Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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David Ecker

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Biography 
    Collapse awards and honors
    2015Spirit of Interprofessionalism Award, University of South Florida
    2014Dean's Recognition of Teaching Excellence Award, University of South Florida
    2014Outstanding Resident Teaching Award at Tampa General Hospital, University of South Florida
    2012Housestaff Teaching Award, Memorial Sloan-Kettering Cancer Center
    2010Internal Medicine Resident of the Year, New York University
    2007Arnold P. Gold Humanism in Medicine Honor Society, Tulane University

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. O'Dwyer MJ, Starczewska MH, Schrenzel J, Zacharowski K, Ecker DJ, Sampath R, Brealey D, Singer M, Libert N, Wilks M, Vincent JL. The detection of microbial DNA but not cultured bacteria is associated with increased mortality in patients with suspected sepsis-a prospective multi-centre European observational study. Clin Microbiol Infect. 2017 Mar; 23(3):208.e1-208.e6. PMID: 27890455.
      View in: PubMed
    2. Vincent JL, Brealey D, Libert N, Abidi NE, O'Dwyer M, Zacharowski K, Mikaszewska-Sokolewicz M, Schrenzel J, Simon F, Wilks M, Picard-Maureau M, Chalfin DB, Ecker DJ, Sampath R, Singer M. Rapid Diagnosis of Infection in the Critically Ill, a Multicenter Study of Molecular Detection in Bloodstream Infections, Pneumonia, and Sterile Site Infections. Crit Care Med. 2015 Nov; 43(11):2283-91. PMID: 26327198; PMCID: PMC4603364.
    3. Taylor SP, Ecker DJ, Taylor B. CMS Reimbursement Reform. J Gen Intern Med. 2015 Nov; 30(11):1587. PMID: 26163008; PMCID: PMC4617944 [Available on 11/01/16].
    4. Schmukat A, Duester L, Goryunova E, Ecker D, Heininger P, Ternes TA. Influence of environmental parameters and of their interactions on the release of metal(loid)s from a construction material in hydraulic engineering. J Hazard Mater. 2016 Mar 05; 304:58-65. PMID: 26546704.
      View in: PubMed
    5. Evans SR, Hujer AM, Jiang H, Hujer KM, Hall T, Marzan C, Jacobs MR, Sampath R, Ecker DJ, Manca C, Chavda K, Zhang P, Fernandez H, Chen L, Mediavilla JR, Hill CB, Perez F, Caliendo AM, Fowler VG, Chambers HF, Kreiswirth BN, Bonomo RA. Rapid Molecular Diagnostics, Antibiotic Treatment Decisions, and Developing Approaches to Inform Empiric Therapy: PRIMERS I and II. Clin Infect Dis. 2016 Jan 15; 62(2):181-9. PMID: 26409063; PMCID: PMC4690483 [Available on 01/15/17].
    6. Eshoo MW, Carolan HE, Massire C, Chou DM, Crowder CD, Rounds MA, Phillipson CA, Schutzer SE, Ecker DJ. Survey of Ixodes pacificus Ticks in California Reveals a Diversity of Microorganisms and a Novel and Widespread Anaplasmataceae Species. PLoS One. 2015; 10(9):e0135828. PMID: 26375033; PMCID: PMC4574436.
    7. Crowder CD, Carolan HE, Rounds MA, Honig V, Mothes B, Haag H, Nolte O, Luft BJ, Grubhoffer L, Ecker DJ, Schutzer SE, Eshoo MW. Prevalence of Borrelia miyamotoi in Ixodes ticks in Europe and the United States. Emerg Infect Dis. 2014 Oct; 20(10):1678-82. PMID: 25280366; PMCID: PMC4193165.
    8. Eshoo MW, Crowder CD, Carolan HE, Rounds MA, Ecker DJ, Haag H, Mothes B, Nolte O. Broad-range survey of tick-borne pathogens in Southern Germany reveals a high prevalence of Babesia microti and a diversity of other tick-borne pathogens. Vector Borne Zoonotic Dis. 2014 Aug; 14(8):584-91. PMID: 25072989; PMCID: PMC4117270.
    9. Bacconi A, Richmond GS, Baroldi MA, Laffler TG, Blyn LB, Carolan HE, Frinder MR, Toleno DM, Metzgar D, Gutierrez JR, Massire C, Rounds M, Kennel NJ, Rothman RE, Peterson S, Carroll KC, Wakefield T, Ecker DJ, Sampath R. Improved sensitivity for molecular detection of bacterial and Candida infections in blood. J Clin Microbiol. 2014 Sep; 52(9):3164-74. PMID: 24951806; PMCID: PMC4313132.
    10. Ecker DJ. Germ catcher. Sci Am. 2014 Jun; 310(6):50-5. PMID: 25004575.
      View in: PubMed
    11. Kecojevic A, Ranken R, Ecker DJ, Massire C, Sampath R, Blyn LB, Hsieh YH, Rothman RE, Gaydos CA. Rapid PCR/ESI-MS-based molecular genotyping of Staphylococcus aureus from nasal swabs of emergency department patients. BMC Infect Dis. 2014 Jan 09; 14:16. PMID: 24405766; PMCID: PMC3937163.
    12. Chen J, Fu Y, Ju L, Miao X, Shen Y, He L, Wang W, Jin J, Shao L, Sampath R, Ecker DJ, Zhang Y, Li M, Cheng X, Zhang W. Detection and identification of viral pathogens in patients with hand, foot, and mouth disease by multilocus PCR, reverse-transcription PCR and electrospray ionization mass spectrometry. J Clin Virol. 2014 Feb; 59(2):115-9. PMID: 24365476.
      View in: PubMed
    13. Eshoo MW, Schutzer SE, Crowder CD, Carolan HE, Ecker DJ. Achieving molecular diagnostics for Lyme disease. Expert Rev Mol Diagn. 2013 Nov; 13(8):875-83. PMID: 24151851.
