 Sialic Acid Binding Ig-like Lectin 1
"Sialic Acid Binding Ig-like Lectin 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sialic acid binding lectin that was originally identified as an adhesion molecule for inflammatory MACROPHAGES and activated MONOCYTES. This protein is the largest known siglec subtype and contains 16 immunoglobulin C2-set domains. It plays a role in cell to cell interactions and interactions with bacteria.
| Descriptor ID |
D063267
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| MeSH Number(s) |
D12.776.503.921.100
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Sialic Acid Binding Ig-like Lectin 1".
Below are MeSH descriptors whose meaning is more specific than "Sialic Acid Binding Ig-like Lectin 1".
This graph shows the total number of publications written about "Sialic Acid Binding Ig-like Lectin 1" by people in this website by year, and whether "Sialic Acid Binding Ig-like Lectin 1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2018 | 2 | 0 | 2 | | 2022 | 0 | 1 | 1 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Sialic Acid Binding Ig-like Lectin 1" by people in Profiles.
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Fukuda R, Fujiwara Y, Maeda H, Pan C, Minayoshi Y, Yano H, Mizuta Y, Takano M, Yamada R, Saito Y, Hirata K, Imoto S, Yamasaki K, Oniki K, Saruwatari J, Otagiri M, Watanabe H, Komohara Y, Maruyama T. Lymph node macrophage-targeted interferon alpha boosts anticancer immune responses by regulating CD169-positive phenotype of macrophages. Mol Cancer. 2025 May 03; 24(1):132.
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Kawaguchi S, Kawahara K, Fujiwara Y, Ohnishi K, Pan C, Yano H, Hirosue A, Nagata M, Hirayama M, Sakata J, Nakashima H, Arita H, Yamana K, Gohara S, Nagao Y, Maeshiro M, Iwamoto A, Hirayama M, Yoshida R, Komohara Y, Nakayama H. Naringenin potentiates anti-tumor immunity against oral cancer by inducing lymph node CD169-positive macrophage activation and cytotoxic T cell infiltration. Cancer Immunol Immunother. 2022 Sep; 71(9):2127-2139.
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Uchil PD, Pi R, Haugh KA, Ladinsky MS, Ventura JD, Barrett BS, Santiago ML, Bjorkman PJ, Kassiotis G, Sewald X, Mothes W. A Protective Role for the Lectin CD169/Siglec-1 against a Pathogenic Murine Retrovirus. Cell Host Microbe. 2019 01 09; 25(1):87-100.e10.
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Fujiwara Y, Saito Y, Shiota T, Cheng P, Ikeda T, Ohnishi K, Takeya M, Komohara Y. Natural compounds that regulate lymph node sinus macrophages: Inducing an anti-tumor effect by regulating macrophage activation. J Clin Exp Hematop. 2018; 58(1):17-23.
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