Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
Institution

Christopher P. Ford

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PHARM General Operations

    Collapse Research 
    Collapse research activities and funding
    R21MH123085     (FORD, CHRISTOPHER PETER)Apr 1, 2020 - Mar 31, 2022
    NIH
    Stress induced plasticity of excitatory inputs to the LC
    Role: Principal Investigator
    RF1MH123085     (FORD, CHRISTOPHER PETER)Apr 1, 2020 - Mar 31, 2022
    NIH/NIMH
    Stress induced plasticity of excitatory inputs to the LC
    Role: Principal Investigator
    UF1NS107710     (KENNEDY, MATTHEW J)Sep 30, 2018 - Sep 29, 2021
    NIH
    Validating and extending optical tools for extended neural silencing
    Role: Co-Principal Investigator
    R01NS095809     (FORD, CHRISTOPHER PETER)Jan 15, 2016 - Feb 28, 2025
    NIH
    Regulation of Striatal Acetylcholine Transmission by Choinergic Interneurons
    Role: Principal Investigator
    R01DA035821     (FORD, CHRISTOPHER PETER)Aug 1, 2013 - Feb 28, 2025
    NIH
    Encoding dopamine signals in the mesolimbic system
    Role: Principal Investigator
    R00DA026417     (FORD, CHRISTOPHER PETER)Apr 1, 2011 - Mar 31, 2014
    NIH
    Mechanisms of Dopamine Transmission in the VTA
    Role: Principal Investigator
    K99DA026417     (FORD, CHRISTOPHER PETER)Apr 1, 2009 - Mar 31, 2011
    NIH
    Mechanisms of Dopamine Transmission in the VTA
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Luskin AT, Li L, Fu X, Martin MM, Barcomb K, Girven KS, Blackburn T, Wells BA, Thai ST, Li EM, Rana AN, Simon RC, Sun L, Gao L, Murry AD, Golden SA, Stuber GD, Ford CP, Gu L, Bruchas MR. Heterogeneous pericoerulear neurons tune arousal and exploratory behaviours. Nature. 2025 May 07. PMID: 40335695.
      View in: PubMed
    2. Ly A, Karnosky R, Pr?vost ED, Hotchkiss H, Pelletier J, Spencer RL, Ford CP, Root DH. VGluT3 BNST neurons transmit GABA and restrict feeding without affecting rewarding or aversive processing. bioRxiv. 2025 Jan 02. PMID: 39803518.
      View in: PubMed
    3. Nielsen BE, Ford CP. Reduced striatal M4-cholinergic signaling following dopamine loss contributes to parkinsonian and l-DOPA-induced dyskinetic behaviors. Sci Adv. 2024 Nov 22; 10(47):eadp6301. PMID: 39565858.
      View in: PubMed
    4. Welle TM, Rajgor D, Kareemo DJ, Garcia JD, Zych SM, Wolfe SE, Gookin SE, Martinez TP, Dell'Acqua ML, Ford CP, Kennedy MJ, Smith KR. miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity. EMBO Rep. 2024 Nov; 25(11):5141-5168. PMID: 39294503.
      View in: PubMed
    5. Labouesse MA, Wilhelm M, Kagiampaki Z, Yee AG, Denis R, Harada M, Gresch A, Marinescu AM, Otomo K, Curreli S, Serratosa Capdevila L, Zhou X, Cola RB, Ravotto L, Gl?ck C, Cherepanov S, Weber B, Zhou X, Katner J, Svensson KA, Fellin T, Trudeau LE, Ford CP, Sych Y, Patriarchi T. A chemogenetic approach for dopamine imaging with tunable sensitivity. Nat Commun. 2024 Jul 02; 15(1):5551. PMID: 38956067.
      View in: PubMed
    6. McGovern DJ, Phillips A, Ly A, Pr?vost ED, Ward L, Siletti K, Kim YS, Fenno LE, Ramakrishnan C, Deisseroth K, Ford CP, Root DH. Salience signaling and stimulus scaling of ventral tegmental area glutamate neuron subtypes. bioRxiv. 2024 Jun 12. PMID: 38915564.
