Bradford J Smith
Title | Associate Professor |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | CEDC-Bioengineering |
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Title | Associate Professor |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | CEDC-Bioengineering |
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Research R01HL151630 (SMITH, BRADFORD J)Jan 1, 2021 - Dec 31, 2025 NIH Predicting and Preventing Ventilator-Induced Lung Injury Role: Principal Investigator |
| R00HL128944 (SMITH, BRADFORD J)Jan 1, 2017 - Dec 31, 2020 NIH The Importance of Inhomogeneity in the Pathogenesis of Lung Injury Role: Principal Investigator |
| K99HL128944 (SMITH, BRADFORD J)Jul 15, 2015 - Jun 30, 2017 NIH The Importance of Inhomogeneity in the Pathogenesis of Lung Injury Role: Principal Investigator |
Bibliographic
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Casey DT, Sosa A, Mori V, Hall JK, Suki B, Smith BJ, Bates JHT. Lung architecture amplifies tissue deposition in an agent-based model of fibrotic development. bioRxiv. 2025 Apr 06. PMID: 40236173.
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Cookson MW, Gonzalez T, Bye EM, Seedorf G, Ellor S, Smith BJ, Fleet JC, Mandell EW. Intraamniotic vitamin D preserves lung development and prevents pulmonary hypertension in experimental bronchopulmonary dysplasia due to intraamniotic sFlt-1. Am J Physiol Lung Cell Mol Physiol. 2025 Apr 01; 328(4):L603-L615. PMID: 40125892.
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Grayck MR, Smith BJ, Sosa A, Golden E, McCarthy WC, Solar M, Balasubramaniyan N, Zheng L, Dobrinskikh E, Rincon M, McCulley DJ, Orlicky DJ, Wright CJ. A Single Early Life Acetaminophen Exposure Causes Persistent Abnormalities in the Murine Lung. Am J Respir Cell Mol Biol. 2025 Jan 21. PMID: 39836061.
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Stroh JN, Sottile PD, Wang Y, Smith BJ, Bennett TD, Moss M, Albers DJ. Empirical phenotyping in coupled patient+care systems: Generating low-dimensional categories for hypothesis-driven investigation of mechanically-ventilated patients. medRxiv. 2025 Jan 16. PMID: 38168309.
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Wallbank A, Sosa A, Colson A, Farooqi H, Kaye E, Warner K, Albers DJ, Sottile PD, Smith BJ. Dynamic driving pressure predicts ventilator-induced lung injury in mice with and without endotoxin-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2025 Jan 01; 328(1):L159-L175. PMID: 39601347.
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Perlman CE, Knudsen L, Smith BJ. The fix is not yet in: recommendation for fixation of lungs within physiological/pathophysiological volume range in preclinical pulmonary structure-function studies. Am J Physiol Lung Cell Mol Physiol. 2024 Aug 01; 327(2):L218-L231. PMID: 38712433.
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Zimmermann R, Roeder F, Ruppert C, Smith BJ, Knudsen L. Low-volume ventilation of preinjured lungs degrades lung function via stress concentration and progressive alveolar collapse. Am J Physiol Lung Cell Mol Physiol. 2024 Jul 01; 327(1):L19-L39. PMID: 38712429.
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Gottman DC, Smith BJ. A scale-free model of acute and ventilator-induced lung injury: a network theory approach inspired by seismology. Front Netw Physiol. 2024; 4:1392701. PMID: 38757066.
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McGinn EA, Mandell EW, Smith BJ, Duke JW, Bush A, Abman SH. Reply to Tepper et al.: Additional Thoughts on Intrinsic Dysanapsis. Am J Respir Crit Care Med. 2024 04 15; 209(8):1041-1042. PMID: 38301260.
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Roeder F, R?pke T, Steinmetz LK, Kolb M, Maus UA, Smith BJ, Knudsen L. Exploring alveolar recruitability using positive end-expiratory pressure in mice overexpressing TGF-?1: a structure-function analysis. Sci Rep. 2024 04 06; 14(1):8080. PMID: 38582767.
