Staurosporine
"Staurosporine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)
Descriptor ID |
D019311
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MeSH Number(s) |
D03.132.436.750 D03.633.100.473.144.750 D03.633.100.473.402.750 D03.633.300.148.750
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Staurosporine".
Below are MeSH descriptors whose meaning is more specific than "Staurosporine".
This graph shows the total number of publications written about "Staurosporine" by people in this website by year, and whether "Staurosporine" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1997 | 0 | 1 | 1 | 1999 | 0 | 2 | 2 | 2000 | 0 | 1 | 1 | 2003 | 0 | 1 | 1 | 2005 | 0 | 1 | 1 | 2007 | 0 | 1 | 1 | 2010 | 0 | 1 | 1 | 2011 | 0 | 1 | 1 | 2013 | 2 | 1 | 3 | 2015 | 0 | 1 | 1 | 2017 | 1 | 0 | 1 | 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Staurosporine" by people in Profiles.
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Jamieson LE, Harrison DJ, Campbell CJ. Raman spectroscopy investigation of biochemical changes in tumor spheroids with aging and after treatment with staurosporine. J Biophotonics. 2019 05; 12(5):e201800201.
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Le-Rademacher JG, Peterson RA, Therneau TM, Sanford BL, Stone RM, Mandrekar SJ. Application of multi-state models in cancer clinical trials. Clin Trials. 2018 10; 15(5):489-498.
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Al-Tamari HM, Dabral S, Schmall A, Sarvari P, Ruppert C, Paik J, DePinho RA, Grimminger F, Eickelberg O, Guenther A, Seeger W, Savai R, Pullamsetti SS. FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis. EMBO Mol Med. 2018 02; 10(2):276-293.
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Stansfield LC, Pollyea DA. Midostaurin: A New Oral Agent Targeting FMS-Like Tyrosine Kinase 3-Mutant Acute Myeloid Leukemia. Pharmacotherapy. 2017 12; 37(12):1586-1599.
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Kumar S, Tomar MS, Acharya A. Activation of p53-dependent/-independent pathways of apoptotic cell death by chelerythrine in a murine T cell lymphoma. Leuk Lymphoma. 2015 Jun; 56(6):1846-55.
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Mukthavaram R, Jiang P, Saklecha R, Simberg D, Bharati IS, Nomura N, Chao Y, Pastorino S, Pingle SC, Fogal V, Wrasidlo W, Makale M, Kesari S. High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile. Int J Nanomedicine. 2013; 8:3991-4006.
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Barcomb K, Coultrap SJ, Bayer KU. Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B. Mol Pharmacol. 2013 Dec; 84(6):834-43.
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Sawant DA, Tharakan B, Tobin RP, Reilly J, Hunter FA, Newell MK, Smythe WR, Childs EW. Microvascular endothelial cell hyperpermeability induced by endogenous caspase 3 activator staurosporine. J Trauma Acute Care Surg. 2013 Feb; 74(2):516-23.
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Roberson EC, Tully JE, Guala AS, Reiss JN, Godburn KE, Pociask DA, Alcorn JF, Riches DW, Dienz O, Janssen-Heininger YM, Anathy V. Influenza induces endoplasmic reticulum stress, caspase-12-dependent apoptosis, and c-Jun N-terminal kinase-mediated transforming growth factor-? release in lung epithelial cells. Am J Respir Cell Mol Biol. 2012 May; 46(5):573-81.
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MacEneaney OJ, Kushner EJ, Westby CM, Cech JN, Greiner JJ, Stauffer BL, DeSouza CA. Endothelial progenitor cell function, apoptosis, and telomere length in overweight/obese humans. Obesity (Silver Spring). 2010 Sep; 18(9):1677-82.
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