Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Peter Douglas Sottile

TitleAssistant Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
    Other Positions
    TitleDirector-Faculty
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-MED
    DivisionPUL GENERAL OPERATIONS


    Collapse Research 
    Collapse research activities and funding
    K23HL145011     (SOTTILE, PETER D)Jan 15, 2019 - Jul 31, 2024
    NIH
    The Detection, Quantification, and Management of Ventilator Dyssynchrony
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dunbar PJ, Peterson RA, McGrath M, Kiser TH, Ho PM, Vandivier RW, Burnham EL, Moss M, Sottile PD. Sedation Practices During Continuous Neuromuscular Blockade for Acute Respiratory Distress Syndrome. Ann Am Thorac Soc. 2025 May 09. PMID: 40344163.
      View in: PubMed
    2. Stroh JN, Sottile PD, Wang Y, Smith BJ, Bennett TD, Moss M, Albers DJ. Empirical phenotyping in coupled patient+care systems: Generating low-dimensional categories for hypothesis-driven investigation of mechanically-ventilated patients. medRxiv. 2025 Jan 16. PMID: 38168309.
      View in: PubMed
    3. Wallbank A, Sosa A, Colson A, Farooqi H, Kaye E, Warner K, Albers DJ, Sottile PD, Smith BJ. Dynamic driving pressure predicts ventilator-induced lung injury in mice with and without endotoxin-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2025 Jan 01; 328(1):L159-L175. PMID: 39601347.
      View in: PubMed
    4. DeMasi SC, Self WH, Aggarawal NR, April MD, Andrea L, Barnes CR, Brainard J, Blinder V, Dagan A, Driver B, Doerschug KC, Douglas I, Exline M, Fein DG, Gaillard JP, Gandotra S, Gibbs KW, Ginde AA, Halliday SJ, Han JH, Herbert T, High K, Hughes CG, Khan A, Latimer AJ, Maiga AW, Mitchell SH, Muhs AL, Mohamed A, Moskowitz A, Page DB, Palakshappa JA, Prekker ME, Qian ET, Resnick-Ault D, Rice TW, Russel DW, Schauer SG, Seitz KP, Shapiro NI, Smith LM, Sottile P, Stempek S, Trent SA, Vonderhaar DJ, Walker JE, Wang L, Whitson MR, Casey JD, Semler MW. Association Between Neuromuscular Blocking Agents and Outcomes of Emergency Tracheal Intubation: A Secondary Analysis of Randomized Trials. Ann Emerg Med. 2025 Jan; 85(1):6-13. PMID: 39387758.
      View in: PubMed
    5. Sottile PD. The author replies. Crit Care Med. 2024 Jul 01; 52(7):e406-e407. PMID: 38869398.
      View in: PubMed
    6. Gibbs KW, Semler MW, Driver BE, Seitz KP, Stempek SB, Taylor C, Resnick-Ault D, White HD, Gandotra S, Doerschug KC, Mohamed A, Prekker ME, Khan A, Gaillard JP, Andrea L, Aggarwal NR, Brainard JC, Barnett LH, Halliday SJ, Blinder V, Dagan A, Whitson MR, Schauer SG, Walker JE, Barker AB, Palakshappa JA, Muhs A, Wozniak JM, Kramer PJ, Withers C, Ghamande SA, Russell DW, Schwartz A, Moskowitz A, Hansen SJ, Allada G, Goranson JK, Fein DG, Sottile PD, Kelly N, Alwood SM, Long MT, Malhotra R, Shapiro NI, Page DB, Long BJ, Thomas CB, Trent SA, Janz DR, Rice TW, Self WH, Bebarta VS, Lloyd BD, Rhoads J, Womack K, Imhoff B, Ginde AA, Casey JD. Noninvasive Ventilation for Preoxygenation during Emergency Intubation. N Engl J Med. 2024 06 20; 390(23):2165-2177. PMID: 38869091.