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McGinn EA, Bye E, Gonzalez T, Sosa A, Bilodeaux J, Seedorf G, Smith BJ, Abman SH, Mandell EW. Antenatal Endotoxin Induces Dysanapsis in Experimental Bronchopulmonary Dysplasia. Am J Respir Cell Mol Biol. 2024 Apr; 70(4):283-294. PMID: 38207120.
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Agrawal DK, Smith BJ, Sottile PD, Hripcsak G, Albers DJ. Quantifiable identification of flow-limited ventilator dyssynchrony with the deformed lung ventilator model. Comput Biol Med. 2024 05; 173:108349. PMID: 38547660.
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Adams AN, Smith BJ, Raad TJ, Mueller RL. Gigantic animal cells suggest organellar scaling mechanisms across a 50-fold range in cell volume. Evolution. 2024 Feb 29; 78(3):442-452. PMID: 38113239.
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McGinn EA, Mandell EW, Smith BJ, Duke JW, Bush A, Abman SH. Dysanapsis as a Determinant of Lung Function in Development and Disease. Am J Respir Crit Care Med. 2023 11 01; 208(9):956-963. PMID: 37677135.
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Colvin KL, Nguyen K, Boncella KL, Goodman DM, Elliott RJ, Harral JW, Bilodeaux J, Smith BJ, Yeager ME. Lung and Heart Biology of the Dp16 Mouse Model of down Syndrome: Implications for Studying Cardiopulmonary Disease. Genes (Basel). 2023 09 19; 14(9). PMID: 37761959.
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Mattson CL, Smith BJ. Modeling Ventilator-Induced Lung Injury and Neutrophil Infiltration to Infer Injury Interdependence. Ann Biomed Eng. 2023 Dec; 51(12):2837-2852. PMID: 37592044.
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Bilodeaux J, Farooqi H, Osovskaya M, Sosa A, Wallbank A, Knudsen L, Sottile PD, Albers DJ, Smith BJ. Differential effects of two-hit models of acute and ventilator-induced lung injury on lung structure, function, and inflammation. Front Physiol. 2023; 14:1217183. PMID: 37565138.
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Wallbank AM, Vaughn AE, Niemiec S, Bilodeaux J, Lehmann T, Knudsen L, Kolanthai E, Seal S, Zgheib C, Nozik E, Liechty KW, Smith BJ. CNP-miR146a improves outcomes in a two-hit acute- and ventilator-induced lung injury model. Nanomedicine. 2023 06; 50:102679. PMID: 37116556.
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Knudsen L, Hummel B, Wrede C, Zimmermann R, Perlman CE, Smith BJ. Acinar micromechanics in health and lung injury: what we have learned from quantitative morphology. Front Physiol. 2023; 14:1142221. PMID: 37025383.
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Stroh JN, Smith BJ, Sottile PD, Hripcsak G, Albers DJ. Hypothesis-driven modeling of the human lung-ventilator system: A characterization tool for Acute Respiratory Distress Syndrome research. J Biomed Inform. 2023 01; 137:104275. PMID: 36572279.
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Hume PS, McClendon J, Kopf KW, Harral JW, Poczobutt JM, McCubbrey AL, Smith BJ, Henson PM, Majka SM, Petrache I, Janssen WJ. Cigarette smoke-induced airspace disease in mice develops independently of HIF-1a signaling in leukocytes. Am J Physiol Lung Cell Mol Physiol. 2022 10 01; 323(4):L391-L399. PMID: 35943156.
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Saleh KS, Hewawasam R, ?erbed?ija P, Blomberg R, Noreldeen SE, Edelman B, Smith BJ, Riches DWH, Magin CM. Engineering Hybrid-Hydrogels Comprised of Healthy or Diseased Decellularized Extracellular Matrix to Study Pulmonary Fibrosis. Cell Mol Bioeng. 2022 Oct; 15(5):505-519. PMID: 36444345.
