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Irina Petrache

TitleAffiliate - NJH
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Research 
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    T32HL007085     (SCHWARTZ, DAVID ALBERT)Jul 1, 1975 - Jun 30, 2025
    NIH
    Multi-Disciplinary Research Training in Respiratory Disease
    Role: Co-Principal Investigator

    F32HL010028     (PETRACHE, IRINA)Mar 5, 1999
    NIH
    OXIDANT STRESS INDUCED APOPTOSIS--ROLE OF HEME OXYGENASE
    Role: Principal Investigator

    K08HL004396     (PETRACHE, IRINA)Aug 1, 2000 - Jul 31, 2005
    NIH
    CYTOSKELETAL REGULATION OF ENDOTHELIAL CELL APOPTOSIS
    Role: Principal Investigator

    R01HL077328     (PETRACHE, IRINA)Jul 1, 2004 - Apr 30, 2025
    NIH
    Ceramide-Induced Destruction In Emphysema
    Role: Principal Investigator

    R01HL090950     (CLAUSS, MATTHIAS)Jul 8, 2008 - May 31, 2014
    NIH
    EMAP II, a molecular link of inflammation and apoptosis in pulmonary emphysema.
    Role: Co-Principal Investigator

    R03HL095440     (BERDYSHEV, EVGENY V)Sep 19, 2008 - Jul 31, 2011
    NIH
    Signaling Sphingolipids in COPD
    Role: Co-Principal Investigator

    R21DA029249     (PETRACHE, IRINA)Apr 1, 2010 - Mar 31, 2012
    NIH
    Molecular mechanism of alveolar injury caused by cigarette smoke
    Role: Principal Investigator

    R01HL105772     (PETRACHE, IRINA)Dec 15, 2011 - Nov 30, 2016
    NIH
    Direct and Bone Marrow Mediated Effects of Adipose Stem Cells in Emphysema
    Role: Principal Investigator

    I01BX001150     (PETRACHE, IRINA)Apr 1, 2012 - Mar 31, 2016
    NIH
    Optimizing vascular protective effects of antitrypsin in COPD
    Role: Principal Investigator

    R56HL125043     (PETRACHE, IRINA)Sep 11, 2014 - Oct 31, 2016
    NIH
    Endothelial mechanisms of impaired lung gas exchange by HIV
    Role: Principal Investigator

    R44HL127873     (MODERY, CHRISTA LYNN)Sep 1, 2015 - Jul 31, 2021
    NIH
    Development of a Fully Humanized Antibody for Treating Lung Emphysema
    Role: Co-Principal Investigator

    R13HL142192     (VANDIVIER, RICHARD W)May 1, 2018 - Apr 30, 2019
    NIH
    Aspen Lung Conference on COPD: Translating Resilience and Pathogenesis to Personalized Therapy for COPD
    Role: Co-Principal Investigator

