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Jed N. Lampe

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-Administration
Phone303/724-3397

    Collapse Research 
    Collapse research activities and funding
    R01AI183687     (LAMPE, JED NOAH)Feb 5, 2024 - Dec 31, 2028
    NIH
    Understanding the underlying toxicological mechanisms of drug-hormone interactions to improve the safety profile of antiviral medications in pregnant people, developing fetuses, and neonates
    Role: Principal Investigator

    R01AI176245     (LAMPE, JED NOAH)Dec 11, 2023 - Oct 31, 2028
    NIH
    Impact of Pseudomonas aeruginosa cytochrome P450 enzymes and secondary metabolites on drug metabolism and disposition in the cystic fibrosis patient
    Role: Principal Investigator

    R21ES032529     (LAMPE, JED NOAH)Dec 1, 2021 - Nov 30, 2023
    NIH
    Perfluoroalkanoate (PFAS) modulation of the inflammatory response through potent inhibition of arachidonic acid metabolizing cyclooxygenase and cytochrome P450 enzymes
    Role: Principal Investigator

    R01AI150494     (LAMPE, JED NOAH)Aug 1, 2018 - May 31, 2023
    NIH
    The role of CYP3A7 in the disposition and toxicity of HIV inhibitors in the developing infant
    Role: Principal Investigator

