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Bradford J Smith

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentCEDC-Bioengineering

    Collapse Research 
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    R01HL151630     (SMITH, BRADFORD J)Jan 1, 2021 - Dec 31, 2025
    NIH
    Predicting and Preventing Ventilator-Induced Lung Injury
    Role: Principal Investigator
    R00HL128944     (SMITH, BRADFORD J)Jan 1, 2017 - Dec 31, 2020
    NIH
    The Importance of Inhomogeneity in the Pathogenesis of Lung Injury
    Role: Principal Investigator
    K99HL128944     (SMITH, BRADFORD J)Jul 15, 2015 - Jun 30, 2017
    NIH
    The Importance of Inhomogeneity in the Pathogenesis of Lung Injury
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Adams AN, Smith BJ, Raad TJ, Mueller RL. Gigantic animal cells suggest organellar scaling mechanisms across a 50-fold range in cell volume. Evolution. 2024 Feb 29; 78(3):442-452. PMID: 38113239.
      View in: PubMed
    2. Mattson CL, Smith BJ. Modeling Ventilator-Induced Lung Injury and Neutrophil Infiltration to Infer Injury Interdependence. Ann Biomed Eng. 2023 Dec; 51(12):2837-2852. PMID: 37592044.
      View in: PubMed
    3. Bilodeaux J, Farooqi H, Osovskaya M, Sosa A, Wallbank A, Knudsen L, Sottile PD, Albers DJ, Smith BJ. Differential effects of two-hit models of acute and ventilator-induced lung injury on lung structure, function, and inflammation. Front Physiol. 2023; 14:1217183. PMID: 37565138.
      View in: PubMed
    4. Wallbank AM, Vaughn AE, Niemiec S, Bilodeaux J, Lehmann T, Knudsen L, Kolanthai E, Seal S, Zgheib C, Nozik E, Liechty KW, Smith BJ. CNP-miR146a improves outcomes in a two-hit acute- and ventilator-induced lung injury model. Nanomedicine. 2023 06; 50:102679. PMID: 37116556.
      View in: PubMed
    5. Stroh JN, Smith BJ, Sottile PD, Hripcsak G, Albers DJ. Hypothesis-driven modeling of the human lung-ventilator system: A characterization tool for Acute Respiratory Distress Syndrome research. J Biomed Inform. 2023 01; 137:104275. PMID: 36572279.
      View in: PubMed
    6. Hume PS, McClendon J, Kopf KW, Harral JW, Poczobutt JM, McCubbrey AL, Smith BJ, Henson PM, Majka SM, Petrache I, Janssen WJ. Cigarette smoke-induced airspace disease in mice develops independently of HIF-1a signaling in leukocytes. Am J Physiol Lung Cell Mol Physiol. 2022 10 01; 323(4):L391-L399. PMID: 35943156.
      View in: PubMed
    7. Saleh KS, Hewawasam R, ?erbed?ija P, Blomberg R, Noreldeen SE, Edelman B, Smith BJ, Riches DWH, Magin CM. Engineering Hybrid-Hydrogels Comprised of Healthy or Diseased Decellularized Extracellular Matrix to Study Pulmonary Fibrosis. Cell Mol Bioeng. 2022 Oct; 15(5):505-519. PMID: 36444345.
      View in: PubMed
    8. Mattson CL, Okamura K, Hume PS, Smith BJ. Spatiotemporal distribution of cellular injury and leukocytes during the progression of ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2022 09 01; 323(3):L281-L296. PMID: 35700201.
      View in: PubMed
    9. Agrawal DK, Smith BJ, Sottile PD, Albers DJ. A Damaged-Informed Lung Ventilator Model for Ventilator Waveforms. Front Physiol. 2021; 12:724046. PMID: 34658911.
      View in: PubMed
    10. Sottile PD, Albers D, Smith BJ, Moss MM. Ventilator dyssynchrony - Detection, pathophysiology, and clinical relevance: A Narrative review. Ann Thorac Med. 2020 Oct-Dec; 15(4):190-198. PMID: 33381233.
