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Michael J. Mitchell

TitleInstructor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Emergency Medicine

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhang R, Billingsley MM, Mitchell MJ. Biomaterials for vaccine-based cancer immunotherapy. J Control Release. 2018 Oct 09. PMID: 30312721.
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    2. Guimaraes PPG, Tan M, Tammela T, Wu K, Chung A, Oberli M, Wang K, Spektor R, Riley RS, Viana CTR, Jacks T, Langer R, Mitchell MJ. Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes. J Control Release. 2018 Oct 02. PMID: 30290244.
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    3. Auguste Y, Delague V, Desvignes JP, Longepied G, Gnisci A, Besnier P, Levy N, Beroud C, Megarbane A, Metzler-Guillemain C, Mitchell MJ. Loss of Calmodulin- and Radial-Spoke-Associated Complex Protein CFAP251 Leads to Immotile Spermatozoa Lacking Mitochondria and Infertility in Men. Am J Hum Genet. 2018 Sep 06; 103(3):413-420. PMID: 30122541.
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    4. Paci M, Elkhatib R, Longepied G, Bourgeois P, Ray PF, Levy N, Mitchell MJ, Metzler-Guillemain C. The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review. Basic Clin Androl. 2018; 28:7. PMID: 29946470.
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    5. Fenton OS, Olafson KN, Pillai PS, Mitchell MJ, Langer R. Advances in Biomaterials for Drug Delivery. Adv Mater. 2018 May 07; e1705328. PMID: 29736981.
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    6. Guimarães PPG, Gaglione S, Sewastianik T, Carrasco RD, Langer R, Mitchell MJ. Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy. ACS Nano. 2018 Feb 27; 12(2):912-931. PMID: 29378114.
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    7. Mitchell MJ, Jain RK, Langer R. Engineering and physical sciences in oncology: challenges and opportunities. Nat Rev Cancer. 2017 11; 17(11):659-675. PMID: 29026204.
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    8. Nasajpour A, Mandla S, Shree S, Mostafavi E, Sharifi R, Khalilpour A, Saghazadeh S, Hassan S, Mitchell MJ, Leijten J, Hou X, Moshaverinia A, Annabi N, Adelung R, Mishra YK, Shin SR, Tamayol A, Khademhosseini A. Nanostructured Fibrous Membranes with Rose Spike-Like Architecture. Nano Lett. 2017 10 11; 17(10):6235-6240. PMID: 28819978.
      View in: PubMed
    9. Elkhatib RA, Paci M, Longepied G, Saias-Magnan J, Courbière B, Guichaoua MR, Lévy N, Metzler-Guillemain C, Mitchell MJ. Homozygous deletion of SUN5 in three men with decapitated spermatozoa. Hum Mol Genet. 2017 08 15; 26(16):3167-3171. PMID: 28541472.
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    10. Paci M, Elkhatib R, Longepied G, Hennebicq S, Bessonat J, Courbière B, Bourgeois P, Levy N, Mitchell MJ, Metzler-Guillemain C. Abnormal retention of nuclear lamina and disorganization of chromatin-related proteins in spermatozoa from DPY19L2-deleted globozoospermic patients. Reprod Biomed Online. 2017 Nov; 35(5):562-570. PMID: 28882431.
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    11. Kherraf ZE, Christou-Kent M, Karaouzene T, Amiri-Yekta A, Martinez G, Vargas AS, Lambert E, Borel C, Dorphin B, Aknin-Seifer I, Mitchell MJ, Metzler-Guillemain C, Escoffier J, Nef S, Grepillat M, Thierry-Mieg N, Satre V, Bailly M, Boitrelle F, Pernet-Gallay K, Hennebicq S, Fauré J, Bottari SP, Coutton C, Ray PF, Arnoult C. SPINK2 deficiency causes infertility by inducing sperm defects in heterozygotes and azoospermia in homozygotes. EMBO Mol Med. 2017 08; 9(8):1132-1149. PMID: 28554943.
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    12. Elkhatib RA, Paci M, Boissier R, Longepied G, Auguste Y, Achard V, Bourgeois P, Levy N, Branger N, Mitchell MJ, Metzler-Guillemain C. LEM-domain proteins are lost during human spermiogenesis but BAF and BAF-L persist. Reproduction. 2017 10; 154(4):387-401. PMID: 28684548.
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    13. Mitchell MJ, Webster J, Chung A, Guimarães PP, Khan OF, Langer R. Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis. Nat Commun. 2017 Mar 20; 8:14179. PMID: 28317839.
