Immunophilins
"Immunophilins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.
Descriptor ID |
D020104
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MeSH Number(s) |
D08.811.399.325.500.400 D12.776.543.750.705.400 D12.776.827.275
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Immunophilins".
Below are MeSH descriptors whose meaning is more specific than "Immunophilins".
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