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Lisa Ann Spencer

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Research 
    Collapse research activities and funding
    R56AI121186     (SPENCER, LISA ANN)May 10, 2024 - Apr 30, 2025
    NIH
    Eosinophil functions in allergic gastrointestinal diseases
    Role: Principal Investigator
    R01AI168134     (SPENCER, LISA ANN)May 1, 2022 - Apr 30, 2026
    NIH
    Cellular and molecular mechanisms of mucosal organ crosstalk in allergic diseases
    Role: Principal Investigator
    R01AI121186     (SPENCER, LISA ANN)Mar 7, 2017 - Feb 28, 2022
    NIH
    Eosinophil functions in allergic gastrointestinal diseases
    Role: Principal Investigator
    R01HL095699     (SPENCER, LISA ANN)Jan 18, 2010 - Dec 31, 2015
    NIH
    Notch signaling-mediated functions of airway eosinophils in lung disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Menard-Katcher C, Liu C, Galbraith MD, Benson T, Burger C, Dobias D, Larsen L, O'Brien C, Spencer LA, Furuta GT, Masterson JC. Fibrostenotic eosinophilic esophagitis phenotype is defined by a proliferative gene signature. Allergy. 2023 02; 78(2):579-583. PMID: 36273270.
      View in: PubMed
    2. Quinn L, Nguyen B, Menard-Katcher C, Spencer L. IgG4+ cells are increased in the gastrointestinal tissue of pediatric patients with active eosinophilic gastritis and duodenitis and decrease in remission. Dig Liver Dis. 2023 01; 55(1):53-60. PMID: 36064648.
      View in: PubMed
    3. Larsen LD, Dockstader K, Olbrich CL, Cartwright IM, Spencer LA. Modulation of surface CD11c expression tracks plasticity in murine intestinal tissue eosinophils. J Leukoc Biol. 2022 05; 111(5):943-952. PMID: 35141942.
      View in: PubMed
    4. Ruppe LB, Spencer LA, Kriebs JM. Pre-Exposure Prophylaxis for HIV Infection and the Role of the Women's Health Care Provider in HIV Prevention. J Midwifery Womens Health. 2021 May; 66(3):322-333. PMID: 34086396.
      View in: PubMed
    5. Masterson JC, Menard-Katcher C, Larsen LD, Furuta GT, Spencer LA. Heterogeneity of Intestinal Tissue Eosinophils: Potential Considerations for Next-Generation Eosinophil-Targeting Strategies. Cells. 2021 02 17; 10(2). PMID: 33671475.
      View in: PubMed
    6. Olbrich CL, Larsen LD, Spencer LA. Assessing Phenotypic Heterogeneity in Intestinal Tissue Eosinophils. Methods Mol Biol. 2021; 2241:243-255. PMID: 33486741.
      View in: PubMed
    7. Olbrich CL, Bivas-Benita M, Xenakis JJ, Maldonado S, Cornwell E, Fink J, Yuan Q, Gill N, Mansfield R, Dockstader K, Spencer LA. Remote allergen exposure elicits eosinophil infiltration into allergen nonexposed mucosal organs and primes for allergic inflammation. Mucosal Immunol. 2020 09; 13(5):777-787. PMID: 32518365.
      View in: PubMed
    8. Olbrich CL, Simerly L, de Zoeten EF, Furuta GT, Spencer LA. Climbing New Mountains: How Antibodies Blocking a4?7 Integrins Tamed Eosinophilic Inflammation of the Intestinal Tract. Dig Dis Sci. 2019 08; 64(8):2068-2071. PMID: 31273593.
      View in: PubMed
    9. Ueki S, Miyabe Y, Yamamoto Y, Fukuchi M, Hirokawa M, Spencer LA, Weller PF. Correction to: Charcot-Leyden Crystals in Eosinophilic Inflammation: Active Cytolysis Leads to Crystal Formation. Curr Allergy Asthma Rep. 2019 Jul 13; 19(8):38. PMID: 31302821.
      View in: PubMed
    10. Ueki S, Miyabe Y, Yamamoto Y, Fukuchi M, Hirokawa M, Spencer LA, Weller PF. Charcot-Leyden Crystals in Eosinophilic Inflammation: Active Cytolysis Leads to Crystal Formation. Curr Allergy Asthma Rep. 2019 06 15; 19(8):35. PMID: 31203469.
      View in: PubMed
    11. Ueki S, Tokunaga T, Melo RCN, Saito H, Honda K, Fukuchi M, Konno Y, Takeda M, Yamamoto Y, Hirokawa M, Fujieda S, Spencer LA, Weller PF. Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death. Blood. 2018 11 15; 132(20):2183-2187. PMID: 30154112.
      View in: PubMed
    12. Carmo LAS, Bonjour K, Spencer LA, Weller PF, Melo RCN. Single-Cell Analyses of Human Eosinophils at High Resolution to Understand Compartmentalization and Vesicular Trafficking of Interferon-Gamma. Front Immunol. 2018; 9:1542. PMID: 30038615.
