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Keith Benjamin Neeves

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentENGR-Bioengineering
Phone303/724-4634
    Other Positions
    TitleDirector-Faculty
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentENGR-Bioengineering


    Collapse Research 
    Collapse research activities and funding
    F32HL090304     (NEEVES, KEITH B)Aug 1, 2007 - Jul 31, 2008
    NIH/NHLBI
    Combinatorial Microfluidic Devices for Studying Thrombosis
    Role: Principal Investigator

    R21NS082933     (MARR, DAVID WM)Sep 30, 2013 - Aug 31, 2015
    NIH/NINDS
    Bead-Based Approach for Combined Mechanical and Pharmacological Treatment of Acut
    Role: Co-Principal Investigator

    R01HL120728     (NEEVES, KEITH B)Sep 1, 2014 - May 31, 2019
    NIH/NHLBI
    A Systems Biology Approach to Predicting Bleeding in Hemophilia
    Role: Principal Investigator

    R61HL141794     (NEEVES, KEITH B)Apr 16, 2018 - Mar 31, 2020
    NIH/NHLBI
    A systems biology approach to identifying the mechanisms of sex hormone induced thromboembolism in pre-menopausal women
    Role: Principal Investigator

    R01NS102465     (MARR, DAVID WM)Jul 1, 2018 - Mar 31, 2023
    NIH/NINDS
    Magnetically propelled microwheels for rapid thrombolysis in small arteries
    Role: Co-Principal Investigator

    R21AI138214     (MARR, DAVID WM)Nov 23, 2018 - Oct 31, 2020
    NIH/NIAID
    Airborne delivery of microbots for chemical and mechanical attack of pulmonary biofilms
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Disharoon D, Neeves KB, Marr DWM. ac/dc Magnetic Fields for Enhanced Translation of Colloidal Microwheels. Langmuir. 2019 Mar 05; 35(9):3455-3460. PMID: 30726100.
      View in: PubMed
    2. Link KG, Stobb MT, Di Paola J, Neeves KB, Fogelson AL, Sindi SS, Leiderman K. A local and global sensitivity analysis of a mathematical model of coagulation and platelet deposition under flow. PLoS One. 2018; 13(7):e0200917. PMID: 30048479.
      View in: PubMed
    3. Rod K, Um W, Chun J, Wu N, Yin X, Wang G, Neeves K. Effect of chemical and physical heterogeneities on colloid-facilitated cesium transport. J Contam Hydrol. 2018 06; 213:22-27. PMID: 29657081.
      View in: PubMed
    4. Lehmann M, Schoeman RM, Krohl PJ, Wallbank AM, Samaniuk JR, Jandrot-Perrus M, Neeves KB. Platelets Drive Thrombus Propagation in a Hematocrit and Glycoprotein VI-Dependent Manner in an In Vitro Venous Thrombosis Model. Arterioscler Thromb Vasc Biol. 2018 May; 38(5):1052-1062. PMID: 29472230.
      View in: PubMed
    5. Branchford BR, Stalker TJ, Law L, Acevedo G, Sather S, Brzezinski C, Wilson KM, Minson K, Lee-Sherick AB, Davizon-Castillo P, Ng C, Zhang W, Neeves KB, Lentz SR, Wang X, Frye SV, Shelton Earp H, DeRyckere D, Brass LF, Graham DK, Di Paola JA. The small-molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis. J Thromb Haemost. 2018 02; 16(2):352-363. PMID: 29045015.
      View in: PubMed
    6. Lehmann M, Ashworth K, Manco-Johnson M, Di Paola J, Neeves KB, Ng CJ. Evaluation of a microfluidic flow assay to screen for von Willebrand disease and low von Willebrand factor levels. J Thromb Haemost. 2018 01; 16(1):104-115. PMID: 29064615.
      View in: PubMed
    7. Tasci TO, Disharoon D, Schoeman RM, Rana K, Herson PS, Marr DWM, Neeves KB. Enhanced Fibrinolysis with Magnetically Powered Colloidal Microwheels. Small. 2017 09; 13(36). PMID: 28719063.
