31+ T cells represent a functionally distinct vascular T cell phenotype. Blood Cells Mol Dis. 2010 Mar-Apr; 44(2):74-8. PMID: 19897387.
      View in: PubMed
    72. Kushner EJ, Van Guilder GP, Maceneaney OJ, Cech JN, Stauffer BL, DeSouza CA. Aging and endothelial progenitor cell telomere length in healthy men. Clin Chem Lab Med. 2009; 47(1):47-50. PMID: 19055473.
      View in: PubMed
    73. MacEneaney OJ, Kushner EJ, Van Guilder GP, Greiner JJ, Stauffer BL, DeSouza CA. Endothelial progenitor cell number and colony-forming capacity in overweight and obese adults. Int J Obes (Lond). 2009 Feb; 33(2):219-25. PMID: 19079361.
      View in: PubMed
    74. Stauffer BL, Maceneaney OJ, Kushner EJ, Cech JN, Greiner JJ, Westby CM, Desouza CA. Gender and Endothelial Progenitor Cell Number in Middle-Aged Adults. Artery Res. 2008 Nov; 2(4):156-160. PMID: 19884973.
      View in: PubMed
    75. Stauffer BL, Westby CM, DeSouza CA. Endothelin-1, aging and hypertension. Curr Opin Cardiol. 2008 Jul; 23(4):350-5. PMID: 18520719.
      View in: PubMed
    76. Seals DR, Desouza CA, Donato AJ, Tanaka H. Habitual exercise and arterial aging. J Appl Physiol (1985). 2008 Oct; 105(4):1323-32. PMID: 18583377.
      View in: PubMed
    77. Van Guilder GP, Hoetzer GL, Greiner JJ, Stauffer BL, DeSouza CA. Acute and chronic effects of vitamin C on endothelial fibrinolytic function in overweight and obese adult humans. J Physiol. 2008 Jul 15; 586(14):3525-35. PMID: 18499730.
      View in: PubMed
    78. Van Guilder GP, Stauffer BL, Greiner JJ, Desouza CA. Impaired endothelium-dependent vasodilation in overweight and obese adult humans is not limited to muscarinic receptor agonists. Am J Physiol Heart Circ Physiol. 2008 Apr; 294(4):H1685-92. PMID: 18281379.
      View in: PubMed
    79. Van Guilder GP, Hoetzer GL, Greiner JJ, Stauffer BL, DeSouza CA. Metabolic syndrome and endothelial fibrinolytic capacity in obese adults. Am J Physiol Regul Integr Comp Physiol. 2008 Jan; 294(1):R39-44. PMID: 17959703.
      View in: PubMed
    80. Van Guilder GP, Westby CM, Greiner JJ, Stauffer BL, DeSouza CA. Endothelin-1 vasoconstrictor tone increases with age in healthy men but can be reduced by regular aerobic exercise. Hypertension. 2007 Aug; 50(2):403-9. PMID: 17576858.
      View in: PubMed
    81. Hoetzer GL, Van Guilder GP, Irmiger HM, Keith RS, Stauffer BL, DeSouza CA. Aging, exercise, and endothelial progenitor cell clonogenic and migratory capacity in men. J Appl Physiol (1985). 2007 Mar; 102(3):847-52. PMID: 17158243.
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    82. Van Guilder GP, Hoetzer GL, Greiner JJ, Stauffer BL, Desouza CA. Influence of metabolic syndrome on biomarkers of oxidative stress and inflammation in obese adults. Obesity (Silver Spring). 2006 Dec; 14(12):2127-31. PMID: 17189537.
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    83. Hoetzer GL, MacEneaney OJ, Irmiger HM, Keith R, Van Guilder GP, Stauffer BL, DeSouza CA. Gender differences in circulating endothelial progenitor cell colony-forming capacity and migratory activity in middle-aged adults. Am J Cardiol. 2007 Jan 01; 99(1):46-8. PMID: 17196460.
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    84. Van Guilder GP, Hoetzer GL, Dengel DR, Stauffer BL, DeSouza CA. Impaired endothelium-dependent vasodilation in normotensive and normoglycemic obese adult humans. J Cardiovasc Pharmacol. 2006 Feb; 47(2):310-3. PMID: 16495771.
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    85. Hoetzer GL, Irmiger HM, Keith RS, Westbrook KM, DeSouza CA. Endothelial nitric oxide synthase inhibition does not alter endothelial progenitor cell colony forming capacity or migratory activity. J Cardiovasc Pharmacol. 2005 Sep; 46(3):387-9. PMID: 16116346.