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Mattson CL, Okamura K, Hume PS, Smith BJ. Spatiotemporal distribution of cellular injury and leukocytes during the progression of ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2022 09 01; 323(3):L281-L296. PMID: 35700201.
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Neelakantan S, Xin Y, Gaver DP, Cereda M, Rizi R, Smith BJ, Avazmohammadi R. Computational lung modelling in respiratory medicine. J R Soc Interface. 2022 06; 19(191):20220062. PMID: 35673857.
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Rizzo AN, Haeger SM, Oshima K, Yang Y, Wallbank AM, Jin Y, Lettau M, McCaig LA, Wickersham NE, McNeil JB, Zakharevich I, McMurtry SA, Langou?t-Astri? CJ, Kopf KW, Voelker DR, Hansen KC, Shaver CM, Kerchberger VE, Peterson RA, Kuebler WM, Ochs M, Veldhuizen RA, Smith BJ, Ware LB, Bastarache JA, Schmidt EP. Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome. JCI Insight. 2022 01 25; 7(2). PMID: 34874923.
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Agrawal DK, Smith BJ, Sottile PD, Albers DJ. A Damaged-Informed Lung Ventilator Model for Ventilator Waveforms. Front Physiol. 2021; 12:724046. PMID: 34658911.
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Stancil IT, Michalski JE, Davis-Hall D, Chu HW, Park JA, Magin CM, Yang IV, Smith BJ, Dobrinskikh E, Schwartz DA. Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional. Nat Commun. 2021 07 27; 12(1):4566. PMID: 34315881.
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Wang B, Chan YL, Li G, Ho KF, Anwer AG, Smith BJ, Guo H, Jalaludin B, Herbert C, Thomas PS, Liao J, Chapman DG, Foster PS, Saad S, Chen H, Oliver BG. Maternal Particulate Matter Exposure Impairs Lung Health and Is Associated with Mitochondrial Damage. Antioxidants (Basel). 2021 Jun 25; 10(7). PMID: 34202305.
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Knudsen L, Ochs M, Smith BJ. Editorial: Understanding Lung Acinar Micromechanics in Health and Disease: Linking Quantitative Imaging and Organ Scale Mechanics by Computational Modeling. Front Physiol. 2020; 11:640398. PMID: 33551853.
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Mandell EW, Mattson C, Seedorf G, Ryan S, Gonzalez T, Wallbank A, Bye EM, Abman SH, Smith BJ. Antenatal Endotoxin Impairs Lung Mechanics and Increases Sensitivity to Ventilator-Induced Lung Injury in Newborn Rat Pups. Front Physiol. 2020; 11:614283. PMID: 33519519.
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Krischer JM, Albert K, Pfaffenroth A, Lopez-Rodriguez E, Ruppert C, Smith BJ, Knudsen L. Mechanical ventilation-induced alterations of intracellular surfactant pool and blood-gas barrier in healthy and pre-injured lungs. Histochem Cell Biol. 2021 Feb; 155(2):183-202. PMID: 33188462.
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Mori V, Smith BJ, Suki B, Bates JHT. Modeling Lung Derecruitment in VILI Due to Fluid-Occlusion: The Role of Emergent Behavior. Front Physiol. 2020; 11:542744. PMID: 33192546.
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Sottile PD, Albers D, Smith BJ, Moss MM. Ventilator dyssynchrony - Detection, pathophysiology, and clinical relevance: A Narrative review. Ann Thorac Med. 2020 Oct-Dec; 15(4):190-198. PMID: 33381233.
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Albert K, Krischer JM, Pfaffenroth A, Wilde S, Lopez-Rodriguez E, Braun A, Smith BJ, Knudsen L. Hidden Microatelectases Increase Vulnerability to Ventilation-Induced Lung Injury. Front Physiol. 2020; 11:530485. PMID: 33071807.