      View in: PubMed
    7. Agrawal DK, Smith BJ, Sottile PD, Hripcsak G, Albers DJ. Quantifiable identification of flow-limited ventilator dyssynchrony with the deformed lung ventilator model. Comput Biol Med. 2024 05; 173:108349. PMID: 38547660.
      View in: PubMed
    8. Dunbar PJ, Peterson R, McGrath M, Pomponio R, Kiser TH, Ho PM, Vandivier RW, Burnham EL, Moss M, Sottile PD. Analgesia and Sedation Use During Noninvasive Ventilation for Acute Respiratory Failure. Crit Care Med. 2024 Jul 01; 52(7):1043-1053. PMID: 38506571.
      View in: PubMed
    9. Sottile PD, Smith B, Stroh JN, Albers DJ, Moss M. Flow-Limited and Reverse-Triggered Ventilator Dyssynchrony Are Associated With Increased Tidal and Dynamic Transpulmonary Pressure. Crit Care Med. 2024 05 01; 52(5):743-751. PMID: 38214566.
      View in: PubMed
    10. Sottile PD, Smith B, Moss M, Albers DJ. The Development, Optimization, and Validation of Four Different Machine Learning Algorithms to Identify Ventilator Dyssynchrony. medRxiv. 2023 Nov 29. PMID: 38076801.
      View in: PubMed
    11. Bilodeaux J, Farooqi H, Osovskaya M, Sosa A, Wallbank A, Knudsen L, Sottile PD, Albers DJ, Smith BJ. Differential effects of two-hit models of acute and ventilator-induced lung injury on lung structure, function, and inflammation. Front Physiol. 2023; 14:1217183. PMID: 37565138.
      View in: PubMed
    12. Reynolds PM, Afshar M, Wright GC, Ho PM, Kiser TH, Sottile PD, Althoff MD, Moss M, Jolley SE, Vandivier RW, Burnham EL. Association between Substance Misuse and Outcomes in Critically III Patients with Pneumonia. Ann Am Thorac Soc. 2023 04; 20(4):556-565. PMID: 37000145.
      View in: PubMed
    13. Gibbs KW, Ginde AA, Prekker ME, Seitz KP, Stempek SB, Taylor C, Gandotra S, White H, Resnick-Ault D, Khan A, Mohmed A, Brainard JC, Fein DG, Aggarwal NR, Whitson MR, Halliday SJ, Gaillard JP, Blinder V, Driver BE, Palakshappa JA, Lloyd BD, Wozniak JM, Exline MC, Russell DW, Ghamande S, Withers C, Hubel KA, Moskowitz A, Bastman J, Andrea L, Sottile PD, Page DB, Long MT, Goranson JK, Malhotra R, Long BJ, Schauer SG, Connor A, Anderson E, Maestas K, Rhoads JP, Womack K, Imhoff B, Janz DR, Trent SA, Self WH, Rice TW, Semler MW, Casey JD. Protocol and statistical analysis plan for the PREOXI trial of preoxygenation with noninvasive ventilation vs oxygen mask. medRxiv. 2023 Mar 24. PMID: 36993496.
      View in: PubMed
    14. Stroh JN, Smith BJ, Sottile PD, Hripcsak G, Albers DJ. Hypothesis-driven modeling of the human lung-ventilator system: A characterization tool for Acute Respiratory Distress Syndrome research. J Biomed Inform. 2023 01; 137:104275. PMID: 36572279.
      View in: PubMed
    15. Zakrajsek JK, Min SJ, Ho PM, Kiser TH, Kannappan A, Sottile PD, Allen RR, Althoff MD, Reynolds PM, Moss M, Burnham EL, Mikkelsen ME, Vandivier RW. Extracorporeal Membrane Oxygenation for Refractory Asthma Exacerbations With Respiratory Failure. Chest. 2023 01; 163(1):38-51. PMID: 36191634.
      View in: PubMed
    16. Sottile PD, Albert RK, Moss M. Prone Positioning for Nonintubated Patients With COVID-19-Potential Dangers of Extrapolation and Intermediate Outcome Variables. JAMA Intern Med. 2022 06 01; 182(6):622-623. PMID: 35435933.
