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Leigh Perreault

TitleAssoc Professor-Clinical
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-3947

    Collapse Research 
    Collapse research activities and funding
    K23DK064811     (PERREAULT, LEIGH)Apr 1, 2004 - Mar 31, 2010
    NIH/NIDDK
    Intramuscular Triglyceride in Impaired Glucose Tolerance
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Goldberg RB, Bray GA, Marcovina SM, Mather KJ, Orchard TJ, Perreault L, Temprosa M. Non-traditional biomarkers and incident diabetes in the Diabetes Prevention Program: comparative effects of lifestyle and metformin interventions. Diabetologia. 2018 Oct 17. PMID: 30334082.
      View in: PubMed
    2. Perreault L. GOALS FOR MEDICAL TREATMENT IN OBESITY AND PREDIABETES: IMPROVING OUTCOMES FOR BOTH. Endocr Pract. 2018 Oct 05. PMID: 30289308.
      View in: PubMed
    3. Harman NL, Wilding J, Curry D, Harris J, Logue J, Pemberton RJ, Perreault L, Thompson G, Tunis S, Williamson PR. Selecting Core Outcomes for Randomised Effectiveness trials In Type 2 Diabetes (SCORE-IT): study protocol for the development of a core outcome set. Trials. 2018 Aug 07; 19(1):427. PMID: 30086771.
      View in: PubMed
    4. Su W, Chen F, Dall TM, Zvenyach T, Kyle TK, Perreault L. Where can obesity management policy make the largest impact? Evaluating sub-populations through a microsimulation approach. J Med Econ. 2018 Sep; 21(9):936-943. PMID: 29973101.
      View in: PubMed
    5. Herman WH, Pan Q, Edelstein SL, Mather KJ, Perreault L, Barrett-Connor E, Dabelea DM, Horton E, Kahn SE, Knowler WC, Lorenzo C, Pi-Sunyer X, Venditti E, Ye W. Erratum. Impact of Lifestyle and Metformin Interventions on the Risk of Progression to Diabetes and Regression to Normal Glucose Regulation in Overweight or Obese People With Impaired Glucose Regulation. Diabetes Care 2017;40:1668-1677. Diabetes Care. 2018 04; 41(4):913. PMID: 29475844.
      View in: PubMed
    6. Perreault L, Newsom SA, Strauss A, Kerege A, Kahn DE, Harrison KA, Snell-Bergeon JK, Nemkov T, D'Alessandro A, Jackman MR, MacLean PS, Bergman BC. Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle. JCI Insight. 2018 Feb 08; 3(3). PMID: 29415895.
      View in: PubMed
    7. Herman WH, Pan Q, Edelstein SL, Mather KJ, Perreault L, Barrett-Connor E, Dabelea DM, Horton E, Kahn SE, Knowler WC, Lorenzo C, Pi-Sunyer X, Venditti E, Ye W. Impact of Lifestyle and Metformin Interventions on the Risk of Progression to Diabetes and Regression to Normal Glucose Regulation in Overweight or Obese People With Impaired Glucose Regulation. Diabetes Care. 2017 12; 40(12):1668-1677. PMID: 29021207.
      View in: PubMed
    8. Bergman BC, Perreault L, Strauss A, Bacon S, Kerege A, Harrison K, Brozinick JT, Hunerdosse DM, Playdon MC, Holmes W, Bui HH, Sanders P, Siddall P, Wei T, Thomas MK, Kuo MS, Eckel RH. Intramuscular triglyceride synthesis: importance in muscle lipid partitioning in humans. Am J Physiol Endocrinol Metab. 2018 02 01; 314(2):E152-E164. PMID: 28978544.
      View in: PubMed
    9. Perreault L, Pan Q, Aroda VR, Barrett-Connor E, Dabelea D, Dagogo-Jack S, Hamman RF, Kahn SE, Mather KJ, Knowler WC. Exploring residual risk for diabetes and microvascular disease in the Diabetes Prevention Program Outcomes Study (DPPOS). Diabet Med. 2017 12; 34(12):1747-1755. PMID: 28833481.
      View in: PubMed
    10. Perreault L, Færch K, Gregg EW. Can Cardiovascular Epidemiology and Clinical Trials Close the Risk Management Gap Between Diabetes and Prediabetes? Curr Diab Rep. 2017 Sep; 17(9):77. PMID: 28766246.
