 Neural Tube Defects
"Neural Tube Defects" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
| Descriptor ID |
D009436
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| MeSH Number(s) |
C10.500.680 C16.131.666.680
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| Concept/Terms |
Neural Tube Defects- Neural Tube Defects
- Defect, Neural Tube
- Defects, Neural Tube
- Neural Tube Defect
- Developmental Neural Tube Defects
- Neural Tube Developmental Defects
- Developmental Defects, Neural Tube
Tethered Cord Syndrome- Tethered Cord Syndrome
- Tethered Cord Syndromes
- Occult Spinal Dysraphism Sequence
- Tethered Spinal Cord Syndrome
- Occult Spinal Dysraphism
- Dysraphism, Occult Spinal
- Dysraphisms, Occult Spinal
- Occult Spinal Dysraphisms
- Spinal Dysraphism, Occult
- Spinal Dysraphisms, Occult
Neurenteric Cyst- Neurenteric Cyst
- Cyst, Neurenteric
- Cysts, Neurenteric
- Neurenteric Cysts
- Neuroenteric Cyst
- Cyst, Neuroenteric
- Cysts, Neuroenteric
- Neuroenteric Cysts
Spinal Cord Myelodysplasia- Spinal Cord Myelodysplasia
- Myelodysplasia, Spinal Cord
- Myelodysplasias, Spinal Cord
- Spinal Cord Myelodysplasias
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Below are MeSH descriptors whose meaning is more general than "Neural Tube Defects".
Below are MeSH descriptors whose meaning is more specific than "Neural Tube Defects".
This graph shows the total number of publications written about "Neural Tube Defects" by people in this website by year, and whether "Neural Tube Defects" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 0 | 1 | 1 | | 1995 | 1 | 0 | 1 | | 1996 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 | | 2002 | 1 | 1 | 2 | | 2003 | 1 | 0 | 1 | | 2005 | 2 | 1 | 3 | | 2006 | 0 | 1 | 1 | | 2007 | 2 | 0 | 2 | | 2008 | 0 | 1 | 1 | | 2010 | 2 | 1 | 3 | | 2011 | 3 | 0 | 3 | | 2012 | 2 | 2 | 4 | | 2013 | 1 | 1 | 2 | | 2014 | 2 | 2 | 4 | | 2015 | 0 | 1 | 1 | | 2016 | 3 | 1 | 4 | | 2017 | 1 | 1 | 2 | | 2018 | 5 | 0 | 5 | | 2019 | 1 | 2 | 3 | | 2020 | 2 | 0 | 2 |
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Below are the most recent publications written about "Neural Tube Defects" by people in Profiles.
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Brown HM, Murray SA, Northrup H, Au KS, Niswander LA. Snx3 is important for mammalian neural tube closure via its role in canonical and non-canonical WNT signaling. Development. 2020 11 19; 147(22).
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Lachenauer ER, Stabler SP, Field MS, Stover PJ. p53 Disruption Increases Uracil Accumulation in DNA of Murine Embryonic Fibroblasts and Leads to Folic Acid-Nonresponsive Neural Tube Defects in Mice. J Nutr. 2020 07 01; 150(7):1705-1712.
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Goldstein HE, Shao B, Madsen PJ, Hartnett SM, Blount JP, Brockmeyer DL, Campbell RM, Conklin M, Hankinson TC, Heuer GG, Jea AH, Kennedy BC, Tuite GF, Rodriguez L, Feldstein NA, Vitale MG, Anderson RCE. Increased complications without neurological benefit are associated with prophylactic spinal cord untethering prior to scoliosis surgery in children with myelomeningocele. Childs Nerv Syst. 2019 11; 35(11):2187-2194.
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Jackson T, Jones A, Miller N, Georgopoulos G. Clubfoot and Tethered Cord Syndrome: Results of Treatment With the Ponseti Method. J Pediatr Orthop. 2019 Jul; 39(6):318-321.
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Kousa YA, Zhu H, Fakhouri WD, Lei Y, Kinoshita A, Roushangar RR, Patel NK, Agopian AJ, Yang W, Leslie EJ, Busch TD, Mansour TA, Li X, Smith AL, Li EB, Sharma DB, Williams TJ, Chai Y, Amendt BA, Liao EC, Mitchell LE, Bassuk AG, Gregory S, Ashley-Koch A, Shaw GM, Finnell RH, Schutte BC. The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation. Hum Mol Genet. 2019 05 15; 28(10):1726-1737.
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Li H, Zhang J, Niswander L. Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation. Development. 2018 12 13; 145(24).
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Alexiades NG, Ahn ES, Blount JP, Brockmeyer DL, Browd SR, Grant GA, Heuer GG, Hankinson TC, Iskandar BJ, Jea A, Krieger MD, Leonard JR, Limbrick DD, Maher CO, Proctor MR, Sandberg DI, Wellons JC, Shao B, Feldstein NA, Anderson RCE. Development of best practices to minimize wound complications after complex tethered spinal cord surgery: a modified Delphi study. J Neurosurg Pediatr. 2018 Dec 01; 22(6):701-709.
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Bischoff A, Peña A, Ketzer J, Campbell K, O' Neill B, Stence N, Mirsky D. The conus medullaris ratio: A new way to identify tethered cord on MRI. J Pediatr Surg. 2019 Feb; 54(2):280-284.
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Li H, Niswander L. Does DNA methylation provide a link between folate and neural tube closure? Epigenomics. 2018 10; 10(10):1263-1265.
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Li H, Zhang J, Chen S, Wang F, Zhang T, Niswander L. Genetic contribution of retinoid-related genes to neural tube defects. Hum Mutat. 2018 04; 39(4):550-562.
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