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    86. Hoetzer GL, Irmiger HM, Stauffer BL, DeSouza CA. Estrogen receptor-alpha thymidine and adenine repeat polymorphism and endothelial fibrinolytic regulation in postmenopausal women. Am J Obstet Gynecol. 2005 Aug; 193(2):366-70. PMID: 16098857.
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    87. DeSouza CA, Van Guilder GP, Greiner JJ, Smith DT, Hoetzer GL, Stauffer BL. Basal endothelial nitric oxide release is preserved in overweight and obese adults. Obes Res. 2005 Aug; 13(8):1303-6. PMID: 16129710.
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    88. Van Guilder GP, Hoetzer GL, Smith DT, Irmiger HM, Greiner JJ, Stauffer BL, DeSouza CA. Endothelial t-PA release is impaired in overweight and obese adults but can be improved with regular aerobic exercise. Am J Physiol Endocrinol Metab. 2005 Nov; 289(5):E807-13. PMID: 15985456.
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    89. Stauffer BL, Hoetzer GL, Van Guilder GP, Smith DT, Desouza CA. Gender differences in endothelial tissue-type plasminogen activator release in middle-aged adults. J Am Coll Cardiol. 2005 May 03; 45(9):1547-9. PMID: 15862434.
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    90. Christou DD, Gentile CL, DeSouza CA, Seals DR, Gates PE. Fatness is a better predictor of cardiovascular disease risk factor profile than aerobic fitness in healthy men. Circulation. 2005 Apr 19; 111(15):1904-14. PMID: 15837943.
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    91. Stauffer BL, Hoetzer GL, Smith DT, DeSouza CA. Plasma C-reactive protein is not elevated in physically active postmenopausal women taking hormone replacement therapy. J Appl Physiol (1985). 2004 Jan; 96(1):143-8. PMID: 12949021.
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    92. Smith DT, Hoetzer GL, Greiner JJ, Stauffer BL, DeSouza CA. Endothelial release of tissue-type plasminogen activator in the human forearm: role of nitric oxide. J Cardiovasc Pharmacol. 2003 Aug; 42(2):311-4. PMID: 12883337.
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    93. Hoetzer GL, Stauffer BL, Irmiger HM, Ng M, Smith DT, DeSouza CA. Acute and chronic effects of oestrogen on endothelial tissue-type plasminogen activator release in postmenopausal women. J Physiol. 2003 Sep 01; 551(Pt 2):721-8. PMID: 12815179.
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    94. Moreau KL, Donato AJ, Seals DR, DeSouza CA, Tanaka H. Regular exercise, hormone replacement therapy and the age-related decline in carotid arterial compliance in healthy women. Cardiovasc Res. 2003 Mar; 57(3):861-8. PMID: 12618248.
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    95. Capell WH, DeSouza CA, Poirier P, Bell ML, Stauffer BL, Weil KM, Hernandez TL, Eckel RH. Short-term triglyceride lowering with fenofibrate improves vasodilator function in subjects with hypertriglyceridemia. Arterioscler Thromb Vasc Biol. 2003 Feb 01; 23(2):307-13. PMID: 12588776.
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    96. Smith DT, Hoetzer GL, Greiner JJ, Stauffer BL, DeSouza CA. Effects of ageing and regular aerobic exercise on endothelial fibrinolytic capacity in humans. J Physiol. 2003 Jan 01; 546(Pt 1):289-98. PMID: 12509496.
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    97. DeSouza CA, Clevenger CM, Greiner JJ, Smith DT, Hoetzer GL, Shapiro LF, Stauffer BL. Evidence for agonist-specific endothelial vasodilator dysfunction with ageing in healthy humans. J Physiol. 2002 Jul 01; 542(Pt 1):255-62. PMID: 12096067.
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    98. Moreau KL, Donato AJ, Seals DR, Dinenno FA, Blackett SD, Hoetzer GL, Desouza CA, Tanaka H. Arterial intima-media thickness: site-specific associations with HRT and habitual exercise. Am J Physiol Heart Circ Physiol. 2002 Oct; 283(4):H1409-17. PMID: 12234791.
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    99. Sugawara J, Miyachi M, Moreau KL, Dinenno FA, DeSouza CA, Tanaka H. Age-related reductions in appendicular skeletal muscle mass: association with habitual aerobic exercise status. Clin Physiol Funct Imaging. 2002 May; 22(3):169-72. PMID: 12076341.
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    100. Tanaka H, Seals DR, Monahan KD, Clevenger CM, DeSouza CA, Dinenno FA. Regular aerobic exercise and the age-related increase in carotid artery intima-media thickness in healthy men. J Appl Physiol (1985). 2002 Apr; 92(4):1458-64. PMID: 11896010.
