 Dideoxyadenosine
"Dideoxyadenosine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.
| Descriptor ID |
D016048
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| MeSH Number(s) |
D03.633.100.759.590.138.325.105 D13.570.230.229.105 D13.570.230.500.105 D13.570.583.138.325.105
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| Concept/Terms |
Dideoxyadenosine- Dideoxyadenosine
- 2',3'-Dideoxyadenosine
- 2',3' Dideoxyadenosine
- ddA (Antiviral)
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Below are MeSH descriptors whose meaning is more general than "Dideoxyadenosine".
Below are MeSH descriptors whose meaning is more specific than "Dideoxyadenosine".
This graph shows the total number of publications written about "Dideoxyadenosine" by people in this website by year, and whether "Dideoxyadenosine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dideoxyadenosine" by people in Profiles.
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Rabie H, Yin DE, Ward S, Rani Y, Ziemba L, Brooks KM, Cressey TR, Masheto GR, Cassim H, Deville JG, Ponatshego PL, Patel F, Aurpibul L, Barnabas SL, Mustich I, Coletti A, Heckman B, Krotje C, Townley E, Moye J, Majji S, Acosta EP, Ryan K, Chandasana H, Brothers CH, Buchanan AM, Flynn PM. Efficacy, Safety and Tolerability of Dispersible and Immediate Release Abacavir/Dolutegravir/Lamivudine Tablets in Children With HIV: IMPAACT 2019 Week 48 Results. Pediatr Infect Dis J. 2025 May 29; 44(8):777-784.
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Boyle MJ, Connors M, Flanigan ME, Geiger SP, Ford H, Baseler M, Adelsberger J, Davey RT, Lane HC. The human HIV/peripheral blood lymphocyte (PBL)-SCID mouse. A modified human PBL-SCID model for the study of HIV pathogenesis and therapy. J Immunol. 1995 Jun 15; 154(12):6612-23.
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Teitelbaum I, Strasheim A. AVP stimulates adenylyl cyclase and phospholipase C in reciprocal fashion in cultured RIMCT cells. Am J Physiol. 1990 Oct; 259(4 Pt 1):C693-6.
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