      View in: PubMed
    11. Albert K, Krischer JM, Pfaffenroth A, Wilde S, Lopez-Rodriguez E, Braun A, Smith BJ, Knudsen L. Hidden Microatelectases Increase Vulnerability to Ventilation-Induced Lung Injury. Front Physiol. 2020; 11:530485. PMID: 33071807.
      View in: PubMed
    12. Menson KE, Mank MM, Reed LF, Walton CJ, Van Der Vliet KE, Ather JL, Chapman DG, Smith BJ, Rincon M, Poynter ME. Therapeutic efficacy of IL-17A neutralization with corticosteroid treatment in a model of antigen-driven mixed-granulocytic asthma. Am J Physiol Lung Cell Mol Physiol. 2020 10 01; 319(4):L693-L709. PMID: 32783616.
      View in: PubMed
    13. Kheyfets VO, Lammers SR, Wagner J, Bartels K, Piccoli J, Smith BJ. PEEP/ FIO2 ARDSNet Scale Grouping of a Single Ventilator for Two Patients: Modeling Tidal Volume Response. Respir Care. 2020 08; 65(8):1094-1103. PMID: 32712582.
      View in: PubMed
    14. Pertile J, Mellenthin M, Wagner J, DeBoer EM, Fink D, Smith B. The Effects of Laryngoscope Shape and Needle Position on Distal Airway Pressure in Jet Ventilation. Laryngoscope. 2021 02; 131(2):E354-E357. PMID: 32717125.
      View in: PubMed
    15. Mandell EW, Ryan S, Seedorf GJ, Gonzalez T, Smith BJ, Fleet JC, Abman SH. Maternal Vitamin D Deficiency Causes Sustained Impairment of Lung Structure and Function and Increases Susceptibility to Hyperoxia-induced Lung Injury in Infant Rats. Am J Respir Cell Mol Biol. 2020 07; 63(1):79-91. PMID: 32135073.
      View in: PubMed
    16. Smith BJ, Roy GS, Cleveland A, Mattson C, Okamura K, Charlebois CM, Hamlington KL, Novotny MV, Knudsen L, Ochs M, Hite RD, Bates JHT. Three Alveolar Phenotypes Govern Lung Function in Murine Ventilator-Induced Lung Injury. Front Physiol. 2020; 11:660. PMID: 32695013.
      View in: PubMed
    17. Hume PS, Gibbings SL, Jakubzick CV, Tuder RM, Curran-Everett D, Henson PM, Smith BJ, Janssen WJ. Localization of Macrophages in the Human Lung via Design-based Stereology. Am J Respir Crit Care Med. 2020 05 15; 201(10):1209-1217. PMID: 32197050.
      View in: PubMed
    18. Bou Jawde S, Walkey AJ, Majumdar A, O'Connor GT, Smith BJ, Bates JHT, Lutchen KR, Suki B. Tracking respiratory mechanics around natural breathing rates via variable ventilation. Sci Rep. 2020 04 21; 10(1):6722. PMID: 32317734.
      View in: PubMed
    19. R?hl N, Lopez-Rodriguez E, Albert K, Smith BJ, Weaver TE, Ochs M, Knudsen L. Surfactant Protein B Deficiency Induced High Surface Tension: Relationship between Alveolar Micromechanics, Alveolar Fluid Properties and Alveolar Epithelial Cell Injury. Int J Mol Sci. 2019 Aug 30; 20(17). PMID: 31480246.
      View in: PubMed
    20. Albert RK, Smith B, Perlman CE, Schwartz DA. Is Progression of Pulmonary Fibrosis due to Ventilation-induced Lung Injury? Am J Respir Crit Care Med. 2019 07 15; 200(2):140-151. PMID: 31022350.
      View in: PubMed
    21. Mellenthin MM, Seong SA, Roy GS, Bartol?k-Suki E, Hamlington KL, Bates JHT, Smith BJ. Using injury cost functions from a predictive single-compartment model to assess the severity of mechanical ventilator-induced lung injuries. J Appl Physiol (1985). 2019 07 01; 127(1):58-70. PMID: 31046518.