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    101. Eskurza I, Seals DR, DeSouza CA, Tanaka H. Pharmacologic versus flow-mediated assessments of peripheral vascular endothelial vasodilatory function in humans. Am J Cardiol. 2001 Nov 01; 88(9):1067-9. PMID: 11704016.
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    102. Dinenno FA, Tanaka H, Monahan KD, Clevenger CM, Eskurza I, DeSouza CA, Seals DR. Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men. J Physiol. 2001 Jul 01; 534(Pt 1):287-95. PMID: 11433009.
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    103. Dinenno FA, Seals DR, DeSouza CA, Tanaka H. Age-related decreases in basal limb blood flow in humans: time course, determinants and habitual exercise effects. J Physiol. 2001 Mar 01; 531(Pt 2):573-9. PMID: 11230528.
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    104. Tanaka H, Dinenno FA, Monahan KD, DeSouza CA, Seals DR. Carotid artery wall hypertrophy with age is related to local systolic blood pressure in healthy men. Arterioscler Thromb Vasc Biol. 2001 Jan; 21(1):82-7. PMID: 11145937.
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    105. Casas YG, Schiller BC, DeSouza CA, Seals DR. Total and regional body composition across age in healthy Hispanic and white women of similar socioeconomic status. Am J Clin Nutr. 2001 Jan; 73(1):13-8. PMID: 11124743.
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    106. Schiller BC, Casas YG, Tracy BL, DeSouza CA, Seals DR. Age-related declines in knee extensor strength and physical performance in healthy Hispanic and Caucasian women. J Gerontol A Biol Sci Med Sci. 2000 Dec; 55(12):B563-9. PMID: 11129385.
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    107. Monahan KD, Dinenno FA, Tanaka H, Clevenger CM, DeSouza CA, Seals DR. Regular aerobic exercise modulates age-associated declines in cardiovagal baroreflex sensitivity in healthy men. J Physiol. 2000 Nov 15; 529 Pt 1:263-71. PMID: 11080267.
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    108. DeSouza CA, Shapiro LF, Clevenger CM, Dinenno FA, Monahan KD, Tanaka H, Seals DR. Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation. 2000 Sep 19; 102(12):1351-7. PMID: 10993851.
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    109. Tanaka H, Dinenno FA, Monahan KD, Clevenger CM, DeSouza CA, Seals DR. Aging, habitual exercise, and dynamic arterial compliance. Circulation. 2000 Sep 12; 102(11):1270-5. PMID: 10982542.
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    110. Seals DR, Stevenson ET, Jones PP, DeSouza CA, Tanaka H. Lack of age-associated elevations in 24-h systolic and pulse pressures in women who exercise regularly. Am J Physiol. 1999 09; 277(3):H947-55. PMID: 10484415.
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    111. Parker Jones P, Davy KP, Desouza CA, Tanaka H. Total blood volume in endurance-trained postmenopausal females: relation to exercise mode and maximal aerobic capacity. Acta Physiol Scand. 1999 Aug; 166(4):327-33. PMID: 10468670.
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    112. Tanaka H, Dinenno FA, Hunt BE, Jones PP, DeSouza CA, Seals DR. Hemodynamic sequelae of age-related increases in arterial stiffness in healthy women. Am J Cardiol. 1998 Nov 01; 82(9):1152-5, A10. PMID: 9817505.
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    113. Van Pelt RE, Davy KP, Stevenson ET, Wilson TM, Jones PP, Desouza CA, Seals DR. Smaller differences in total and regional adiposity with age in women who regularly perform endurance exercise. Am J Physiol. 1998 10; 275(4):E626-34. PMID: 9755081.
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    114. Hunt BE, Davy KP, Jones PP, DeSouza CA, Van Pelt RE, Tanaka H, Seals DR. Role of central circulatory factors in the fat-free mass-maximal aerobic capacity relation across age. Am J Physiol. 1998 10; 275(4):H1178-82. PMID: 9746464.
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    115. Tanaka H, DeSouza CA, Seals DR. Arterial stiffness and hormone replacement use in healthy postmenopausal women. J Gerontol A Biol Sci Med Sci. 1998 Sep; 53(5):M344-6. PMID: 9754139.
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    116. Tanaka H, Clevenger CM, Jones PP, Seals DR, DeSouza CA. Influence of body fatness on the coronary risk profile of physically active postmenopausal women. Metabolism. 1998 Sep; 47(9):1112-20. PMID: 9751241.
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    117. Davy KP, DeSouza CA, Jones PP, Seals DR. Elevated heart rate variability in physically active young and older adult women. Clin Sci (Lond). 1998 Jun; 94(6):579-84. PMID: 9854454.