    R01HL144396     (CHU, HONG W)Sep 20, 2018 - Aug 31, 2022
    NIH
    Immunosuppressive injurious effects of e-cigarettes on human lung parenchyma
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Petrache I, Serban KA. Can Metformin Downshift the Gears of Aging to Slow Emphysema Progression? Am J Respir Crit Care Med. 2021 Sep 15; 204(6):621-622. PMID: 34191690.
      View in: PubMed
    2. Takeda K, Kim SH, Joetham A, Petrache I, Gelfand EW. Therapeutic benefits of recombinant alpha1-antitrypsin IgG1 Fc-fusion protein in experimental emphysema. Respir Res. 2021 Jul 16; 22(1):207. PMID: 34271910.
      View in: PubMed
    3. Schweitzer KS, Crue T, Nall JM, Foster D, Sajuthi S, Correll KA, Nakamura M, Everman JL, Downey GP, Seibold MA, Bridges JP, Serban KA, Chu HW, Petrache I. Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells. Eur Respir J. 2021 07; 58(1). PMID: 33419885.
      View in: PubMed
    4. Goel K, Beatman EL, Egersdorf N, Scruggs A, Cao D, Berdyshev EV, Schweitzer KS, Petrache I. Sphingosine 1 Phosphate (S1P) Receptor 1 Is Decreased in Human Lung Microvascular Endothelial Cells of Smokers and Mediates S1P Effect on Autophagy. Cells. 2021 05 14; 10(5). PMID: 34068927.
      View in: PubMed
    5. Poczobutt JM, Mikosz AM, Poirier C, Beatman EL, Serban KA, Gally F, Cao D, McCubbrey AL, Cornell CF, Schweitzer KS, Berdyshev EV, Bronova IA, Paris F, Petrache I. Altered Macrophage Function Associated with Crystalline Lung Inflammation in Acid Sphingomyelinase Deficiency. Am J Respir Cell Mol Biol. 2021 05; 64(5):629-640. PMID: 33662226.
      View in: PubMed
    6. Petrache I, de Boer E. Cooling off the heated controversy of a safer cigarette: heat-not-burn no better than traditional combustion cigarettes. Thorax. 2021 06; 76(6):536. PMID: 34161919.
      View in: PubMed
    7. Gillenwater LA, Kechris KJ, Pratte KA, Reisdorph N, Petrache I, Labaki WW, O'Neal W, Krishnan JA, Ortega VE, DeMeo DL, Bowler RP. Metabolomic Profiling Reveals Sex Specific Associations with Chronic Obstructive Pulmonary Disease and Emphysema. Metabolites. 2021 Mar 11; 11(3). PMID: 33799786.
      View in: PubMed
    8. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touzé N, Bellarosa C, Belleudi F, Belló Pérez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Burón MI, Bustos V, Büttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairó M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, Camuzard O, Cancino J, Candido de Almeida D, Canesi L, Caniggia I, Canonico B, Cantí C, Cao B, Caraglia M, Caramés B, Carchman EH, Cardenal-Muñoz E, Cardenas C, Cardenas L, Cardoso SM, Carew JS, Carle GF, Carleton G, Carloni S, Carmona-Gutierrez D, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382. PMID: 33634751.
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    9. Berdyshev EV, Serban KA, Schweitzer KS, Bronova IA, Mikosz A, Petrache I. Ceramide and sphingosine-1 phosphate in COPD lungs. Thorax. 2021 Jan 29. PMID: 33514670.
      View in: PubMed
    10. Gillenwater LA, Pratte KA, Hobbs BD, Cho MH, Zhuang Y, Halper-Stromberg E, Cruickshank-Quinn C, Reisdorph N, Petrache I, Labaki WW, O'Neal WK, Ortega VE, Jones DP, Uppal K, Jacobson S, Michelotti G, Wendt CH, Kechris KJ, Bowler RP. Plasma Metabolomic Signatures of Chronic Obstructive Pulmonary Disease and the Impact of Genetic Variants on Phenotype-Driven Modules. Netw Syst Med. 2020 Dec 01; 3(1):159-181. PMID: 33987620.
      View in: PubMed
    11. Liao SY, Petrache I, Fingerlin TE, Maier LA. Association of inhaled and systemic corticosteroid use with Coronavirus Disease 2019 (COVID-19) test positivity in patients with chronic pulmonary diseases. Respir Med. 2021 01; 176:106275. PMID: 33276252.
      View in: PubMed
    12. Koslow M, Petrache I. A Finale on EVALI?: The Abated but Not Forgotten Outbreak of Acute Respiratory Illness in Individuals Who Vape. JAMA Netw Open. 2020 11 02; 3(11):e2019366. PMID: 33156344.
