 Neural Tube Defects
"Neural Tube Defects" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
| Descriptor ID |
D009436
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| MeSH Number(s) |
C10.500.680 C16.131.666.680
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| Concept/Terms |
Neural Tube Defects- Neural Tube Defects
- Defect, Neural Tube
- Defects, Neural Tube
- Neural Tube Defect
- Developmental Neural Tube Defects
- Neural Tube Developmental Defects
- Developmental Defects, Neural Tube
Tethered Cord Syndrome- Tethered Cord Syndrome
- Tethered Cord Syndromes
- Occult Spinal Dysraphism Sequence
- Tethered Spinal Cord Syndrome
- Occult Spinal Dysraphism
- Dysraphism, Occult Spinal
- Dysraphisms, Occult Spinal
- Occult Spinal Dysraphisms
- Spinal Dysraphism, Occult
- Spinal Dysraphisms, Occult
Neurenteric Cyst- Neurenteric Cyst
- Cyst, Neurenteric
- Cysts, Neurenteric
- Neurenteric Cysts
- Neuroenteric Cyst
- Cyst, Neuroenteric
- Cysts, Neuroenteric
- Neuroenteric Cysts
Spinal Cord Myelodysplasia- Spinal Cord Myelodysplasia
- Myelodysplasia, Spinal Cord
- Myelodysplasias, Spinal Cord
- Spinal Cord Myelodysplasias
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Below are MeSH descriptors whose meaning is more general than "Neural Tube Defects".
Below are MeSH descriptors whose meaning is more specific than "Neural Tube Defects".
This graph shows the total number of publications written about "Neural Tube Defects" by people in this website by year, and whether "Neural Tube Defects" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 1996 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 1 | 0 | 1 | | 2005 | 2 | 1 | 3 | | 2006 | 0 | 1 | 1 | | 2007 | 2 | 0 | 2 | | 2008 | 0 | 1 | 1 | | 2010 | 1 | 1 | 2 | | 2011 | 2 | 0 | 2 | | 2012 | 2 | 2 | 4 | | 2013 | 1 | 1 | 2 | | 2014 | 3 | 2 | 5 | | 2015 | 0 | 1 | 1 | | 2016 | 3 | 1 | 4 | | 2017 | 0 | 1 | 1 | | 2018 | 5 | 0 | 5 | | 2019 | 1 | 2 | 3 | | 2020 | 3 | 0 | 3 | | 2021 | 3 | 0 | 3 | | 2022 | 3 | 0 | 3 | | 2024 | 0 | 1 | 1 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Neural Tube Defects" by people in Profiles.
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Engelhardt D, Petersen JR, Martyr C, Kuhn-Gale H, Niswander LA. Moderate levels of folic acid benefit outcomes for cilia based neural tube defects. Dev Biol. 2025 04; 520:62-74.
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Engelhardt D, Marean A, McKean D, Petersen J, Niswander L. RSG1 is required for cilia-dependent neural tube closure. Genesis. 2024 06; 62(3):e23602.
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Li B, Brusman L, Dahlka J, Niswander LA. TMEM132A ensures mouse caudal neural tube closure and regulates integrin-based mesodermal migration. Development. 2022 09 01; 149(17).
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Kunes J, Quan T, Iyer R, Fano AN, Matsumoto H, Erickson M, McCarthy R, Brockmeyer D, Anderson RCE, Vitale MG. Reduced complication rate with simultaneous detethering and spinal deformity correction surgery compared to staged surgeries in patients with early onset scoliosis. Spine Deform. 2022 11; 10(6):1473-1480.
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Engelhardt DM, Martyr CA, Niswander L. Pathogenesis of neural tube defects: The regulation and disruption of cellular processes underlying neural tube closure. WIREs Mech Dis. 2022 09; 14(5):e1559.
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Carrera EJ, Summers W, Yeung G, Sanchez O. Congenital Tethered Cord Presenting as Chronic Back Pain in a 29-Yr-Old Woman. Am J Phys Med Rehabil. 2021 11 01; 100(11):e162-e163.
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Kakebeen AD, Niswander L. Micronutrient imbalance and common phenotypes in neural tube defects. Genesis. 2021 11; 59(11):e23455.
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Svokos K, Batista-Silverman L, Graber SJ, O'Neill BR, Handler MH. International survey on the management of lumbosacral cutaneous stigmata in infants with suspected occult spinal dysraphism. J Neurosurg Pediatr. 2021 11 01; 28(5):592-599.
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Lepage N, Wyatt P, Ashwood ER, Best RG, Long T, Palomaki GE. Prenatal serum screening for Down syndrome and neural tube defects in the United States: Changes in utilization patterns from 2012 to 2020. J Med Screen. 2021 12; 28(4):405-410.
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Brown HM, Murray SA, Northrup H, Au KS, Niswander LA. Snx3 is important for mammalian neural tube closure via its role in canonical and non-canonical WNT signaling. Development. 2020 11 19; 147(22).
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