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    14. Ray PF, Toure A, Metzler-Guillemain C, Mitchell MJ, Arnoult C, Coutton C. Genetic abnormalities leading to qualitative defects of sperm morphology or function. Clin Genet. 2017 Feb; 91(2):217-232. PMID: 27779748.
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    15. Oberli MA, Reichmuth AM, Dorkin JR, Mitchell MJ, Fenton OS, Jaklenec A, Anderson DG, Langer R, Blankschtein D. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Lett. 2017 03 08; 17(3):1326-1335. PMID: 28273716.
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    16. Mitchell MJ, Metzler-Guillemain C, Toure A, Coutton C, Arnoult C, Ray PF. Single gene defects leading to sperm quantitative anomalies. Clin Genet. 2017 Feb; 91(2):208-216. PMID: 27779755.
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    17. Bradshaw H, Mitchell MJ, Edwards CJ, Stolz U, Naser O, Peck A, Patanwala AE. Medication Palatability Affects Physician Prescribing Preferences for Common Pediatric Conditions. Acad Emerg Med. 2016 11; 23(11):1243-1247. PMID: 27264915.
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    18. Bednarska-Makaruk M, Graban A, Sobczynska-Malefora A, Harrington DJ, Mitchell M, Voong K, Dai L, Lojkowska W, Bochynska A, Ryglewicz D, Wisniewska A, Wehr H. Homocysteine metabolism and the associations of global DNA methylation with selected gene polymorphisms and nutritional factors in patients with dementia. Exp Gerontol. 2016 08; 81:83-91. PMID: 27167582.
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    19. Yamauchi Y, Riel JM, Ruthig VA, Ortega EA, Mitchell MJ, Ward MA. Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction. Science. 2016 Jan 29; 351(6272):514-6. PMID: 26823431.
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    20. Vernet N, Mahadevaiah SK, Decarpentrie F, Longepied G, de Rooij DG, Burgoyne PS, Mitchell MJ. Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Head Remodelling and Sperm Tail Development. PLoS One. 2016; 11(1):e0145398. PMID: 26765744; PMCID: PMC4713206.
    21. Wayne EC, Chandrasekaran S, Mitchell MJ, Chan MF, Lee RE, Schaffer CB, King MR. TRAIL-coated leukocytes that prevent the bloodborne metastasis of prostate cancer. J Control Release. 2016 Feb 10; 223:215-223. PMID: 26732555; PMCID: PMC4724502 [Available on 02/10/17].
    22. Decarpentrie F, Ojarikre OA, Mitchell MJ, Burgoyne PS. Recombination between the mouse Y chromosome short arm and an additional Y short arm-derived chromosomal segment attached distal to the X chromosome PAR. Chromosoma. 2016 Jun; 125(2):177-88. PMID: 26596988; PMCID: PMC4830887.
    23. Mitchell MJ, Denais C, Chan MF, Wang Z, Lammerding J, King MR. Lamin A/C deficiency reduces circulating tumor cell resistance to fluid shear stress. Am J Physiol Cell Physiol. 2015 Dec 01; 309(11):C736-46. PMID: 26447202; PMCID: PMC4725441 [Available on 12/01/16].
    24. Okoli S, Madan B, Mwirigi A, Moore G, Drew A, Mitchell MJ, Cutler JA. A diagnostic dilemma: variant Bernard-Soulier syndrome, a difficult clinical and genetic diagnosis. Haemophilia. 2015 Nov; 21(6):e510-3. PMID: 26226975.
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    25. Wheeler RB, Cutler JA, Alamelu J, Mitchell MJ. The first report of a multi-exon duplication in the F9 gene causative of severe haemophilia B. Haemophilia. 2015 Sep; 21(5):e433-5. PMID: 26389844.
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    26. Mitchell MJ, Castellanos CA, King MR. Surfactant functionalization induces robust, differential adhesion of tumor cells and blood cells to charged nanotube-coated biomaterials under flow. Biomaterials. 2015 Jul; 56:179-86. PMID: 25934290; PMCID: PMC4428905.
    27. Mitchell MJ, Castellanos CA, King MR. Immobilized surfactant-nanotube complexes support selectin-mediated capture of viable circulating tumor cells in the absence of capture antibodies. J Biomed Mater Res A. 2015 Oct; 103(10):3407-18. PMID: 25761664; PMCID: PMC4552621 [Available on 10/01/16].