      View in: PubMed
    8. Schoeman RM, Lehmann M, Neeves KB. Flow chamber and microfluidic approaches for measuring thrombus formation in genetic bleeding disorders. Platelets. 2017 Jul; 28(5):463-471. PMID: 28532218.
      View in: PubMed
    9. Yang T, Tasci TO, Neeves KB, Wu N, Marr DWM. Magnetic Microlassos for Reversible Cargo Capture, Transport, and Release. Langmuir. 2017 06 13; 33(23):5932-5937. PMID: 28318267.
      View in: PubMed
    10. Cooper S, Lloyd S, Koch A, Lin X, Dobbs K, Theisen T, Zuberbuehler M, Bernhardt K, Gyorfi M, Tenpas T, Hying S, Mortimer S, Lamont C, Lehmann M, Neeves K. Temperature effects on the activity, shape, and storage of platelets from 13-lined ground squirrels. J Comp Physiol B. 2017 Jul; 187(5-6):815-825. PMID: 28332020.
      View in: PubMed
    11. Walton BL, Lehmann M, Skorczewski T, Holle LA, Beckman JD, Cribb JA, Mooberry MJ, Wufsus AR, Cooley BC, Homeister JW, Pawlinski R, Falvo MR, Key NS, Fogelson AL, Neeves KB, Wolberg AS. Elevated hematocrit enhances platelet accumulation following vascular injury. Blood. 2017 05 04; 129(18):2537-2546. PMID: 28251913.
      View in: PubMed
    12. Naik MU, Patel P, Derstine R, Turaga R, Chen X, Golla K, Neeves KB, Ichijo H, Naik UP. Ask1 regulates murine platelet granule secretion, thromboxane A2 generation, and thrombus formation. Blood. 2017 03 02; 129(9):1197-1209. PMID: 28028021.
      View in: PubMed
    13. Maier FJ, Lachner T, Vilfan A, Tasci TO, Neeves KB, Marr DW, Fischer TM. Non reciprocal skewed rolling of a colloidal wheel due to induced chirality. Soft Matter. 2016 Nov 23; 12(46):9314-9320. PMID: 27824198.
      View in: PubMed
    14. Schoeman RM, Rana K, Danes N, Lehmann M, Di Paola JA, Fogelson AL, Leiderman K, Neeves KB. A microfluidic model of hemostasis sensitive to platelet function and coagulation. Cell Mol Bioeng. 2017 Feb; 10(1):3-15. PMID: 28529666.
      View in: PubMed
    15. Guo Y, Huang J, Xiao F, Yin X, Chun J, Um W, Neeves KB, Wu N. Bead-Based Microfluidic Sediment Analogues: Fabrication and Colloid Transport. Langmuir. 2016 09 13; 32(36):9342-50. PMID: 27548505.
      View in: PubMed
    16. Rana K, Neeves KB. Blood flow and mass transfer regulation of coagulation. Blood Rev. 2016 09; 30(5):357-68. PMID: 27133256.
      View in: PubMed
    17. McCarty OJ, Ku D, Sugimoto M, King MR, Cosemans JM, Neeves KB. Dimensional analysis and scaling relevant to flow models of thrombus formation: communication from the SSC of the ISTH. J Thromb Haemost. 2016 Mar; 14(3):619-22. PMID: 26933837.
      View in: PubMed
    18. Tasci TO, Herson PS, Neeves KB, Marr DW. Surface-enabled propulsion and control of colloidal microwheels. Nat Commun. 2016 Jan 04; 7:10225. PMID: 26725747.
      View in: PubMed
    19. Lehmann M, Wallbank AM, Dennis KA, Wufsus AR, Davis KM, Rana K, Neeves KB. On-chip recalcification of citrated whole blood using a microfluidic herringbone mixer. Biomicrofluidics. 2015 Nov; 9(6):064106. PMID: 26634014.
      View in: PubMed
    20. Roth KB, Neeves KB, Squier J, Marr DW. High-throughput linear optical stretcher for mechanical characterization of blood cells. Cytometry A. 2016 04; 89(4):391-7. PMID: 26565892.
