Mannich Bases
"Mannich Bases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Ketonic amines prepared from the condensation of a ketone with formaldehyde and ammonia or a primary or secondary amine. A Mannich base can act as the equivalent of an alpha,beta unsaturated ketone in synthesis or can be reduced to form physiologically active amino alcohols.
| Descriptor ID |
D008352
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| MeSH Number(s) |
D02.092.650 D02.522.650
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Mannich Bases".
Below are MeSH descriptors whose meaning is more specific than "Mannich Bases".
This graph shows the total number of publications written about "Mannich Bases" by people in this website by year, and whether "Mannich Bases" was a major or minor topic of these publications.
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Below are the most recent publications written about "Mannich Bases" by people in Profiles.
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Mazzei M, Nieddu E, Miele M, Balbi A, Ferrone M, Fermeglia M, Mazzei MT, Pricl S, La Colla P, Marongiu F, Ibba C, Loddo R. Activity of Mannich bases of 7-hydroxycoumarin against Flaviviridae. Bioorg Med Chem. 2008 Mar 01; 16(5):2591-605.
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Cogan PS, Koch TH. Studies of targeting and intracellular trafficking of an anti-androgen doxorubicin-formaldehyde conjugate in PC-3 prostate cancer cells bearing androgen receptor-GFP chimera. J Med Chem. 2004 Nov 04; 47(23):5690-9.