      View in: PubMed
    11. Aroda VR, Knowler WC, Crandall JP, Perreault L, Edelstein SL, Jeffries SL, Molitch ME, Pi-Sunyer X, Darwin C, Heckman-Stoddard BM, Temprosa M, Kahn SE, Nathan DM. Metformin for diabetes prevention: insights gained from the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study. Diabetologia. 2017 09; 60(9):1601-1611. PMID: 28770322.
      View in: PubMed
    12. Perreault L. EMPA-REG OUTCOME: The Endocrinologist's Point of View. Am J Med. 2017 Jun; 130(6S):S51-S56. PMID: 28526185.
      View in: PubMed
    13. Perreault L. EMPA-REG OUTCOME: The Endocrinologist's Point of View. Am J Cardiol. 2017 Jul 01; 120(1S):S48-S52. PMID: 28606344.
      View in: PubMed
    14. Goldberg RB, Temprosa M, Mele L, Orchard T, Mather K, Bray G, Horton E, Kitabchi A, Krakoff J, Marcovina S, Perreault L, White N. Erratum to: "Change in adiponectin explains most of the change in HDL particles induced by lifestyle intervention but not metformin treatment in the diabetes prevention program" [Metabolism (2016) 65; 764-775]. Metabolism. 2017 03; 68:184-186. PMID: 28065437.
      View in: PubMed
    15. Newsom SA, Brozinick JT, Kiseljak-Vassiliades K, Strauss AN, Bacon SD, Kerege AA, Bui HH, Sanders P, Siddall P, Wei T, Thomas M, Kuo MS, Nemkov T, D'Alessandro A, Hansen KC, Perreault L, Bergman BC. Skeletal muscle phosphatidylcholine and phosphatidylethanolamine are related to insulin sensitivity and respond to acute exercise in humans. J Appl Physiol (1985). 2016 Jun 01; 120(11):1355-63. PMID: 27032901; PMCID: PMC4891931 [Available on 06/01/17].
      View in: PubMed, PubMed Central
    16. Guess N, Perreault L, Kerege A, Strauss A, Bergman BC. Dietary Fatty Acids Differentially Associate with Fasting Versus 2-Hour Glucose Homeostasis: Implications for The Management of Subtypes of Prediabetes. PLoS One. 2016; 11(3):e0150148. PMID: 26999667; PMCID: PMC4801380.
      View in: PubMed, PubMed Central
    17. Su W, Chen F, Dall TM, Iacobucci W, Perreault L. Return on Investment for Digital Behavioral Counseling in Patients With Prediabetes and Cardiovascular Disease. Prev Chronic Dis. 2016 Jan 28; 13:E13. PMID: 26820045; PMCID: PMC4747438.
      View in: PubMed, PubMed Central
    18. Bergman BC, Brozinick JT, Strauss A, Bacon S, Kerege A, Bui HH, Sanders P, Siddall P, Wei T, Thomas MK, Kuo MS, Perreault L. Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans. Diabetologia. 2016 Apr; 59(4):785-98. PMID: 26739815.
      View in: PubMed
    19. Goldberg RB, Temprosa M, Mele L, Orchard T, Mather K, Bray G, Horton E, Kitabchi A, Krakoff J, Marcovina S, Perreault L, White N. Change in adiponectin explains most of the change in HDL particles induced by lifestyle intervention but not metformin treatment in the Diabetes Prevention Program. Metabolism. 2016 May; 65(5):764-75. PMID: 27085783.
      View in: PubMed
    20. Perreault L, Starling AP, Glueck D, Brozinick JT, Sanders P, Siddall P, Kuo MS, Dabelea D, Bergman BC. Biomarkers of Ectopic Fat Deposition: The Next Frontier in Serum Lipidomics. J Clin Endocrinol Metab. 2016 Jan; 101(1):176-82. PMID: 26574956; PMCID: PMC4701843 [Available on 01/01/17].
      View in: PubMed, PubMed Central
    21. Eckel RH, Depner CM, Perreault L, Markwald RR, Smith MR, McHill AW, Higgins J, Melanson EL, Wright KP. Morning Circadian Misalignment during Short Sleep Duration Impacts Insulin Sensitivity. Curr Biol. 2015 Nov 16; 25(22):3004-10. PMID: 26549253.