      View in: PubMed
    7. Welle TM, Rajgor D, Garcia JD, Kareemo D, Zych SM, Gookin SE, Martinez TP, Dell'Acqua ML, Ford CP, Kennedy MJ, Smith KR. miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity. bioRxiv. 2023 Dec 12. PMID: 38168421.
      View in: PubMed
    8. Jain S, Yee AG, Maas J, Gierok S, Xu H, Stansil J, Eriksen J, Nelson AB, Silm K, Ford CP, Edwards RH. Adaptor protein-3 produces synaptic vesicles that release phasic dopamine. Proc Natl Acad Sci U S A. 2023 10 17; 120(42):e2309843120. PMID: 37812725.
      View in: PubMed
    9. Barcomb K, Ford CP. Alterations in neurotransmitter co-release in Parkinson's disease. Exp Neurol. 2023 12; 370:114562. PMID: 37802381.
      View in: PubMed
    10. Jain S, Yee AG, Maas J, Gierok S, Xu H, Stansil J, Eriksen J, Nelson A, Silm K, Ford CP, Edwards RH. Adaptor Protein-3 Produces Synaptic Vesicles that Release Phasic Dopamine. bioRxiv. 2023 Aug 08. PMID: 37609166.
      View in: PubMed
    11. Rodriguez-Contreras D, Gong S, Lebowitz JJ, Fedorov LM, Asad N, Dore TM, Phillips TJ, Ford CP, Williams JT, Neve KA. Gait Abnormalities and Aberrant D2 Receptor Expression and Signaling in Mice Carrying the Human Pathogenic Mutation DRD2I212F. Mol Pharmacol. 2023 03; 103(3):188-198. PMID: 36456191.
      View in: PubMed
    12. Barcomb K, Olah SS, Kennedy MJ, Ford CP. Properties and modulation of excitatory inputs to the locus coeruleus. J Physiol. 2022 11; 600(22):4897-4916. PMID: 36156249.
      View in: PubMed
    13. Zych SM, Ford CP. Divergent properties and independent regulation of striatal dopamine and GABA co-transmission. Cell Rep. 2022 05 17; 39(7):110823. PMID: 35584679.
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    14. Gong S, Fayette N, Heinsbroek JA, Ford CP. Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors. Neuron. 2022 Apr 06; 110(7):1272. PMID: 35390291.
      View in: PubMed
    15. Gong S, Fayette N, Heinsbroek JA, Ford CP. Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors. Neuron. 2021 11 03; 109(21):3421-3435.e5. PMID: 34506723.
      View in: PubMed
    16. Giannotti G, Gong S, Fayette N, Heinsbroek JA, Orfila JE, Herson PS, Ford CP, Peters J. Extinction blunts paraventricular thalamic contributions to heroin relapse. Cell Rep. 2021 08 24; 36(8):109605. PMID: 34433067.
      View in: PubMed
    17. Cai Y, Nielsen BE, Boxer EE, Aoto J, Ford CP. Loss of nigral excitation of cholinergic interneurons contributes to parkinsonian motor impairments. Neuron. 2021 04 07; 109(7):1137-1149.e5. PMID: 33600762.
      View in: PubMed
    18. Zych S, Ford CP. Opioid-Induced Adaptations of cAMP Dynamics in the Nucleus Accumbens. Trends Pharmacol Sci. 2020 04; 41(4):230-232. PMID: 31964511.
      View in: PubMed
    19. Gong S, Ford CP. Cholinergic Interneurons Provide a Link to Balance Excitation across Striatal Output Neurons. Neuron. 2019 08 07; 103(3):351-353. PMID: 31394056.
      View in: PubMed
    20. Mamaligas AA, Barcomb K, Ford CP. Cholinergic Transmission at Muscarinic Synapses in the Striatum Is Driven Equally by Cortical and Thalamic Inputs. Cell Rep. 2019 07 23; 28(4):1003-1014.e3. PMID: 31340139.