    R01GM128508     (LAMPE, JED NOAH)Aug 1, 2018 - May 31, 2023
    NIH
    The role of CYP3A7 in the disposition and Toxicity of HIV inhibitors in the developing infant
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Work HM, Hackett JC, Lampe JN. HCV Antiviral Drugs Have the Potential to Adversely Perturb the Fetal-Maternal Communication Axis through Inhibition of CYP3A7 DHEA-S Oxidation. Drug Metab Dispos. 2024 May 16; 52(6):516-525. PMID: 38267095.
      View in: PubMed
    2. Liu J, Kandel SE, Lampe JN, Scott EE. Correction: Human cytochrome P450 3A7 binding four copies of its native substrate dehydroepiandrosterone 3-sulfate. J Biol Chem. 2023 Oct; 299(10):105283. PMID: 37783037.
      View in: PubMed
    3. Kandel SE, Gracey EG, Lampe JN. Consideration of Nevirapine Analogs To Reduce Metabolically Linked Hepatotoxicity: A Cautionary Tale of the Deuteration Approach. Chem Res Toxicol. 2023 Sep 28. PMID: 37769118.
      View in: PubMed
    4. Liu J, Kandel SE, Lampe JN, Scott EE. Human cytochrome P450 3A7 binding four copies of its native substrate dehydroepiandrosterone 3-sulfate. J Biol Chem. 2023 08; 299(8):104993. PMID: 37392852.
      View in: PubMed
    5. Malachowska B, Yang WL, Qualman A, Muro I, Boe DM, Lampe JN, Kovacs EJ, Idrovo JP. Transcriptomics, metabolomics, and in-silico drug predictions for liver damage in young and aged burn victims. Commun Biol. 2023 06 02; 6(1):597. PMID: 37268765.
      View in: PubMed
    6. Hvizdak M, Kandel SE, Work HM, Gracey EG, McCullough RL, Lampe JN. Per- and polyfluoroalkyl substances (PFAS) inhibit cytochrome P450 CYP3A7 through direct coordination to the heme iron and water displacement. J Inorg Biochem. 2023 03; 240:112120. PMID: 36638633.
      View in: PubMed
    7. Haynes AS, Prinzi A, Silveira LJ, Parker SK, Lampe JN, Kavanaugh JS, Horswill AR, Fish D. Cefadroxil Comparable to Cephalexin: Minimum Inhibitory Concentrations among Methicillin-Susceptible Staphylococcus aureus Isolates from Pediatric Musculoskeletal Infections. Microbiol Spectr. 2022 08 31; 10(4):e0103922. PMID: 35730963.
      View in: PubMed
    8. Hicks EG, Kandel SE, Lampe JN. Identification of Aloe-derived natural products as prospective lead scaffolds for SARS-CoV-2 main protease (Mpro) inhibitors. Bioorg Med Chem Lett. 2022 06 15; 66:128732. PMID: 35427739.
      View in: PubMed
    9. Tooker BC, Kandel SE, Work HM, Lampe JN. Pseudomonas aeruginosa cytochrome P450 CYP168A1 is a fatty acid hydroxylase that metabolizes arachidonic acid to the vasodilator 19-HETE. J Biol Chem. 2022 03; 298(3):101629. PMID: 35085556.
      View in: PubMed
    10. Work HM, Kandel SE, Lampe JN. Characterization of fluorescent probe substrates to develop an efficient high-throughput assay for neonatal hepatic CYP3A7 inhibition screening. Sci Rep. 2021 09 30; 11(1):19443. PMID: 34593846.
      View in: PubMed
    11. Kandel SE, Lampe JN. Inhibition of CYP3A7 DHEA-S Oxidation by Lopinavir and Ritonavir: An Alternative Mechanism for Adrenal Impairment in HIV Antiretroviral-Treated Neonates. Chem Res Toxicol. 2021 04 19; 34(4):1150-1160. PMID: 33821626.
      View in: PubMed
    12. Li H, Lampe JN. Neonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism. Arch Biochem Biophys. 2019 09 30; 673:108078. PMID: 31445893.
      View in: PubMed
    13. Bishop SC, Winefield R, Anbanandam A, Lampe JN. Aqueous synthesis of a small-molecule lanthanide chelator amenable to copper-free click chemistry. PLoS One. 2019; 14(3):e0209726. PMID: 30917122.
      View in: PubMed
    14. Boxberger KH, Hagenbuch B, Lampe JN. Ligand-dependent modulation of hOCT1 transport reveals discrete ligand binding sites within the substrate translocation channel. Biochem Pharmacol. 2018 10; 156:371-384. PMID: 30138624.
      View in: PubMed
    15. Kandel SE, Han LW, Mao Q, Lampe JN. Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7. Drug Metab Dispos. 2017 12; 45(12):1266-1275. PMID: 28986474.
      View in: PubMed
    16. Lampe JN. Advances in the Understanding of Protein-Protein Interactions in Drug Metabolizing Enzymes through the Use of Biophysical Techniques. Front Pharmacol. 2017; 8:521. PMID: 28848438.
      View in: PubMed
    17. Beggs KM, McGreal SR, McCarthy A, Gunewardena S, Lampe JN, Lau C, Apte U. The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction. Toxicol Appl Pharmacol. 2016 08 01; 304:18-29. PMID: 27153767.
      View in: PubMed
