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Benjamin Guy Bitler

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-OB/GYN BRS

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bitler BG, Wu S, Park PH, Hai Y, Aird KM, Wang Y, Zhai Y, Kossenkov AV, Vara-Ailor A, Rauscher Iii FJ, Zou W, Speicher DW, Huntsman DG, Conejo-Garcia JR, Cho KR, Christianson DW, Zhang R. ARID1A-mutated ovarian cancers depend on HDAC6 activity. Nat Cell Biol. 2017 Aug; 19(8):962-973. PMID: 28737768.
      View in: PubMed
    2. Baumgartner HK, Rudolph MC, Ramanathan P, Burns V, Webb P, Bitler BG, Stein T, Kobayashi K, Neville MC. Developmental Expression of Claudins in the Mammary Gland. J Mammary Gland Biol Neoplasia. 2017 Jun; 22(2):141-157. PMID: 28455726.
      View in: PubMed
    3. Yokoyama Y, Zhu H, Lee JH, Kossenkov AV, Wu SY, Wickramasinghe JM, Yin X, Palozola KC, Gardini A, Showe LC, Zaret KS, Liu Q, Speicher D, Conejo-Garcia JR, Bradner JE, Zhang Z, Sood AK, Ordog T, Bitler BG, Zhang R. BET Inhibitors Suppress ALDH Activity by Targeting ALDH1A1 Super-Enhancer in Ovarian Cancer. Cancer Res. 2016 Nov 01; 76(21):6320-6330. PMID: 27803105.
      View in: PubMed
    4. Aird KM, Iwasaki O, Kossenkov AV, Tanizawa H, Fatkhutdinov N, Bitler BG, Le L, Alicea G, Yang TL, Johnson FB, Noma KI, Zhang R. HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci. J Cell Biol. 2016 Nov 07; 215(3):325-334. PMID: 27799366.
      View in: PubMed
    5. Goldman AR, Bitler BG, Schug Z, Conejo-Garcia JR, Zhang R, Speicher DW. The Primary Effect on the Proteome of ARID1A-mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-transcriptional Level. Mol Cell Proteomics. 2016 Nov; 15(11):3348-3360. PMID: 27654507.
      View in: PubMed
    6. Zhu H, Bengsch F, Svoronos N, Rutkowski MR, Bitler BG, Allegrezza MJ, Yokoyama Y, Kossenkov AV, Bradner JE, Conejo-Garcia JR, Zhang R. BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression. Cell Rep. 2016 Sep 13; 16(11):2829-37. PMID: 27626654.
      View in: PubMed
    7. Wu S, Zhang R, Bitler BG. Arid1a controls tissue regeneration. Stem Cell Investig. 2016; 3:35. PMID: 27582418; PMCID: PMC4981703.
      View in: PubMed, PubMed Central
    8. Zhu H, Ren S, Bitler BG, Aird KM, Tu Z, Skordalakes E, Zhu Y, Yan J, Sun Y, Zhang R. SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase. Cell Rep. 2015 Nov 10; 13(6):1183-93. PMID: 26527005; PMCID: PMC4644472.
      View in: PubMed, PubMed Central
    9. Bitler BG, Fatkhutdinov N, Zhang R. Potential therapeutic targets in ARID1A-mutated cancers. Expert Opin Ther Targets. 2015; 19(11):1419-22. PMID: 26125128; PMCID: PMC4674066.
      View in: PubMed, PubMed Central
    10. Bitler BG, Aird KM, Zhang R. Epigenetic synthetic lethality in ovarian clear cell carcinoma: EZH2 and ARID1A mutations. Mol Cell Oncol. 2016 Jan; 3(1):e1032476. PMID: 27308548; PMCID: PMC4845188.
      View in: PubMed, PubMed Central
    11. Bitler BG, Aird KM, Garipov A, Li H, Amatangelo M, Kossenkov AV, Schultz DC, Liu Q, Shih IeM, Conejo-Garcia JR, Speicher DW, Zhang R. Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers. Nat Med. 2015 Mar; 21(3):231-8. PMID: 25686104; PMCID: PMC4352133.
      View in: PubMed, PubMed Central
    12. Bitler BG, Fink LS, Wei Z, Peterson JR, Zhang R. A high-content screening assay for small-molecule modulators of oncogene-induced senescence. J Biomol Screen. 2013 Oct; 18(9):1054-61. PMID: 23733845; PMCID: PMC3870888.
      View in: PubMed, PubMed Central
    13. Aird KM, Zhang G, Li H, Tu Z, Bitler BG, Garipov A, Wu H, Wei Z, Wagner SN, Herlyn M, Zhang R. Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence. Cell Rep. 2013 Apr 25; 3(4):1252-65. PMID: 23562156; PMCID: PMC3840499.