      View in: PubMed
    14. Metzgar D, Sampath R, Rounds MA, Ecker DJ. The value and validation of broad spectrum biosensors for diagnosis and biodefense. Virulence. 2013 Nov 15; 4(8):752-8. PMID: 24128433; PMCID: PMC3925709.
    15. Laffler TG, Cummins LL, McClain CM, Quinn CD, Toro MA, Carolan HE, Toleno DM, Rounds MA, Eshoo MW, Stratton CW, Sampath R, Blyn LB, Ecker DJ, Tang YW. Enhanced diagnostic yields of bacteremia and candidemia in blood specimens by PCR-electrospray ionization mass spectrometry. J Clin Microbiol. 2013 Nov; 51(11):3535-41. PMID: 23966503; PMCID: PMC3889730.
    16. Lindsay B, Pop M, Antonio M, Walker AW, Mai V, Ahmed D, Oundo J, Tamboura B, Panchalingam S, Levine MM, Kotloff K, Li S, Magder LS, Paulson JN, Liu B, Ikumapayi U, Ebruke C, Dione M, Adeyemi M, Rance R, Stares MD, Ukhanova M, Barnes B, Lewis I, Ahmed F, Alam MT, Amin R, Siddiqui S, Ochieng JB, Ouma E, Juma J, Mailu E, Omore R, O'Reilly CE, Hannis J, Manalili S, Deleon J, Yasuda I, Blyn L, Ranken R, Li F, Housley R, Ecker DJ, Hossain MA, Breiman RF, Morris JG, McDaniel TK, Parkhill J, Saha D, Sampath R, Stine OC, Nataro JP. Survey of culture, goldengate assay, universal biosensor assay, and 16S rRNA Gene sequencing as alternative methods of bacterial pathogen detection. J Clin Microbiol. 2013 Oct; 51(10):3263-9. PMID: 23884998; PMCID: PMC3811648.
    17. Farrell JJ, Sampath R, Ecker DJ, Bonomo RA. "Salvage microbiology": detection of bacteria directly from clinical specimens following initiation of antimicrobial treatment. PLoS One. 2013; 8(6):e66349. PMID: 23825537; PMCID: PMC3692526.
    18. Metzgar D, Frinder M, Lovari R, Toleno D, Massire C, Blyn LB, Ranken R, Carolan HE, Hall TA, Moore D, Hansen CJ, Sampath R, Ecker DJ. Broad-spectrum biosensor capable of detecting and identifying diverse bacterial and Candida species in blood. J Clin Microbiol. 2013 Aug; 51(8):2670-8. PMID: 23761152; PMCID: PMC3719611.
    19. Sarovich DS, Colman RE, Price EP, Massire C, Von Schulze AT, Waddell V, Anderson SM, Ecker DJ, Liguori AP, Engelthaler DM, Sampath R, Keim P, Eshoo MW, Wagner DM. Molecular genotyping of Acinetobacter spp. isolated in Arizona, USA, using multilocus PCR and mass spectrometry. J Med Microbiol. 2013 Sep; 62(Pt 9):1295-300. PMID: 23741021.
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    20. Schutzer SE, Berger BW, Krueger JG, Eshoo MW, Ecker DJ, Aucott JN. Atypical erythema migrans in patients with PCR-positive Lyme disease. Emerg Infect Dis. 2013 May; 19(5):815-7. PMID: 23697348; PMCID: PMC3647494.
    21. Jordana-Lluch E, Carolan HE, Giménez M, Sampath R, Ecker DJ, Quesada MD, Mòdol JM, Arméstar F, Blyn LB, Cummins LL, Ausina V, Martró E. Rapid diagnosis of bloodstream infections with PCR followed by mass spectrometry. PLoS One. 2013; 8(4):e62108. PMID: 23626775; PMCID: PMC3633912.
    22. Perreten V, Endimiani A, Thomann A, Wipf JR, Rossano A, Bodmer M, Raemy A, Sannes-Lowery KA, Ecker DJ, Sampath R, Bonomo RA, Washington C. Evaluation of PCR electrospray-ionization mass spectrometry for rapid molecular diagnosis of bovine mastitis. J Dairy Sci. 2013 Jun; 96(6):3611-20. PMID: 23587378.
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    23. Magalhães FP, do Nascimento HM, Ecker DJ, Sannes-Lowery KA, Sampath R, Rosenblatt MI, de Sousa LB, de Oliveira LA. Microbiota evaluation of patients with a Boston type I keratoprosthesis treated with topical 0.5% moxifloxacin and 5% povidone-iodine. Cornea. 2013 Apr; 32(4):407-11. PMID: 22488148.
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    24. Massire C, Buelow DR, Zhang SX, Lovari R, Matthews HE, Toleno DM, Ranken RR, Hall TA, Metzgar D, Sampath R, Blyn LB, Ecker DJ, Gu Z, Walsh TJ, Hayden RT. PCR followed by electrospray ionization mass spectrometry for broad-range identification of fungal pathogens. J Clin Microbiol. 2013 Mar; 51(3):959-66. PMID: 23303501; PMCID: PMC3592073.
    25. Rounds MA, Crowder CD, Stratton CW, Ecker DJ, Eshoo MW, Tang YW. Detection of Plasmodium vivax in a child returning from India by use of broad-range PCR and electrospray ionization mass spectrometry. Emerg Microbes Infect. 2012 Dec; 1(12):e48. PMID: 26038414; PMCID: PMC3630909.
    26. Duncan DD, Vogler AJ, Wolcott MJ, Li F, Sarovich DS, Birdsell DN, Watson LM, Hall TA, Sampath R, Housley R, Blyn LB, Hofstadler SA, Ecker DJ, Keim P, Wagner DM, Eshoo MW. Identification and typing of Francisella tularensis with a highly automated genotyping assay. Lett Appl Microbiol. 2013 Feb; 56(2):128-34. PMID: 23121644.
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    27. Bhatia NS, Farrell JJ, Sampath R, Ranken R, Rounds MA, Ecker DJ, Bonomo RA. Identification of Streptococcus intermedius central nervous system infection by use of PCR and electrospray ionization mass spectrometry. J Clin Microbiol. 2012 Dec; 50(12):4160-2. PMID: 23035188; PMCID: PMC3502992.
