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Irina Petrache

TitleAffiliate - NJH
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Research 
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    T32HL007085     (SCHWARTZ, DAVID ALBERT)Jul 1, 1975 - Jun 30, 2020
    NIH/NHLBI
    Multi-Disciplinary Research Training in Respiratory Disease
    Role: Co-Principal Investigator

    F32HL010028     (PETRACHE, IRINA)Mar 5, 1999
    NIH/NHLBI
    OXIDANT STRESS INDUCED APOPTOSIS--ROLE OF HEME OXYGENASE
    Role: Principal Investigator

    K08HL004396     (PETRACHE, IRINA)Aug 1, 2000 - Jul 31, 2005
    NIH/NHLBI
    CYTOSKELETAL REGULATION OF ENDOTHELIAL CELL APOPTOSIS
    Role: Principal Investigator

    R01HL077328     (PETRACHE, IRINA)Jul 1, 2004 - Mar 31, 2016
    NIH/NHLBI
    Ceramide-Induced Destruction In Emphysema
    Role: Principal Investigator

    R01HL090950     (CLAUSS, MATTHIAS)Jul 8, 2008 - May 31, 2014
    NIH/NHLBI
    EMAP II, a molecular link of inflammation and apoptosis in pulmonary emphysema.
    Role: Co-Principal Investigator

    R03HL095440     (BERDYSHEV, EVGENY V)Sep 19, 2008 - Jul 31, 2011
    NIH/NHLBI
    Signaling Sphingolipids in COPD
    Role: Co-Principal Investigator

    R21DA029249     (PETRACHE, IRINA)Apr 1, 2010 - Mar 31, 2012
    NIH/NIDA
    Molecular mechanism of alveolar injury caused by cigarette smoke
    Role: Principal Investigator

    R01HL105772     (PETRACHE, IRINA)Dec 15, 2011 - Nov 30, 2015
    NIH/NHLBI
    Direct and Bone-Marrow Mediated Effects of Adipose Stem Cells in Emphysema
    Role: Principal Investigator

    I01BX001150     (PETRACHE, IRINA)Apr 1, 2012 - Mar 31, 2016
    VA
    Optimizing vascular protective effects of antitrypsin in COPD
    Role: Principal Investigator

    R56HL125043     (PETRACHE, IRINA)Sep 11, 2014 - Oct 31, 2015
    NIH/NHLBI
    Endothelial mechanisms of impaired lung gas exchange by HIV
    Role: Principal Investigator

    R44HL127873     (HAY, DOUGLAS W.P.)Sep 1, 2015 - Jul 31, 2019
    NIH/NHLBI
    Development of a Fully Humanized Antibody for Treating Lung Emphysema
    Role: Co-Principal Investigator

    R13HL142192     (VANDIVIER, RICHARD W)May 1, 2018 - Apr 30, 2019
    NIH/NHLBI
    Aspen Lung Conference on COPD: Translating Resilience and Pathogenesis to Personalized Therapy for COPD
    Role: Co-Principal Investigator

    R01HL144396     (CHU, HONG W)Sep 20, 2018 - Aug 31, 2022
    NIH/NHLBI
    Immunosuppressive injurious effects of e-cigarettes on human lung parenchyma
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Do-Umehara HC, Chen C, Zhang Q, Misharin AV, Abdala-Valencia H, Casalino-Matsuda SM, Reyfman PA, Anekalla KR, Gonzalez-Gonzalez FJ, Sala MA, Peng C, Wu P, Wong CCL, Kalhan R, Bharat A, Perlman H, Ridge KM, Sznajder JI, Sporn PHS, Chandel NS, Yu J, Fu X, Petrache I, Tuder R, Budinger GRS, Liu J. Epithelial cell-specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice. Sci Adv. 2020 08; 6(33):eabb7238. PMID: 32851183.
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    2. Schweitzer KS, Jinawath N, Yonescu R, Ni K, Rush N, Charoensawan V, Bronova I, Berdyshev E, Leach SM, Gillenwater LA, Bowler RP, Pearse DB, Griffin CA, Petrache I. IGSF3 mutation identified in patient with severe COPD alters cell function and motility. JCI Insight. 2020 Jul 23; 5(14). PMID: 32573489.
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    3. Gellatly S, Pavelka N, Crue T, Schweitzer KS, Day BJ, Min E, Numata M, Voelker DR, Scruggs A, Petrache I, Chu HW. Nicotine-Free e-Cigarette Vapor Exposure Stimulates IL6 and Mucin Production in Human Primary Small Airway Epithelial Cells. J Inflamm Res. 2020; 13:175-185. PMID: 32368126.
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    4. Cao D, Mikosz AM, Ringsby AJ, Anderson KC, Beatman EL, Koike K, Petrache I. MicroRNA-126-3p Inhibits Angiogenic Function of Human Lung Microvascular Endothelial Cells via LAT1 (L-Type Amino Acid Transporter 1)-Mediated mTOR (Mammalian Target of Rapamycin) Signaling. Arterioscler Thromb Vasc Biol. 2020 05; 40(5):1195-1206. PMID: 32212853.