      View in: PubMed
    22. Knudsen L, Lopez-Rodriguez E, Berndt L, Steffen L, Ruppert C, Bates JHT, Ochs M, Smith BJ. Alveolar Micromechanics in Bleomycin-induced Lung Injury. Am J Respir Cell Mol Biol. 2018 12; 59(6):757-769. PMID: 30095988.
      View in: PubMed
    23. Bates JHT, Smith BJ. Ventilator-induced lung injury and lung mechanics. Ann Transl Med. 2018 Oct; 6(19):378. PMID: 30460252.
      View in: PubMed
    24. Jawde SB, Smith BJ, Sonnenberg A, Bates JHT, Suki B. Design and nonlinear modeling of a sensitive sensor for the measurement of flow in mice. Physiol Meas. 2018 07 03; 39(7):075002. PMID: 29877866.
      View in: PubMed
    25. Hamlington KL, Smith BJ, Dunn CM, Charlebois CM, Roy GS, Bates JHT. Linking lung function to structural damage of alveolar epithelium in ventilator-induced lung injury. Respir Physiol Neurobiol. 2018 09; 255:22-29. PMID: 29742448.
      View in: PubMed
    26. Hamlington KL, Bates JHT, Roy GS, Julianelle AJ, Charlebois C, Suki B, Smith BJ. Alveolar leak develops by a rich-get-richer process in ventilator-induced lung injury. PLoS One. 2018; 13(3):e0193934. PMID: 29590136.
      View in: PubMed
    27. Smith BJ, Bartolak-Suki E, Suki B, Roy GS, Hamlington KL, Charlebois CM, Bates JHT. Linking Ventilator Injury-Induced Leak across the Blood-Gas Barrier to Derangements in Murine Lung Function. Front Physiol. 2017; 8:466. PMID: 28736528.
      View in: PubMed
    28. Broche L, Perchiazzi G, Porra L, Tannoia A, Pellegrini M, Derosa S, Sindaco A, Batista Borges J, Degrugilliers L, Larsson A, Hedenstierna G, Wexler AS, Bravin A, Verbanck S, Smith BJ, Bates JH, Bayat S. Dynamic Mechanical Interactions Between Neighboring Airspaces Determine Cyclic Opening and Closure in Injured Lung. Crit Care Med. 2017 Apr; 45(4):687-694. PMID: 28107207.
      View in: PubMed
    29. Habashi NM, Andrews P, Nieman GF, Kollisch-Singule M, Bates JH. Failure to Disclose Conflicts of Interest. JAMA Surg. 2016 12 01; 151(12):1190. PMID: 27602556.
      View in: PubMed
    30. Pothen JJ, Rajendran V, Wagner D, Weiss DJ, Smith BJ, Ma B, Bates JH. A Computational Model of Cellular Engraftment on Lung Scaffolds. Biores Open Access. 2016; 5(1):308-319. PMID: 27843709.
      View in: PubMed
    31. Smith BJ. Strain heterogeneity in the injured lung: cause or consequence? J Appl Physiol (1985). 2016 12; 121(6):1363-1364. PMID: 27633744.
      View in: PubMed
    32. Hamlington KL, Smith BJ, Allen GB, Bates JH. Predicting ventilator-induced lung injury using a lung injury cost function. J Appl Physiol (1985). 2016 07 01; 121(1):106-14. PMID: 27174922.
      View in: PubMed
    33. Hamlington KL, Ma B, Smith BJ, Bates JH. Modeling the Progression of Epithelial Leak Caused by Overdistension. Cell Mol Bioeng. 2016 Mar; 9(1):151-161. PMID: 26951764.
      View in: PubMed
    34. Ma B, Smith BJ, Bates JH. Resistance to alveolar shape change limits range of force propagation in lung parenchyma. Respir Physiol Neurobiol. 2015 Jun; 211:22-8. PMID: 25812796.