    28. Rounds MA, Crowder CD, Matthews HE, Philipson CA, Scoles GA, Ecker DJ, Schutzer SE, Eshoo MW. Identification of endosymbionts in ticks by broad-range polymerase chain reaction and electrospray ionization mass spectrometry. J Med Entomol. 2012 Jul; 49(4):843-50. PMID: 22897044; PMCID: PMC3535486.
    29. Jacob D, Sauer U, Housley R, Washington C, Sannes-Lowery K, Ecker DJ, Sampath R, Grunow R. Rapid and high-throughput detection of highly pathogenic bacteria by Ibis PLEX-ID technology. PLoS One. 2012; 7(6):e39928. PMID: 22768173; PMCID: PMC3386907.
    30. Sampath R, Mulholland N, Blyn LB, Massire C, Whitehouse CA, Waybright N, Harter C, Bogan J, Miranda MS, Smith D, Baldwin C, Wolcott M, Norwood D, Kreft R, Frinder M, Lovari R, Yasuda I, Matthews H, Toleno D, Housley R, Duncan D, Li F, Warren R, Eshoo MW, Hall TA, Hofstadler SA, Ecker DJ. Comprehensive biothreat cluster identification by PCR/electrospray-ionization mass spectrometry. PLoS One. 2012; 7(6):e36528. PMID: 22768032; PMCID: PMC3387173.
    31. Crowder CD, Matthews HE, Rounds MA, Li F, Schutzer SE, Sampath R, Sampath R, Hofstadler SA, Ecker DJ, Eshoo MW. Detection of heartworm infection in dogs via PCR amplification and electrospray ionization mass spectrometry of nucleic acid extracts from whole blood samples. Am J Vet Res. 2012 Jun; 73(6):854-9. PMID: 22620700.
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    32. Eshoo MW, Crowder CC, Rebman AW, Rounds MA, Matthews HE, Picuri JM, Soloski MJ, Ecker DJ, Schutzer SE, Aucott JN. Direct molecular detection and genotyping of Borrelia burgdorferi from whole blood of patients with early Lyme disease. PLoS One. 2012; 7(5):e36825. PMID: 22590620; PMCID: PMC3348129.
    33. Decker BK, Perez F, Hujer AM, Hujer KM, Hall GS, Jacobs MR, Gebreyes WA, Zoll ST, Massire C, Eshoo MW, Ecker DJ, Rather PN, Bonomo RA. Longitudinal analysis of the temporal evolution of Acinetobacter baumannii strains in Ohio, USA, by using rapid automated typing methods. PLoS One. 2012; 7(4):e33443. PMID: 22511922; PMCID: PMC3325217.
    34. Massire C, Gertz RE, Svoboda P, Levert K, Reed MS, Pohl J, Kreft R, Li F, White N, Ranken R, Blyn LB, Ecker DJ, Sampath R, Beall B. Concurrent serotyping and genotyping of pneumococci by use of PCR and electrospray ionization mass spectrometry. J Clin Microbiol. 2012 Jun; 50(6):2018-25. PMID: 22442313; PMCID: PMC3372165.
    35. Wang F, Massire C, Li H, Cummins LL, Li F, Jin J, Fan X, Wang S, Shao L, Zhang S, Meng S, Wu J, Lu C, Blyn LB, Sampath R, Ecker DJ, Zhang W, Tang YW. Molecular characterization of drug-resistant Mycobacterium tuberculosis isolates circulating in China by multilocus PCR and electrospray ionization mass spectrometry. J Clin Microbiol. 2011 Jul; 49(7):2719-21. PMID: 21525214; PMCID: PMC3147815.
    36. Schutzer SE, Rounds MA, Natelson BH, Ecker DJ, Eshoo MW. Analysis of cerebrospinal fluid from chronic fatigue syndrome patients for multiple human ubiquitous viruses and xenotropic murine leukemia-related virus. Ann Neurol. 2011 Apr; 69(4):735-8. PMID: 21472770.
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    37. Chen KF, Blyn L, Rothman RE, Ramachandran P, Valsamakis A, Ecker D, Sampath R, Gaydos CA. Reverse transcription polymerase chain reaction and electrospray ionization mass spectrometry for identifying acute viral upper respiratory tract infections. Diagn Microbiol Infect Dis. 2011 Feb; 69(2):179-86. PMID: 21251562; PMCID: PMC3026598.
    38. Chen KF, Rothman RE, Ramachandran P, Blyn L, Sampath R, Ecker DJ, Valsamakis A, Gaydos CA. Rapid identification viruses from nasal pharyngeal aspirates in acute viral respiratory infections by RT-PCR and electrospray ionization mass spectrometry. J Virol Methods. 2011 Apr; 173(1):60-6. PMID: 21256867; PMCID: PMC3221309.
    39. Massire C, Ivy CA, Lovari R, Kurepina N, Li H, Blyn LB, Hofstadler SA, Khechinashvili G, Stratton CW, Sampath R, Tang YW, Ecker DJ, Kreiswirth BN. Simultaneous identification of mycobacterial isolates to the species level and determination of tuberculosis drug resistance by PCR followed by electrospray ionization mass spectrometry. J Clin Microbiol. 2011 Mar; 49(3):908-17. PMID: 21191060; PMCID: PMC3067746.
    40. Sampath R, Blyn LB, Ecker DJ. Rapid molecular assays for microbial contaminant monitoring in the bioprocess industry. PDA J Pharm Sci Technol. 2010 Sep-Oct; 64(5):458-64. PMID: 21502053.
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    41. Endimiani A, Hujer KM, Hujer AM, Sampath R, Ecker DJ, Bonomo RA. Rapid identification of bla KPC-possessing Enterobacteriaceae by PCR/electrospray ionization-mass spectrometry. J Antimicrob Chemother. 2010 Aug; 65(8):1833-4. PMID: 20538868; PMCID: PMC2904668.