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    5. Kopf KW, Harral JW, Staker EA, Summers ME, Petrache I, Kheyfets V, Irwin DC, Majka SM. Optimization of combined measures of airway physiology and cardiovascular hemodynamics in mice. Pulm Circ. 2020 Jan-Mar; 10(1):2045894020912937. PMID: 32206308.
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    6. Tong X, Chaudhry Z, Lee CC, Bone RN, Kanojia S, Maddatu J, Sohn P, Weaver SA, Robertson MA, Petrache I, Evans-Molina C, Kono T. Cigarette smoke exposure impairs ß-cell function through activation of oxidative stress and ceramide accumulation. Mol Metab. 2020 Jul; 37:100975. PMID: 32283079.
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    7. Tseng V, Ni K, Allawzi A, Prohaska C, Hernandez-Lagunas L, Elajaili H, Cali V, Midura R, Hascall V, Triggs-Raine B, Petrache I, Hart CM, Nozik-Grayck E. Extracellular Superoxide Dismutase Regulates Early Vascular Hyaluronan Remodeling in Hypoxic Pulmonary Hypertension. Sci Rep. 2020 01 14; 10(1):280. PMID: 31937874.
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    8. Koike K, Berdyshev EV, Mikosz AM, Bronova IA, Bronoff AS, Jung JP, Beatman EL, Ni K, Cao D, Scruggs AK, Serban KA, Petrache I. Role of Glucosylceramide in Lung Endothelial Cell Fate and Emphysema. Am J Respir Crit Care Med. 2019 11 01; 200(9):1113-1125. PMID: 31265321.
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    9. Majka SM, Rojas M, Petrache I, Foronjy RF. Mesenchymal Regulation of the Microvascular Niche in Chronic Lung Diseases. Compr Physiol. 2019 09 19; 9(4):1431-1441. PMID: 31688970.
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    10. Petrache I. Is More Better? Promising Biological Effects of Double-Dose Alpha 1-Antitrypsin Therapy. Am J Respir Crit Care Med. 2019 Aug 01; 200(3):270-272. PMID: 31063431.
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    11. Halper-Stromberg E, Gillenwater L, Cruickshank-Quinn C, O'Neal WK, Reisdorph N, Petrache I, Zhuang Y, Labaki WW, Curtis JL, Wells J, Rennard S, Pratte KA, Woodruff P, Stringer KA, Kechris K, Bowler RP. Bronchoalveolar Lavage Fluid from COPD Patients Reveals More Compounds Associated with Disease than Matched Plasma. Metabolites. 2019 Jul 25; 9(8). PMID: 31349744.
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    12. Serban KA, Mikosz A, Strange C, Janciauskiene SM, Stolk J, Jonigk D, Sandhaus RA, Petrache I. Lectin Complement Pathway in Emphysema. Am J Respir Crit Care Med. 2019 03 01; 199(5):659-661. PMID: 30557515.
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    13. Koike K, Beatman EL, Schweitzer KS, Justice MJ, Mikosz AM, Ni K, Clauss MA, Petrache I. Subcutaneous administration of neutralizing antibodies to endothelial monocyte-activating protein II attenuates cigarette smoke-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2019 03 01; 316(3):L558-L566. PMID: 30628489.
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    14. Ni K, Gill A, Cao D, Koike K, Schweitzer KS, Garantziotis S, Petrache I. Intravascular heavy chain-modification of hyaluronan during endotoxic shock. Biochem Biophys Rep. 2019 Mar; 17:114-121. PMID: 30623115.
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    15. Koike K, Berdyshev EV, Bowler RP, Scruggs AK, Cao D, Schweitzer KS, Serban KA, Petrache I. Bioactive Sphingolipids in the Pathogenesis of Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2018 12; 15(Suppl 4):S249-S252. PMID: 30759004.
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    16. Cruickshank-Quinn CI, Jacobson S, Hughes G, Powell RL, Petrache I, Kechris K, Bowler R, Reisdorph N. Metabolomics and transcriptomics pathway approach reveals outcome-specific perturbations in COPD. Sci Rep. 2018 11 20; 8(1):17132. PMID: 30459441.
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    17. Frump AL, Selej M, Wood JA, Albrecht M, Yakubov B, Petrache I, Lahm T. Hypoxia Upregulates Estrogen Receptor ß in Pulmonary Artery Endothelial Cells in a HIF-1a-Dependent Manner. Am J Respir Cell Mol Biol. 2018 07; 59(1):114-126. PMID: 29394091.
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    18. Ni K, Gill A, Tseng V, Mikosz AM, Koike K, Beatman EL, Xu CY, Cao D, Gally F, Mould KJ, Serban KA, Schweitzer KS, March KL, Janssen WJ, Nozik-Grayck E, Garantziotis S, Petrache I. Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury. Respir Res. 2018 05 31; 19(1):107. PMID: 29855321.
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    19. Barwinska D, Oueini H, Poirier C, Albrecht ME, Bogatcheva NV, Justice MJ, Saliba J, Schweitzer KS, Broxmeyer HE, March KL, Petrache I. AMD3100 ameliorates cigarette smoke-induced emphysema-like manifestations in mice. Am J Physiol Lung Cell Mol Physiol. 2018 09 01; 315(3):L382-L386. PMID: 29745251.