      View in: PubMed
    21. Silm K, Yang J, Marcott PF, Asensio CS, Eriksen J, Guthrie DA, Newman AH, Ford CP, Edwards RH. Synaptic Vesicle Recycling Pathway Determines Neurotransmitter Content and Release Properties. Neuron. 2019 05 22; 102(4):786-800.e5. PMID: 31003725.
      View in: PubMed
    22. Liu Q, Sinnen BL, Boxer EE, Schneider MW, Grybko MJ, Buchta WC, Gibson ES, Wysoczynski CL, Ford CP, Gottschalk A, Aoto J, Tucker CL, Kennedy MJ. A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission. Neuron. 2019 03 06; 101(5):863-875.e6. PMID: 30704911.
      View in: PubMed
    23. Cai Y, Ford CP. Dopamine Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of Dopamine and Glutamate. Cell Rep. 2018 12 11; 25(11):3148-3157.e3. PMID: 30540946.
      View in: PubMed
    24. Mulvey B, Bhatti DL, Gyawali S, Lake AM, Kriaucionis S, Ford CP, Bruchas MR, Heintz N, Dougherty JD. Molecular and Functional Sex Differences of Noradrenergic Neurons in the Mouse Locus Coeruleus. Cell Rep. 2018 05 22; 23(8):2225-2235. PMID: 29791834.
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    25. Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun. 2018 05 18; 9(1):1996. PMID: 29777099.
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    26. Marcott PF, Gong S, Donthamsetti P, Grinnell SG, Nelson MN, Newman AH, Birnbaumer L, Martemyanov KA, Javitch JA, Ford CP. Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens. Neuron. 2018 05 02; 98(3):575-587.e4. PMID: 29656874.
      View in: PubMed
    27. Gantz SC, Ford CP, Morikawa H, Williams JT. The Evolving Understanding of Dopamine Neurons in the Substantia Nigra and Ventral Tegmental Area. Annu Rev Physiol. 2018 02 10; 80:219-241. PMID: 28938084.
      View in: PubMed
    28. Mamaligas AA, Ford CP. Revealing a Role for NMDA Receptors in Regulating STN Inputs following the Loss of Dopamine. Neuron. 2017 Sep 13; 95(6):1227-1229. PMID: 28910611.
      View in: PubMed
    29. Mamaligas AA, Cai Y, Ford CP. Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission. Sci Rep. 2016 11 25; 6:37834. PMID: 27886263.
      View in: PubMed
    30. Mamaligas AA, Ford CP. Spontaneous Synaptic Activation of Muscarinic Receptors by Striatal Cholinergic Neuron Firing. Neuron. 2016 Aug 03; 91(3):574-86. PMID: 27373830.
      View in: PubMed
    31. Courtney NA, Ford CP. Mechanisms of 5-HT1A receptor-mediated transmission in dorsal raphe serotonin neurons. J Physiol. 2016 Feb 15; 594(4):953-65. PMID: 26634643.
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    32. Piccart E, Courtney NA, Branch SY, Ford CP, Beckstead MJ. Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. J Neurosci. 2015 Aug 05; 35(31):11144-52. PMID: 26245975.
      View in: PubMed
    33. McCall JG, Al-Hasani R, Siuda ER, Hong DY, Norris AJ, Ford CP, Bruchas MR. CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety. Neuron. 2015 Aug 05; 87(3):605-20. PMID: 26212712.
      View in: PubMed
    34. Marcott PF, Mamaligas AA, Ford CP. Phasic dopamine release drives rapid activation of striatal D2-receptors. Neuron. 2014 Oct 01; 84(1):164-176. PMID: 25242218.
      View in: PubMed
    35. Courtney NA, Ford CP. The timing of dopamine- and noradrenaline-mediated transmission reflects underlying differences in the extent of spillover and pooling. J Neurosci. 2014 May 28; 34(22):7645-56. PMID: 24872568.