    42. Perez F, Endimiani A, Ray AJ, Decker BK, Wallace CJ, Hujer KM, Ecker DJ, Adams MD, Toltzis P, Dul MJ, Windau A, Bajaksouzian S, Jacobs MR, Salata RA, Bonomo RA. Carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae across a hospital system: impact of post-acute care facilities on dissemination. J Antimicrob Chemother. 2010 Aug; 65(8):1807-18. PMID: 20513702; PMCID: PMC2904665.
    43. Crowder CD, Matthews HE, Schutzer S, Rounds MA, Luft BJ, Nolte O, Campbell SR, Phillipson CA, Li F, Sampath R, Ecker DJ, Eshoo MW. Genotypic variation and mixtures of Lyme Borrelia in Ixodes ticks from North America and Europe. PLoS One. 2010 May 14; 5(5):e10650. PMID: 20498837; PMCID: PMC2871049.
    44. Murray PR, Jain A, Uzel G, Ranken R, Ivy C, Blyn LB, Ecker DJ, Sampath R, Lee CC, Turner ML. Pyoderma gangrenosum-like ulcer in a patient with X-linked agammaglobulinemia: identification of Helicobacter bilis by mass spectrometry analysis. Arch Dermatol. 2010 May; 146(5):523-6. PMID: 20479300; PMCID: PMC3179848.
    45. Ecker DJ, Sampath R, Li H, Massire C, Matthews HE, Toleno D, Hall TA, Blyn LB, Eshoo MW, Ranken R, Hofstadler SA, Tang YW. New technology for rapid molecular diagnosis of bloodstream infections. Expert Rev Mol Diagn. 2010 May; 10(4):399-415. PMID: 20465496.
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    46. Grant-Klein RJ, Baldwin CD, Turell MJ, Rossi CA, Li F, Lovari R, Crowder CD, Matthews HE, Rounds MA, Eshoo MW, Blyn LB, Ecker DJ, Sampath R, Whitehouse CA. Rapid identification of vector-borne flaviviruses by mass spectrometry. Mol Cell Probes. 2010 Aug; 24(4):219-28. PMID: 20412852.
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    47. Crowder CD, Rounds MA, Phillipson CA, Picuri JM, Matthews HE, Halverson J, Schutzer SE, Ecker DJ, Eshoo MW. Extraction of total nucleic acids from ticks for the detection of bacterial and viral pathogens. J Med Entomol. 2010 Jan; 47(1):89-94. PMID: 20180313; PMCID: PMC2837073.
    48. Eshoo MW, Crowder CD, Li H, Matthews HE, Meng S, Sefers SE, Sampath R, Stratton CW, Blyn LB, Ecker DJ, Tang YW. Detection and identification of Ehrlichia species in blood by use of PCR and electrospray ionization mass spectrometry. J Clin Microbiol. 2010 Feb; 48(2):472-8. PMID: 19955274; PMCID: PMC2815638.
    49. Wolk DM, Blyn LB, Hall TA, Sampath R, Ranken R, Ivy C, Melton R, Matthews H, White N, Li F, Harpin V, Ecker DJ, Limbago B, McDougal LK, Wysocki VH, Cai M, Carroll KC. Pathogen profiling: rapid molecular characterization of Staphylococcus aureus by PCR/electrospray ionization-mass spectrometry and correlation with phenotype. J Clin Microbiol. 2009 Oct; 47(10):3129-37. PMID: 19710268; PMCID: PMC2756914.
    50. Eshoo MW, Whitehouse CA, Nalca A, Zoll S, Ecker JA, Hall TA, Pennella TT, Duncan DD, Desai A, Moradi EK, Rudnick K, Libby B, Ranken R, Sampath R, Hofstadler SA, Ecker DJ, Blyn LB. Rapid and high-throughput pan-Orthopoxvirus detection and identification using PCR and mass spectrometry. PLoS One. 2009 Jul 22; 4(7):e6342. PMID: 19623263; PMCID: PMC2710004.
    51. Hujer KM, Hujer AM, Endimiani A, Thomson JM, Adams MD, Goglin K, Rather PN, Pennella TT, Massire C, Eshoo MW, Sampath R, Blyn LB, Ecker DJ, Bonomo RA. Rapid determination of quinolone resistance in Acinetobacter spp. J Clin Microbiol. 2009 May; 47(5):1436-42. PMID: 19297590; PMCID: PMC2681857.
    52. Hall TA, Sampath R, Blyn LB, Ranken R, Ivy C, Melton R, Matthews H, White N, Li F, Harpin V, Ecker DJ, McDougal LK, Limbago B, Ross T, Wolk DM, Wysocki V, Carroll KC. Rapid molecular genotyping and clonal complex assignment of Staphylococcus aureus isolates by PCR coupled to electrospray ionization-mass spectrometry. J Clin Microbiol. 2009 Jun; 47(6):1733-41. PMID: 19297593; PMCID: PMC2691079.
    53. McAlpine J, Romano A, Ecker D. Natural products, both small and large, and a focus on cancer treatment. Curr Opin Drug Discov Devel. 2009 Mar; 12(2):186-8. PMID: 19333863.
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    54. Ecker DJ, Massire C, Blyn LB, Hofstadler SA, Hannis JC, Eshoo MW, Hall TA, Sampath R. Molecular genotyping of microbes by multilocus PCR and mass spectrometry: a new tool for hospital infection control and public health surveillance. Methods Mol Biol. 2009; 551:71-87. PMID: 19521868.
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    55. Jacobs MR, Bajaksouzian S, Bonomo RA, Good CE, Windau AR, Hujer AM, Massire C, Melton R, Blyn LB, Ecker DJ, Sampath R. Occurrence, distribution, and origins of Streptococcus pneumoniae Serotype 6C, a recently recognized serotype. J Clin Microbiol. 2009 Jan; 47(1):64-72. PMID: 18971356; PMCID: PMC2620864.