      View in: PubMed
    21. Neeves KB. Physiochemical artifacts in FeCl3 thrombosis models. Blood. 2015 Aug 06; 126(6):700-1. PMID: 26251225.
      View in: PubMed
    22. Sylman JL, Artzer DT, Rana K, Neeves KB. A vascular injury model using focal heat-induced activation of endothelial cells. Integr Biol (Camb). 2015 Jul; 7(7):801-14. PMID: 26087748.
      View in: PubMed
    23. Branchford BR, Ng CJ, Neeves KB, Di Paola J. Microfluidic technology as an emerging clinical tool to evaluate thrombosis and hemostasis. Thromb Res. 2015 Jul; 136(1):13-9. PMID: 26014643.
      View in: PubMed
    24. Roth KB, Neeves KB, Squier J, Marr DW. Imaging of a linear diode bar for an optical cell stretcher. Biomed Opt Express. 2015 Mar 01; 6(3):807-14. PMID: 25798305.
      View in: PubMed
    25. Neeves KB. Down in a hole: a new laser ablation model of hemostasis. J Thromb Haemost. 2015 Mar; 13(3):414-6. PMID: 25510738.
      View in: PubMed
    26. Wufsus AR, Rana K, Brown A, Dorgan JR, Liberatore MW, Neeves KB. Elastic behavior and platelet retraction in low- and high-density fibrin gels. Biophys J. 2015 Jan 06; 108(1):173-83. PMID: 25564864.
      View in: PubMed
    27. Fogelson AL, Neeves KB. Fluid Mechanics of Blood Clot Formation. Annu Rev Fluid Mech. 2015 Jan 01; 47:377-403. PMID: 26236058.
      View in: PubMed
    28. Zhu S, Herbig BA, Li R, Colace TV, Muthard RW, Neeves KB, Diamond SL. In microfluidico: Recreating in vivo hemodynamics using miniaturized devices. Biorheology. 2015; 52(5-6):303-18. PMID: 26600269.
      View in: PubMed
    29. Rana K, Timmer BJ, Neeves KB. A combined microfluidic-microstencil method for patterning biomolecules and cells. Biomicrofluidics. 2014 Sep; 8(5):056502. PMID: 25332748.
      View in: PubMed
    30. Thon JN, Mazutis L, Wu S, Sylman JL, Ehrlicher A, Machlus KR, Feng Q, Lu S, Lanza R, Neeves KB, Weitz DA, Italiano JE. Platelet bioreactor-on-a-chip. Blood. 2014 Sep 18; 124(12):1857-67. PMID: 25606631.
      View in: PubMed
    31. Ahmad S, Ahmad A, Neeves KB, Hendry-Hofer T, Loader JE, White CW, Veress L. In vitro cell culture model for toxic inhaled chemical testing. J Vis Exp. 2014 May 08; (87). PMID: 24837339.
      View in: PubMed
    32. Neeves KB, McCarty OJ, Reininger AJ, Sugimoto M, King MR. Flow-dependent thrombin and fibrin generation in vitro: opportunities for standardization: communication from SSC of the ISTH. J Thromb Haemost. 2014; 12(3):418-20. PMID: 24330648.
      View in: PubMed
    33. Onasoga-Jarvis AA, Puls TJ, O'Brien SK, Kuang L, Liang HJ, Neeves KB. Thrombin generation and fibrin formation under flow on biomimetic tissue factor-rich surfaces. J Thromb Haemost. 2014; 12(3):373-82. PMID: 24345079.
      View in: PubMed
    34. Onasoga-Jarvis AA, Leiderman K, Fogelson AL, Wang M, Manco-Johnson MJ, Di Paola JA, Neeves KB. The effect of factor VIII deficiencies and replacement and bypass therapies on thrombus formation under venous flow conditions in microfluidic and computational models. PLoS One. 2013; 8(11):e78732. PMID: 24236042.
      View in: PubMed
    35. Neeves KB, Onasoga AA, Wufsus AR. The use of microfluidics in hemostasis: clinical diagnostics and biomimetic models of vascular injury. Curr Opin Hematol. 2013 Sep; 20(5):417-23. PMID: 23872531.