    28. Kohn JC, Zhou DW, Bordeleau F, Zhou AL, Mason BN, Mitchell MJ, King MR, Reinhart-King CA. Cooperative effects of matrix stiffness and fluid shear stress on endothelial cell behavior. Biophys J. 2015 Feb 03; 108(3):471-8. PMID: 25650915; PMCID: PMC4317546.
    29. Keskin EY, Gürsel T, Kaya Z, Dai L, Koçak Ü, Yenicesu I, Belen FB, Mitchell M. Molecular basis and bleeding manifestations of factor XI deficiency in 11 Turkish families. Blood Coagul Fibrinolysis. 2015 Jan; 26(1):63-8. PMID: 25158988.
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    30. Elkhatib R, Longepied G, Paci M, Achard V, Grillo JM, Levy N, Mitchell MJ, Metzler-Guillemain C. Nuclear envelope remodelling during human spermiogenesis involves somatic B-type lamins and a spermatid-specific B3 lamin isoform. Mol Hum Reprod. 2015 Mar; 21(3):225-36. PMID: 25477337.
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    31. Mitchell MJ, King MR. Leukocytes as carriers for targeted cancer drug delivery. Expert Opin Drug Deliv. 2015 Mar; 12(3):375-92. PMID: 25270379.
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    32. Vernet N, Mahadevaiah SK, Yamauchi Y, Decarpentrie F, Mitchell MJ, Ward MA, Burgoyne PS. Mouse Y-linked Zfy1 and Zfy2 are expressed during the male-specific interphase between meiosis I and meiosis II and promote the 2nd meiotic division. PLoS Genet. 2014 Jun; 10(6):e1004444. PMID: 24967676.
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    33. Bajpai S, Mitchell MJ, King MR, Reinhart-King CA. A microfluidic device to select for cells based on chemotactic phenotype. Technology (Singap World Sci). 2014 Jun; 2(2):101-105. PMID: 24999488.
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    34. Mitchell MJ, Lin KS, King MR. Fluid shear stress increases neutrophil activation via platelet-activating factor. Biophys J. 2014 May 20; 106(10):2243-53. PMID: 24853753; PMCID: PMC4052238.
    35. Mitchell MJ, King MR. Unnatural killer cells to prevent bloodborne metastasis: inspiration from biology and engineering. Expert Rev Anticancer Ther. 2014 Jun; 14(6):641-4. PMID: 24791860.
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    36. Mitchell MJ, Wayne E, Rana K, Schaffer CB, King MR. TRAIL-coated leukocytes that kill cancer cells in the circulation. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):930-5. PMID: 24395803; PMCID: PMC3903223.
    37. Mitchell MJ, King MR. Physical biology in cancer. 3. The role of cell glycocalyx in vascular transport of circulating tumor cells. Am J Physiol Cell Physiol. 2014 Jan 15; 306(2):C89-97. PMID: 24133067; PMCID: PMC3919988.
    38. Cao TM, Mitchell MJ, Liesveld J, King MR. Stem cell enrichment with selectin receptors: mimicking the pH environment of trauma. Sensors (Basel). 2013 Sep 17; 13(9):12516-26. PMID: 24048341; PMCID: PMC3821329.
    39. Eckhardt CL, van Velzen AS, Peters M, Astermark J, Brons PP, Castaman G, Cnossen MH, Dors N, Escuriola-Ettingshausen C, Hamulyak K, Hart DP, Hay CR, Haya S, van Heerde WL, Hermans C, Holmström M, Jimenez-Yuste V, Keenan RD, Klamroth R, Laros-van Gorkom BA, Leebeek FW, Liesner R, Mäkipernaa A, Male C, Mauser-Bunschoten E, Mazzucconi MG, McRae S, Meijer K, Mitchell M, Morfini M, Nijziel M, Oldenburg J, Peerlinck K, Petrini P, Platokouki H, Reitter-Pfoertner SE, Santagostino E, Schinco P, Smiers FJ, Siegmund B, Tagliaferri A, Yee TT, Kamphuisen PW, van der Bom JG, Fijnvandraat K. Factor VIII gene (F8) mutation and risk of inhibitor development in nonsevere hemophilia A. Blood. 2013 Sep 12; 122(11):1954-62. PMID: 23926300.
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    40. Mitchell MJ, King MR. Computational and experimental models of cancer cell response to fluid shear stress. Front Oncol. 2013; 3:44. PMID: 23467856; PMCID: PMC3587800.
    41. Mitchell MJ, King MR. Fluid Shear Stress Sensitizes Cancer Cells to Receptor-Mediated Apoptosis via Trimeric Death Receptors. New J Phys. 2013 Jan 18; 15:015008. PMID: 25110459.