    56. Hari KL, Goates AT, Jain R, Towers A, Harpin VS, Robertson JM, Wilson MR, Samant VS, Ecker DJ, McNeil JA, Budowle B. The Microbial Rosetta Stone: a database system for tracking infectious microorganisms. Int J Legal Med. 2009 Jan; 123(1):65-9. PMID: 18607616.
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    57. Ecker DJ, Sampath R, Massire C, Blyn LB, Hall TA, Eshoo MW, Hofstadler SA. Ibis T5000: a universal biosensor approach for microbiology. Nat Rev Microbiol. 2008 07; 6(7):553-8. PMID: 18521073.
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    58. Wortmann G, Weintrob A, Barber M, Scott P, Zoll ST, Eshoo MW, Sampath R, Ecker DJ, Massire C. Genotypic evolution of Acinetobacter baumannii strains in an outbreak associated with war trauma. Infect Control Hosp Epidemiol. 2008 Jun; 29(6):553-5. PMID: 18510464.
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    59. Romano A, McAlpine J, Ecker D. Post genomics - from antibody production to small molecule discovery. Curr Opin Drug Discov Devel. 2008 Mar; 11(2):166-7. PMID: 18283603.
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    60. Hannis JC, Manalili SM, Hall TA, Ranken R, White N, Sampath R, Blyn LB, Ecker DJ, Mandrell RE, Fagerquist CK, Bates AH, Miller WG, Hofstadler SA. High-resolution genotyping of Campylobacter species by use of PCR and high-throughput mass spectrometry. J Clin Microbiol. 2008 Apr; 46(4):1220-5. PMID: 18272701; PMCID: PMC2292959.
    61. Blyn LB, Hall TA, Libby B, Ranken R, Sampath R, Rudnick K, Moradi E, Desai A, Metzgar D, Russell KL, Freed NE, Balansay M, Broderick MP, Osuna MA, Hofstadler SA, Ecker DJ. Rapid detection and molecular serotyping of adenovirus by use of PCR followed by electrospray ionization mass spectrometry. J Clin Microbiol. 2008 Feb; 46(2):644-51. PMID: 18094138; PMCID: PMC2238145.
    62. Eshoo MW, Whitehouse CA, Zoll ST, Massire C, Pennella TT, Blyn LB, Sampath R, Hall TA, Ecker JA, Desai A, Wasieloski LP, Li F, Turell MJ, Schink A, Rudnick K, Otero G, Weaver SC, Ludwig GV, Hofstadler SA, Ecker DJ. Direct broad-range detection of alphaviruses in mosquito extracts. Virology. 2007 Nov 25; 368(2):286-95. PMID: 17655905.
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    63. Sampath R, Russell KL, Massire C, Eshoo MW, Harpin V, Blyn LB, Melton R, Ivy C, Pennella T, Li F, Levene H, Hall TA, Libby B, Fan N, Walcott DJ, Ranken R, Pear M, Schink A, Gutierrez J, Drader J, Moore D, Metzgar D, Addington L, Rothman R, Gaydos CA, Yang S, St George K, Fuschino ME, Dean AB, Stallknecht DE, Goekjian G, Yingst S, Monteville M, Saad MD, Whitehouse CA, Baldwin C, Rudnick KH, Hofstadler SA, Lemon SM, Ecker DJ. Global surveillance of emerging Influenza virus genotypes by mass spectrometry. PLoS One. 2007 May 30; 2(5):e489. PMID: 17534439; PMCID: PMC1876795.
    64. Sampath R, Hall TA, Massire C, Li F, Blyn LB, Eshoo MW, Hofstadler SA, Ecker DJ. Rapid identification of emerging infectious agents using PCR and electrospray ionization mass spectrometry. Ann N Y Acad Sci. 2007 Apr; 1102:109-20. PMID: 17470915.
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    65. Hujer KM, Hujer AM, Hulten EA, Bajaksouzian S, Adams JM, Donskey CJ, Ecker DJ, Massire C, Eshoo MW, Sampath R, Thomson JM, Rather PN, Craft DW, Fishbain JT, Ewell AJ, Jacobs MR, Paterson DL, Bonomo RA. Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center. Antimicrob Agents Chemother. 2006 Dec; 50(12):4114-23. PMID: 17000742; PMCID: PMC1694013.
    66. Russell KL, Broderick MP, Franklin SE, Blyn LB, Freed NE, Moradi E, Ecker DJ, Kammerer PE, Osuna MA, Kajon AE, Morn CB, Ryan MA. Transmission dynamics and prospective environmental sampling of adenovirus in a military recruit setting. J Infect Dis. 2006 Oct 01; 194(7):877-85. PMID: 16960774.
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    67. Ecker JA, Massire C, Hall TA, Ranken R, Pennella TT, Agasino Ivy C, Blyn LB, Hofstadler SA, Endy TP, Scott PT, Lindler L, Hamilton T, Gaddy C, Snow K, Pe M, Fishbain J, Craft D, Deye G, Riddell S, Milstrey E, Petruccelli B, Brisse S, Harpin V, Schink A, Ecker DJ, Sampath R, Eshoo MW. Identification of Acinetobacter species and genotyping of Acinetobacter baumannii by multilocus PCR and mass spectrometry. J Clin Microbiol. 2006 Aug; 44(8):2921-32. PMID: 16891513; PMCID: PMC1594644.
    68. Seth PP, Miyaji A, Jefferson EA, Sannes-Lowery KA, Osgood SA, Propp SS, Ranken R, Massire C, Sampath R, Ecker DJ, Swayze EE, Griffey RH. SAR by MS: discovery of a new class of RNA-binding small molecules for the hepatitis C virus: internal ribosome entry site IIA subdomain. J Med Chem. 2005 Nov 17; 48(23):7099-102. PMID: 16279767.
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    69. Hall TA, Budowle B, Jiang Y, Blyn L, Eshoo M, Sannes-Lowery KA, Sampath R, Drader JJ, Hannis JC, Harrell P, Samant V, White N, Ecker DJ, Hofstadler SA. Base composition analysis of human mitochondrial DNA using electrospray ionization mass spectrometry: a novel tool for the identification and differentiation of humans. Anal Biochem. 2005 Sep 01; 344(1):53-69. PMID: 16054106.