      View in: PubMed
    36. Roth KB, Eggleton CD, Neeves KB, Marr DW. Measuring cell mechanics by optical alignment compression cytometry. Lab Chip. 2013 Apr 21; 13(8):1571-7. PMID: 23440063.
      View in: PubMed
    37. Wufsus AR, Macera NE, Neeves KB. The hydraulic permeability of blood clots as a function of fibrin and platelet density. Biophys J. 2013 Apr 16; 104(8):1812-23. PMID: 23601328.
      View in: PubMed
    38. Sylman JL, Lantvit SM, Vedepo MC, Reynolds MM, Neeves KB. Transport limitations of nitric oxide inhibition of platelet aggregation under flow. Ann Biomed Eng. 2013 Oct; 41(10):2193-205. PMID: 23563992.
      View in: PubMed
    39. Wu Q, Ok JT, Sun Y, Retterer ST, Neeves KB, Yin X, Bai B, Ma Y. Optic imaging of single and two-phase pressure-driven flows in nano-scale channels. Lab Chip. 2013 Mar 21; 13(6):1165-71. PMID: 23370894.
      View in: PubMed
    40. Neeves KB, Onasoga AA, Hansen RR, Lilly JJ, Venckunaite D, Sumner MB, Irish AT, Brodsky G, Manco-Johnson MJ, Di Paola JA. Sources of variability in platelet accumulation on type 1 fibrillar collagen in microfluidic flow assays. PLoS One. 2013; 8(1):e54680. PMID: 23355889.
      View in: PubMed
    41. Neeves KB. Collagen-induced thrombosis in large vessels using native prothrombotic substrates. Thromb Res. 2013 Jan; 131(1):1-2. PMID: 23174625.
      View in: PubMed
    42. Ahmad S, Ahmad A, Rancourt RC, Neeves KB, Loader JE, Hendry-Hofer T, Di Paola J, Reynolds SD, White CW. Tissue factor signals airway epithelial basal cell survival via coagulation and protease-activated receptor isoforms 1 and 2. Am J Respir Cell Mol Biol. 2013 Jan; 48(1):94-104. PMID: 23065128.
      View in: PubMed
    43. Hansen RR, Wufsus AR, Barton ST, Onasoga AA, Johnson-Paben RM, Neeves KB. High content evaluation of shear dependent platelet function in a microfluidic flow assay. Ann Biomed Eng. 2013 Feb; 41(2):250-62. PMID: 23001359.
      View in: PubMed
    44. Gupta VK, Neeves KB, Eggleton CD. Effect of viscoelasticity on the analysis of single-molecule force spectroscopy on live cells. Biophys J. 2012 Jul 03; 103(1):137-45. PMID: 22828340.
      View in: PubMed
    45. Neeves KB. Catch me if you can: isolating circulating tumor cells from flowing blood. Clin Chem. 2012 May; 58(5):803-4. PMID: 22353214.
      View in: PubMed
    46. Wu M, Xiao F, Johnson-Paben RM, Retterer ST, Yin X, Neeves KB. Single- and two-phase flow in microfluidic porous media analogs based on Voronoi tessellation. Lab Chip. 2012 Jan 21; 12(2):253-61. PMID: 22094719.
      View in: PubMed
    47. Foley CP, Nishimura N, Neeves KB, Schaffer CB, Olbricht WL. Real-time imaging of perivascular transport of nanoparticles during convection-enhanced delivery in the rat cortex. Ann Biomed Eng. 2012 Feb; 40(2):292-303. PMID: 22009318.
      View in: PubMed
    48. Hansen RR, Tipnis AA, White-Adams TC, Di Paola JA, Neeves KB. Characterization of collagen thin films for von Willebrand factor binding and platelet adhesion. Langmuir. 2011 Nov 15; 27(22):13648-58. PMID: 21967679.
      View in: PubMed
    49. Ahmad S, Raemy DO, Loader JE, Kailey JM, Neeves KB, White CW, Ahmad A, Gehr P, Rothen-Rutishauser BM. Interaction and localization of synthetic nanoparticles in healthy and cystic fibrosis airway epithelial cells: effect of ozone exposure. J Aerosol Med Pulm Drug Deliv. 2012 Feb; 25(1):7-15. PMID: 22007674.
