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Judith Tamara Blaine

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-4841

    Collapse Research 
    Collapse research activities and funding
    F30MH011349     (BLAINE, JUDITH T)Oct 17, 1996
    NIH/NIMH
    MOLECULAR IDENTIFICATION OF FUNCTIONAL K+ CHANNELS
    Role: Principal Investigator
    F32DK076441     (BLAINE, JUDITH T)Jul 1, 2006 - Jun 30, 2007
    NIH/NIDDK
    Trafficking of NaPilla in brush border microvilli
    Role: Principal Investigator
    K08DK080989     (BLAINE, JUDITH T)Sep 1, 2009 - Aug 31, 2014
    NIH/NIDDK
    Molecular Mechanisms of PTH-Mediated Trafficking in Renal Tubular Cells
    Role: Principal Investigator
    R03DK099544     (BLAINE, JUDITH T)Jul 1, 2013 - Jun 30, 2015
    NIH/NIDDK
    Molecular Mechanisms of Albumin Trafficking in Podocytes
    Role: Principal Investigator
    R01DK104264     (BLAINE, JUDITH T.)Sep 1, 2015 - Jul 31, 2020
    NIH/NIDDK
    The Dual Role of the Neonatal Fc Receptor (FcRn) in Podocytes
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dylewski JF, Tonsawan P, Garcia G, Lewis L, Blaine J. Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of glomerulonephritis. PLoS One. 2020; 15(12):e0230401. PMID: 33370294.
      View in: PubMed
    2. Dylewski JF, Wilson N, Lu S, Jat P, Weiser-Evans M, Panzer SE, Blaine J. Isolation, purification, and conditional immortalization of murine glomerular endothelial cells of microvascular phenotype. MethodsX. 2020; 7:101048. PMID: 32944514.
      View in: PubMed
    3. Blaine J, Dylewski J. Regulation of the Actin Cytoskeleton in Podocytes. Cells. 2020 07 16; 9(7). PMID: 32708597.
      View in: PubMed
    4. Wilson NA, Dylewski J, Degner KR, O'Neill MA, Reese SR, Hidalgo LG, Blaine J, Panzer SE. An in vitro model of antibody-mediated injury to glomerular endothelial cells: Upregulation of MHC class II and adhesion molecules. Transpl Immunol. 2020 02; 58:101261. PMID: 31887408.
      View in: PubMed
    5. Skrypnyk NI, Gist KM, Okamura K, Montford JR, You Z, Yang H, Moldovan R, Bodoni E, Blaine JT, Edelstein CL, Soranno DE, Kirkbride-Romeo LA, Griffin BR, Altmann C, Faubel S. IL-6-mediated hepatocyte production is the primary source of plasma and urine neutrophil gelatinase-associated lipocalin during acute kidney injury. Kidney Int. 2020 05; 97(5):966-979. PMID: 32081304.
      View in: PubMed
    6. Tonsawan P, Dylewski J, Lewis L, Blaine J. Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton. Am J Physiol Cell Physiol. 2019 11 01; 317(5):C1048-C1060. PMID: 31553647.
      View in: PubMed
    7. Dylewski J, Dobrinskikh E, Lewis L, Tonsawan P, Miyazaki M, Jat PS, Blaine J. Differential trafficking of albumin and IgG facilitated by the neonatal Fc receptor in podocytes in vitro and in vivo. PLoS One. 2019; 14(2):e0209732. PMID: 30811433.
      View in: PubMed
    8. Dobrinskikh E, Lewis L, Brian Doctor R, Okamura K, Lee MG, Altmann C, Faubel S, Kopp JB, Blaine J. Shank2 Regulates Renal Albumin Endocytosis. Physiol Rep. 2015 Sep; 3(9). PMID: 26333830.
      View in: PubMed
    9. Blaine J, Chonchol M, Levi M. Renal control of calcium, phosphate, and magnesium homeostasis. Clin J Am Soc Nephrol. 2015 Jul 07; 10(7):1257-72. PMID: 25287933.
      View in: PubMed
    10. Hung KW, Blaine J, Faubel S. Dual therapy difficulties in angiotensin blockade for proteinuria: a teachable moment. JAMA Intern Med. 2014 Sep; 174(9):1429-30. PMID: 25089763.
      View in: PubMed
    11. Carson JM, Okamura K, Wakashin H, McFann K, Dobrinskikh E, Kopp JB, Blaine J. Podocytes degrade endocytosed albumin primarily in lysosomes. PLoS One. 2014; 9(6):e99771. PMID: 24924335.
      View in: PubMed
    12. Dobrinskikh E, Okamura K, Kopp JB, Doctor RB, Blaine J. Human podocytes perform polarized, caveolae-dependent albumin endocytosis. Am J Physiol Renal Physiol. 2014 May 01; 306(9):F941-51. PMID: 24573386.