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    70. Ecker DJ, Sampath R, Blyn LB, Eshoo MW, Ivy C, Ecker JA, Libby B, Samant V, Sannes-Lowery KA, Melton RE, Russell K, Freed N, Barrozo C, Wu J, Rudnick K, Desai A, Moradi E, Knize DJ, Robbins DW, Hannis JC, Harrell PM, Massire C, Hall TA, Jiang Y, Ranken R, Drader JJ, White N, McNeil JA, Crooke ST, Hofstadler SA. Rapid identification and strain-typing of respiratory pathogens for epidemic surveillance. Proc Natl Acad Sci U S A. 2005 May 31; 102(22):8012-7. PMID: 15911764; PMCID: PMC1138257.
    71. Ecker DJ, Sampath R, Willett P, Wyatt JR, Samant V, Massire C, Hall TA, Hari K, McNeil JA, Büchen-Osmond C, Budowle B. The Microbial Rosetta Stone Database: a compilation of global and emerging infectious microorganisms and bioterrorist threat agents. BMC Microbiol. 2005 Apr 25; 5:19. PMID: 15850481; PMCID: PMC1127111.
    72. Sampath R, Hofstadler SA, Blyn LB, Eshoo MW, Hall TA, Massire C, Levene HM, Hannis JC, Harrell PM, Neuman B, Buchmeier MJ, Jiang Y, Ranken R, Drader JJ, Samant V, Griffey RH, McNeil JA, Crooke ST, Ecker DJ. Rapid identification of emerging pathogens: coronavirus. Emerg Infect Dis. 2005 Mar; 11(3):373-9. PMID: 15757550; PMCID: PMC3298233.
    73. Lesnik EA, Fogel GB, Weekes D, Henderson TJ, Levene HB, Sampath R, Ecker DJ. Identification of conserved regulatory RNA structures in prokaryotic metabolic pathway genes. Biosystems. 2005 May; 80(2):145-54. PMID: 15823413.
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    74. Van Ert MN, Hofstadler SA, Jiang Y, Busch JD, Wagner DM, Drader JJ, Ecker DJ, Hannis JC, Huynh LY, Schupp JM, Simonson TS, Keim P. Mass spectrometry provides accurate characterization of two genetic marker types in Bacillus anthracis. Biotechniques. 2004 Oct; 37(4):642-4, 646, 648 passim. PMID: 15517976.
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    75. Ecker DJ, Stein P, Xu Z, Williams CJ, Kopf GS, Bilker WB, Abel T, Schultz RM. Long-term effects of culture of preimplantation mouse embryos on behavior. Proc Natl Acad Sci U S A. 2004 Feb 10; 101(6):1595-600. PMID: 14747652; PMCID: PMC341785.
    76. Ecker DJ, McAlpine J, Culver K. Model organisms and new tools: choose your weapons wisely. Curr Opin Drug Discov Devel. 2003 Mar; 6(2):159-60. PMID: 12669449.
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    77. Fogel GB, Porto VW, Weekes DG, Fogel DB, Griffey RH, McNeil JA, Lesnik E, Ecker DJ, Sampath R. Discovery of RNA structural elements using evolutionary computation. Nucleic Acids Res. 2002 Dec 01; 30(23):5310-7. PMID: 12466557; PMCID: PMC137967.
    78. Lesnik EA, Sampath R, Ecker DJ. Rev response elements (RRE) in lentiviruses: an RNAMotif algorithm-based strategy for RRE prediction. Med Res Rev. 2002 Nov; 22(6):617-36. PMID: 12369091.
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    79. Macke TJ, Ecker DJ, Gutell RR, Gautheret D, Case DA, Sampath R. RNAMotif, an RNA secondary structure definition and search algorithm. Nucleic Acids Res. 2001 Nov 15; 29(22):4724-35. PMID: 11713323; PMCID: PMC92549.
    80. Lesnik EA, Sampath R, Levene HB, Henderson TJ, McNeil JA, Ecker DJ. Prediction of rho-independent transcriptional terminators in Escherichia coli. Nucleic Acids Res. 2001 Sep 01; 29(17):3583-94. PMID: 11522828; PMCID: PMC55870.
    81. Kao CC, Singh P, Ecker DJ. De novo initiation of viral RNA-dependent RNA synthesis. Virology. 2001 Sep 01; 287(2):251-60. PMID: 11531403.
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    82. McAlpine J, Ecker D, Culver K. The chemistry of biological products. Editorial overview. Curr Opin Drug Discov Devel. 2000 Mar; 3(2):139-40. PMID: 19649845.
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    83. Kung PP, Casper MD, Cook KL, Wilson-Lingardo L, Risen LM, Vickers TA, Ranken R, Blyn LB, Wyatt JR, Cook PD, Ecker DJ. Structure-activity relationships of novel 2-substituted quinazoline antibacterial agents. J Med Chem. 1999 Nov 04; 42(22):4705-13. PMID: 10579832.
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    84. Griffey RH, Hofstadler SA, Sannes-Lowery KA, Ecker DJ, Crooke ST. Determinants of aminoglycoside-binding specificity for rRNA by using mass spectrometry. Proc Natl Acad Sci U S A. 1999 Aug 31; 96(18):10129-33. PMID: 10468574; PMCID: PMC17854.
    85. Hofstadler SA, Sannes-Lowery KA, Crooke ST, Ecker DJ, Sasmor H, Manalili S, Griffey RH. Multiplexed screening of neutral mass-tagged RNA targets against ligand libraries with electrospray ionization FTICR MS: a paradigm for high-throughput affinity screening. Anal Chem. 1999 Aug 15; 71(16):3436-40. PMID: 10464476.
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    86. Silomon M, Bach F, Ecker D, Graeter T, Grundmann U, Larsen R. [Procalcitonin after extracorporeal circulation. Synthesis in the hepatosplanchnic region]. Anaesthesist. 1999 Jun; 48(6):395-8. PMID: 10421923.