      View in: PubMed
    13. Summers ME, Richmond BW, Kropski JA, Majka SA, Bastarache JA, Hatzopoulos AK, Bylund J, Ghosh M, Petrache I, Foronjy RF, Geraghty P, Majka SM. Balanced Wnt/Dickkopf-1 signaling by mesenchymal vascular progenitor cells in the microvascular niche maintains distal lung structure and function. Am J Physiol Cell Physiol. 2021 01 01; 320(1):C119-C131. PMID: 33085496.
      View in: PubMed
    14. Do-Umehara HC, Chen C, Zhang Q, Misharin AV, Abdala-Valencia H, Casalino-Matsuda SM, Reyfman PA, Anekalla KR, Gonzalez-Gonzalez FJ, Sala MA, Peng C, Wu P, Wong CCL, Kalhan R, Bharat A, Perlman H, Ridge KM, Sznajder JI, Sporn PHS, Chandel NS, Yu J, Fu X, Petrache I, Tuder R, Budinger GRS, Liu J. Epithelial cell-specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice. Sci Adv. 2020 08; 6(33):eabb7238. PMID: 32851183.
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    15. Schweitzer KS, Jinawath N, Yonescu R, Ni K, Rush N, Charoensawan V, Bronova I, Berdyshev E, Leach SM, Gillenwater LA, Bowler RP, Pearse DB, Griffin CA, Petrache I. IGSF3 mutation identified in patient with severe COPD alters cell function and motility. JCI Insight. 2020 07 23; 5(14). PMID: 32573489.
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    16. Panettieri RA, Kolls JK, Lazarus S, Corder S, Harshman A, Langmack E, Petrache I. Impact of a Respiratory Disease Young Investigators' Forum on the Career Development of Physician-Scientists. ATS Sch. 2020 Jun 16; 1(3):243-259. PMID: 33870292.
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    17. Gellatly S, Pavelka N, Crue T, Schweitzer KS, Day BJ, Min E, Numata M, Voelker DR, Scruggs A, Petrache I, Chu HW. Nicotine-Free e-Cigarette Vapor Exposure Stimulates IL6 and Mucin Production in Human Primary Small Airway Epithelial Cells. J Inflamm Res. 2020; 13:175-185. PMID: 32368126.
      View in: PubMed
    18. Cao D, Mikosz AM, Ringsby AJ, Anderson KC, Beatman EL, Koike K, Petrache I. MicroRNA-126-3p Inhibits Angiogenic Function of Human Lung Microvascular Endothelial Cells via LAT1 (L-Type Amino Acid Transporter 1)-Mediated mTOR (Mammalian Target of Rapamycin) Signaling. Arterioscler Thromb Vasc Biol. 2020 05; 40(5):1195-1206. PMID: 32212853.
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    19. Kopf KW, Harral JW, Staker EA, Summers ME, Petrache I, Kheyfets V, Irwin DC, Majka SM. Optimization of combined measures of airway physiology and cardiovascular hemodynamics in mice. Pulm Circ. 2020 Jan-Mar; 10(1):2045894020912937. PMID: 32206308.
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    20. Tong X, Chaudhry Z, Lee CC, Bone RN, Kanojia S, Maddatu J, Sohn P, Weaver SA, Robertson MA, Petrache I, Evans-Molina C, Kono T. Cigarette smoke exposure impairs ß-cell function through activation of oxidative stress and ceramide accumulation. Mol Metab. 2020 07; 37:100975. PMID: 32283079.
      View in: PubMed
    21. Tseng V, Ni K, Allawzi A, Prohaska C, Hernandez-Lagunas L, Elajaili H, Cali V, Midura R, Hascall V, Triggs-Raine B, Petrache I, Hart CM, Nozik-Grayck E. Extracellular Superoxide Dismutase Regulates Early Vascular Hyaluronan Remodeling in Hypoxic Pulmonary Hypertension. Sci Rep. 2020 01 14; 10(1):280. PMID: 31937874.
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    22. Koike K, Berdyshev EV, Mikosz AM, Bronova IA, Bronoff AS, Jung JP, Beatman EL, Ni K, Cao D, Scruggs AK, Serban KA, Petrache I. Role of Glucosylceramide in Lung Endothelial Cell Fate and Emphysema. Am J Respir Crit Care Med. 2019 11 01; 200(9):1113-1125. PMID: 31265321.
      View in: PubMed
    23. Majka SM, Rojas M, Petrache I, Foronjy RF. Mesenchymal Regulation of the Microvascular Niche in Chronic Lung Diseases. Compr Physiol. 2019 09 19; 9(4):1431-1441. PMID: 31688970.