      View in: PubMed
    22. Hivert MF, Christophi CA, Franks PW, Jablonski KA, Ehrmann DA, Kahn SE, Horton ES, Pollin TI, Mather KJ, Perreault L, Barrett-Connor E, Knowler WC, Florez JC. Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants. Diabetes. 2016 Feb; 65(2):520-6. PMID: 26525880; PMCID: PMC4747453 [Available on 02/01/17].
      View in: PubMed, PubMed Central
    23. Su W, Huang J, Chen F, Iacobucci W, Mocarski M, Dall TM, Perreault L. Modeling the clinical and economic implications of obesity using microsimulation. J Med Econ. 2015; 18(11):886-97. PMID: 26057567.
      View in: PubMed
    24. Bergman BC, Brozinick JT, Strauss A, Bacon S, Kerege A, Bui HH, Sanders P, Siddall P, Kuo MS, Perreault L. Serum sphingolipids: relationships to insulin sensitivity and changes with exercise in humans. Am J Physiol Endocrinol Metab. 2015 Aug 15; 309(4):E398-408. PMID: 26126684; PMCID: PMC4537923.
      View in: PubMed, PubMed Central
    25. Kim C, Christophi CA, Goldberg RB, Perreault L, Dabelea D, Marcovina SM, Pi-Sunyer X, Barrett-Connor E. Adiponectin, C-reactive protein, fibrinogen and tissue plasminogen activator antigen levels among glucose-intolerant women with and without histories of gestational diabetes. Diabet Med. 2016 Jan; 33(1):32-8. PMID: 25970741; PMCID: PMC4644121 [Available on 01/01/17].
      View in: PubMed, PubMed Central
    26. Delahanty LM, Pan Q, Jablonski KA, Aroda VR, Watson KE, Bray GA, Kahn SE, Florez JC, Perreault L, Franks PW. Effects of weight loss, weight cycling, and weight loss maintenance on diabetes incidence and change in cardiometabolic traits in the Diabetes Prevention Program. Diabetes Care. 2014 Oct; 37(10):2738-45. PMID: 25024396; PMCID: PMC4170126.
      View in: PubMed, PubMed Central
    27. Perreault L, Temprosa M, Mather KJ, Horton E, Kitabchi A, Larkin M, Montez MG, Thayer D, Orchard TJ, Hamman RF, Goldberg RB. Regression from prediabetes to normal glucose regulation is associated with reduction in cardiovascular risk: results from the Diabetes Prevention Program outcomes study. Diabetes Care. 2014 Sep; 37(9):2622-31. PMID: 24969574; PMCID: PMC4140157.
      View in: PubMed, PubMed Central
    28. Perreault L, Færch K, Kerege AA, Bacon SD, Bergman BC. Hepatic glucose sensing is impaired, but can be normalized, in people with impaired fasting glucose. J Clin Endocrinol Metab. 2014 Jul; 99(7):E1154-62. PMID: 24731008; PMCID: PMC4079303.
      View in: PubMed, PubMed Central
    29. Perreault L, Færch K. Approaching pre-diabetes. J Diabetes Complications. 2014 Mar-Apr; 28(2):226-33. PMID: 24342268.
      View in: PubMed
    30. Perreault L, McCurdy C, Kerege AA, Houck J, Færch K, Bergman BC. Bisphenol A impairs hepatic glucose sensing in C57BL/6 male mice. PLoS One. 2013; 8(7):e69991. PMID: 23922885; PMCID: PMC3726717.
      View in: PubMed, PubMed Central
    31. Markwald RR, Melanson EL, Smith MR, Higgins J, Perreault L, Eckel RH, Wright KP. Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5695-700. PMID: 23479616; PMCID: PMC3619301.
      View in: PubMed, PubMed Central
    32. Færch K, Witte DR, Tabák AG, Perreault L, Herder C, Brunner EJ, Kivimäki M, Vistisen D. Trajectories of cardiometabolic risk factors before diagnosis of three subtypes of type 2 diabetes: a post-hoc analysis of the longitudinal Whitehall II cohort study. Lancet Diabetes Endocrinol. 2013 Sep; 1(1):43-51. PMID: 24622266.