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    42. Mitchell MJ, King MR. Shear-induced resistance to neutrophil activation via the formyl peptide receptor. Biophys J. 2012 Apr 18; 102(8):1804-14. PMID: 22768936; PMCID: PMC3328724.
    43. Streichemberger E, Perrin J, Saias-Magnan J, Karsenty G, Malzac P, Grillo JM, Mitchell MJ, Metzler-Guillemain C. Case report of apoptosis in testis of four AZFc-deleted patients: increased DNA fragmentation during meiosis, but decreased apoptotic markers in post-meiotic germ cells. Hum Reprod. 2012 Jul; 27(7):1939-45. PMID: 22508792.
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    44. Decarpentrie F, Vernet N, Mahadevaiah SK, Longepied G, Streichemberger E, Aknin-Seifer I, Ojarikre OA, Burgoyne PS, Metzler-Guillemain C, Mitchell MJ. Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential. Hum Mol Genet. 2012 Jun 15; 21(12):2631-45. PMID: 22407129; PMCID: PMC3363334.
    45. Mitchell MJ, Chen CS, Ponmudi V, Hughes AD, King MR. E-selectin liposomal and nanotube-targeted delivery of doxorubicin to circulating tumor cells. J Control Release. 2012 Jun 28; 160(3):609-17. PMID: 22421423; PMCID: PMC3749772.
    46. Schlaberg R, Mitchell MJ, Taggart EW, She RC. Verification of performance specifications for a US Food and Drug Administration-approved molecular microbiology test: Clostridium difficile cytotoxin B using the Becton, Dickinson and Company GeneOhm Cdiff assay. Arch Pathol Lab Med. 2012 Jan; 136(1):20-5. PMID: 22208483.
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    47. Mitchell MJ, Castellanos CA, King MR. Nanostructured Surfaces to Target and Kill Circulating Tumor Cells While Repelling Leukocytes. J Nanomater. 2012; 2012. PMID: 25152752.
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    48. Kichine E, Rozé V, Di Cristofaro J, Taulier D, Navarro A, Streichemberger E, Decarpentrie F, Metzler-Guillemain C, Lévy N, Chiaroni J, Paquis-Flucklinger V, Fellmann F, Mitchell MJ. HSFY genes and the P4 palindrome in the AZFb interval of the human Y chromosome are not required for spermatocyte maturation. Hum Reprod. 2012 Feb; 27(2):615-24. PMID: 22158087.
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    49. Hayden RT, Yan X, Wick MT, Rodriguez AB, Xiong X, Ginocchio CC, Mitchell MJ, Caliendo AM. Factors contributing to variability of quantitative viral PCR results in proficiency testing samples: a multivariate analysis. J Clin Microbiol. 2012 Feb; 50(2):337-45. PMID: 22116152; PMCID: PMC3264161.
    50. Vernet N, Mahadevaiah SK, Ojarikre OA, Longepied G, Prosser HM, Bradley A, Mitchell MJ, Burgoyne PS. The Y-encoded gene zfy2 acts to remove cells with unpaired chromosomes at the first meiotic metaphase in male mice. Curr Biol. 2011 May 10; 21(9):787-93. PMID: 21530259; PMCID: PMC3176893.
    51. Cutler JA, Patel R, Rangarajan S, Tait RC, Mitchell MJ. Molecular characterization of 11 novel mutations in patients with heterozygous and homozygous FV deficiency. Haemophilia. 2010 Nov; 16(6):937-42. PMID: 20546033.
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    52. Hayden RT, Wick MT, Rodriguez AB, Caliendo AM, Mitchell MJ, Ginocchio CC. A survey-based assessment of United States clinical laboratory response to the 2009 H1N1 influenza outbreak. Arch Pathol Lab Med. 2010 Nov; 134(11):1671-8. PMID: 21043821.
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    53. Wagar EA, Mitchell MJ, Carroll KC, Beavis KG, Petti CA, Schlaberg R, Yasin B. A review of sentinel laboratory performance: identification and notification of bioterrorism agents. Arch Pathol Lab Med. 2010 Oct; 134(10):1490-503. PMID: 20923306.
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    54. Longepied G, Saut N, Aknin-Seifer I, Levy R, Frances AM, Metzler-Guillemain C, Guichaoua MR, Mitchell MJ. Complete deletion of the AZFb interval from the Y chromosome in an oligozoospermic man. Hum Reprod. 2010 Oct; 25(10):2655-63. PMID: 20716563.