      View in: PubMed
    24. Petrache I. Is More Better? Promising Biological Effects of Double-Dose Alpha 1-Antitrypsin Therapy. Am J Respir Crit Care Med. 2019 Aug 01; 200(3):270-272. PMID: 31063431.
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    25. Halper-Stromberg E, Gillenwater L, Cruickshank-Quinn C, O'Neal WK, Reisdorph N, Petrache I, Zhuang Y, Labaki WW, Curtis JL, Wells J, Rennard S, Pratte KA, Woodruff P, Stringer KA, Kechris K, Bowler RP. Bronchoalveolar Lavage Fluid from COPD Patients Reveals More Compounds Associated with Disease than Matched Plasma. Metabolites. 2019 Jul 25; 9(8). PMID: 31349744.
      View in: PubMed
    26. Serban KA, Mikosz A, Strange C, Janciauskiene SM, Stolk J, Jonigk D, Sandhaus RA, Petrache I. Lectin Complement Pathway in Emphysema. Am J Respir Crit Care Med. 2019 03 01; 199(5):659-661. PMID: 30557515.
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    27. Koike K, Beatman EL, Schweitzer KS, Justice MJ, Mikosz AM, Ni K, Clauss MA, Petrache I. Subcutaneous administration of neutralizing antibodies to endothelial monocyte-activating protein II attenuates cigarette smoke-induced lung injury in mice. . 2019 03 01; 316(3):L558-L566. PMID: 30628489.
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    28. Ni K, Gill A, Cao D, Koike K, Schweitzer KS, Garantziotis S, Petrache I. Intravascular heavy chain-modification of hyaluronan during endotoxic shock. Biochem Biophys Rep. 2019 Mar; 17:114-121. PMID: 30623115.
      View in: PubMed
    29. Koike K, Berdyshev EV, Bowler RP, Scruggs AK, Cao D, Schweitzer KS, Serban KA, Petrache I. Bioactive Sphingolipids in the Pathogenesis of Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2018 12; 15(Suppl 4):S249-S252. PMID: 30759004.
      View in: PubMed
    30. Cruickshank-Quinn CI, Jacobson S, Hughes G, Powell RL, Petrache I, Kechris K, Bowler R, Reisdorph N. Metabolomics and transcriptomics pathway approach reveals outcome-specific perturbations in COPD. Sci Rep. 2018 11 20; 8(1):17132. PMID: 30459441.
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    31. Frump AL, Selej M, Wood JA, Albrecht M, Yakubov B, Petrache I, Lahm T. Hypoxia Upregulates Estrogen Receptor ß in Pulmonary Artery Endothelial Cells in a HIF-1a-Dependent Manner. Am J Respir Cell Mol Biol. 2018 07; 59(1):114-126. PMID: 29394091.
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    32. Ni K, Gill A, Tseng V, Mikosz AM, Koike K, Beatman EL, Xu CY, Cao D, Gally F, Mould KJ, Serban KA, Schweitzer KS, March KL, Janssen WJ, Nozik-Grayck E, Garantziotis S, Petrache I. Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury. Respir Res. 2018 05 31; 19(1):107. PMID: 29855321.
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    33. Barwinska D, Oueini H, Poirier C, Albrecht ME, Bogatcheva NV, Justice MJ, Saliba J, Schweitzer KS, Broxmeyer HE, March KL, Petrache I. AMD3100 ameliorates cigarette smoke-induced emphysema-like manifestations in mice. Am J Physiol Lung Cell Mol Physiol. 2018 09 01; 315(3):L382-L386. PMID: 29745251.
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    34. Walmsley S, Cruickshank-Quinn C, Quinn K, Zhang X, Petrache I, Bowler RP, Reisdorph R, Reisdorph N. A prototypic small molecule database for bronchoalveolar lavage-based metabolomics. Sci Data. 2018 04 17; 5:180060. PMID: 29664467.
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    35. Barwinska D, Traktuev DO, Merfeld-Clauss S, Cook TG, Lu H, Petrache I, March KL. Cigarette Smoking Impairs Adipose Stromal Cell Vasculogenic Activity and Abrogates Potency to Ameliorate Ischemia. Stem Cells. 2018 06; 36(6):856-867. PMID: 29589872.
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    36. Sears CR, Zhou H, Justice MJ, Fisher AJ, Saliba J, Lamb I, Wicker J, Schweitzer KS, Petrache I. Xeroderma Pigmentosum Group C Deficiency Alters Cigarette Smoke DNA Damage Cell Fate and Accelerates Emphysema Development. Am J Respir Cell Mol Biol. 2018 03; 58(3):402-411. PMID: 29111769.