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    20. Walmsley S, Cruickshank-Quinn C, Quinn K, Zhang X, Petrache I, Bowler RP, Reisdorph R, Reisdorph N. A prototypic small molecule database for bronchoalveolar lavage-based metabolomics. Sci Data. 2018 04 17; 5:180060. PMID: 29664467.
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    21. Barwinska D, Traktuev DO, Merfeld-Clauss S, Cook TG, Lu H, Petrache I, March KL. Cigarette Smoking Impairs Adipose Stromal Cell Vasculogenic Activity and Abrogates Potency to Ameliorate Ischemia. Stem Cells. 2018 06; 36(6):856-867. PMID: 29589872.
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    22. Sears CR, Zhou H, Justice MJ, Fisher AJ, Saliba J, Lamb I, Wicker J, Schweitzer KS, Petrache I. Xeroderma Pigmentosum Group C Deficiency Alters Cigarette Smoke DNA Damage Cell Fate and Accelerates Emphysema Development. Am J Respir Cell Mol Biol. 2018 03; 58(3):402-411. PMID: 29111769.
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    23. Justice MJ, Bronova I, Schweitzer KS, Poirier C, Blum JS, Berdyshev EV, Petrache I. Inhibition of acid sphingomyelinase disrupts LYNUS signaling and triggers autophagy. J Lipid Res. 2018 04; 59(4):596-606. PMID: 29378782.
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    24. Mizumura K, Justice MJ, Schweitzer KS, Krishnan S, Bronova I, Berdyshev EV, Hubbard WC, Pewzner-Jung Y, Futerman AH, Choi AMK, Petrache I. Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure. FASEB J. 2018 04; 32(4):1880-1890. PMID: 29196503.
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    25. Serban KA, Petrache I. Mouse Models of COPD. Methods Mol Biol. 2018; 1809:379-394. PMID: 29987802.
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    26. Stephenson SE, Wilson CL, Crothers K, Attia EF, Wongtrakool C, Petrache I, Schnapp LM. Impact of HIV infection on a1-antitrypsin in the lung. Am J Physiol Lung Cell Mol Physiol. 2018 04 01; 314(4):L583-L592. PMID: 29351445.
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    27. Ni K, Umair Mukhtar Mian M, Meador C, Gill A, Barwinska D, Cao D, Justice MJ, Jiang D, Schaefer N, Schweitzer KS, Chu HW, March KL, Petrache I. Oncostatin M and TNF-a Induce Alpha-1 Antitrypsin Production in Undifferentiated Adipose Stromal Cells. Stem Cells Dev. 2017 10 15; 26(20):1468-1476. PMID: 28825379.
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    28. Cruickshank-Quinn C, Powell R, Jacobson S, Kechris K, Bowler RP, Petrache I, Reisdorph N. Metabolomic similarities between bronchoalveolar lavage fluid and plasma in humans and mice. Sci Rep. 2017 07 11; 7(1):5108. PMID: 28698669.
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    29. Miller MA, Danhorn T, Cruickshank-Quinn CI, Leach SM, Jacobson S, Strand MJ, Reisdorph NA, Bowler RP, Petrache I, Kechris K. Gene and metabolite time-course response to cigarette smoking in mouse lung and plasma. PLoS One. 2017; 12(6):e0178281. PMID: 28575117.
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    30. Suratt BT, Ubags NDJ, Rastogi D, Tantisira KG, Marsland BJ, Petrache I, Allen JB, Bates JHT, Holguin F, McCormack MC, Michelakis ED, Black SM, Jain M, Mora AL, Natarajan V, Miller YI, Fessler MB, Birukov KG, Summer RS, Shore SA, Dixon AE. An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease. Ann Am Thorac Soc. 2017 Jun; 14(6):1050-1059. PMID: 28570148.
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    31. Serban KA, Petrusca DN, Mikosz A, Poirier C, Lockett AD, Saint L, Justice MJ, Twigg HL, Campos MA, Petrache I. Alpha-1 antitrypsin supplementation improves alveolar macrophages efferocytosis and phagocytosis following cigarette smoke exposure. PLoS One. 2017; 12(4):e0176073. PMID: 28448535.
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    32. Petrache I, Serban K. Lost in Trans-IL-6 Signaling: Alveolar Type II Cell Death in Emphysema. Am J Respir Crit Care Med. 2016 12 15; 194(12):1441-1443. PMID: 27976936.
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    33. Brown MB, Neves E, Long G, Graber J, Gladish B, Wiseman A, Owens M, Fisher AJ, Presson RG, Petrache I, Kline J, Lahm T. High-intensity interval training, but not continuous training, reverses right ventricular hypertrophy and dysfunction in a rat model of pulmonary hypertension. Am J Physiol Regul Integr Comp Physiol. 2017 02 01; 312(2):R197-R210. PMID: 27784688.
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    34. Serban KA, Rezania S, Petrusca DN, Poirier C, Cao D, Justice MJ, Patel M, Tsvetkova I, Kamocki K, Mikosz A, Schweitzer KS, Jacobson S, Cardoso A, Carlesso N, Hubbard WC, Kechris K, Dragnea B, Berdyshev EV, McClintock J, Petrache I. Structural and functional characterization of endothelial microparticles released by cigarette smoke. Sci Rep. 2016 08 17; 6:31596. PMID: 27530098.
