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Jonathan Van Blerkom

TitleResearch Professor
InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction
Phone303/492-6664

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    R01HD031907     (VAN BLERKOM, JONATHAN)May 1, 1994 - Apr 30, 1999
    NIH
    CAUSES OF OOCYTE DEVELOPMENT HETEROGENEITY
    Role: Principal Investigator
    R01HD021582     (VAN BLERKOM, JONATHAN)Apr 1, 1986 - Mar 31, 1989
    NIH
    ASSESSMENT OF CRYOPRESERVED EMBRYO VIABILITY
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ombelet W, Van Blerkom J, Bruckers L, Dhont N, Nargund G, Campo R. Promising Perinatal Outcome after Using a Simplified Low-Cost IVF Culture System Specifically Designed for Resource-Poor Countries. J Clin Med. 2023 Mar 15; 12(6). PMID: 36983264.
      View in: PubMed
    2. Ombelet W, Van Blerkom J, Nargund G, Janssen M, Jacobs P, Van der Auwera I, Dhont N, Bosmans E, Vertessen VJ, Campo R. Perinatal outcome of babies born after using a simplified IVF culture system versus ICSI with sibling oocytes: a prospective cohort study. Reprod Biomed Online. 2022 09; 45(3):574-582. PMID: 35760665.
      View in: PubMed
    3. Ombelet W, Van Blerkom J, Nargund G, Van der Auwera I, Janssen M, Dhont N, Bosmans E, Boshoff G, Vertessen VJ, Campo R. Multiyear outcomes using sibling oocytes demonstrates safety and efficacy of a simplified culture system consistent with use in a low-cost IVF setting. Reprod Biomed Online. 2022 09; 45(3):481-490. PMID: 36064261.
      View in: PubMed
    4. Van Blerkom J, Alikani M. Perivitelline threads: an overlooked feature of cleavage-stage human embryos or an epiphenomenon in search of a function? Reprod Biomed Online. 2017 12; 35(6):625-626. PMID: 29198321.
      View in: PubMed
    5. Van Blerkom J, Zimmermann S. Ganglioside-enriched microdomains define an oolemma that is functionally polarized with respect to fertilizability in the mouse. Reprod Biomed Online. 2016 Oct; 33(4):458-475. PMID: 27515228.
      View in: PubMed
    6. van Blerkom J, Cohen J, Johnson M. A plea for caution and more research in the 'experimental' use of ionophores in ICSI. Reprod Biomed Online. 2015 Apr; 30(4):323-4. PMID: 25841874.
      View in: PubMed
    7. Ombelet W, Van Blerkom J, Klerkx E, Janssen M, Dhont N, Mestdagh G, Nargund G, Campo R. The (t)WE lab Simplified IVF Procedure: First Births after freezing/thawing. Facts Views Vis Obgyn. 2014; 6(1):45-9. PMID: 25009725.
      View in: PubMed
    8. Van Blerkom J, Ombelet W, Klerkx E, Janssen M, Dhont N, Nargund G, Campo R. First births with a simplified culture system for clinical IVF and embryo transfer. Reprod Biomed Online. 2014 Mar; 28(3):310-20. PMID: 24456702.
      View in: PubMed
    9. Van Blerkom J, Caltrider K. Sperm attachment and penetration competence in the human oocyte: a possible aetiology of fertilization failure involving the organization of oolemmal lipid raft microdomains influenced by the ??m of subplasmalemmal mitochondria. Reprod Biomed Online. 2013 Dec; 27(6):690-701. PMID: 24157131.
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    10. Van Blerkom J. Mitochondrial function in the human oocyte and embryo and their role in developmental competence. Mitochondrion. 2011 Sep; 11(5):797-813. PMID: 20933103.
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    11. Van Blerkom J. Mitochondria in early mammalian development. Semin Cell Dev Biol. 2009 May; 20(3):354-64. PMID: 19136067.
      View in: PubMed
    12. Van Blerkom J, Davis P, Thalhammer V. Regulation of mitochondrial polarity in mouse and human oocytes: the influence of cumulus derived nitric oxide. Mol Hum Reprod. 2008 Aug; 14(8):431-44. PMID: 18591214.
      View in: PubMed
    13. Van Blerkom J. Mitochondria as regulatory forces in oocytes, preimplantation embryos and stem cells. Reprod Biomed Online. 2008 Apr; 16(4):553-69. PMID: 18413065.