      View in: PubMed
    33. Bergman BC, Howard D, Schauer IE, Maahs DM, Snell-Bergeon JK, Clement TW, Eckel RH, Perreault L, Rewers M. The importance of palmitoleic acid to adipocyte insulin resistance and whole-body insulin sensitivity in type 1 diabetes. J Clin Endocrinol Metab. 2013 Jan; 98(1):E40-50. PMID: 23150678; PMCID: PMC3537110.
      View in: PubMed, PubMed Central
    34. Price DW, Ma Y, Rubin RR, Perreault L, Bray GA, Marrero D, Knowler WC, Barrett-Connor E, Lacoursiere DY. Depression as a predictor of weight regain among successful weight losers in the diabetes prevention program. Diabetes Care. 2013 Feb; 36(2):216-21. PMID: 23002085; PMCID: PMC3554307.
      View in: PubMed, PubMed Central
    35. Bergman BC, Perreault L, Hunerdosse D, Kerege A, Playdon M, Samek AM, Eckel RH. Novel and reversible mechanisms of smoking-induced insulin resistance in humans. Diabetes. 2012 Dec; 61(12):3156-66. PMID: 22966072; PMCID: PMC3501865.
      View in: PubMed, PubMed Central
    36. Færch K, Bergman B, Perreault L. Does insulin resistance drive the association between hyperglycemia and cardiovascular risk? PLoS One. 2012; 7(6):e39260. PMID: 22720085; PMCID: PMC3376119.
      View in: PubMed, PubMed Central
    37. Perreault L, Pan Q, Mather KJ, Watson KE, Hamman RF, Kahn SE. Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk: results from the Diabetes Prevention Program Outcomes Study. Lancet. 2012 Jun 16; 379(9833):2243-51. PMID: 22683134; PMCID: PMC3555407.
      View in: PubMed, PubMed Central
    38. Bergman BC, Howard D, Schauer IE, Maahs DM, Snell-Bergeon JK, Eckel RH, Perreault L, Rewers M. Features of hepatic and skeletal muscle insulin resistance unique to type 1 diabetes. J Clin Endocrinol Metab. 2012 May; 97(5):1663-72. PMID: 22362823; PMCID: PMC3339891.
      View in: PubMed, PubMed Central
    39. Bergman BC, Hunerdosse DM, Kerege A, Playdon MC, Perreault L. Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans. Diabetologia. 2012 Apr; 55(4):1140-50. PMID: 22252470; PMCID: PMC3296871.
      View in: PubMed, PubMed Central
    40. Florez H, Ma Y, Crandall JP, Perreault L, Marcovina SM, Bray GA, Saudek CD, Barrett-Connor E, Knowler WC. Parental longevity and diabetes risk in the Diabetes Prevention Program. J Gerontol A Biol Sci Med Sci. 2011 Nov; 66(11):1211-7. PMID: 21852284; PMCID: PMC3193521.
      View in: PubMed, PubMed Central
    41. Kim C, Edelstein SL, Crandall JP, Dabelea D, Kitabchi AE, Hamman RF, Montez MG, Perreault L, Foulkes MA, Barrett-Connor E. Menopause and risk of diabetes in the Diabetes Prevention Program. Menopause. 2011 Aug; 18(8):857-68. PMID: 21709591; PMCID: PMC3500880.
      View in: PubMed, PubMed Central
    42. Hivert MF, Jablonski KA, Perreault L, Saxena R, McAteer JB, Franks PW, Hamman RF, Kahn SE, Haffner S, Meigs JB, Altshuler D, Knowler WC, Florez JC. Updated genetic score based on 34 confirmed type 2 diabetes Loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program. Diabetes. 2011 Apr; 60(4):1340-8. PMID: 21378175; PMCID: PMC3064108.
      View in: PubMed, PubMed Central
    43. Perreault L, Bergman BC, Hunerdosse DM, Howard DJ, Eckel RH. Fenofibrate administration does not affect muscle triglyceride concentration or insulin sensitivity in humans. Metabolism. 2011 Aug; 60(8):1107-14. PMID: 21306746; PMCID: PMC3135750.