      View in: PubMed
    13. Spergel JM, Aceves SS, Kliewer K, Gonsalves N, Chehade M, Wechsler JB, Groetch M, Friedlander J, Dellon ES, Book W, Hirano I, Muir AB, Cianferoni A, Spencer L, Liacouras CA, Cheng E, Kottyan L, Wen T, Platts-Mills T, Rothenberg ME. New developments in patients with eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERS Symposium at the 2018 American Academy of Allergy, Asthma & Immunology Meeting. J Allergy Clin Immunol. 2018 07; 142(1):48-53. PMID: 29803797.
      View in: PubMed
    14. Khoury P, Akuthota P, Ackerman SJ, Arron JR, Bochner BS, Collins MH, Kahn JE, Fulkerson PC, Gleich GJ, Gopal-Srivastava R, Jacobsen EA, Leiferman KM, Francesca LS, Mathur SK, Minnicozzi M, Prussin C, Rothenberg ME, Roufosse F, Sable K, Simon D, Simon HU, Spencer LA, Steinfeld J, Wardlaw AJ, Wechsler ME, Weller PF, Klion AD. Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD). J Leukoc Biol. 2018 07; 104(1):69-83. PMID: 29672914.
      View in: PubMed
    15. Xenakis JJ, Howard ED, Smith KM, Olbrich CL, Huang Y, Anketell D, Maldonado S, Cornwell EW, Spencer LA. Resident intestinal eosinophils constitutively express antigen presentation markers and include two phenotypically distinct subsets of eosinophils. Immunology. 2018 06; 154(2):298-308. PMID: 29281125.
      View in: PubMed
    16. Sallis BF, Erkert L, Mo?ino-Romero S, Acar U, Wu R, Konnikova L, Lexmond WS, Hamilton MJ, Dunn WA, Szepfalusi Z, Vanderhoof JA, Snapper SB, Turner JR, Goldsmith JD, Spencer LA, Nurko S, Fiebiger E. An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learning. J Allergy Clin Immunol. 2018 04; 141(4):1354-1364.e9. PMID: 29273402.
      View in: PubMed
    17. Weller PF, Spencer LA. Functions of tissue-resident eosinophils. Nat Rev Immunol. 2017 Dec; 17(12):746-760. PMID: 28891557.
      View in: PubMed
    18. Smith KM, Rahman RS, Spencer LA. Humoral Immunity Provides Resident Intestinal Eosinophils Access to Luminal Antigen via Eosinophil-Expressed Low-Affinity Fc? Receptors. J Immunol. 2016 11 01; 197(9):3716-3724. PMID: 27683752.
      View in: PubMed
    19. Ueki S, Tokunaga T, Fujieda S, Honda K, Hirokawa M, Spencer LA, Weller PF. Eosinophil ETosis and DNA Traps: a New Look at Eosinophilic Inflammation. Curr Allergy Asthma Rep. 2016 07; 16(8):54. PMID: 27393701.
      View in: PubMed
    20. Carmo LA, Bonjour K, Ueki S, Neves JS, Liu L, Spencer LA, Dvorak AM, Weller PF, Melo RC. CD63 is tightly associated with intracellular, secretory events chaperoning piecemeal degranulation and compound exocytosis in human eosinophils. J Leukoc Biol. 2016 08; 100(2):391-401. PMID: 26965633.
      View in: PubMed
    21. Bettigole SE, Lis R, Adoro S, Lee AH, Spencer LA, Weller PF, Glimcher LH. The transcription factor XBP1 is selectively required for eosinophil differentiation. Nat Immunol. 2015 Aug; 16(8):829-37. PMID: 26147683.
      View in: PubMed
    22. Liu LY, Wang H, Xenakis JJ, Spencer LA. Notch signaling mediates granulocyte-macrophage colony-stimulating factor priming-induced transendothelial migration of human eosinophils. Allergy. 2015 Jul; 70(7):805-12. PMID: 25846339.
      View in: PubMed
    23. Spencer L, Rollo M, Hauck Y, MacDonald-Wicks L, Wood L, Hutchesson M, Giglia R, Smith R, Collins C. The effect of weight management interventions that include a diet component on weight-related outcomes in pregnant and postpartum women: a systematic review protocol. JBI Database System Rev Implement Rep. 2015 01; 13(1):88-98. PMID: 26447010.
      View in: PubMed
    24. Spencer LA, Bonjour K, Melo RC, Weller PF. Eosinophil secretion of granule-derived cytokines. Front Immunol. 2014; 5:496. PMID: 25386174.
      View in: PubMed
    25. Melo RC, Liu L, Xenakis JJ, Spencer LA. Eosinophil-derived cytokines in health and disease: unraveling novel mechanisms of selective secretion. Allergy. 2013 Mar; 68(3):274-84. PMID: 23347072.
      View in: PubMed
    26. Ueki S, Melo RC, Ghiran I, Spencer LA, Dvorak AM, Weller PF. Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans. Blood. 2013 Mar 14; 121(11):2074-83. PMID: 23303825.