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    35. Ni K, Serban KA, Batra C, Petrache I. Alpha-1 Antitrypsin Investigations Using Animal Models of Emphysema. Ann Am Thorac Soc. 2016 08; 13 Suppl 4:S311-6. PMID: 27564666.
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    36. Serban KA, Petrache I. Alpha-1 Antitrypsin and Lung Cell Apoptosis. Ann Am Thorac Soc. 2016 04; 13 Suppl 2:S146-9. PMID: 27115949.
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    37. Crothers K, Petrache I, Wongtrakool C, Lee PJ, Schnapp LM, Gharib SA. Widespread activation of immunity and pro-inflammatory programs in peripheral blood leukocytes of HIV-infected patients with impaired lung gas exchange. Physiol Rep. 2016 Apr; 4(8). PMID: 27117807.
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    38. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
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    39. Petrache I, Berdyshev EV. Ceramide Signaling and Metabolism in Pathophysiological States of the Lung. Annu Rev Physiol. 2016; 78:463-80. PMID: 26667073.
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    40. Lu H, Cook T, Poirier C, Merfeld-Clauss S, Petrache I, March KL, Bogatcheva NV. Pulmonary Retention of Adipose Stromal Cells Following Intravenous Delivery Is Markedly Altered in the Presence of ARDS. Cell Transplant. 2016; 25(9):1635-1643. PMID: 26609693.
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    41. Lockett AD, Petrusca DN, Justice MJ, Poirier C, Serban KA, Rush NI, Kamocka M, Predescu D, Predescu S, Petrache I. Scavenger receptor class B, type I-mediated uptake of A1AT by pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15; 309(4):L425-34. PMID: 26092999.
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    42. Brown MB, Chingombe TJ, Zinn AB, Reddy JG, Novack RA, Cooney SA, Fisher AJ, Presson RG, Lahm T, Petrache I. Novel assessment of haemodynamic kinetics with acute exercise in a rat model of pulmonary arterial hypertension. Exp Physiol. 2015 Jun; 100(6):742-54. PMID: 25867528.
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    43. Schweitzer KS, Chen SX, Law S, Van Demark M, Poirier C, Justice MJ, Hubbard WC, Kim ES, Lai X, Wang M, Kranz WD, Carroll CJ, Ray BD, Bittman R, Goodpaster J, Petrache I. Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures. Am J Physiol Lung Cell Mol Physiol. 2015 Jul 15; 309(2):L175-87. PMID: 25979079.
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    44. Lu H, Poirier C, Cook T, Traktuev DO, Merfeld-Clauss S, Lease B, Petrache I, March KL, Bogatcheva NV. Conditioned media from adipose stromal cells limit lipopolysaccharide-induced lung injury, endothelial hyperpermeability and apoptosis. J Transl Med. 2015 Feb 21; 13:67. PMID: 25889857.
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    45. Goss KN, Cucci AR, Fisher AJ, Albrecht M, Frump A, Tursunova R, Gao Y, Brown MB, Petrache I, Tepper RS, Ahlfeld SK, Lahm T. Neonatal hyperoxic lung injury favorably alters adult right ventricular remodeling response to chronic hypoxia exposure. Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15; 308(8):L797-806. PMID: 25659904.
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    46. Bowler RP, Jacobson S, Cruickshank C, Hughes GJ, Siska C, Ory DS, Petrache I, Schaffer JE, Reisdorph N, Kechris K. Plasma sphingolipids associated with chronic obstructive pulmonary disease phenotypes. Am J Respir Crit Care Med. 2015 Feb 01; 191(3):275-84. PMID: 25494452.
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    47. Xie J, Broxmeyer HE, Feng D, Schweitzer KS, Yi R, Cook TG, Chitteti BR, Barwinska D, Traktuev DO, Van Demark MJ, Justice MJ, Ou X, Srour EF, Prockop DJ, Petrache I, March KL. Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG-6. Stem Cells. 2015 Feb; 33(2):468-78. PMID: 25329668.
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    48. Christofidou-Solomidou M, Pietrofesa RA, Arguiri E, Schweitzer KS, Berdyshev EV, McCarthy M, Corbitt A, Alwood JS, Yu Y, Globus RK, Solomides CC, Ullrich RL, Petrache I. Space radiation-associated lung injury in a murine model. Am J Physiol Lung Cell Mol Physiol. 2015 Mar 01; 308(5):L416-28. PMID: 25526737.
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    49. Zhang X, Shan P, Homer R, Zhang Y, Petrache I, Mannam P, Lee PJ. Cathepsin E promotes pulmonary emphysema via mitochondrial fission. Am J Pathol. 2014 Oct; 184(10):2730-41. PMID: 25239563.
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    50. Voiles L, Lewis DE, Han L, Lupov IP, Lin TL, Robertson MJ, Petrache I, Chang HC. Overexpression of type VI collagen in neoplastic lung tissues. Oncol Rep. 2014 Nov; 32(5):1897-904. PMID: 25176343.