      View in: PubMed
    36. Courtney NA, Mamaligas AA, Ford CP. Species differences in somatodendritic dopamine transmission determine D2-autoreceptor-mediated inhibition of ventral tegmental area neuron firing. J Neurosci. 2012 Sep 26; 32(39):13520-8. PMID: 23015441.
      View in: PubMed
    37. Gantz SC, Ford CP, Neve KA, Williams JT. Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway. J Neurosci. 2011 Aug 31; 31(35):12629-37. PMID: 21880923.
      View in: PubMed
    38. Bender KJ, Ford CP, Trussell LO. Dopaminergic modulation of axon initial segment calcium channels regulates action potential initiation. Neuron. 2010 Nov 04; 68(3):500-11. PMID: 21040850.
      View in: PubMed
    39. Ford CP, Gantz SC, Phillips PE, Williams JT. Control of extracellular dopamine at dendrite and axon terminals. J Neurosci. 2010 May 19; 30(20):6975-83. PMID: 20484639.
      View in: PubMed
    40. Ford CP, Phillips PE, Williams JT. The time course of dopamine transmission in the ventral tegmental area. J Neurosci. 2009 Oct 21; 29(42):13344-52. PMID: 19846722.
      View in: PubMed
    41. Beckstead MJ, Gantz SC, Ford CP, Stenzel-Poore MP, Phillips PE, Mark GP, Williams JT. CRF enhancement of GIRK channel-mediated transmission in dopamine neurons. Neuropsychopharmacology. 2009 Jul; 34(8):1926-35. PMID: 19279570.
      View in: PubMed
    42. Ford CP, Williams JT. Mesoprefrontal dopamine neurons distinguish themselves. Neuron. 2008 Mar 13; 57(5):631-2. PMID: 18341984.
      View in: PubMed
    43. Ford CP, Wong KV, Lu VB, Posse de Chaves E, Smith PA. Differential neurotrophic regulation of sodium and calcium channels in an adult sympathetic neuron. J Neurophysiol. 2008 Mar; 99(3):1319-32. PMID: 18216230.
      View in: PubMed
    44. Beckstead MJ, Ford CP, Phillips PE, Williams JT. Presynaptic regulation of dendrodendritic dopamine transmission. Eur J Neurosci. 2007 Sep; 26(6):1479-88. PMID: 17822435.
      View in: PubMed
    45. Ford CP, Beckstead MJ, Williams JT. Kappa opioid inhibition of somatodendritic dopamine inhibitory postsynaptic currents. J Neurophysiol. 2007 Jan; 97(1):883-91. PMID: 17122312.
      View in: PubMed
    46. Ford CP, Mark GP, Williams JT. Properties and opioid inhibition of mesolimbic dopamine neurons vary according to target location. J Neurosci. 2006 Mar 08; 26(10):2788-97. PMID: 16525058.
      View in: PubMed
    47. Ford CP, Stemkowski PL, Smith PA. Possible role of phosphatidylinositol 4,5 bisphosphate in luteinizing hormone releasing hormone-mediated M-current inhibition in bullfrog sympathetic neurons. Eur J Neurosci. 2004 Dec; 20(11):2990-8. PMID: 15579153.
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    48. Ford CP, Dryden WF, Smith PA. Neurotrophic regulation of calcium channels by the peptide neurotransmitter luteinizing hormone releasing hormone. J Neurosci. 2003 Aug 06; 23(18):7169-75. PMID: 12904477.
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    49. Ford CP, Stemkowski PL, Light PE, Smith PA. Experiments to test the role of phosphatidylinositol 4,5-bisphosphate in neurotransmitter-induced M-channel closure in bullfrog sympathetic neurons. J Neurosci. 2003 Jun 15; 23(12):4931-41. PMID: 12832515.
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    50. Stemkowski PL, Tse FW, Peuckmann V, Ford CP, Colmers WF, Smith PA. ATP-inhibition of M current in frog sympathetic neurons involves phospholipase C but not Ins P(3), Ca(2+), PKC, or Ras. J Neurophysiol. 2002 Jul; 88(1):277-88. PMID: 12091553.
      View in: PubMed
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