    18. Basudhar D, Madrona Y, Kandel S, Lampe JN, Nishida CR, de Montellano PR. Analysis of cytochrome P450 CYP119 ligand-dependent conformational dynamics by two-dimensional NMR and X-ray crystallography. J Biol Chem. 2015 Apr 17; 290(16):10000-17. PMID: 25670859.
      View in: PubMed
    19. Kandel SE, Lampe JN. Role of protein-protein interactions in cytochrome P450-mediated drug metabolism and toxicity. Chem Res Toxicol. 2014 Sep 15; 27(9):1474-86. PMID: 25133307.
      View in: PubMed
    20. Boxberger KH, Hagenbuch B, Lampe JN. Common drugs inhibit human organic cation transporter 1 (OCT1)-mediated neurotransmitter uptake. Drug Metab Dispos. 2014 Jun; 42(6):990-5. PMID: 24688079.
      View in: PubMed
    21. Kandel SE, Wienkers LC, Lampe JN. Cytochrome P450 Enzyme Metabolites in Lead Discovery and Development. Annu Rep Med Chem. 2014; 49:347-359. PMID: 25797999.
      View in: PubMed
    22. Varfaj F, Lampe JN, Ortiz de Montellano PR. Role of cysteine residues in heme binding to human heme oxygenase-2 elucidated by two-dimensional NMR spectroscopy. J Biol Chem. 2012 Oct 12; 287(42):35181-35191. PMID: 22923613.
      View in: PubMed
    23. Williams CD, Koerner MR, Lampe JN, Farhood A, Jaeschke H. Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation. Toxicol Appl Pharmacol. 2011 Dec 15; 257(3):449-58. PMID: 22023962.
      View in: PubMed
    24. Brandman R, Lampe JN, Brandman Y, de Montellano PR. Active-site residues move independently from the rest of the protein in a 200 ns molecular dynamics simulation of cytochrome P450 CYP119. Arch Biochem Biophys. 2011 May 15; 509(2):127-32. PMID: 21356195.
      View in: PubMed
    25. Lampe JN, Brandman R, Sivaramakrishnan S, de Montellano PRO. Two-dimensional NMR and all-atom molecular dynamics of cytochrome P450 CYP119 reveal hidden conformational substates. J Biol Chem. 2010 Mar 26; 285(13):9594-9603. PMID: 20097757.
      View in: PubMed
    26. Lampe JN, Floor SN, Gross JD, Nishida CR, Jiang Y, Trnka MJ, Ortiz de Montellano PR. Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine. J Am Chem Soc. 2008 Dec 03; 130(48):16168-9. PMID: 18998650.
      View in: PubMed
    27. Nath A, Fern?ndez C, Lampe JN, Atkins WM. Spectral resolution of a second binding site for Nile Red on cytochrome P4503A4. Arch Biochem Biophys. 2008 Jun 01; 474(1):198-204. PMID: 18395506.
      View in: PubMed
    28. Lampe JN, Fernandez C, Nath A, Atkins WM. Nile Red is a fluorescent allosteric substrate of cytochrome P450 3A4. Biochemistry. 2008 Jan 15; 47(2):509-16. PMID: 18092806.
      View in: PubMed
    29. Siahpush SH, Vaughan TL, Lampe JN, Freeman R, Lewis S, Odze RD, Blount PL, Ayub K, Rabinovitch PS, Reid BJ, Chen C. Longitudinal study of insulin-like growth factor, insulin-like growth factor binding protein-3, and their polymorphisms: risk of neoplastic progression in Barrett's esophagus. Cancer Epidemiol Biomarkers Prev. 2007 Nov; 16(11):2387-95. PMID: 18006928.
      View in: PubMed
    30. Lampe JN, Atkins WM. Time-resolved fluorescence studies of heterotropic ligand binding to cytochrome P450 3A4. Biochemistry. 2006 Oct 10; 45(40):12204-15. PMID: 17014074.
      View in: PubMed
    31. Wen B, Lampe JN, Roberts AG, Atkins WM, David Rodrigues A, Nelson SD. Cysteine 98 in CYP3A4 contributes to conformational integrity required for P450 interaction with CYP reductase. Arch Biochem Biophys. 2006 Oct 01; 454(1):42-54. PMID: 16959210.
      View in: PubMed
    32. Roberts AG, D?az MD, Lampe JN, Shireman LM, Grinstead JS, Dabrowski MJ, Pearson JT, Bowman MK, Atkins WM, Campbell AP. NMR studies of ligand binding to P450(eryF) provides insight into the mechanism of cooperativity. Biochemistry. 2006 Feb 14; 45(6):1673-84. PMID: 16460014.
      View in: PubMed
    33. Wen B, Doneanu CE, Lampe JN, Roberts AG, Atkins WM, Nelson SD. Probing the CYP3A4 active site by cysteine scanning mutagenesis and photoaffinity labeling. Arch Biochem Biophys. 2005 Dec 15; 444(2):100-11. PMID: 16289363.
      View in: PubMed
    34. Compagno D, Lampe JN, Bourget C, Kutyavin IV, Yurchenko L, Lukhtanov EA, Gorn VV, Gamper HB, Toulm? JJ. Antisense oligonucleotides containing modified bases inhibit in vitro translation of Leishmania amazonensis mRNAs by invading the mini-exon hairpin. J Biol Chem. 1999 Mar 19; 274(12):8191-8. PMID: 10075723.
      View in: PubMed
    35. Lampe JN, Kutyavin IV, Rhinehart R, Reed MW, Meyer RB, Gamper HB. Factors influencing the extent and selectivity of alkylation within triplexes by reactive G/A motif oligonucleotides. Nucleic Acids Res. 1997 Oct 15; 25(20):4123-31. PMID: 9321668.
      View in: PubMed
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