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    118. DeSouza CA, Jones PP, Seals DR. Physical activity status and adverse age-related differences in coagulation and fibrinolytic factors in women. Arterioscler Thromb Vasc Biol. 1998 Mar; 18(3):362-8. PMID: 9514404.
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    119. Tanaka H, DeSouza CA, Seals DR. Absence of age-related increase in central arterial stiffness in physically active women. Arterioscler Thromb Vasc Biol. 1998 Jan; 18(1):127-32. PMID: 9445266.
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    120. Tanaka H, Desouza CA, Jones PP, Stevenson ET, Davy KP, Seals DR. Greater rate of decline in maximal aerobic capacity with age in physically active vs. sedentary healthy women. J Appl Physiol (1985). 1997 Dec; 83(6):1947-53. PMID: 9390967.
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    121. DeSouza CA, Dengel DR, Macko RF, Cox K, Seals DR. Elevated levels of circulating cell adhesion molecules in uncomplicated essential hypertension. Am J Hypertens. 1997 Dec; 10(12 Pt 1):1335-41. PMID: 9443768.
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    122. Stevenson ET, DeSouza CA, Jones PP, Van Pelt RE, Seals DR. Physically active women demonstrate less adverse age-related changes in plasma lipids and lipoproteins. Am J Cardiol. 1997 Nov 15; 80(10):1360-4. PMID: 9388117.
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    123. Van Pelt RE, Jones PP, Davy KP, Desouza CA, Tanaka H, Davy BM, Seals DR. Regular exercise and the age-related decline in resting metabolic rate in women. J Clin Endocrinol Metab. 1997 Oct; 82(10):3208-12. PMID: 9329340.
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    124. DeSouza CA, Stevenson ET, Davy KP, Jones PP, Seals DR. Plasma fibrinogen levels in healthy postmenopausal women: physical activity and hormone replacement status. J Gerontol A Biol Sci Med Sci. 1997 Sep; 52(5):M294-8. PMID: 9310083.
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    125. Hunt BE, Davy KP, Jones PP, DeSouza CA, Van Pelt RE, Tanaka H, Seals DR. Systemic hemodynamic determinants of blood pressure in women: age, physical activity, and hormone replacement. Am J Physiol. 1997 Aug; 273(2 Pt 2):H777-85. PMID: 9277495.
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    126. DeSouza CA, Dengel DR, Rogers MA, Cox K, Macko RF. Fibrinolytic responses to acute physical activity in older hypertensive men. J Appl Physiol (1985). 1997 Jun; 82(6):1765-70. PMID: 9173939.
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    127. Jones PP, Davy KP, DeSouza CA, van Pelt RE, Seals DR. Absence of age-related decline in total blood volume in physically active females. Am J Physiol. 1997 Jun; 272(6 Pt 2):H2534-40. PMID: 9227528.
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    128. Macko RF, Katzel LI, Yataco A, Tretter LD, DeSouza CA, Dengel DR, Smith GV, Silver KH. Low-velocity graded treadmill stress testing in hemiparetic stroke patients. Stroke. 1997 May; 28(5):988-92. PMID: 9158639.
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    129. Stevenson ET, Davy KP, Jones PP, Desouza CA, Seals DR. Blood pressure risks factors in healthy postmenopausal women: physical activity and hormone replacement. J Appl Physiol (1985). 1997 Feb; 82(2):652-60. PMID: 9049749.
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    130. Macko RF, DeSouza CA, Tretter LD, Silver KH, Smith GV, Anderson PA, Tomoyasu N, Gorman P, Dengel DR. Treadmill aerobic exercise training reduces the energy expenditure and cardiovascular demands of hemiparetic gait in chronic stroke patients. A preliminary report. Stroke. 1997 Feb; 28(2):326-30. PMID: 9040684.
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    131. Haffajee C, Martin D, Bhandari A, Bardy GH, DeSouza C, Kuehlkamp V, Church T. A multicenter, randomized trial comparing an active can implantable defibrillator with a passive can system. Jewel Active Can Investigators. Pacing Clin Electrophysiol. 1997 Jan; 20(1 Pt 2):215-9. PMID: 9121993.
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    132. DeSouza CA, Dengel DR, Rogers MA, Cox K, Macko RF. The fibrinolytic system is not impaired in older men with hypertension. Hypertension. 1996 May; 27(5):1053-8. PMID: 8621196.
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    133. Hallmark MA, Reynolds TH, DeSouza CA, Dotson CO, Anderson RA, Rogers MA. Effects of chromium and resistive training on muscle strength and body composition. Med Sci Sports Exerc. 1996 Jan; 28(1):139-44. PMID: 8775366.
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