      View in: PubMed
    35. Lutz D, Gazdhar A, Lopez-Rodriguez E, Ruppert C, Mahavadi P, G?nther A, Klepetko W, Bates JH, Smith B, Geiser T, Ochs M, Knudsen L. Alveolar derecruitment and collapse induration as crucial mechanisms in lung injury and fibrosis. Am J Respir Cell Mol Biol. 2015 Feb; 52(2):232-43. PMID: 25033427.
      View in: PubMed
    36. Smith BJ, Lundblad LK, Kollisch-Singule M, Satalin J, Nieman G, Habashi N, Bates JH. Predicting the response of the injured lung to the mechanical breath profile. J Appl Physiol (1985). 2015 Apr 01; 118(7):932-40. PMID: 25635004.
      View in: PubMed
    37. Kollisch-Singule M, Emr B, Smith B, Roy S, Jain S, Satalin J, Snyder K, Andrews P, Habashi N, Bates J, Marx W, Nieman G, Gatto LA. Mechanical breath profile of airway pressure release ventilation: the effect on alveolar recruitment and microstrain in acute lung injury. JAMA Surg. 2014 Nov; 149(11):1138-45. PMID: 25230047.
      View in: PubMed
    38. Kollisch-Singule M, Emr B, Smith B, Ruiz C, Roy S, Meng Q, Jain S, Satalin J, Snyder K, Ghosh A, Marx WH, Andrews P, Habashi N, Nieman GF, Gatto LA. Airway pressure release ventilation reduces conducting airway micro-strain in lung injury. J Am Coll Surg. 2014 Nov; 219(5):968-76. PMID: 25440027.
      View in: PubMed
    39. Bates JH, Smith BJ, Allen GB. Computational Models of Ventilator Induced Lung Injury and Surfactant Dysfunction. Drug Discov Today Dis Models. 2015; 15:17-22. PMID: 26904138.
      View in: PubMed
    40. Smith BJ, Bates JH. Variable Ventilation as a Diagnostic Tool for the Injured Lung. IEEE Trans Biomed Eng. 2015 Sep; 62(9):2106-13. PMID: 24723623.
      View in: PubMed
    41. Smith BJ, Bates JH. Assessing the Progression of Ventilator-Induced Lung Injury in Mice. IEEE Trans Biomed Eng. 2013 Dec; 60(12):3449-57. PMID: 23751952.
      View in: PubMed
    42. Smith BJ, Grant KA, Bates JH. Linking the development of ventilator-induced injury to mechanical function in the lung. Ann Biomed Eng. 2013 Mar; 41(3):527-36. PMID: 23161164.
      View in: PubMed
    43. Smith BJ, Lukens S, Yamaguchi E, Gaver DP. Lagrangian transport properties of pulmonary interfacial flows. J Fluid Mech. 2011 Nov 09; 705:234-257. PMID: 23049141.
      View in: PubMed
    44. Glindmeyer HW, Smith BJ, Gaver DP. In situ enhancement of pulmonary surfactant function using temporary flow reversal. J Appl Physiol (1985). 2012 Jan; 112(1):149-58. PMID: 21998268.
      View in: PubMed
    45. Smith BJ, Gaver DP. Agent-based simulations of complex droplet pattern formation in a two-branch microfluidic network. Lab Chip. 2010 Feb 07; 10(3):303-12. PMID: 20091001.
      View in: PubMed
    46. Smith BJ, Yamaguchi E, Gaver DP. A translating stage system for ?-PIV measurements surrounding the tip of a migrating semi-infinite bubble. Meas Sci Technol. 2010 Jan 01; 21(1). PMID: 23049168.
      View in: PubMed
    47. Yamaguchi E, Smith BJ, Gaver DP. ?-PIV measurements of the ensemble flow fields surrounding a migrating semi-infinite bubble. Exp Fluids. 2009 Aug 01; 47(2):309-320. PMID: 23049158.
      View in: PubMed
    48. Smith BJ, Gaver DP. The Pulsatile Propagation of a Finger of Air Within a Fluid-Occluded Cylindrical Tube. J Fluid Mech. 2008 Apr; 601:1-23. PMID: 19081756.
      View in: PubMed
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