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    51. Janes K, Little JW, Li C, Bryant L, Chen C, Chen Z, Kamocki K, Doyle T, Snider A, Esposito E, Cuzzocrea S, Bieberich E, Obeid L, Petrache I, Nicol G, Neumann WL, Salvemini D. The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. J Biol Chem. 2014 Jul 25; 289(30):21082-97. PMID: 24876379.
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    52. Petrache I, Patel D, Wolf KM, Winer-Muram H. Vertebral erosion: an uncommon complication of tracheal tubes. Am J Respir Crit Care Med. 2014 Jul 15; 190(2):e4. PMID: 25025361.
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    53. McCaslin CA, Petrusca DN, Poirier C, Serban KA, Anderson GG, Petrache I. Impact of alginate-producing Pseudomonas aeruginosa on alveolar macrophage apoptotic cell clearance. J Cyst Fibros. 2015 Jan; 14(1):70-77. PMID: 25027418.
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    54. Cruickshank-Quinn CI, Mahaffey S, Justice MJ, Hughes G, Armstrong M, Bowler RP, Reisdorph R, Petrache I, Reisdorph N. Transient and persistent metabolomic changes in plasma following chronic cigarette smoke exposure in a mouse model. PLoS One. 2014; 9(7):e101855. PMID: 25007263.
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    55. Toney BM, Fisher AJ, Albrecht M, Lockett AD, Presson RG, Petrache I, Lahm T. Selective endothelin-A receptor blockade attenuates endotoxin-induced pulmonary hypertension and pulmonary vascular dysfunction. Pulm Circ. 2014 Jun; 4(2):300-10. PMID: 25006449.
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    56. Brown MB, Hunt WR, Noe JE, Rush NI, Schweitzer KS, Leece TC, Moldobaeva A, Wagner EM, Dudek SM, Poirier C, Presson RG, Gulbins E, Petrache I. Loss of cystic fibrosis transmembrane conductance regulator impairs lung endothelial cell barrier function and increases susceptibility to microvascular damage from cigarette smoke. Pulm Circ. 2014 Jun; 4(2):260-8. PMID: 25006445.
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    57. Lahm T, Tuder RM, Petrache I. Progress in solving the sex hormone paradox in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Jul 01; 307(1):L7-26. PMID: 24816487.
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    58. Lockett AD, Brown MB, Santos-Falcon N, Rush NI, Oueini H, Oberle AJ, Bolanis E, Fragoso MA, Petrusca DN, Serban KA, Schweitzer KS, Presson RG, Campos M, Petrache I. Active trafficking of alpha 1 antitrypsin across the lung endothelium. PLoS One. 2014; 9(4):e93979. PMID: 24743137.
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    59. Petrusca DN, Van Demark M, Gu Y, Justice MJ, Rogozea A, Hubbard WC, Petrache I. Smoking exposure induces human lung endothelial cell adaptation to apoptotic stress. Am J Respir Cell Mol Biol. 2014 Mar; 50(3):513-25. PMID: 24079644.
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    60. Justice MJ, Petrusca DN, Rogozea AL, Williams JA, Schweitzer KS, Petrache I, Wassall SR, Petrache HI. Effects of lipid interactions on model vesicle engulfment by alveolar macrophages. Biophys J. 2014 Feb 04; 106(3):598-609. PMID: 24507600.
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    61. Green LA, Yi R, Petrusca D, Wang T, Elghouche A, Gupta SK, Petrache I, Clauss M. HIV envelope protein gp120-induced apoptosis in lung microvascular endothelial cells by concerted upregulation of EMAP II and its receptor, CXCR3. Am J Physiol Lung Cell Mol Physiol. 2014 Feb 15; 306(4):L372-82. PMID: 24318111.
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    62. Hughes G, Cruickshank-Quinn C, Reisdorph R, Lutz S, Petrache I, Reisdorph N, Bowler R, Kechris K. MSPrep--summarization, normalization and diagnostics for processing of mass spectrometry-based metabolomic data. Bioinformatics. 2014 Jan 01; 30(1):133-4. PMID: 24174567.
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    63. Lockett AD, Kimani S, Ddungu G, Wrenger S, Tuder RM, Janciauskiene SM, Petrache I. a1-Antitrypsin modulates lung endothelial cell inflammatory responses to TNF-a. Am J Respir Cell Mol Biol. 2013 Jul; 49(1):143-50. PMID: 23526215.
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    64. Petrache I, Kamocki K, Poirier C, Pewzner-Jung Y, Laviad EL, Schweitzer KS, Van Demark M, Justice MJ, Hubbard WC, Futerman AH. Ceramide synthases expression and role of ceramide synthase-2 in the lung: insight from human lung cells and mouse models. PLoS One. 2013; 8(5):e62968. PMID: 23690971.
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    65. Sahu RP, Petrache I, Van Demark MJ, Rashid BM, Ocana JA, Tang Y, Yi Q, Turner MJ, Konger RL, Travers JB. Cigarette smoke exposure inhibits contact hypersensitivity via the generation of platelet-activating factor agonists. J Immunol. 2013 Mar 01; 190(5):2447-54. PMID: 23355733.
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    66. Bardita C, Predescu D, Justice MJ, Petrache I, Predescu S. In vivo knockdown of intersectin-1s alters endothelial cell phenotype and causes microvascular remodeling in the mouse lungs. Apoptosis. 2013 Jan; 18(1):57-76. PMID: 23054079.