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    55. Msaidie S, Ducourneau A, Boetsch G, Longepied G, Papa K, Allibert C, Yahaya AA, Chiaroni J, Mitchell MJ. Genetic diversity on the Comoros Islands shows early seafaring as major determinant of human biocultural evolution in the Western Indian Ocean. Eur J Hum Genet. 2011 Jan; 19(1):89-94. PMID: 20700146; PMCID: PMC3039498.
    56. Chiaroni J, King RJ, Myres NM, Henn BM, Ducourneau A, Mitchell MJ, Boetsch G, Sheikha I, Lin AA, Nik-Ahd M, Ahmad J, Lattanzi F, Herrera RJ, Ibrahim ME, Brody A, Semino O, Kivisild T, Underhill PA. The emergence of Y-chromosome haplogroup J1e among Arabic-speaking populations. Eur J Hum Genet. 2010 Mar; 18(3):348-53. PMID: 19826455; PMCID: PMC2987219.
    57. Gostjeva EV, Koledova V, Tomita-Mitchell A, Mitchell M, Goetsch MA, Varmuza S, Fomina JN, Darroudi F, Thilly WG. Metakaryotic stem cell lineages in organogenesis of humans and other metazoans. Organogenesis. 2009 Oct; 5(4):191-200. PMID: 20539738; PMCID: PMC2878747.
    58. Mitchell MJ, Stubbs BA, Eisenberg MS. Socioeconomic status is associated with provision of bystander cardiopulmonary resuscitation. Prehosp Emerg Care. 2009 Oct-Dec; 13(4):478-86. PMID: 19731160; PMCID: PMC3041986.
    59. Metzler-Guillemain C, Depetris D, Luciani JJ, Mignon-Ravix C, Mitchell MJ, Mattei MG. In human pachytene spermatocytes, SUMO protein is restricted to the constitutive heterochromatin. Chromosome Res. 2008; 16(5):761-82. PMID: 18592385.
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    60. Ehrmann I, Dalgliesh C, Tsaousi A, Paronetto MP, Heinrich B, Kist R, Cairns P, Li W, Mueller C, Jackson M, Peters H, Nayernia K, Saunders P, Mitchell M, Stamm S, Sette C, Elliott DJ. Haploinsufficiency of the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse. Hum Mol Genet. 2008 Sep 15; 17(18):2803-18. PMID: 18562473.
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    61. Kichine E, Msaidie S, Bokilo AD, Ducourneau A, Navarro A, Levy N, Terriou P, Collignon P, Boetsch G, Chiaroni J, Mitchell MJ. Low-frequency protamine 1 gene transversions c.102G->T and c.-107G->C do not correlate with male infertility. J Med Genet. 2008 Apr; 45(4):255-6. PMID: 18381856.
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    62. Mitchell MJ, Montgomery M, Reiter CG, Culp WC. Pericardial tamponade following CT-guided lung biopsy. Cardiovasc Intervent Radiol. 2008 Jul; 31 Suppl 2:S227-30. PMID: 17962996.
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    63. Dai L, Cutler JA, Savidge GF, Mitchell MJ. Characterization of a causative mutation of hemophilia A identified in the promoter region of the factor VIII gene (F8). J Thromb Haemost. 2008 Jan; 6(1):193-5. PMID: 17944985.
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    64. Mitchell MJ, Dai L, Clarke JB, Bolton-Maggs PH, Savidge GF, Alhaq A. Characterisation of five factor XI mutations. Thromb Haemost. 2007 Jun; 97(6):884-9. PMID: 17549289.
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    65. Karcanias AC, Ichimura K, Mitchell MJ, Sargent CA, Affara NA. Analysis of sex chromosome abnormalities using X and Y chromosome DNA tiling path arrays. J Med Genet. 2007 Jul; 44(7):429-36. PMID: 17327287; PMCID: PMC2598010.
    66. Bolton-Maggs PH, Hay CR, Shanks D, Mitchell MJ, McVey JH. The importance of tissue factor source in the management of Factor VII deficiency. Thromb Haemost. 2007 Jan; 97(1):151-2. PMID: 17200783.
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    67. Mitchell M, Mountford R, Butler R, Alhaq A, Dai L, Savidge G, Bolton-Maggs PH. Spectrum of factor XI (F11) mutations in the UK population--116 index cases and 140 mutations. Hum Mutat. 2006 Aug; 27(8):829. PMID: 16835901.