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    37. Justice MJ, Bronova I, Schweitzer KS, Poirier C, Blum JS, Berdyshev EV, Petrache I. Inhibition of acid sphingomyelinase disrupts LYNUS signaling and triggers autophagy. J Lipid Res. 2018 04; 59(4):596-606. PMID: 29378782.
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    38. Mizumura K, Justice MJ, Schweitzer KS, Krishnan S, Bronova I, Berdyshev EV, Hubbard WC, Pewzner-Jung Y, Futerman AH, Choi AMK, Petrache I. Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure. FASEB J. 2018 04; 32(4):1880-1890. PMID: 29196503.
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    39. Serban KA, Petrache I. Mouse Models of COPD. Methods Mol Biol. 2018; 1809:379-394. PMID: 29987802.
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    40. Stephenson SE, Wilson CL, Crothers K, Attia EF, Wongtrakool C, Petrache I, Schnapp LM. Impact of HIV infection on a1-antitrypsin in the lung. . 2018 04 01; 314(4):L583-L592. PMID: 29351445.
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    41. Ni K, Umair Mukhtar Mian M, Meador C, Gill A, Barwinska D, Cao D, Justice MJ, Jiang D, Schaefer N, Schweitzer KS, Chu HW, March KL, Petrache I. Oncostatin M and TNF-a Induce Alpha-1 Antitrypsin Production in Undifferentiated Adipose Stromal Cells. Stem Cells Dev. 2017 10 15; 26(20):1468-1476. PMID: 28825379.
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    42. Cruickshank-Quinn C, Powell R, Jacobson S, Kechris K, Bowler RP, Petrache I, Reisdorph N. Metabolomic similarities between bronchoalveolar lavage fluid and plasma in humans and mice. Sci Rep. 2017 07 11; 7(1):5108. PMID: 28698669.
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    43. Miller MA, Danhorn T, Cruickshank-Quinn CI, Leach SM, Jacobson S, Strand MJ, Reisdorph NA, Bowler RP, Petrache I, Kechris K. Gene and metabolite time-course response to cigarette smoking in mouse lung and plasma. PLoS One. 2017; 12(6):e0178281. PMID: 28575117.
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    44. Suratt BT, Ubags NDJ, Rastogi D, Tantisira KG, Marsland BJ, Petrache I, Allen JB, Bates JHT, Holguin F, McCormack MC, Michelakis ED, Black SM, Jain M, Mora AL, Natarajan V, Miller YI, Fessler MB, Birukov KG, Summer RS, Shore SA, Dixon AE. An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease. Ann Am Thorac Soc. 2017 Jun; 14(6):1050-1059. PMID: 28570148.
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    45. Serban KA, Petrusca DN, Mikosz A, Poirier C, Lockett AD, Saint L, Justice MJ, Twigg HL, Campos MA, Petrache I. Alpha-1 antitrypsin supplementation improves alveolar macrophages efferocytosis and phagocytosis following cigarette smoke exposure. PLoS One. 2017; 12(4):e0176073. PMID: 28448535.
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    46. Petrache I, Serban K. Lost in Trans-IL-6 Signaling: Alveolar Type II Cell Death in Emphysema. Am J Respir Crit Care Med. 2016 12 15; 194(12):1441-1443. PMID: 27976936.
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    47. Brown MB, Neves E, Long G, Graber J, Gladish B, Wiseman A, Owens M, Fisher AJ, Presson RG, Petrache I, Kline J, Lahm T. High-intensity interval training, but not continuous training, reverses right ventricular hypertrophy and dysfunction in a rat model of pulmonary hypertension. . 2017 02 01; 312(2):R197-R210. PMID: 27784688.
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    48. Serban KA, Rezania S, Petrusca DN, Poirier C, Cao D, Justice MJ, Patel M, Tsvetkova I, Kamocki K, Mikosz A, Schweitzer KS, Jacobson S, Cardoso A, Carlesso N, Hubbard WC, Kechris K, Dragnea B, Berdyshev EV, McClintock J, Petrache I. Structural and functional characterization of endothelial microparticles released by cigarette smoke. Sci Rep. 2016 08 17; 6:31596. PMID: 27530098.