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Menson KE, Mank MM, Reed LF, Walton CJ, Van Der Vliet KE, Ather JL, Chapman DG, Smith BJ, Rincon M, Poynter ME. Therapeutic efficacy of IL-17A neutralization with corticosteroid treatment in a model of antigen-driven mixed-granulocytic asthma. Am J Physiol Lung Cell Mol Physiol. 2020 10 01; 319(4):L693-L709. PMID: 32783616.
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Kheyfets VO, Lammers SR, Wagner J, Bartels K, Piccoli J, Smith BJ. PEEP/ FIO2 ARDSNet Scale Grouping of a Single Ventilator for Two Patients: Modeling Tidal Volume Response. Respir Care. 2020 08; 65(8):1094-1103. PMID: 32712582.
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Pertile J, Mellenthin M, Wagner J, DeBoer EM, Fink D, Smith B. The Effects of Laryngoscope Shape and Needle Position on Distal Airway Pressure in Jet Ventilation. Laryngoscope. 2021 02; 131(2):E354-E357. PMID: 32717125.
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Mandell EW, Ryan S, Seedorf GJ, Gonzalez T, Smith BJ, Fleet JC, Abman SH. Maternal Vitamin D Deficiency Causes Sustained Impairment of Lung Structure and Function and Increases Susceptibility to Hyperoxia-induced Lung Injury in Infant Rats. Am J Respir Cell Mol Biol. 2020 07; 63(1):79-91. PMID: 32135073.
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Smith BJ, Roy GS, Cleveland A, Mattson C, Okamura K, Charlebois CM, Hamlington KL, Novotny MV, Knudsen L, Ochs M, Hite RD, Bates JHT. Three Alveolar Phenotypes Govern Lung Function in Murine Ventilator-Induced Lung Injury. Front Physiol. 2020; 11:660. PMID: 32695013.
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Hume PS, Gibbings SL, Jakubzick CV, Tuder RM, Curran-Everett D, Henson PM, Smith BJ, Janssen WJ. Localization of Macrophages in the Human Lung via Design-based Stereology. Am J Respir Crit Care Med. 2020 05 15; 201(10):1209-1217. PMID: 32197050.
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Bou Jawde S, Walkey AJ, Majumdar A, O'Connor GT, Smith BJ, Bates JHT, Lutchen KR, Suki B. Tracking respiratory mechanics around natural breathing rates via variable ventilation. Sci Rep. 2020 04 21; 10(1):6722. PMID: 32317734.
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R?hl N, Lopez-Rodriguez E, Albert K, Smith BJ, Weaver TE, Ochs M, Knudsen L. Surfactant Protein B Deficiency Induced High Surface Tension: Relationship between Alveolar Micromechanics, Alveolar Fluid Properties and Alveolar Epithelial Cell Injury. Int J Mol Sci. 2019 Aug 30; 20(17). PMID: 31480246.
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Albert RK, Smith B, Perlman CE, Schwartz DA. Is Progression of Pulmonary Fibrosis due to Ventilation-induced Lung Injury? Am J Respir Crit Care Med. 2019 07 15; 200(2):140-151. PMID: 31022350.
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Mellenthin MM, Seong SA, Roy GS, Bartol?k-Suki E, Hamlington KL, Bates JHT, Smith BJ. Using injury cost functions from a predictive single-compartment model to assess the severity of mechanical ventilator-induced lung injuries. J Appl Physiol (1985). 2019 07 01; 127(1):58-70. PMID: 31046518.
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Knudsen L, Lopez-Rodriguez E, Berndt L, Steffen L, Ruppert C, Bates JHT, Ochs M, Smith BJ. Alveolar Micromechanics in Bleomycin-induced Lung Injury. Am J Respir Cell Mol Biol. 2018 12; 59(6):757-769. PMID: 30095988.
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Mori V, Smith BJ, Suki B, Bates JHT. Linking Physiological Biomarkers of Ventilator-Induced Lung Injury to a Rich-Get-Richer Mechanism of Injury Progression. Ann Biomed Eng. 2019 Feb; 47(2):638-645. PMID: 30421177.