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    14. Van Blerkom J, Davis P. Mitochondrial signaling and fertilization. Mol Hum Reprod. 2007 Nov; 13(11):759-70. PMID: 17893093.
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    15. Van Blerkom J. Translocation of the subplasmalemmal cytoplasm in human blastomeres: possible effects on the distribution and inheritance of regulatory domains. Reprod Biomed Online. 2007 Feb; 14(2):191-200. PMID: 17298722.
      View in: PubMed
    16. Van Blerkom J, Davis P. High-polarized (Delta Psi m(HIGH)) mitochondria are spatially polarized in human oocytes and early embryos in stable subplasmalemmal domains: developmental significance and the concept of vanguard mitochondria. Reprod Biomed Online. 2006 Aug; 13(2):246-54. PMID: 16895640.
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    17. Van Blerkom J, Cox H, Davis P. Regulatory roles for mitochondria in the peri-implantation mouse blastocyst: possible origins and developmental significance of differential DeltaPsim. Reproduction. 2006 May; 131(5):961-76. PMID: 16672360.
      View in: PubMed
    18. Van Blerkom J. Mitochondria in human oogenesis and preimplantation embryogenesis: engines of metabolism, ionic regulation and developmental competence. Reproduction. 2004 Sep; 128(3):269-80. PMID: 15333778.
      View in: PubMed
    19. Jones A, Van Blerkom J, Davis P, Toledo AA. Cryopreservation of metaphase II human oocytes effects mitochondrial membrane potential: implications for developmental competence. Hum Reprod. 2004 Aug; 19(8):1861-6. PMID: 15229209.
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    20. Van Blerkom J, Davis P, Alexander S. Occurrence of maternal and paternal spindles in unfertilized human oocytes: possible relationship to nucleation defects after silent fertilization. Reprod Biomed Online. 2004 Apr; 8(4):454-9. PMID: 15149570.
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    21. Van Blerkom J, Davis P, Alexander S. Inner mitochondrial membrane potential (DeltaPsim), cytoplasmic ATP content and free Ca2+ levels in metaphase II mouse oocytes. Hum Reprod. 2003 Nov; 18(11):2429-40. PMID: 14585897.
      View in: PubMed
    22. Van Blerkom J, Davis P. Differential effects of repeated ovarian stimulation on cytoplasmic and spindle organization in metaphase II mouse oocytes matured in vivo and in vitro. Hum Reprod. 2001 Apr; 16(4):757-64. PMID: 11278229.
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    23. Van Blerkom J, Davis P, Alexander S. A microscopic and biochemical study of fragmentation phenotypes in stage-appropriate human embryos. Hum Reprod. 2001 Apr; 16(4):719-29. PMID: 11278225.
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    24. Van Blerkom J, Davis P, Alexander S. Differential mitochondrial distribution in human pronuclear embryos leads to disproportionate inheritance between blastomeres: relationship to microtubular organization, ATP content and competence. Hum Reprod. 2000 Dec; 15(12):2621-33. PMID: 11098036.
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    25. Antczak M, Van Blerkom J. The vascular character of ovarian follicular granulosa cells: phenotypic and functional evidence for an endothelial-like cell population. Hum Reprod. 2000 Nov; 15(11):2306-18. PMID: 11056124.
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    26. Van Blerkom J. Intrafollicular influences on human oocyte developmental competence: perifollicular vascularity, oocyte metabolism and mitochondrial function. Hum Reprod. 2000 Jul; 15 Suppl 2:173-88. PMID: 11041523.
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    27. Antczak M, Van Blerkom J. Temporal and spatial aspects of fragmentation in early human embryos: possible effects on developmental competence and association with the differential elimination of regulatory proteins from polarized domains. Hum Reprod. 1999 Feb; 14(2):429-47. PMID: 10099991.
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    28. Van Blerkom J, Sinclair J, Davis P. Mitochondrial transfer between oocytes: potential applications of mitochondrial donation and the issue of heteroplasmy. Hum Reprod. 1998 Oct; 13(1O):2857-68. PMID: 9804246.
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    29. Van Blerkom J, Davis PW. DNA strand breaks and phosphatidylserine redistribution in newly ovulated and cultured mouse and human oocytes: occurrence and relationship to apoptosis. Hum Reprod. 1998 May; 13(5):1317-24. PMID: 9647566.
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    30. Van Blerkom J. Epigenetic influences on oocyte developmental competence: perifollicular vascularity and intrafollicular oxygen. J Assist Reprod Genet. 1998 May; 15(5):226-34. PMID: 9604752.