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    87. Ecker D, Horwell D. The chemistry of biological products. Editorial overview. Curr Opin Drug Discov Devel. 1999 Mar; 2(2):81-2. PMID: 19649933.
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    88. Stoddart CA, Rabin L, Hincenbergs M, Moreno M, Linquist-Stepps V, Leeds JM, Truong LA, Wyatt JR, Ecker DJ, McCune JM. Inhibition of human immunodeficiency virus type 1 infection in SCID-hu Thy/Liv mice by the G-quartet-forming oligonucleotide, ISIS 5320. Antimicrob Agents Chemother. 1998 Aug; 42(8):2113-5. PMID: 9687417; PMCID: PMC105876.
    89. Konings DA, Wyatt JR, Ecker DJ, Freier SM. Strategies for rapid deconvolution of combinational libraries: comparative evaluation using a model system. J Med Chem. 1997 Dec 19; 40(26):4386-95. PMID: 9435908.
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    90. Konings DA, Wyatt JR, Ecker DJ, Freier SM. Deconvolution of combinatorial libraries for Drug discovery: theoretical comparison of pooling strategies. J Med Chem. 1996 Jul 05; 39(14):2710-9. PMID: 8709101.
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    91. Wilson-Lingardo L, Davis PW, Ecker DJ, Hébert N, Acevedo O, Sprankle K, Brennan T, Schwarcz L, Freier SM, Wyatt JR. Deconvolution of combinatorial libraries for drug discovery: experimental comparison of pooling strategies. J Med Chem. 1996 Jul 05; 39(14):2720-6. PMID: 8709102.
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    92. Freier SM, Konings DA, Wyatt JR, Ecker DJ. 'Mutational SURF': a strategy for improving lead compounds identified from combinatorial libraries. Bioorg Med Chem. 1996 May; 4(5):717-25. PMID: 8804538.
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    93. Bennett CF, Dean N, Ecker DJ, Monia BP. Pharmacology of antisense therapeutic agents : cancer and inflamination. Methods Mol Med. 1996; 1:13-46. PMID: 21359715.
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    94. Davis PW, Vickers TA, Wilson-Lingardo L, Wyatt JR, Guinosso CJ, Sanghvi YS, DeBaets EA, Acevedo OL, Cook PD, Ecker DJ. Drug leads from combinatorial phosphodiester libraries. J Med Chem. 1995 Oct 27; 38(22):4363-6. PMID: 7473564.
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    95. Ecker DJ, Crooke ST. Combinatorial drug discovery: which methods will produce the greatest value? Biotechnology (N Y). 1995 Apr; 13(4):351-60. PMID: 9634776.
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    96. Freier SM, Konings DA, Wyatt JR, Ecker DJ. Deconvolution of combinatorial libraries for drug discovery: a model system. J Med Chem. 1995 Jan 20; 38(2):344-52. PMID: 7830277.
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    97. Stadel JM, Ecker DJ, Powers DA, Marsh J, Hoyle K, Gross M, Minnich MD, Butt TR, Crooke ST. Characterization of mammalian Gs-alpha proteins expressed in yeast. J Recept Res. 1994 Dec; 14(6-8):357-79. PMID: 7877135.
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    98. Buckheit RW, Roberson JL, Lackman-Smith C, Wyatt JR, Vickers TA, Ecker DJ. Potent and specific inhibition of HIV envelope-mediated cell fusion and virus binding by G quartet-forming oligonucleotide (ISIS 5320). AIDS Res Hum Retroviruses. 1994 Nov; 10(11):1497-506. PMID: 7888204.
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    99. Finley D, Sadis S, Monia BP, Boucher P, Ecker DJ, Crooke ST, Chau V. Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant. Mol Cell Biol. 1994 Aug; 14(8):5501-9. PMID: 8035826; PMCID: PMC359070.
    100. Wyatt JR, Vickers TA, Roberson JL, Buckheit RW, Klimkait T, DeBaets E, Davis PW, Rayner B, Imbach JL, Ecker DJ. Combinatorially selected guanosine-quartet structure is a potent inhibitor of human immunodeficiency virus envelope-mediated cell fusion. Proc Natl Acad Sci U S A. 1994 Feb 15; 91(4):1356-60. PMID: 7906414; PMCID: PMC43157.
    101. Graham MJ, Freier SM, Crooke RM, Ecker DJ, Maslova RN, Lesnik EA. Tritium labeling of antisense oligonucleotides by exchange with tritiated water. Nucleic Acids Res. 1993 Aug 11; 21(16):3737-43. PMID: 8367289; PMCID: PMC309879.
    102. Lesnik EA, Guinosso CJ, Kawasaki AM, Sasmor H, Zounes M, Cummins LL, Ecker DJ, Cook PD, Freier SM. Oligodeoxynucleotides containing 2'-O-modified adenosine: synthesis and effects on stability of DNA:RNA duplexes. Biochemistry. 1993 Aug 03; 32(30):7832-8. PMID: 7688569.
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    103. Ecker DJ, Vickers TA, Hanecak R, Driver V, Anderson K. Rational screening of oligonucleotide combinatorial libraries for drug discovery. Nucleic Acids Res. 1993 Apr 25; 21(8):1853-6. PMID: 7684128; PMCID: PMC309424.
    104. Lima WF, Monia BP, Ecker DJ, Freier SM. Implication of RNA structure on antisense oligonucleotide hybridization kinetics. Biochemistry. 1992 Dec 08; 31(48):12055-61. PMID: 1280997.
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    105. Manoharan M, Johnson LK, McGee DP, Guinosso CJ, Ramasamy K, Springer RH, Bennett CF, Ecker DJ, Vickers T, Cowsert L, et al. Chemical modifications to improve uptake and bioavailability of antisense oligonucleotides. Ann N Y Acad Sci. 1992 Oct 28; 660:306-9. PMID: 1364095.