      View in: PubMed
    13. Okamura K, Dummer P, Kopp J, Qiu L, Levi M, Faubel S, Blaine J. Endocytosis of albumin by podocytes elicits an inflammatory response and induces apoptotic cell death. PLoS One. 2013; 8(1):e54817. PMID: 23382978.
      View in: PubMed
    14. Blaine J, Levi M. Chronic kidney disease: Albuminuria or CKD stage as best marker of CVD in diabetes? Nat Rev Nephrol. 2012 May 29; 8(7):376-7. PMID: 22641078.
      View in: PubMed
    15. Caldas YA, Giral H, Cortázar MA, Sutherland E, Okamura K, Blaine J, Sorribas V, Koepsell H, Levi M. Liver X receptor-activating ligands modulate renal and intestinal sodium-phosphate transporters. Kidney Int. 2011 Sep; 80(5):535-44. PMID: 21677638.
      View in: PubMed
    16. Lanzano L, Lei T, Okamura K, Giral H, Caldas Y, Masihzadeh O, Gratton E, Levi M, Blaine J. Differential modulation of the molecular dynamics of the type IIa and IIc sodium phosphate cotransporters by parathyroid hormone. . 2011 Oct; 301(4):C850-61. PMID: 21593452.
      View in: PubMed
    17. Giral H, Lanzano L, Caldas Y, Blaine J, Verlander JW, Lei T, Gratton E, Levi M. Role of PDZK1 protein in apical membrane expression of renal sodium-coupled phosphate transporters. J Biol Chem. 2011 Apr 29; 286(17):15032-42. PMID: 21388960.
      View in: PubMed
    18. Blaine J, Weinman EJ, Cunningham R. The regulation of renal phosphate transport. Adv Chronic Kidney Dis. 2011 Mar; 18(2):77-84. PMID: 21406291.
      View in: PubMed
    19. Blaine J, Lanzano L, Giral H, Caldas Y, Levi M, Gratton E, Moldovan R, Lei T. Dynamic imaging of the sodium phosphate cotransporters. Adv Chronic Kidney Dis. 2011 Mar; 18(2):145-50. PMID: 21406299.
      View in: PubMed
    20. Blaine J, Okamura K, Giral H, Breusegem S, Caldas Y, Millard A, Barry N, Levi M. PTH-induced internalization of apical membrane NaPi2a: role of actin and myosin VI. . 2009 Dec; 297(6):C1339-46. PMID: 19776390.
      View in: PubMed
    21. Giral H, Caldas Y, Sutherland E, Wilson P, Breusegem S, Barry N, Blaine J, Jiang T, Wang XX, Levi M. Regulation of rat intestinal Na-dependent phosphate transporters by dietary phosphate. Am J Physiol Renal Physiol. 2009 Nov; 297(5):F1466-75. PMID: 19675183.
      View in: PubMed
    22. Breusegem SY, Takahashi H, Giral-Arnal H, Wang X, Jiang T, Verlander JW, Wilson P, Miyazaki-Anzai S, Sutherland E, Caldas Y, Blaine JT, Segawa H, Miyamoto K, Barry NP, Levi M. Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency. Am J Physiol Renal Physiol. 2009 Aug; 297(2):F350-61. PMID: 19493963.
      View in: PubMed
    23. Levi M, Blaine J, Breusegem S, Takahashi H, Sorribas V, Barry N. Renal phosphate-wasting disorders. Adv Chronic Kidney Dis. 2006 Apr; 13(2):155-65. PMID: 16580617.
      View in: PubMed
    24. Perry C, Blaine J, Le H, Grichtchenko II. PMA- and ANG II-induced PKC regulation of the renal Na+-HCO3- cotransporter (hkNBCe1). Am J Physiol Renal Physiol. 2006 Feb; 290(2):F417-27. PMID: 16159892.
      View in: PubMed
    25. Blaine JT, Taylor AD, Ribera AB. Carboxyl tail region of the Kv2.2 subunit mediates novel developmental regulation of channel density. J Neurophysiol. 2004 Dec; 92(6):3446-54. PMID: 15306626.
      View in: PubMed
    26. Blaine JT, Ribera AB. Kv2 channels form delayed-rectifier potassium channels in situ. J Neurosci. 2001 Mar 01; 21(5):1473-80. PMID: 11222637.
      View in: PubMed
    27. Blaine JT, Ribera AB. Heteromultimeric potassium channels formed by members of the Kv2 subfamily. J Neurosci. 1998 Dec 01; 18(23):9585-93. PMID: 9822719.
      View in: PubMed
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