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Anastacia Marie Garcia

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Research 
    Collapse research activities and funding
    KL2-TR002534     (Anastacia Garcia)Dec 1, 2019 - Nov 30, 2021
    NIH/NCATS Colorado CTSI
    Metabolic Remodeling in the Failing Pediatric Right Ventricle
    Role Description: The purpose of this project is to determine changes in mitochondrial bioenergetics in explanted pediatric heart tissue and assess the impact of PDE5 inhibition in human SV myocardium and in primary cardiomyocytes treated with SV patient serum. The PDE5-mediated metabolic consequences of sphingolipid remodeling in vitro and in vivo will also be assessed.
    Role: PI

    UL1TR002535 CMH-Pilot     (Anastacia Garcia)May 1, 2020 - Apr 30, 2021
    NIH/NCATS Colorado CTSI
    Peripheral Mononuclear Cells as Biomarkers for Myocardial Mitochondrial Function in Single Ventricle Congenital Heart Disease Patients
    Role Description: The purpose of this pilot project is to evaluate mitochondrial bioenergetics and reactive oxygen species, and the metabolic signature in circulating PBMCs from pediatric SV patients compared to normal non-failing controls. These data will provide new insights into SV heart failure and has the potential to identify novel biomarkers of disease progression in this population.
    Role: PI

    25M9264 NORC Pilot     (Anastacia Garcia)Aug 1, 2020 - Jul 30, 2022
    NIH/NIDDK
    Mechanistic Investigations of PDE5-Inhibitor Improved Myocardial Energetics in Congenital Heart Disease
    Role Description: The purpose of this pilot project is to (1) determine the PDE5-mediated changes in carnitine palmitoyltransferase activity and the metabolic lipid profile in the SV failing heart, and (2) to investigate the PDE5-medated changes in mitochondrial lipid oxidation in the SV failing heart.

    SRP Award     (Anastacia Garcia)Nov 1, 2020 - Dec 31, 2021
    NIH/NHLBI PRIDE CVD-CGE
    Defining the Transcriptional Landscape in the Systemic Right Ventricle
    Role Description: The purpose of this small research project is to evaluate mRNA and lncRNA expression in human cardiac tissue, and to identify mRNA-lncRNA regulatory networks with potential roles in the progression to heart failure in the pediatric single ventricle congenital heart disease population relative to healthy age-matched non-failing controls.
    Role: PI