      View in: PubMed, PubMed Central
    44. Jung CM, Melanson EL, Frydendall EJ, Perreault L, Eckel RH, Wright KP. Energy expenditure during sleep, sleep deprivation and sleep following sleep deprivation in adult humans. J Physiol. 2011 Jan 01; 589(Pt 1):235-44. PMID: 21059762; PMCID: PMC3039272.
      View in: PubMed, PubMed Central
    45. Perreault L, Man CD, Hunerdosse DM, Cobelli C, Bergman BC. Incretin action maintains insulin secretion, but not hepatic insulin action, in people with impaired fasting glucose. Diabetes Res Clin Pract. 2010 Oct; 90(1):87-94. PMID: 20708814.
      View in: PubMed
    46. Perreault L, Bergman BC, Hunerdosse DM, Eckel RH. Altered intramuscular lipid metabolism relates to diminished insulin action in men, but not women, in progression to diabetes. Obesity (Silver Spring). 2010 Nov; 18(11):2093-100. PMID: 20379150; PMCID: PMC3230250.
      View in: PubMed, PubMed Central
    47. Bergman BC, Perreault L, Hunerdosse DM, Koehler MC, Samek AM, Eckel RH. Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes. J Appl Physiol (1985). 2010 May; 108(5):1134-41. PMID: 20299618; PMCID: PMC2867538.
      View in: PubMed, PubMed Central
    48. Perreault L, Bergman BC, Hunerdosse DM, Playdon MC, Eckel RH. Inflexibility in intramuscular triglyceride fractional synthesis distinguishes prediabetes from obesity in humans. Obesity (Silver Spring). 2010 Aug; 18(8):1524-31. PMID: 20035285; PMCID: PMC3232014.
      View in: PubMed, PubMed Central
    49. Crandall JP, Polsky S, Howard AA, Perreault L, Bray GA, Barrett-Connor E, Brown-Friday J, Whittington T, Foo S, Ma Y, Edelstein SL. Alcohol consumption and diabetes risk in the Diabetes Prevention Program. Am J Clin Nutr. 2009 Sep; 90(3):595-601. PMID: 19640960; PMCID: PMC2728644.
      View in: PubMed, PubMed Central
    50. Perreault L, Kahn SE, Christophi CA, Knowler WC, Hamman RF. Regression from pre-diabetes to normal glucose regulation in the diabetes prevention program. Diabetes Care. 2009 Sep; 32(9):1583-8. PMID: 19587364; PMCID: PMC2732165.
      View in: PubMed, PubMed Central
    51. Bergman BC, Perreault L, Hunerdosse DM, Koehler MC, Samek AM, Eckel RH. Intramuscular lipid metabolism in the insulin resistance of smoking. Diabetes. 2009 Oct; 58(10):2220-7. PMID: 19581421; PMCID: PMC2750212.
      View in: PubMed, PubMed Central
    52. Perreault L, Bergman BC, Playdon MC, Dalla Man C, Cobelli C, Eckel RH. Impaired fasting glucose with or without impaired glucose tolerance: progressive or parallel states of prediabetes? Am J Physiol Endocrinol Metab. 2008 Aug; 295(2):E428-35. PMID: 18523123; PMCID: PMC2519761.
      View in: PubMed, PubMed Central
    53. Perreault L, Ma Y, Dagogo-Jack S, Horton E, Marrero D, Crandall J, Barrett-Connor E. Sex differences in diabetes risk and the effect of intensive lifestyle modification in the Diabetes Prevention Program. Diabetes Care. 2008 Jul; 31(7):1416-21. PMID: 18356403; PMCID: PMC2453677.
      View in: PubMed, PubMed Central
    54. Perreault L, Lavely JM, Bergman BC, Horton TJ. Gender differences in insulin action after a single bout of exercise. J Appl Physiol (1985). 2004 Sep; 97(3):1013-21. PMID: 15145925.
      View in: PubMed
    55. Perreault L, Lavely JM, Kittelson JM, Horton TJ. Gender differences in lipoprotein lipase activity after acute exercise. Obes Res. 2004 Feb; 12(2):241-9. PMID: 14981216.
      View in: PubMed
    56. Dean TM, Perreault L, Mazzeo RS, Horton TJ. No effect of menstrual cycle phase on lactate threshold. J Appl Physiol (1985). 2003 Dec; 95(6):2537-43. PMID: 14600163.
      View in: PubMed
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