      View in: PubMed
    17. Sottile PD, Albers D, DeWitt PE, Russell S, Stroh JN, Kao DP, Adrian B, Levine ME, Mooney R, Larchick L, Kutner JS, Wynia MK, Glasheen JJ, Bennett TD. Real-time electronic health record mortality prediction during the COVID-19 pandemic: a prospective cohort study. J Am Med Inform Assoc. 2021 10 12; 28(11):2354-2365. PMID: 33973011.
      View in: PubMed
    18. Agrawal DK, Smith BJ, Sottile PD, Albers DJ. A Damaged-Informed Lung Ventilator Model for Ventilator Waveforms. Front Physiol. 2021; 12:724046. PMID: 34658911.
      View in: PubMed
    19. Lane T, Sottile PD, Peterson R, Jin Y, Moss M. Significant Variability in Surrogate Informed Consent Rates in ARDS and Prevention and Early Treatment of Acute Lung Injury Network Multicenter Trials. Chest. 2022 05; 161(5):1306-1309. PMID: 34543666.
      View in: PubMed
    20. Sottile PD, Albers D, DeWitt PE, Russell S, Stroh JN, Kao DP, Adrian B, Levine ME, Mooney R, Larchick L, Kutner JS, Wynia MK, Glasheen JJ, Bennett TD. Real-Time Electronic Health Record Mortality Prediction During the COVID-19 Pandemic: A Prospective Cohort Study. medRxiv. 2021 Jan 15. PMID: 33469601.
      View in: PubMed
    21. Lin CT, Bookman K, Sieja A, Markley K, Altman RL, Sippel J, Perica K, Reece L, Davis C, Horowitz E, Pisney L, Sottile PD, Kao D, Adrian B, Szkil M, Griffin J, Youngwerth J, Drew B, Pell J. Clinical informatics accelerates health system adaptation to the COVID-19 pandemic: examples from Colorado. J Am Med Inform Assoc. 2020 12 09; 27(12):1955-1963. PMID: 32687152.
      View in: PubMed
    22. Hraiech S, Yoshida T, Annane D, Duggal A, Fanelli V, Gacouin A, Heunks L, Jaber S, Sottile PD, Papazian L. Myorelaxants in ARDS patients. Intensive Care Med. 2020 12; 46(12):2357-2372. PMID: 33159530.
      View in: PubMed
    23. Sottile PD, Albers D, Smith BJ, Moss MM. Ventilator dyssynchrony - Detection, pathophysiology, and clinical relevance: A Narrative review. Ann Thorac Med. 2020 Oct-Dec; 15(4):190-198. PMID: 33381233.
      View in: PubMed
    24. Wynia MK, Sottile PD. Ethical Triage Demands a Better Triage Survivability Score. Am J Bioeth. 2020 07; 20(7):75-77. PMID: 32716810.
      View in: PubMed
    25. Prohaska CC, Sottile PD, Nordon-Craft A, Gallagher MD, Burnham EL, Clark BJ, Ho M, Kiser TH, Vandivier RW, Liu W, Schenkman M, Moss M. Patterns of utilization and effects of hospital-specific factors on physical, occupational, and speech therapy for critically ill patients with acute respiratory failure in the USA: results of a 5-year sample. Crit Care. 2019 05 16; 23(1):175. PMID: 31097017.
      View in: PubMed
    26. Sottile PD, Kiser TH, Burnham EL, Ho PM, Allen RR, Vandivier RW, Moss M. An Observational Study of the Efficacy of Cisatracurium Compared with Vecuronium in Patients with or at Risk for Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2018 04 01; 197(7):897-904. PMID: 29241014.
      View in: PubMed
    27. Sottile PD, Albers D, Moss MM. Neuromuscular blockade is associated with the attenuation of biomarkers of epithelial and endothelial injury in patients with moderate-to-severe acute respiratory distress syndrome. Crit Care. 2018 Mar 10; 22(1):63. PMID: 29523157.