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    49. Ni K, Serban KA, Batra C, Petrache I. Alpha-1 Antitrypsin Investigations Using Animal Models of Emphysema. Ann Am Thorac Soc. 2016 08; 13 Suppl 4:S311-6. PMID: 27564666.
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    50. Serban KA, Petrache I. Alpha-1 Antitrypsin and Lung Cell Apoptosis. Ann Am Thorac Soc. 2016 04; 13 Suppl 2:S146-9. PMID: 27115949.
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    51. Crothers K, Petrache I, Wongtrakool C, Lee PJ, Schnapp LM, Gharib SA. Widespread activation of immunity and pro-inflammatory programs in peripheral blood leukocytes of HIV-infected patients with impaired lung gas exchange. Physiol Rep. 2016 Apr; 4(8). PMID: 27117807.
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    119. Petrache I, Natarajan V, Zhen L, Medler TR, Richter AT, Cho C, Hubbard WC, Berdyshev EV, Tuder RM. Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nat Med. 2005 May; 11(5):491-8. PMID: 15852018.
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    120. Rangasamy T, Cho CY, Thimmulappa RK, Zhen L, Srisuma SS, Kensler TW, Yamamoto M, Petrache I, Tuder RM, Biswal S. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest. 2004 Nov; 114(9):1248-59. PMID: 15520857.
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    121. Petrache I, Crow MT, Neuss M, Garcia JG. Central involvement of Rho family GTPases in TNF-alpha-mediated bovine pulmonary endothelial cell apoptosis. Biochem Biophys Res Commun. 2003 Jun 20; 306(1):244-9. PMID: 12788095.
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    122. Petrache I, Birukova A, Ramirez SI, Garcia JG, Verin AD. The role of the microtubules in tumor necrosis factor-alpha-induced endothelial cell permeability. Am J Respir Cell Mol Biol. 2003 May; 28(5):574-81. PMID: 12707013.
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    123. Tuder RM, Petrache I, Elias JA, Voelkel NF, Henson PM. Apoptosis and emphysema: the missing link. Am J Respir Cell Mol Biol. 2003 May; 28(5):551-4. PMID: 12707010.
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    124. Petrache I, Birukov K, Zaiman AL, Crow MT, Deng H, Wadgaonkar R, Romer LH, Garcia JG. Caspase-dependent cleavage of myosin light chain kinase (MLCK) is involved in TNF-alpha-mediated bovine pulmonary endothelial cell apoptosis. FASEB J. 2003 Mar; 17(3):407-16. PMID: 12631580.
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    125. Petrache I, Verin AD, Crow MT, Birukova A, Liu F, Garcia JG. Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction. . 2001 Jun; 280(6):L1168-78. PMID: 11350795.
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    126. Petrache I, Otterbein LE, Alam J, Wiegand GW, Choi AM. Heme oxygenase-1 inhibits TNF-alpha-induced apoptosis in cultured fibroblasts. . 2000 Feb; 278(2):L312-9. PMID: 10666115.
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    127. Petrache I, Choi ME, Otterbein LE, Chin BY, Mantell LL, Horowitz S, Choi AM. Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells. Am J Physiol. 1999 09; 277(3):L589-95. PMID: 10484467.
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    128. Otterbein LE, Lee PJ, Chin BY, Petrache I, Camhi SL, Alam J, Choi AM. Protective effects of heme oxygenase-1 in acute lung injury. Chest. 1999 Jul; 116(1 Suppl):61S-63S. PMID: 10424595.
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    129. Chin BY, Petrache I, Choi AM, Choi ME. Transforming growth factor beta1 rescues serum deprivation-induced apoptosis via the mitogen-activated protein kinase (MAPK) pathway in macrophages. J Biol Chem. 1999 Apr 16; 274(16):11362-8. PMID: 10196228.
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