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    31. Antczak M, Van Blerkom J. Oocyte influences on early development: the regulatory proteins leptin and STAT3 are polarized in mouse and human oocytes and differentially distributed within the cells of the preimplantation stage embryo. Mol Hum Reprod. 1997 Dec; 3(12):1067-86. PMID: 9464852.
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    32. Antczak M, Van Blerkom J, Clark A. A novel mechanism of vascular endothelial growth factor, leptin and transforming growth factor-beta2 sequestration in a subpopulation of human ovarian follicle cells. Hum Reprod. 1997 Oct; 12(10):2226-34. PMID: 9402286.
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    33. Van Blerkom J. Can the developmental competence of early human embryos be predicted effectively in the clinical IVF laboratory? Hum Reprod. 1997 Aug; 12(8):1610-4. PMID: 9308777.
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    34. Cioffi JA, Van Blerkom J, Antczak M, Shafer A, Wittmer S, Snodgrass HR. The expression of leptin and its receptors in pre-ovulatory human follicles. Mol Hum Reprod. 1997 Jun; 3(6):467-72. PMID: 9239734.
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    35. Van Blerkom J, Antczak M, Schrader R. The developmental potential of the human oocyte is related to the dissolved oxygen content of follicular fluid: association with vascular endothelial growth factor levels and perifollicular blood flow characteristics. Hum Reprod. 1997 May; 12(5):1047-55. PMID: 9194664.
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    36. Tar?n JJ, Vendrell FJ, Ten J, Blanes R, van Blerkom J, Cano A. The oxidizing agent tertiary butyl hydroperoxide induces disturbances in spindle organization, c-meiosis, and aneuploidy in mouse oocytes. Mol Hum Reprod. 1996 Dec; 2(12):895-901. PMID: 9237232.
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    37. Van Blerkom J. Sperm centrosome dysfunction: a possible new class of male factor infertility in the human. Mol Hum Reprod. 1996 May; 2(5):349-54. PMID: 9238702.
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    38. Van Blerkom J. The influence of intrinsic and extrinsic factors on the developmental potential and chromosomal normality of the human oocyte. J Soc Gynecol Investig. 1996 Jan-Feb; 3(1):3-11. PMID: 8796799.
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    39. Van Blerkom J, Davis P, Merriam J, Sinclair J. Nuclear and cytoplasmic dynamics of sperm penetration, pronuclear formation and microtubule organization during fertilization and early preimplantation development in the human. Hum Reprod Update. 1995 Sep; 1(5):429-61. PMID: 9080219.
      View in: PubMed
    40. Van Blerkom J, Davis P. Evolution of the sperm aster after microinjection of isolated human sperm centrosomes into meiotically mature human oocytes. Hum Reprod. 1995 Aug; 10(8):2179-82. PMID: 8567869.
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    41. Van Blerkom J, Davis PW, Lee J. ATP content of human oocytes and developmental potential and outcome after in-vitro fertilization and embryo transfer. Hum Reprod. 1995 Feb; 10(2):415-24. PMID: 7769073.
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    42. Van Blerkom J, Davis PW, Merriam J. A retrospective analysis of unfertilized and presumed parthenogentically activated human oocytes demonstrates a high frequency of sperm penetration. Hum Reprod. 1994 Dec; 9(12):2381-8. PMID: 7714162.
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    43. Van Blerkom J, Davis PW, Merriam J. The developmental ability of human oocytes penetrated at the germinal vesicle stage after insemination in vitro. Hum Reprod. 1994 Apr; 9(4):697-708. PMID: 8046026.
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    44. Van Blerkom J, Davis PW. Cytogenetic, cellular, and developmental consequences of cryopreservation of immature and mature mouse and human oocytes. Microsc Res Tech. 1994 Feb 01; 27(2):165-93. PMID: 8123908.
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    45. Van Blerkom J. Development of human embryos to the hatched blastocyst stage in the presence or absence of a monolayer of Vero cells. Hum Reprod. 1993 Sep; 8(9):1525-39. PMID: 8253948.
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    46. Van Blerkom J, Henry G. Oocyte dysmorphism and aneuploidy in meiotically mature human oocytes after ovarian stimulation. Hum Reprod. 1992 Mar; 7(3):379-90. PMID: 1587948.
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    47. Van Blerkom J. Microtubule mediation of cytoplasmic and nuclear maturation during the early stages of resumed meiosis in cultured mouse oocytes. Proc Natl Acad Sci U S A. 1991 Jun 01; 88(11):5031-5. PMID: 2052585.