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    67. Petrache I, Petrusca DN. The involvement of sphingolipids in chronic obstructive pulmonary diseases. Handb Exp Pharmacol. 2013; (216):247-64. PMID: 23563660.
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    68. Kamocki K, Van Demark M, Fisher A, Rush NI, Presson RG, Hubbard W, Berdyshev EV, Adamsky S, Feinstein E, Gandjeva A, Tuder RM, Petrache I. RTP801 is required for ceramide-induced cell-specific death in the murine lung. Am J Respir Cell Mol Biol. 2013 Jan; 48(1):87-93. PMID: 23024063.
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    69. Green LA, Petrusca D, Rajashekhar G, Gianaris T, Schweitzer KS, Wang L, Justice MJ, Petrache I, Clauss M. Cigarette smoke-induced CXCR3 receptor up-regulation mediates endothelial apoptosis. Am J Respir Cell Mol Biol. 2012 Dec; 47(6):807-14. PMID: 22936405.
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    70. Tuder RM, Petrache I. Pathogenesis of chronic obstructive pulmonary disease. J Clin Invest. 2012 Aug; 122(8):2749-55. PMID: 22850885.
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    71. Lahm T, Petrache I. LC3 as a potential therapeutic target in hypoxia-induced pulmonary hypertension. Autophagy. 2012 Jul 01; 8(7):1146-7. PMID: 22627195.
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    72. Lockett AD, Van Demark M, Gu Y, Schweitzer KS, Sigua N, Kamocki K, Fijalkowska I, Garrison J, Fisher AJ, Serban K, Wise RA, Flotte TR, Mueller C, Presson RG, Petrache HI, Tuder RM, Petrache I. Effect of cigarette smoke exposure and structural modifications on the a-1 Antitrypsin interaction with caspases. Mol Med. 2012 May 09; 18:445-54. PMID: 22245800.
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    73. Lahm T, Albrecht M, Fisher AJ, Selej M, Patel NG, Brown JA, Justice MJ, Brown MB, Van Demark M, Trulock KM, Dieudonne D, Reddy JG, Presson RG, Petrache I. 17ß-Estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects. Am J Respir Crit Care Med. 2012 May 01; 185(9):965-80. PMID: 22383500.
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    74. Petrache I, Petrusca DN, Bowler RP, Kamocki K. Involvement of ceramide in cell death responses in the pulmonary circulation. Proc Am Thorac Soc. 2011 Nov; 8(6):492-6. PMID: 22052925.
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    75. Devlin CM, Lahm T, Hubbard WC, Van Demark M, Wang KC, Wu X, Bielawska A, Obeid LM, Ivan M, Petrache I. Dihydroceramide-based response to hypoxia. J Biol Chem. 2011 Nov 04; 286(44):38069-78. PMID: 21914808.
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    76. Schweitzer KS, Hatoum H, Brown MB, Gupta M, Justice MJ, Beteck B, Van Demark M, Gu Y, Presson RG, Hubbard WC, Petrache I. Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramides. Am J Physiol Lung Cell Mol Physiol. 2011 Dec; 301(6):L836-46. PMID: 21873444.
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    77. Clauss M, Voswinckel R, Rajashekhar G, Sigua NL, Fehrenbach H, Rush NI, Schweitzer KS, Yildirim AÖ, Kamocki K, Fisher AJ, Gu Y, Safadi B, Nikam S, Hubbard WC, Tuder RM, Twigg HL, Presson RG, Sethi S, Petrache I. Lung endothelial monocyte-activating protein 2 is a mediator of cigarette smoke-induced emphysema in mice. J Clin Invest. 2011 Jun; 121(6):2470-9. PMID: 21576822.
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    78. Presson RG, Brown MB, Fisher AJ, Sandoval RM, Dunn KW, Lorenz KS, Delp EJ, Salama P, Molitoris BA, Petrache I. Two-photon imaging within the murine thorax without respiratory and cardiac motion artifact. Am J Pathol. 2011 Jul; 179(1):75-82. PMID: 21703395.
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    79. Sehra S, Yao W, Nguyen ET, Ahyi AN, Tuana FM, Ahlfeld SK, Snider P, Tepper RS, Petrache I, Conway SJ, Kaplan MH. Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation. J Immunol. 2011 Apr 15; 186(8):4959-66. PMID: 21402898.
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    80. Tuder RM, Janciauskiene SM, Petrache I. Lung disease associated with alpha1-antitrypsin deficiency. Proc Am Thorac Soc. 2010 Nov; 7(6):381-6. PMID: 21030517.
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    81. Petrusca DN, Gu Y, Adamowicz JJ, Rush NI, Hubbard WC, Smith PA, Berdyshev EV, Birukov KG, Lee CH, Tuder RM, Twigg HL, Vandivier RW, Petrache I. Sphingolipid-mediated inhibition of apoptotic cell clearance by alveolar macrophages. J Biol Chem. 2010 Dec 17; 285(51):40322-32. PMID: 20956540.
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    82. Schweitzer KS, Johnstone BH, Garrison J, Rush NI, Cooper S, Traktuev DO, Feng D, Adamowicz JJ, Van Demark M, Fisher AJ, Kamocki K, Brown MB, Presson RG, Broxmeyer HE, March KL, Petrache I. Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smoking. Am J Respir Crit Care Med. 2011 Jan 15; 183(2):215-25. PMID: 20709815.