      View in: PubMed
    27. Shamri R, Melo RC, Young KM, Bivas-Benita M, Xenakis JJ, Spencer LA, Weller PF. CCL11 elicits secretion of RNases from mouse eosinophils and their cell-free granules. FASEB J. 2012 May; 26(5):2084-93. PMID: 22294786.
      View in: PubMed
    28. Akuthota P, Melo RC, Spencer LA, Weller PF. MHC Class II and CD9 in human eosinophils localize to detergent-resistant membrane microdomains. Am J Respir Cell Mol Biol. 2012 Feb; 46(2):188-95. PMID: 21885678.
      View in: PubMed
    29. Shamri R, Xenakis JJ, Spencer LA. Eosinophils in innate immunity: an evolving story. Cell Tissue Res. 2011 Jan; 343(1):57-83. PMID: 21042920.
      View in: PubMed
    30. Spencer LA, Weller PF. Eosinophils and Th2 immunity: contemporary insights. Immunol Cell Biol. 2010 Mar-Apr; 88(3):250-6. PMID: 20065995.
      View in: PubMed
    31. Melo RC, Spencer LA, Perez SA, Neves JS, Bafford SP, Morgan ES, Dvorak AM, Weller PF. Vesicle-mediated secretion of human eosinophil granule-derived major basic protein. Lab Invest. 2009 Jul; 89(7):769-81. PMID: 19398958.
      View in: PubMed
    32. Neves JS, Perez SA, Spencer LA, Melo RC, Weller PF. Subcellular fractionation of human eosinophils: isolation of functional specific granules on isoosmotic density gradients. J Immunol Methods. 2009 May 15; 344(1):64-72. PMID: 19328806.
      View in: PubMed
    33. Radke AL, Reynolds LE, Melo RC, Dvorak AM, Weller PF, Spencer LA. Mature human eosinophils express functional Notch ligands mediating eosinophil autocrine regulation. Blood. 2009 Mar 26; 113(13):3092-101. PMID: 19171875.
      View in: PubMed
    34. Neves JS, Perez SA, Spencer LA, Melo RC, Reynolds L, Ghiran I, Mahmudi-Azer S, Odemuyiwa SO, Dvorak AM, Moqbel R, Weller PF. Eosinophil granules function extracellularly as receptor-mediated secretory organelles. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18478-83. PMID: 19017810.
      View in: PubMed
    35. Spencer LA, Szela CT, Perez SA, Kirchhoffer CL, Neves JS, Radke AL, Weller PF. Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially. J Leukoc Biol. 2009 Jan; 85(1):117-23. PMID: 18840671.
      View in: PubMed
    36. Akuthota P, Wang HB, Spencer LA, Weller PF. Immunoregulatory roles of eosinophils: a new look at a familiar cell. Clin Exp Allergy. 2008 Aug; 38(8):1254-63. PMID: 18727793.
      View in: PubMed
    37. Melo RC, Spencer LA, Dvorak AM, Weller PF. Mechanisms of eosinophil secretion: large vesiculotubular carriers mediate transport and release of granule-derived cytokines and other proteins. J Leukoc Biol. 2008 Feb; 83(2):229-36. PMID: 17875811.
      View in: PubMed
    38. Spencer LA, Melo RC, Perez SA, Bafford SP, Dvorak AM, Weller PF. Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3333-8. PMID: 16492782.
      View in: PubMed
    39. Melo RC, Spencer LA, Perez SA, Ghiran I, Dvorak AM, Weller PF. Human eosinophils secrete preformed, granule-stored interleukin-4 through distinct vesicular compartments. Traffic. 2005 Nov; 6(11):1047-57. PMID: 16190985.
      View in: PubMed
    40. Melo RC, Perez SA, Spencer LA, Dvorak AM, Weller PF. Intragranular vesiculotubular compartments are involved in piecemeal degranulation by activated human eosinophils. Traffic. 2005 Oct; 6(10):866-79. PMID: 16138901.
      View in: PubMed
    41. Spencer LA, Melo RC, Perez SA, Weller PF. A gel-based dual antibody capture and detection method for assaying of extracellular cytokine secretion: EliCell. Methods Mol Biol. 2005; 302:297-314. PMID: 15937360.
      View in: PubMed
    42. Rajan TV, Ganley L, Paciorkowski N, Spencer L, Klei TR, Shultz LD. Brugian infections in the peritoneal cavities of laboratory mice: kinetics of infection and cellular responses. Exp Parasitol. 2002 Apr; 100(4):235-47. PMID: 12128050.
      View in: PubMed
    43. Larregina AT, Morelli AE, Spencer LA, Logar AJ, Watkins SC, Thomson AW, Falo LD. Dermal-resident CD14+ cells differentiate into Langerhans cells. Nat Immunol. 2001 Dec; 2(12):1151-8. PMID: 11702065.
      View in: PubMed
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