 Kynurenine
"Kynurenine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
| Descriptor ID |
D007737
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| MeSH Number(s) |
D12.125.608
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Kynurenine".
Below are MeSH descriptors whose meaning is more specific than "Kynurenine".
This graph shows the total number of publications written about "Kynurenine" by people in this website by year, and whether "Kynurenine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2002 | 1 | 0 | 1 | | 2005 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 2 | 0 | 2 | | 2010 | 3 | 0 | 3 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 1 | 2 | | 2016 | 3 | 1 | 4 | | 2017 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Kynurenine" by people in Profiles.
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Peng X, Brenner LA, Mathai AJ, Cook TB, Fuchs D, Postolache N, Groer MW, Pandey JP, Mohyuddin F, Giegling I, Wadhawan A, Hartmann AM, Konte B, Brundin L, Friedl M, Stiller JW, Lowry CA, Rujescu D, Postolache TT. Moderation of the relationship between Toxoplasma gondii seropositivity and trait impulsivity in younger men by the phenylalanine-tyrosine ratio. Psychiatry Res. 2018 12; 270:992-1000.
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Lanis JM, Alexeev EE, Curtis VF, Kitzenberg DA, Kao DJ, Battista KD, Gerich ME, Glover LE, Kominsky DJ, Colgan SP. Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia. Mucosal Immunol. 2017 09; 10(5):1133-1144.
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Okusaga O, Fuchs D, Reeves G, Giegling I, Hartmann AM, Konte B, Friedl M, Groer M, Cook TB, Stearns-Yoder KA, Pandey JP, Kelly DL, Hoisington AJ, Lowry CA, Eaton WW, Brenner LA, Rujescu D, Postolache TT. Kynurenine and Tryptophan Levels in Patients With Schizophrenia and Elevated Antigliadin Immunoglobulin G Antibodies. Psychosom Med. 2016 10; 78(8):931-939.
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Coccaro EF, Lee R, Fanning JR, Fuchs D, Goiny M, Erhardt S, Christensen K, Brundin L, Coussons-Read M. Tryptophan, kynurenine, and kynurenine metabolites: Relationship to lifetime aggression and inflammatory markers in human subjects. Psychoneuroendocrinology. 2016 09; 71:189-96.
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Chiappelli J, Postolache TT, Kochunov P, Rowland LM, Wijtenburg SA, Shukla DK, Tagamets M, Du X, Savransky A, Lowry CA, Can A, Fuchs D, Hong LE. Tryptophan Metabolism and White Matter Integrity in Schizophrenia. Neuropsychopharmacology. 2016 09; 41(10):2587-95.
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Rakete S, Nagaraj RH. Identification of Kynoxazine, a Novel Fluorescent Product of the Reaction between 3-Hydroxykynurenine and Erythrulose in the Human Lens, and Its Role in Protein Modification. J Biol Chem. 2016 Apr 29; 291(18):9596-609.
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Okusaga O, Duncan E, Langenberg P, Brundin L, Fuchs D, Groer MW, Giegling I, Stearns-Yoder KA, Hartmann AM, Konte B, Friedl M, Brenner LA, Lowry CA, Rujescu D, Postolache TT. Combined Toxoplasma gondii seropositivity and high blood kynurenine--Linked with nonfatal suicidal self-directed violence in patients with schizophrenia. J Psychiatr Res. 2016 Jan; 72:74-81.
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D'Amato NC, Rogers TJ, Gordon MA, Greene LI, Cochrane DR, Spoelstra NS, Nemkov TG, D'Alessandro A, Hansen KC, Richer JK. A TDO2-AhR signaling axis facilitates anoikis resistance and metastasis in triple-negative breast cancer. Cancer Res. 2015 Nov 01; 75(21):4651-64.
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Linetsky M, Raghavan CT, Johar K, Fan X, Monnier VM, Vasavada AR, Nagaraj RH. UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens aging and cataract formation. J Biol Chem. 2014 Jun 13; 289(24):17111-23.
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Mailankot M, Howell S, Nagaraj RH. Kynurenine inhibits fibroblast growth factor 2-mediated expression of crystallins and MIP26 in lens epithelial cells. Biochim Biophys Acta. 2010 Jul-Aug; 1802(7-8):609-20.
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