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    48. Van Blerkom J, Henry G. Dispermic fertilization of human oocytes. J Electron Microsc Tech. 1991 Apr; 17(4):437-49. PMID: 1865241.
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    49. Van Blerkom J. Occurrence and developmental consequences of aberrant cellular organization in meiotically mature human oocytes after exogenous ovarian hyperstimulation. J Electron Microsc Tech. 1990 Dec; 16(4):324-46. PMID: 2250186.
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    50. Van Blerkom J, Bell H, Weipz D. Cellular and developmental biological aspects of bovine meiotic maturation, fertilization, and preimplantation embryogenesis in vitro. J Electron Microsc Tech. 1990 Dec; 16(4):298-323. PMID: 2250185.
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    51. Van Blerkom J. Maturation at high frequency of germinal-vesicle-stage mouse oocytes after cryopreservation: alterations in cytoplasmic, nuclear, nucleolar and chromosomal structure and organization associated with vitrification. Hum Reprod. 1989 Nov; 4(8):883-98. PMID: 2693483.
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    52. Van Blerkom J. The origin and detection of chromosomal abnormalities in meiotically mature human oocytes obtained from stimulated follicles and after failed fertilization in vitro. Prog Clin Biol Res. 1989; 296:299-310. PMID: 2740382.
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    53. Van Blerkom J. Morphodynamics of nuclear and cytoplasmic reorganization during the resumption of arrested meiosis in the mouse oocyte. Prog Clin Biol Res. 1989; 294:33-51. PMID: 2657780.
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    54. Van Blerkom J, Henry G. Cytogenetic analysis of living human oocytes: cellular basis and developmental consequences of perturbations in chromosomal organization and complement. Hum Reprod. 1988 Aug; 3(6):777-90. PMID: 3220943.
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    55. Van Blerkom J, Bell H, Henry G. The occurrence, recognition and developmental fate of pseudo-multipronuclear eggs after in-vitro fertilization of human oocytes. Hum Reprod. 1987 Apr; 2(3):217-25. PMID: 3597742.
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    56. Van Blerkom J, Bell H. Regulation of development in the fully grown mouse oocyte: chromosome-mediated temporal and spatial differentiation of the cytoplasm and plasma membrane. J Embryol Exp Morphol. 1986 Apr; 93:213-38. PMID: 3734683.
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    57. Van Blerkom J. Extragenomic regulation and autonomous expression of a developmental program in the early mammalian embryo. Ann N Y Acad Sci. 1985; 442:58-72. PMID: 3860060.
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    58. Johnson MH, McConnell J, Van Blerkom J. Programmed development in the mouse embryo. J Embryol Exp Morphol. 1984 Nov; 83 Suppl:197-231. PMID: 6085344.
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    59. Van Blerkom J, Runner MN. Mitochondrial reorganization during resumption of arrested meiosis in the mouse oocyte. Am J Anat. 1984 Nov; 171(3):335-55. PMID: 6517035.
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    60. Janzen RG, Van Blerkom J, Runner MN. Identification and characterization of glycoproteins secreted by the skin of the day 16 fetal mouse. J Exp Zool. 1984 Oct; 232(1):99-105. PMID: 6502095.
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    61. Van Blerkom J, Henry G, Porreco R. Preimplantation human embryonic development from polypronuclear eggs after in vitro fertilization. Fertil Steril. 1984 May; 41(5):686-96. PMID: 6714447.
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    62. Henry GP, Van Blerkom J, Porreco R. Human in vitro fertilization in a private program: Reproductive Genetics in Vitro, P.C. J In Vitro Fert Embryo Transf. 1984 Mar; 1(1):76-9. PMID: 6336090.
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    63. Weil J, Epstein CJ, Epstein LB, van Blerkom J, Xuong NH. Computer-assisted analysis demonstrates that polypeptides induced by natural and recombinant human interferon-alpha are the same and that some have related primary structures. Antiviral Res. 1983 Dec; 3(5-6):303-14. PMID: 6230991.
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    64. Van Blerkom J, Janzen R, Runner MN. The patterns of protein synthesis during foetal and neonatal organ development in the mouse are remarkably similar. J Embryol Exp Morphol. 1982 Dec; 72:97-116. PMID: 6190973.
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    65. Schliwa M, Pryzwansky KB, van Blerkom J. Implications of cytoskeletal interactions for cellular architecture and behavior. Philos Trans R Soc Lond B Biol Sci. 1982 Nov 04; 299(1095):199-205. PMID: 6129656.