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    106. Monia BP, Johnston JF, Ecker DJ, Zounes MA, Lima WF, Freier SM. Selective inhibition of mutant Ha-ras mRNA expression by antisense oligonucleotides. J Biol Chem. 1992 Oct 05; 267(28):19954-62. PMID: 1400312.
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    107. Ecker DJ, Vickers TA, Bruice TW, Freier SM, Jenison RD, Manoharan M, Zounes M. Pseudo--half-knot formation with RNA. Science. 1992 Aug 14; 257(5072):958-61. PMID: 1502560.
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    108. Vickers TA, Ecker DJ. Enhancement of ribosomal frameshifting by oligonucleotides targeted to the HIV gag-pol region. Nucleic Acids Res. 1992 Aug 11; 20(15):3945-53. PMID: 1508680; PMCID: PMC334071.
    109. Hoke GD, Draper K, Freier SM, Gonzalez C, Driver VB, Zounes MC, Ecker DJ. Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection. Nucleic Acids Res. 1991 Oct 25; 19(20):5743-8. PMID: 1658742; PMCID: PMC328985.
    110. Vickers T, Baker BF, Cook PD, Zounes M, Buckheit RW, Germany J, Ecker DJ. Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element. Nucleic Acids Res. 1991 Jun 25; 19(12):3359-68. PMID: 2062653; PMCID: PMC328335.
    111. Monia BP, Ecker DJ, Finley D, Crooke ST. A human ubiquitin carboxyl extension protein functions in yeast. J Biol Chem. 1990 Nov 05; 265(31):19356-61. PMID: 2229081.
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    112. Jonnalagadda S, Butt TR, Monia BP, Mirabelli CK, Gotlib L, Ecker DJ, Crooke ST. Multiple (alpha-NH-ubiquitin)protein endoproteases in cells. J Biol Chem. 1989 Jun 25; 264(18):10637-42. PMID: 2659591.
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    113. Nakada MT, Haskell KM, Ecker DJ, Stadel JM, Crooke ST. Genetic regulation of beta 2-adrenergic receptors in 3T3-L1 fibroblasts. Biochem J. 1989 May 15; 260(1):53-9. PMID: 2549959; PMCID: PMC1138624.
    114. Monia BP, Haskell KM, Ecker JR, Ecker DJ, Crooke ST. Chromosomal mapping of the ubiquitin gene family in Saccharomyces cerevisiae by pulsed field gel electrophoresis. Nucleic Acids Res. 1989 May 11; 17(9):3611-2. PMID: 2542906; PMCID: PMC317823.
    115. Butt TR, Jonnalagadda S, Monia BP, Sternberg EJ, Marsh JA, Stadel JM, Ecker DJ, Crooke ST. Ubiquitin fusion augments the yield of cloned gene products in Escherichia coli. Proc Natl Acad Sci U S A. 1989 Apr; 86(8):2540-4. PMID: 2539593; PMCID: PMC286952.
    116. Monia BP, Ecker DJ, Jonnalagadda S, Marsh J, Gotlib L, Butt TR, Crooke ST. Gene synthesis, expression, and processing of human ubiquitin carboxyl extension proteins. J Biol Chem. 1989 Mar 05; 264(7):4093-103. PMID: 2537304.
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    117. Ecker DJ, Butt TR, Marsh J, Sternberg E, Shatzman A, Dixon JS, Weber PL, Crooke ST. Ubiquitin function studied by disulfide engineering. J Biol Chem. 1989 Jan 25; 264(3):1887-93. PMID: 2536376.
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    118. Butt TR, Khan MI, Marsh J, Ecker DJ, Crooke ST. Ubiquitin-metallothionein fusion protein expression in yeast. A genetic approach for analysis of ubiquitin functions. J Biol Chem. 1988 Nov 05; 263(31):16364-71. PMID: 2846542.
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    119. Jonnalagadda S, Ecker DJ, Sternberg EJ, Butt TR, Crooke ST. Ubiquitin carboxyl-terminal peptides. Substrates for ubiquitin activating enzyme. J Biol Chem. 1988 Apr 15; 263(11):5016-9. PMID: 2833493.
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    120. Jonnalagadda S, Butt TR, Marsh J, Sternberg EJ, Mirabelli CK, Ecker DJ, Crooke ST. Expression and accurate processing of yeast penta-ubiquitin in Escherichia coli. J Biol Chem. 1987 Dec 25; 262(36):17750-6. PMID: 2826431.
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    121. Ecker DJ, Khan MI, Marsh J, Butt TR, Crooke ST. Chemical synthesis and expression of a cassette adapted ubiquitin gene. J Biol Chem. 1987 Mar 15; 262(8):3524-7. PMID: 3029116.
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    122. Khan MI, Ecker DJ, Butt T, Gorman JA, Crooke ST. A vector for construction of gene libraries and the expression of heterologous genes in Saccharomyces cerevisiae. Plasmid. 1987 Mar; 17(2):171-2. PMID: 3303078.
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    123. Monia BP, Butt TR, Mirabelli CK, Ecker DJ, Sternberg E, Crooke ST. Induction of metallothionein is correlated with resistance to auranofin, a gold compound, in Chinese hamster ovary cells. Mol Pharmacol. 1987 Jan; 31(1):21-6. PMID: 3807890.
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    124. Ecker DJ, Butt TR, Sternberg EJ, Neeper MP, Debouck C, Gorman JA, Crooke ST. Yeast metallothionein function in metal ion detoxification. J Biol Chem. 1986 Dec 25; 261(36):16895-900. PMID: 3536930.
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    125. Crooke ST, Snyder RM, Butt TR, Ecker DJ, Allaudeen HS, Monia B, Mirabelli CK. Cellular and molecular pharmacology of auranofin and related gold complexes. Biochem Pharmacol. 1986 Oct 15; 35(20):3423-31. PMID: 3533080.
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    126. Monia BP, Butt TR, Ecker DJ, Mirabelli CK, Crooke ST. Metallothionein turnover in mammalian cells. Implications in metal toxicity. J Biol Chem. 1986 Aug 25; 261(24):10957-9. PMID: 3733742.
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