      View in: PubMed
    50. Olbricht WL, Neeves KB, Foley CP. Microfluidic probes in the treatment of brain-related diseases. Drug News Perspect. 2010 Oct; 23(8):491-7. PMID: 21031165.
      View in: PubMed
    51. Wannemacher KM, Zhu L, Jiang H, Fong KP, Stalker TJ, Lee D, Tran AN, Neeves KB, Maloney S, Kumanogoh A, Kikutani H, Hammer DA, Diamond SL, Brass LF. Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D. Blood. 2010 Dec 16; 116(25):5707-15. PMID: 20855865.
      View in: PubMed
    52. Neeves KB, Illing DA, Diamond SL. Thrombin flux and wall shear rate regulate fibrin fiber deposition state during polymerization under flow. Biophys J. 2010 Apr 07; 98(7):1344-52. PMID: 20371335.
      View in: PubMed
    53. Schmaier AA, Zou Z, Kazlauskas A, Emert-Sedlak L, Fong KP, Neeves KB, Maloney SF, Diamond SL, Kunapuli SP, Ware J, Brass LF, Smithgall TE, Saksela K, Kahn ML. Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role. Proc Natl Acad Sci U S A. 2009 Dec 15; 106(50):21167-72. PMID: 19940238.
      View in: PubMed
    54. Foley CP, Nishimura N, Neeves KB, Schaffer CB, Olbricht WL. Flexible microfluidic devices supported by biodegradable insertion scaffolds for convection-enhanced neural drug delivery. Biomed Microdevices. 2009 Aug; 11(4):915-24. PMID: 19353271.
      View in: PubMed
    55. Zhu L, Stalker TJ, Fong KP, Jiang H, Tran A, Crichton I, Lee EK, Neeves KB, Maloney SF, Kikutani H, Kumanogoh A, Pure E, Diamond SL, Brass LF. Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis. Arterioscler Thromb Vasc Biol. 2009 Jul; 29(7):1039-45. PMID: 19390055.
      View in: PubMed
    56. Neeves KB, Maloney SF, Fong KP, Schmaier AA, Kahn ML, Brass LF, Diamond SL. Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates. J Thromb Haemost. 2008 Dec; 6(12):2193-201. PMID: 18983510.
      View in: PubMed
    57. Neeves KB, Diamond SL. A membrane-based microfluidic device for controlling the flux of platelet agonists into flowing blood. Lab Chip. 2008 May; 8(5):701-9. PMID: 18432339.
      View in: PubMed
    58. Okorie UM, Denney WS, Chatterjee MS, Neeves KB, Diamond SL. Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow. Blood. 2008 Apr 01; 111(7):3507-13. PMID: 18203955.
      View in: PubMed
    59. Neeves KB, Sawyer AJ, Foley CP, Saltzman WM, Olbricht WL. Dilation and degradation of the brain extracellular matrix enhances penetration of infused polymer nanoparticles. Brain Res. 2007 Nov 14; 1180:121-32. PMID: 17920047.
      View in: PubMed
    60. Spence AJ, Neeves KB, Murphy D, Sponberg S, Land BR, Hoy RR, Isaacson MS. Flexible multielectrodes can resolve multiple muscles in an insect appendage. J Neurosci Methods. 2007 Jan 15; 159(1):116-24. PMID: 16899299.
      View in: PubMed
    61. Neeves KB, Lo CT, Foley CP, Saltzman WM, Olbricht WL. Fabrication and characterization of microfluidic probes for convection enhanced drug delivery. J Control Release. 2006 Apr 10; 111(3):252-62. PMID: 16476500.
      View in: PubMed
    62. Retterer ST, Smith KL, Bjornsson CS, Neeves KB, Spence AJ, Turner JN, Shain W, Isaacson MS. Model neural prostheses with integrated microfluidics: a potential intervention strategy for controlling reactive cell and tissue responses. IEEE Trans Biomed Eng. 2004 Nov; 51(11):2063-73. PMID: 15536908.
      View in: PubMed
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