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Bates JHT, Smith BJ. Ventilator-induced lung injury and lung mechanics. Ann Transl Med. 2018 Oct; 6(19):378. PMID: 30460252.
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Jawde SB, Smith BJ, Sonnenberg A, Bates JHT, Suki B. Design and nonlinear modeling of a sensitive sensor for the measurement of flow in mice. Physiol Meas. 2018 07 03; 39(7):075002. PMID: 29877866.
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Hamlington KL, Smith BJ, Dunn CM, Charlebois CM, Roy GS, Bates JHT. Linking lung function to structural damage of alveolar epithelium in ventilator-induced lung injury. Respir Physiol Neurobiol. 2018 09; 255:22-29. PMID: 29742448.
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Hamlington KL, Bates JHT, Roy GS, Julianelle AJ, Charlebois C, Suki B, Smith BJ. Alveolar leak develops by a rich-get-richer process in ventilator-induced lung injury. PLoS One. 2018; 13(3):e0193934. PMID: 29590136.
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Smith BJ, Bartolak-Suki E, Suki B, Roy GS, Hamlington KL, Charlebois CM, Bates JHT. Linking Ventilator Injury-Induced Leak across the Blood-Gas Barrier to Derangements in Murine Lung Function. Front Physiol. 2017; 8:466. PMID: 28736528.
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Broche L, Perchiazzi G, Porra L, Tannoia A, Pellegrini M, Derosa S, Sindaco A, Batista Borges J, Degrugilliers L, Larsson A, Hedenstierna G, Wexler AS, Bravin A, Verbanck S, Smith BJ, Bates JH, Bayat S. Dynamic Mechanical Interactions Between Neighboring Airspaces Determine Cyclic Opening and Closure in Injured Lung. Crit Care Med. 2017 Apr; 45(4):687-694. PMID: 28107207.
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Habashi NM, Andrews P, Nieman GF, Kollisch-Singule M, Bates JH. Failure to Disclose Conflicts of Interest. JAMA Surg. 2016 12 01; 151(12):1190. PMID: 27602556.
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Pothen JJ, Rajendran V, Wagner D, Weiss DJ, Smith BJ, Ma B, Bates JH. A Computational Model of Cellular Engraftment on Lung Scaffolds. Biores Open Access. 2016; 5(1):308-319. PMID: 27843709.
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Smith BJ. Strain heterogeneity in the injured lung: cause or consequence? J Appl Physiol (1985). 2016 12; 121(6):1363-1364. PMID: 27633744.
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Hamlington KL, Smith BJ, Allen GB, Bates JH. Predicting ventilator-induced lung injury using a lung injury cost function. J Appl Physiol (1985). 2016 07 01; 121(1):106-14. PMID: 27174922.
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Hamlington KL, Ma B, Smith BJ, Bates JH. Modeling the Progression of Epithelial Leak Caused by Overdistension. Cell Mol Bioeng. 2016 Mar; 9(1):151-161. PMID: 26951764.
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Kollisch-Singule M, Jain S, Andrews P, Smith BJ, Hamlington-Smith KL, Roy S, DiStefano D, Nuss E, Satalin J, Meng Q, Marx W, Bates JH, Gatto LA, Nieman GF, Habashi NM. Effect of Airway Pressure Release Ventilation on Dynamic Alveolar Heterogeneity. JAMA Surg. 2016 Jan; 151(1):64-72. PMID: 26444302.
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Ma B, Smith BJ, Bates JH. Resistance to alveolar shape change limits range of force propagation in lung parenchyma. Respir Physiol Neurobiol. 2015 Jun; 211:22-8. PMID: 25812796.
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Lutz D, Gazdhar A, Lopez-Rodriguez E, Ruppert C, Mahavadi P, G?nther A, Klepetko W, Bates JH, Smith B, Geiser T, Ochs M, Knudsen L. Alveolar derecruitment and collapse induration as crucial mechanisms in lung injury and fibrosis. Am J Respir Cell Mol Biol. 2015 Feb; 52(2):232-43. PMID: 25033427.