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    83. Yoshida T, Mett I, Bhunia AK, Bowman J, Perez M, Zhang L, Gandjeva A, Zhen L, Chukwueke U, Mao T, Richter A, Brown E, Ashush H, Notkin N, Gelfand A, Thimmulappa RK, Rangasamy T, Sussan T, Cosgrove G, Mouded M, Shapiro SD, Petrache I, Biswal S, Feinstein E, Tuder RM. Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema. Nat Med. 2010 Jul; 16(7):767-73. PMID: 20473305.
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    84. Diab KJ, Adamowicz JJ, Kamocki K, Rush NI, Garrison J, Gu Y, Schweitzer KS, Skobeleva A, Rajashekhar G, Hubbard WC, Berdyshev EV, Petrache I. Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema. Am J Respir Crit Care Med. 2010 Feb 15; 181(4):344-52. PMID: 19965812.
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    85. Rajashekhar G, Mitnacht-Kraus R, Ispe U, Garrison J, Hou Y, Taylor B, Petrache I, Vestweber D, Clauss M. A monoclonal rat anti-mouse EMAP II antibody that functionally neutralizes pro- and mature-EMAP II in vitro. J Immunol Methods. 2009 Oct 31; 350(1-2):22-8. PMID: 19683532.
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    86. Bryant L, Doyle T, Chen Z, Cuzzocrea S, Masini E, Vinci MC, Esposito E, Mazzon E, Petrusca DN, Petrache I, Salvemini D. Spinal ceramide and neuronal apoptosis in morphine antinociceptive tolerance. Neurosci Lett. 2009 Sep 29; 463(1):49-53. PMID: 19631718.
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    87. Petrache I, Hajjar J, Campos M. Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency. Biologics. 2009; 3:193-204. PMID: 19707408.
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    88. Yamada Y, Sekine Y, Yoshida S, Yasufuku K, Petrache I, Benson HL, Brand DD, Yoshino I, Wilkes DS. Type V collagen-induced oral tolerance plus low-dose cyclosporine prevents rejection of MHC class I and II incompatible lung allografts. J Immunol. 2009 Jul 01; 183(1):237-45. PMID: 19542435.
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    89. Sohrab S, Petrusca DN, Lockett AD, Schweitzer KS, Rush NI, Gu Y, Kamocki K, Garrison J, Petrache I. Mechanism of alpha-1 antitrypsin endocytosis by lung endothelium. FASEB J. 2009 Sep; 23(9):3149-58. PMID: 19423638.
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    90. Noe J, Petrusca D, Rush N, Deng P, VanDemark M, Berdyshev E, Gu Y, Smith P, Schweitzer K, Pilewsky J, Natarajan V, Xu Z, Obukhov AG, Petrache I. CFTR regulation of intracellular pH and ceramides is required for lung endothelial cell apoptosis. Am J Respir Cell Mol Biol. 2009 Sep; 41(3):314-23. PMID: 19168702.
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    91. Ndengele MM, Cuzzocrea S, Masini E, Vinci MC, Esposito E, Muscoli C, Petrusca DN, Mollace V, Mazzon E, Li D, Petrache I, Matuschak GM, Salvemini D. Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation. J Pharmacol Exp Ther. 2009 Apr; 329(1):64-75. PMID: 19033555.
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    92. Iwata T, Philipovskiy A, Fisher AJ, Presson RG, Chiyo M, Lee J, Mickler E, Smith GN, Petrache I, Brand DB, Burlingham WJ, Gopalakrishnan B, Greenspan DS, Christie JD, Wilkes DS. Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction. J Immunol. 2008 Oct 15; 181(8):5738-47. PMID: 18832733.
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    93. Giordano RJ, Lahdenranta J, Zhen L, Chukwueke U, Petrache I, Langley RR, Fidler IJ, Pasqualini R, Tuder RM, Arap W. Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse. J Biol Chem. 2008 Oct 24; 283(43):29447-60. PMID: 18718906.
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    94. Cao L, Petrusca DN, Satpathy M, Nakshatri H, Petrache I, Matei D. Tissue transglutaminase protects epithelial ovarian cancer cells from cisplatin-induced apoptosis by promoting cell survival signaling. Carcinogenesis. 2008 Oct; 29(10):1893-900. PMID: 18667446.
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    95. Petrache I, Diab K, Knox KS, Twigg HL, Stephens RS, Flores S, Tuder RM. HIV associated pulmonary emphysema: a review of the literature and inquiry into its mechanism. Thorax. 2008 May; 63(5):463-9. PMID: 18443163.
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    96. Petrache I, Medler TR, Richter AT, Kamocki K, Chukwueke U, Zhen L, Gu Y, Adamowicz J, Schweitzer KS, Hubbard WC, Berdyshev EV, Lungarella G, Tuder RM. Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide. Am J Physiol Lung Cell Mol Physiol. 2008 Jul; 295(1):L44-53. PMID: 18441093.