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    68. Turner JM, Mahadevaiah SK, Ellis PJ, Mitchell MJ, Burgoyne PS. Pachytene asynapsis drives meiotic sex chromosome inactivation and leads to substantial postmeiotic repression in spermatids. Dev Cell. 2006 Apr; 10(4):521-9. PMID: 16580996.
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    69. Perrin J, Metzler-Guillemain C, Karsenty G, Grillo JM, Mitchell MJ, Guichaoua MR. Meiotic arrest at the midpachytene stage in a patient with complete azoospermia factor b deletion of the Y chromosome. Fertil Steril. 2006 Feb; 85(2):494.e5-8. PMID: 16595237.
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    70. Millrain M, Scott D, Addey C, Dewchand H, Ellis P, Ehrmann I, Mitchell M, Burgoyne P, Simpson E, Dyson J. Identification of the immunodominant HY H2-D(k) epitope and evaluation of the role of direct and indirect antigen presentation in HY responses. J Immunol. 2005 Dec 01; 175(11):7209-17. PMID: 16301625.
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    71. Giachini C, Guarducci E, Longepied G, Degl'Innocenti S, Becherini L, Forti G, Mitchell MJ, Krausz C. The gr/gr deletion(s): a new genetic test in male infertility? J Med Genet. 2005 Jun; 42(6):497-502. PMID: 15937085; PMCID: PMC1736069.
    72. Lepretre AC, Patrat C, Mitchell M, Jouannet P, Bienvenu T. No partial DAZ deletions but frequent gene conversion events on the Y chromosome of fertile men. J Assist Reprod Genet. 2005 Apr; 22(4):141-8. PMID: 16021857; PMCID: PMC3455284.
    73. Cutler JA, Patel R, Mitchell MJ, Savidge GF. The significance of published polymorphisms in 14 cases of mild factor VII deficiency. Blood Coagul Fibrinolysis. 2005 Mar; 16(2):91-5. PMID: 15741795.
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    74. Machev N, Saut N, Longepied G, Terriou P, Navarro A, Levy N, Guichaoua M, Metzler-Guillemain C, Collignon P, Frances AM, Belougne J, Clemente E, Chiaroni J, Chevillard C, Durand C, Ducourneau A, Pech N, McElreavey K, Mattei MG, Mitchell MJ. Sequence family variant loss from the AZFc interval of the human Y chromosome, but not gene copy loss, is strongly associated with male infertility. J Med Genet. 2004 Nov; 41(11):814-25. PMID: 15520406; PMCID: PMC1735624.
    75. Cutler JA, Mitchell MJ, Smith MP, Savidge GF. Germline mosaicism resulting in the transmission of severe hemophilia B from a grandfather with a mild deficiency. Am J Med Genet A. 2004 Aug 15; 129A(1):13-5. PMID: 15266608.
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    76. Mitchell M, Dai L, Savidge G, Alhaq A. An Alu-mediated 31.5-kb deletion as the cause of factor XI deficiency in 2 unrelated patients. Blood. 2004 Oct 15; 104(8):2394-6. PMID: 15226185.
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    77. Cutler JA, Mitchell MJ, Savidge GF. More on: unusual expression of the F9 gene in peripheral lymphocytes hinders investigation of F9 mRNA in hemophilia B patients. J Thromb Haemost. 2004 Jun; 2(6):1021. PMID: 15140150.
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    78. Dai L, Mitchell M, Carson P, Creagh D, Cutler J, Savidge G, Alhaq A. Severe factor XI deficiency caused by compound heterozygosity. Br J Haematol. 2004 Jun; 125(6):817-8. PMID: 15180874.
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    79. Delbridge ML, Longepied G, Depetris D, Mattei MG, Disteche CM, Marshall Graves JA, Mitchell MJ. TSPY, the candidate gonadoblastoma gene on the human Y chromosome, has a widely expressed homologue on the X - implications for Y chromosome evolution. Chromosome Res. 2004; 12(4):345-56. PMID: 15241014.
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    80. Mitchell M, Harrington P, Cutler J, Rangarajan S, Savidge G, Alhaq A. Eighteen unrelated patients with factor XI deficiency, four novel mutations and a 100% detection rate by denaturing high-performance liquid chromatography. Br J Haematol. 2003 May; 121(3):500-2. PMID: 12716376.
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    81. Patel YM, Patel K, Rahman S, Smith MP, Spooner G, Sumathipala R, Mitchell M, Flynn G, Aitken A, Savidge G. Evidence for a role for Galphai1 in mediating weak agonist-induced platelet aggregation in human platelets: reduced Galphai1 expression and defective Gi signaling in the platelets of a patient with a chronic bleeding disorder. Blood. 2003 Jun 15; 101(12):4828-35. PMID: 12609843.