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Smith BJ, Lundblad LK, Kollisch-Singule M, Satalin J, Nieman G, Habashi N, Bates JH. Predicting the response of the injured lung to the mechanical breath profile. J Appl Physiol (1985). 2015 Apr 01; 118(7):932-40. PMID: 25635004.
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Kollisch-Singule M, Emr B, Smith B, Roy S, Jain S, Satalin J, Snyder K, Andrews P, Habashi N, Bates J, Marx W, Nieman G, Gatto LA. Mechanical breath profile of airway pressure release ventilation: the effect on alveolar recruitment and microstrain in acute lung injury. JAMA Surg. 2014 Nov; 149(11):1138-45. PMID: 25230047.
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Kollisch-Singule M, Emr B, Smith B, Ruiz C, Roy S, Meng Q, Jain S, Satalin J, Snyder K, Ghosh A, Marx WH, Andrews P, Habashi N, Nieman GF, Gatto LA. Airway pressure release ventilation reduces conducting airway micro-strain in lung injury. J Am Coll Surg. 2014 Nov; 219(5):968-76. PMID: 25440027.
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Bates JH, Smith BJ, Allen GB. Computational Models of Ventilator Induced Lung Injury and Surfactant Dysfunction. Drug Discov Today Dis Models. 2015; 15:17-22. PMID: 26904138.
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Smith BJ, Bates JH. Variable Ventilation as a Diagnostic Tool for the Injured Lung. IEEE Trans Biomed Eng. 2015 Sep; 62(9):2106-13. PMID: 24723623.
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Smith BJ, Bates JH. Assessing the Progression of Ventilator-Induced Lung Injury in Mice. IEEE Trans Biomed Eng. 2013 Dec; 60(12):3449-57. PMID: 23751952.
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Smith BJ, Grant KA, Bates JH. Linking the development of ventilator-induced injury to mechanical function in the lung. Ann Biomed Eng. 2013 Mar; 41(3):527-36. PMID: 23161164.
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Smith BJ, Lukens S, Yamaguchi E, Gaver DP. Lagrangian transport properties of pulmonary interfacial flows. J Fluid Mech. 2011 Nov 09; 705:234-257. PMID: 23049141.
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Glindmeyer HW, Smith BJ, Gaver DP. In situ enhancement of pulmonary surfactant function using temporary flow reversal. J Appl Physiol (1985). 2012 Jan; 112(1):149-58. PMID: 21998268.
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Smith BJ, Gaver DP. Agent-based simulations of complex droplet pattern formation in a two-branch microfluidic network. Lab Chip. 2010 Feb 07; 10(3):303-12. PMID: 20091001.
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Smith BJ, Yamaguchi E, Gaver DP. A translating stage system for ?-PIV measurements surrounding the tip of a migrating semi-infinite bubble. Meas Sci Technol. 2010 Jan 01; 21(1). PMID: 23049168.
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Yamaguchi E, Smith BJ, Gaver DP. ?-PIV measurements of the ensemble flow fields surrounding a migrating semi-infinite bubble. Exp Fluids. 2009 Aug 01; 47(2):309-320. PMID: 23049158.
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Smith BJ, Gaver DP. The Pulsatile Propagation of a Finger of Air Within a Fluid-Occluded Cylindrical Tube. J Fluid Mech. 2008 Apr; 601:1-23. PMID: 19081756.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2008 | 1 | 2009 | 3 | 2011 | 2 | 2012 | 1 | 2013 | 1 | 2014 | 4 | 2015 | 3 | 2016 | 6 | 2017 | 2 | 2018 | 6 | 2019 | 3 | 2020 | 11 | 2021 | 5 | 2022 | 6 | 2023 | 6 | 2024 | 9 | 2025 | 4 |
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