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    97. Medler TR, Petrusca DN, Lee PJ, Hubbard WC, Berdyshev EV, Skirball J, Kamocki K, Schuchman E, Tuder RM, Petrache I. Apoptotic sphingolipid signaling by ceramides in lung endothelial cells. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):639-46. PMID: 18192502.
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    98. Tuder RM, Petrache I. Molecular multitasking in the airspace: alpha1-antitrypsin takes on thrombin and plasmin. Am J Respir Cell Mol Biol. 2007 Aug; 37(2):130-4. PMID: 17541009.
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    99. Tuder RM, Yoshida T, Fijalkowka I, Biswal S, Petrache I. Role of lung maintenance program in the heterogeneity of lung destruction in emphysema. Proc Am Thorac Soc. 2006 Nov; 3(8):673-9. PMID: 17065372.
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    100. Petrache I, Fijalkowska I, Medler TR, Skirball J, Cruz P, Zhen L, Petrache HI, Flotte TR, Tuder RM. alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis. Am J Pathol. 2006 Oct; 169(4):1155-66. PMID: 17003475.
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    101. Tuder RM, Yoshida T, Arap W, Pasqualini R, Petrache I. State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: an evolutionary perspective. Proc Am Thorac Soc. 2006 Aug; 3(6):503-10. PMID: 16921129.
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    102. Petrache I, Natarajan V, Zhen L, Medler TR, Richter A, Berdyshev EV, Tuder RM. Ceramide causes pulmonary cell apoptosis and emphysema: a role for sphingolipid homeostasis in the maintenance of alveolar cells. Proc Am Thorac Soc. 2006 Aug; 3(6):510. PMID: 16921130.
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    103. Petrache I, Fijalkowska I, Zhen L, Medler TR, Brown E, Cruz P, Choe KH, Taraseviciene-Stewart L, Scerbavicius R, Shapiro L, Zhang B, Song S, Hicklin D, Voelkel NF, Flotte T, Tuder RM. A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysema. Am J Respir Crit Care Med. 2006 Jun 01; 173(11):1222-8. PMID: 16514110.
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    104. Wagner EM, Petrache I, Schofield B, Mitzner W. Pulmonary ischemia induces lung remodeling and angiogenesis. J Appl Physiol (1985). 2006 Feb; 100(2):587-93. PMID: 16210444.
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    105. Petrache I, Natarajan V, Zhen L, Medler TR, Richter AT, Cho C, Hubbard WC, Berdyshev EV, Tuder RM. Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nat Med. 2005 May; 11(5):491-8. PMID: 15852018.
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    106. Rangasamy T, Cho CY, Thimmulappa RK, Zhen L, Srisuma SS, Kensler TW, Yamamoto M, Petrache I, Tuder RM, Biswal S. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest. 2004 Nov; 114(9):1248-59. PMID: 15520857.
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    107. Petrache I, Crow MT, Neuss M, Garcia JG. Central involvement of Rho family GTPases in TNF-alpha-mediated bovine pulmonary endothelial cell apoptosis. Biochem Biophys Res Commun. 2003 Jun 20; 306(1):244-9. PMID: 12788095.
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    108. Petrache I, Birukova A, Ramirez SI, Garcia JG, Verin AD. The role of the microtubules in tumor necrosis factor-alpha-induced endothelial cell permeability. Am J Respir Cell Mol Biol. 2003 May; 28(5):574-81. PMID: 12707013.
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    109. Tuder RM, Petrache I, Elias JA, Voelkel NF, Henson PM. Apoptosis and emphysema: the missing link. Am J Respir Cell Mol Biol. 2003 May; 28(5):551-4. PMID: 12707010.
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    110. Petrache I, Birukov K, Zaiman AL, Crow MT, Deng H, Wadgaonkar R, Romer LH, Garcia JG. Caspase-dependent cleavage of myosin light chain kinase (MLCK) is involved in TNF-alpha-mediated bovine pulmonary endothelial cell apoptosis. FASEB J. 2003 Mar; 17(3):407-16. PMID: 12631580.
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    111. Petrache I, Verin AD, Crow MT, Birukova A, Liu F, Garcia JG. Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction. Am J Physiol Lung Cell Mol Physiol. 2001 Jun; 280(6):L1168-78. PMID: 11350795.
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    112. Petrache I, Otterbein LE, Alam J, Wiegand GW, Choi AM. Heme oxygenase-1 inhibits TNF-alpha-induced apoptosis in cultured fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2000 Feb; 278(2):L312-9. PMID: 10666115.
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    113. Petrache I, Choi ME, Otterbein LE, Chin BY, Mantell LL, Horowitz S, Choi AM. Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells. Am J Physiol. 1999 09; 277(3):L589-95. PMID: 10484467.
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    114. Otterbein LE, Lee PJ, Chin BY, Petrache I, Camhi SL, Alam J, Choi AM. Protective effects of heme oxygenase-1 in acute lung injury. Chest. 1999 Jul; 116(1 Suppl):61S-63S. PMID: 10424595.
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    115. Chin BY, Petrache I, Choi AM, Choi ME. Transforming growth factor beta1 rescues serum deprivation-induced apoptosis via the mitogen-activated protein kinase (MAPK) pathway in macrophages. J Biol Chem. 1999 Apr 16; 274(16):11362-8. PMID: 10196228.
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