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    82. Bagai S, Rubio E, Cheng JF, Sweet R, Thomas R, Fuchs E, Grady R, Mitchell M, Bassuk JA. Fibroblast growth factor-10 is a mitogen for urothelial cells. J Biol Chem. 2002 Jun 28; 277(26):23828-37. PMID: 11923311.
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    83. Cutler JA, Mitchell MJ, Smith MP, Savidge GF. The identification and classification of 41 novel mutations in the factor VIII gene (F8C). Hum Mutat. 2002 Mar; 19(3):274-8. PMID: 11857744.
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    84. McElreavey K, Mitchell MJ. The sexually transmitted genome. Trends Genet. 2002 Jan; 18(1):13-4. PMID: 11750690.
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    85. Mazeyrat S, Saut N, Grigoriev V, Mahadevaiah SK, Ojarikre OA, Bishop C, Eicher EM, Mitchell MJ, Burgoyne PS. A Y-encoded subunit of the translation initiation factor Eif2 is essential for mouse spermatogenesis. Nat Genet. 2001 Sep; 29(1):49-53. PMID: 11528390.
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    86. Lingenfelter PA, Delbridge ML, Thomas S, Hoekstra HE, Mitchell MJ, Graves JA, Disteche CM. Expression and conservation of processed copies of the RBMX gene. Mamm Genome. 2001 Jul; 12(7):538-45. PMID: 11420617.
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    87. Cutler JA, Mitchell MJ, Greenslade K, Smith MP, Savidge GF. A rapid and cost-effective method for analysis of three common genetic risk factors for thrombosis. Blood Coagul Fibrinolysis. 2001 Jan; 12(1):33-6. PMID: 11229824.
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    88. Affara NA, Mitchell MJ. The role of human and mouse Y chromosome genes in male infertility. J Endocrinol Invest. 2000 Nov; 23(10):630-45. PMID: 11097427.
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    89. Saut N, Terriou P, Navarro A, Lévy N, Mitchell MJ. The human Y chromosome genes BPY2, CDY1 and DAZ are not essential for sustained fertility. Mol Hum Reprod. 2000 Sep; 6(9):789-93. PMID: 10956550.
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    90. Scott D, Addey C, Ellis P, James E, Mitchell MJ, Saut N, Jurcevic S, Simpson E. Dendritic cells permit identification of genes encoding MHC class II-restricted epitopes of transplantation antigens. Immunity. 2000 Jun; 12(6):711-20. PMID: 10894170.
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    91. Lévy N, Navarro A, Bishop CE, Mitchell MJ. The ubiquitin-activating enzyme E1 homologous genes on the mouse Y chromosome (Ube1y) represent one functional gene and six partial pseudogenes. Mamm Genome. 2000 Feb; 11(2):164-8. PMID: 10656933.
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    92. Mitchell MJ. Spermatogenesis and the mouse Y chromosome: specialisation out of decay. Results Probl Cell Differ. 2000; 28:233-70. PMID: 10626301.
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    93. Bishop CE, Mitchell MJ. Mouse Y chromosome. Mamm Genome. 1999 Oct; 10(10):962. PMID: 10501963.
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    94. Mazeyrat S, Saut N, Mattei MG, Mitchell MJ. RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene. Nat Genet. 1999 Jul; 22(3):224-6. PMID: 10391207.
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    95. Smith MP, Spence KJ, Waters EL, Beresford-Webb R, Mitchell MJ, Cuttler J, Alhaq A, Brown SA, Savidge GF. Immune tolerance therapy for haemophilia A patients with acquired factor VIII alloantibodies: comprehensive analysis of experience at a single institution. Thromb Haemost. 1999 Jan; 81(1):35-8. PMID: 9974371.
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    96. Ehrmann IE, Ellis PS, Mazeyrat S, Duthie S, Brockdorff N, Mattei MG, Gavin MA, Affara NA, Brown GM, Simpson E, Mitchell MJ, Scott DM. Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. Hum Mol Genet. 1998 Oct; 7(11):1725-37. PMID: 9736774.
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    97. Mazeyrat S, Saut N, Sargent CA, Grimmond S, Longepied G, Ehrmann IE, Ellis PS, Greenfield A, Affara NA, Mitchell MJ. The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region. Hum Mol Genet. 1998 Oct; 7(11):1713-24. PMID: 9736773.