      View in: PubMed, PubMed Central
    14. Garipov A, Li H, Bitler BG, Thapa RJ, Balachandran S, Zhang R. NF-YA underlies EZH2 upregulation and is essential for proliferation of human epithelial ovarian cancer cells. Mol Cancer Res. 2013 Apr; 11(4):360-9. PMID: 23360797; PMCID: PMC3631279.
      View in: PubMed, PubMed Central
    15. Horm TM, Bitler BG, Broka DM, Louderbough JM, Schroeder JA. MUC1 drives c-Met-dependent migration and scattering. Mol Cancer Res. 2012 Dec; 10(12):1544-54. PMID: 23193156; PMCID: PMC3528822.
      View in: PubMed, PubMed Central
    16. Li H, Bitler BG, Vathipadiekal V, Maradeo ME, Slifker M, Creasy CL, Tummino PJ, Cairns P, Birrer MJ, Zhang R. ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches. Cancer Prev Res (Phila). 2012 Mar; 5(3):484-91. PMID: 22144423; PMCID: PMC3294119.
      View in: PubMed, PubMed Central
    17. Tu Z, Aird KM, Bitler BG, Nicodemus JP, Beeharry N, Xia B, Yen TJ, Zhang R. Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence. Dev Cell. 2011 Dec 13; 21(6):1077-91. PMID: 22137763; PMCID: PMC3241855.
      View in: PubMed, PubMed Central
    18. Bitler BG, Nicodemus JP, Li H, Cai Q, Wu H, Hua X, Li T, Birrer MJ, Godwin AK, Cairns P, Zhang R. Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence. Cancer Res. 2011 Oct 01; 71(19):6184-94. PMID: 21816908; PMCID: PMC3185156.
      View in: PubMed, PubMed Central
    19. Dang H, Klokk TI, Schaheen B, McLaughlin BM, Thomas AJ, Durns TA, Bitler BG, Sandvig K, Fares H. Derlin-dependent retrograde transport from endosomes to the Golgi apparatus. Traffic. 2011 Oct; 12(10):1417-31. PMID: 21722281; PMCID: PMC4596261.
      View in: PubMed, PubMed Central
    20. Bitler BG, Schroeder JA. Anti-cancer therapies that utilize cell penetrating peptides. Recent Pat Anticancer Drug Discov. 2010 Jun; 5(2):99-108. PMID: 19961434.
      View in: PubMed
    21. Bitler BG, Goverdhan A, Schroeder JA. MUC1 regulates nuclear localization and function of the epidermal growth factor receptor. J Cell Sci. 2010 May 15; 123(Pt 10):1716-23. PMID: 20406885; PMCID: PMC2864713.
      View in: PubMed, PubMed Central
    22. Bitler BG, Menzl I, Huerta CL, Sands B, Knowlton W, Chang A, Schroeder JA. Intracellular MUC1 peptides inhibit cancer progression. Clin Cancer Res. 2009 Jan 01; 15(1):100-9. PMID: 19118037; PMCID: PMC2676873.
      View in: PubMed, PubMed Central
    23. Pfeiler E, Bitler BG, Castrezana S, Matzkin LM, Markow TA. Genetic diversification and demographic history of the cactophilic pseudoscorpion Dinocheirus arizonensis from the Sonoran Desert. Mol Phylogenet Evol. 2009 Jul; 52(1):133-41. PMID: 19166949; PMCID: PMC2693363.
      View in: PubMed, PubMed Central
    24. Pochampalli MR, Bitler BG, Schroeder JA. Transforming growth factor alpha dependent cancer progression is modulated by Muc1. Cancer Res. 2007 Jul 15; 67(14):6591-8. PMID: 17638868.
      View in: PubMed
    25. Matzkin LM, Watts TD, Bitler BG, Machado CA, Markow TA. Functional genomics of cactus host shifts in Drosophila mojavensis. Mol Ecol. 2006 Dec; 15(14):4635-43. PMID: 17107489.
      View in: PubMed
    26. Pfeiler E, Bitler BG, Ramsey JM, Palacios-Cardiel C, Markow TA. Genetic variation, population structure, and phylogenetic relationships of Triatoma rubida and T. recurva (Hemiptera: Reduviidae: Triatominae) from the Sonoran Desert, insect vectors of the Chagas' disease parasite Trypanosoma cruzi. Mol Phylogenet Evol. 2006 Oct; 41(1):209-21. PMID: 16934496.
      View in: PubMed
    27. BITLER B, McELROY WD. The preparation and properties of crystalline firefly luciferin. Arch Biochem Biophys. 1957 Dec; 72(2):358-68. PMID: 13479120.
      View in: PubMed
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