    Single Ventricle Research Fund Award     (Anastacia Garcia)Jan 1, 2021 - Dec 31, 2023
    Additional Ventures Foundation
    Peripheral Mononuclear Cells as Biomarkers for Myocardial Mitochondrial Function in Single Ventricle Congenital Heart Disease Patients
    Role Description: The goal of the award is to evaluate mitochondrial function, transcriptomic, metabolomic, and lipidomic alterations, and reactive oxygen species in circulating peripheral blood mononuclear cells in pediatric single ventricle heart disease patients. Completion of her proposal will provide new insights into metabolic remodeling in the single ventricle population and has the potential to identify a novel non-invasive molecular biomarker of myocardial metabolic function and progression to heart failure in this vulnerable group.
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wall JB, Garcia AM, Jacobsen RM, Miyamoto SD. Important Considerations in Pediatric Heart Failure. Curr Cardiol Rep. 2020 Sep 10; 22(11):141. PMID: 32910348.
      View in: PubMed
    2. Rubinstein J, Woo JG, Garcia AM, Alsaied T, Li J, Lunde PK, Moore RA, Laasmaa M, Sammons A, Mays WA, Miyamoto SD, Louch WE, Veldtman GR. Probenecid Improves Cardiac Function in Subjects with a Fontan Circulation and Augments Cardiomyocyte Calcium Homeostasis. Pediatr Cardiol. 2020 Dec; 41(8):1675-1688. PMID: 32770262.
      View in: PubMed
    3. Ohlstrom D, Hernandez-Lagunas L, Garcia AM, Allawzi A, Karimpour-Fard A, Sucharov CC, Nozik-Grayck E. MicroRNA regulation postbleomycin due to the R213G extracellular superoxide dismutase variant is predicted to suppress inflammatory and immune pathways. Physiol Genomics. 2020 06 01; 52(6):245-254. PMID: 32421439.
      View in: PubMed
    4. Garcia AM, Beatty JT, Nakano SJ. Heart failure in single right ventricle congenital heart disease: physiological and molecular considerations. Am J Physiol Heart Circ Physiol. 2020 04 01; 318(4):H947-H965. PMID: 32108525.
      View in: PubMed
    5. Garcia AM, McPhaul JC, Sparagna GC, Jeffrey DA, Jonscher R, Patel SS, Sucharov CC, Stauffer BL, Miyamoto SD, Chatfield KC. Alteration of cardiolipin biosynthesis and remodeling in single right ventricle congenital heart disease. Am J Physiol Heart Circ Physiol. 2020 04 01; 318(4):H787-H800. PMID: 32056460.
      View in: PubMed
    6. Nakano SJ, Walker JS, Walker LA, Li X, Du Y, Miyamoto SD, Sucharov CC, Garcia AM, Mitchell MB, Ambardekar AV, Stauffer BL. Increased myocyte calcium sensitivity in end-stage pediatric dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2019 12 01; 317(6):H1221-H1230. PMID: 31625780.
      View in: PubMed
    7. Garcia AM, Nakano SJ, Karimpour-Fard A, Nunley K, Blain-Nelson P, Stafford NM, Stauffer BL, Sucharov CC, Miyamoto SD. Phosphodiesterase-5 Is Elevated in Failing Single Ventricle Myocardium and Affects Cardiomyocyte Remodeling In Vitro. Circ Heart Fail. 2018 09; 11(9):e004571. PMID: 30354365.
      View in: PubMed
    8. Garcia AM, Allawzi A, Tatman P, Hernandez-Lagunas L, Swain K, Mouradian G, Bowler R, Karimpour-Fard A, Sucharov CC, Nozik-Grayck E. R213G polymorphism in SOD3 protects against bleomycin-induced inflammation and attenuates induction of proinflammatory pathways. Physiol Genomics. 2018 09 01; 50(9):807-816. PMID: 30004839.
      View in: PubMed
    9. Toni LS, Garcia AM, Jeffrey DA, Jiang X, Stauffer BL, Miyamoto SD, Sucharov CC. Optimization of phenol-chloroform RNA extraction. MethodsX. 2018; 5:599-608. PMID: 29984193.
      View in: PubMed
    10. Nakano SJ, Siomos AK, Garcia AM, Nguyen H, SooHoo M, Galambos C, Nunley K, Stauffer BL, Sucharov CC, Miyamoto SD. Fibrosis-Related Gene Expression in Single Ventricle Heart Disease. J Pediatr. 2017 12; 191:82-90.e2. PMID: 29050751.
      View in: PubMed
    11. Ladage ML, King SD, Burks DJ, Quan DL, Garcia AM, Azad RK, Padilla PA. Glucose or Altered Ceramide Biosynthesis Mediate Oxygen Deprivation Sensitivity Through Novel Pathways Revealed by Transcriptome Analysis in Caenorhabditis elegans. G3 (Bethesda). 2016 10 13; 6(10):3149-3160. PMID: 27507791.
      View in: PubMed
    12. Garcia AM, Ladage ML, Dumesnil DR, Zaman K, Shulaev V, Azad RK, Padilla PA. Glucose induces sensitivity to oxygen deprivation and modulates insulin/IGF-1 signaling and lipid biosynthesis in Caenorhabditis elegans. Genetics. 2015 May; 200(1):167-84. PMID: 25762526.
      View in: PubMed
    13. Padilla PA, Garcia AM, Ladage ML, Toni LS. Caenorhabditis elegans: an old genetic model can learn new epigenetic tricks. . 2014 Jul; 54(1):52-60. PMID: 24861810.
      View in: PubMed
    14. Garcia AM, Ladage ML, Padilla PA. Use of time lapse microscopy to visualize anoxia-induced suspended animation in C. elegans embryos. J Vis Exp. 2012 Dec 03; (70):e4319. PMID: 23242305.
      View in: PubMed
    15. Shi L, Ermis R, Garcia A, Telgenhoff D, Aust D. Degradation of human collagen isoforms by Clostridium collagenase and the effects of degradation products on cell migration. Int Wound J. 2010 Apr; 7(2):87-95. PMID: 20529148.
      View in: PubMed
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