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    98. Mitchell MJ, Wilcox SA, Watson JM, Lerner JL, Woods DR, Scheffler J, Hearn JP, Bishop CE, Graves JA. The origin and loss of the ubiquitin activating enzyme gene on the mammalian Y chromosome. Hum Mol Genet. 1998 Mar; 7(3):429-34. PMID: 9467000.
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    99. Mazeyrat S, Mitchell MJ. Rodent Y chromosome TSPY gene is functional in rat and non-functional in mouse. Hum Mol Genet. 1998 Mar; 7(3):557-62. PMID: 9467017.
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    100. Bishop CE, Mitchell MJ. Encyclopedia of the mouse genome VII. Mouse chromosome Y. Mamm Genome. 1998; 8 Spec No:S378-81. PMID: 9662638.
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    101. Levy N, de Boer P, Mattei J, Mitchell MJ. Molecular analysis of an isoYq chromosome in a sterile male mouse. Mamm Genome. 1996 Aug; 7(8):608-9. PMID: 8678984.
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    102. Laval SH, Blair HJ, Mitchell MJ, Boyd Y. Smcx lies distal to DXHX674 and DXHX679 on the mouse X chromosome. Mamm Genome. 1996 Jul; 7(7):552. PMID: 8672147.
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    103. Bishop CE, Mitchell MJ. Encyclopedia of the mouse genome V. Mouse Y chromosome. Mamm Genome. 1996; 6 Spec No:S331-3. PMID: 8800777.
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    104. Scott DM, Ehrmann IE, Ellis PS, Bishop CE, Agulnik AI, Simpson E, Mitchell MJ. Identification of a mouse male-specific transplantation antigen, H-Y. Nature. 1995 Aug 24; 376(6542):695-8. PMID: 7544442.
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    105. King TR, Christianson GJ, Mitchell MJ, Bishop CE, Scott D, Ehrmann I, Simpson E, Eicher EM, Roopenian DC. Deletion mapping by immunoselection against the H-Y histocompatibility antigen further resolves the Sxra region of the mouse Y chromosome and reveals complexity of the Hya locus. Genomics. 1994 Nov 01; 24(1):159-68. PMID: 7896271.
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    106. Agulnik AI, Mitchell MJ, Mattei MG, Borsani G, Avner PA, Lerner JL, Bishop CE. A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human. Hum Mol Genet. 1994 Jun; 3(6):879-84. PMID: 7951230.
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    107. Agulnik AI, Mitchell MJ, Lerner JL, Woods DR, Bishop CE. A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens. Hum Mol Genet. 1994 Jun; 3(6):873-8. PMID: 7524912.
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    108. McLaren A, Simpson E, Bishop CE, Mitchell MJ, Darling SM. Recombination between the X and Y chromosomes and the Sxr region of the mouse. Genet Res. 1992 Dec; 60(3):175-84. PMID: 1286802.
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    109. Mitchell MJ, Woods DR, Wilcox SA, Graves JA, Bishop CE. Marsupial Y chromosome encodes a homologue of the mouse Y-linked candidate spermatogenesis gene Ube1y. Nature. 1992 Oct 08; 359(6395):528-31. PMID: 1406968.
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    110. Mitchell MJ, Bishop CE. A structural analysis of the Sxr region of the mouse Y chromosome. Genomics. 1992 Jan; 12(1):26-34. PMID: 1733861.
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    111. Zwelling LA, Mitchell MJ, Satitpunwaycha P, Mayes J, Altschuler E, Hinds M, Baguley BC. Relative activity of structural analogues of amsacrine against human leukemia cell lines containing amsacrine-sensitive or -resistant forms of topoisomerase II: use of computer simulations in new drug development. Cancer Res. 1992 Jan 01; 52(1):209-17. PMID: 1309224.
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    112. Mitchell MJ, Woods DR, Tucker PK, Opp JS, Bishop CE. Homology of a candidate spermatogenic gene from the mouse Y chromosome to the ubiquitin-activating enzyme E1. Nature. 1991 Dec 12; 354(6353):483-6. PMID: 1684224.
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    113. Tiersch TR, Mitchell MJ, Wachtel SS. Studies on the phylogenetic conservation of the SRY gene. Hum Genet. 1991 Sep; 87(5):571-3. PMID: 1916759.
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    114. Mitchell MJ, Laughon BE, Lin S. Biochemical studies on the effect of Clostridium difficile toxin B on actin in vivo and in vitro. Infect Immun. 1987 Jul; 55(7):1610-5. PMID: 3596804; PMCID: PMC260566.
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