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    66. Schliwa M, van Blerkom J, Pryzwansky KB. Structural organization of the cytoplasm. Cold Spring Harb Symp Quant Biol. 1982; 46 Pt 1:51-67. PMID: 7049532.
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    67. Van Blerkom J. Structural relationship and posttranslational modification of stage-specific proteins synthesized during early preimplantation development in the mouse. Proc Natl Acad Sci U S A. 1981 Dec; 78(12):7629-33. PMID: 6950405.
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    68. Van Blerkom J, Chavez DJ. Morphodynamics of outgrowths of mouse trophoblast in the presence and absence of a monolayer of uterine epithelium. Am J Anat. 1981 Oct; 162(2):143-55. PMID: 7304469.
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    69. Schliwa M, van Blerkom J, Porter KR. Stabilization and the cytoplasmic ground substance in detergent-opened cells and a structural and biochemical analysis of its composition. Proc Natl Acad Sci U S A. 1981 Jul; 78(7):4329-33. PMID: 6945586.
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    70. Schliwa M, van Blerkom J. Structural interaction of cytoskeletal components. J Cell Biol. 1981 Jul; 90(1):222-35. PMID: 7019221.
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    71. Van Blerkom J. Molecular differentiation of the rabbit ovum. III. Fertilization-autonomous polypeptide synthesis. Dev Biol. 1979 Sep; 72(1):188-94. PMID: 510777.
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    72. Van Blerkom J, Motta P. A scanning electron microscopic study of the luteo-follicular complex. III. Repair of ovulated follicle and the formation of the corpus luteum. Cell Tissue Res. 1978 May 18; 189(1):131-53. PMID: 667907.
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    73. Van Blerkom J, McGaughey RW. Molecular differentiation of the rabbit ovum. II. During the preimplantation development of in vivo and in vitro matured oocytes. Dev Biol. 1978 Mar; 63(1):151-64. PMID: 564792.
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    74. Van Blerkom J, McGaughey RW. Molecular differentiation of the rabbit ovum. I. During oocyte maturation in vivo and in vitro. Dev Biol. 1978 Mar; 63(1):139-50. PMID: 631424.
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    75. Van Blerkom J, Chavez DJ, Bell H. Molecular and cellular aspects of facultative delayed implantation in the mouse. Ciba Found Symp. 1978; (64):141-72. PMID: 259037.
      View in: PubMed
    76. McGaughey RW, Van Blerkom J. Patterns of polypeptide synthesis of porcine oocytes during maturation in vitro. Dev Biol. 1977 Apr; 56(2):241-54. PMID: 849799.
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    77. Van Blerkom J, Runner MN. The fine structural development of preimplantation mouse parthenotes. J Exp Zool. 1976 Apr; 196(1):113-24. PMID: 932654.
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    78. Van Blerkom J, Barton SC, Johnson MH. Molecular differentiation in the preimplantation mouse embryo. Nature. 1976 Jan 29; 259(5541):319-21. PMID: 943045.
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    79. Motta P, Van Blerkom J. A scanning electron microscopic study of rabbit spermatozoa in the female reproductive tract following coitus. Cell Tissue Res. 1975 Nov 17; 163(1):29-44. PMID: 1182779.
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    80. Van Blerkom J, Brockway GO. Qualitative patterns of protein synthesis in the preimplantation mouse embryo. II. During release from facultative delayed implantation. Dev Biol. 1975 Oct; 46(2):446-51. PMID: 1242382.
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    81. Motta P, Van Blerkom J. A scanning electron microscopic study of the luteo-follicular complex. II. Events leading to ovulation. Am J Anat. 1975 Jun; 143(2):241-63. PMID: 1170753.
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    82. van Blerkom J, Brockway GO. Qualitative patterns of protein synthesis in the preimplantation mouse embryo. I. Normal pregnancy. Dev Biol. 1975 May; 44(1):148-57. PMID: 1132583.
      View in: PubMed
    83. Van Blerkom J, Manes C. Development of preimplantation rabbit embryos in vivo and in vitro. Dev Biol. 1974 Sep; 40(1):40-51. PMID: 4472058.
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    84. Van Blerkom J, Manes C, Daniel JC. Development of preimplantation rabbit embryos in vivo and in vitro. I. An ultrastructural comparison. Dev Biol. 1973 Dec; 35(2):262-82. PMID: 4363068.
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