      View in: PubMed
    28. Sottile PD, Albers D, Higgins C, Mckeehan J, Moss MM. The Association Between Ventilator Dyssynchrony, Delivered Tidal Volume, and Sedation Using a Novel Automated Ventilator Dyssynchrony Detection Algorithm. Crit Care Med. 2018 02; 46(2):e151-e157. PMID: 29337804.
      View in: PubMed
    29. Sottile PD, Moss M. The Importance of Coping in Critically Ill Patients. Crit Care Med. 2016 09; 44(9):1797-8. PMID: 27526005.
      View in: PubMed
    30. Sottile PD, Lynch Y, Mealer M, Moss M. Association Between Resilience and Family Member Psychologic Symptoms in Critical Illness. Crit Care Med. 2016 Aug; 44(8):e721-7. PMID: 27097294.
      View in: PubMed
    31. Sottile PD, Nordon-Craft A, Malone D, Schenkman M, Moss M. Patient and family perceptions of physical therapy in the medical intensive care unit. J Crit Care. 2015 Oct; 30(5):891-5. PMID: 26038155.
      View in: PubMed
    32. Sottile PD, Nordon-Craft A, Malone D, Luby DM, Schenkman M, Moss M. Physical Therapist Treatment of Patients in the Neurological Intensive Care Unit: Description of Practice. Phys Ther. 2015 Jul; 95(7):1006-14. PMID: 25655880.
      View in: PubMed
    33. Sottile PD, Moss M, Patel JJ, Truwit JD, Sheikh M, Zimmerman JL, Diwakar A, Schmidt GA, Means GT, Katz JN, Desai AS, MacIntyre NR, Poston JT. ATS Core Curriculum 2014: Part II. Adult critical care medicine. Ann Am Thorac Soc. 2014 Oct; 11(8):1307-15. PMID: 25343197.
      View in: PubMed
    34. Moss M, Yang M, Macht M, Sottile P, Gray L, McNulty M, Quan D. Screening for critical illness polyneuromyopathy with single nerve conduction studies. Intensive Care Med. 2014 May; 40(5):683-90. PMID: 24623137.
      View in: PubMed
    35. Sottile PD, Iturbe D, Katsumoto TR, Connolly MK, Collard HR, Leard LA, Hays S, Golden JA, Hoopes C, Kukreja J, Singer JP. Outcomes in systemic sclerosis-related lung disease after lung transplantation. Transplantation. 2013 Apr 15; 95(7):975-80. PMID: 23545509.
      View in: PubMed
    36. Zier LS, Sottile PD, Hong SY, Weissfield LA, White DB. Surrogate decision makers' interpretation of prognostic information: a mixed-methods study. Ann Intern Med. 2012 Mar 06; 156(5):360-6. PMID: 22393131.
      View in: PubMed
    37. Hutchens M, Luker KE, Sottile P, Sonstein J, Lukacs NW, N??ez G, Curtis JL, Luker GD. TLR3 increases disease morbidity and mortality from vaccinia infection. J Immunol. 2008 Jan 01; 180(1):483-91. PMID: 18097050.
      View in: PubMed
    38. Dubin A, Estenssoro E, Murias G, Canales H, Sottile P, Badie J, Bar?n M, P?lizas F, Laporte M, Rivas D?az M. Effects of hemorrhage on gastrointestinal oxygenation. Intensive Care Med. 2001 Dec; 27(12):1931-6. PMID: 11797030.
      View in: PubMed
    39. Dubin A, Murias G, Estenssoro E, Canales H, Sottile P, Badie J, Bar?n M, Rossi S, Laporte M, P?lizas F, Giampieri J, Mediavilla D, Vacca E, Botta D. End-tidal CO2 pressure determinants during hemorrhagic shock. Intensive Care Med. 2000 Nov; 26(11):1619-23. PMID: 11193267.
      View in: PubMed
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