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Search Results to Melanie G. Cree

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Cree, Melanie

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I am interested in how insulin resistance affects the reproductive axis, risk for diabetes and liver health. As an MD, PhD with clinical training in pediatric endocrinology and research training in human physiology, I perform translational work in youth with endocrine disorders using stable isotope tracers, magnetic resonance spectroscopy and mathematical modeling. In particular, I am challenged by the extent of insulin resistance-related co-morbidities in girls with polycystic ovary syndrome, including a 21 fold increased risk of type 2 diabetes, common pre-diabetes and >50% with elevated liver fat. My overall goal is to improve the long term health for adolescents with polycystic ovary syndrome or type 2 diabetes and to perform work to inform clinical trials for new therapeutic strategies.

One or more keywords matched the following items that are connected to Cree, Melanie

Item Type	Name
Academic Article	Intrahepatic fat is increased in the neonatal offspring of obese women with gestational diabetes.
Concept	Physicians, Women
Academic Article	Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids.
Grant	Skeletal muscle diacylglycerol and sphingolipids: Impact of localization and species on insulin resistance in humans
Academic Article	Insulin Resistance, Hyperinsulinemia, and Mitochondria Dysfunction in Nonobese Girls With Polycystic Ovarian Syndrome.
Academic Article	Oral Glucose Tolerance Test Glucose Peak Time Is Most Predictive of Prediabetes and Hepatic Steatosis in Obese Girls.
Academic Article	Using simple clinical measures to predict insulin resistance or hyperglycemia in girls with polycystic ovarian syndrome.
Academic Article	Postglucose Hyperinsulinemia in Black Women Is Not What We Thought.
Grant	Influence of peripheral insulin resistance and hepatic lipogenesis on liver fat in obese PCOS girls
Academic Article	Increased urinary excretion of 2-hydroxyestrone but not 16alpha-hydroxyestrone in premenopausal women during a soya diet containing isoflavones.
Academic Article	Amino acid and fatty acid metabolomic profile during fasting and hyperinsulinemia in girls with polycystic ovarian syndrome.
Academic Article	Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome.
Grant	Mechanism of insulin resistance in girls with polycystic ovary disease
Grant	Building Interdisciplinary Careers in Women's Health
Grant	Non-invasive assessment of liver glucose metabolism in obese girls
Grant	Impact of obesity and androgens on serum lipoproteins in youth with PCOS
Grant	Use of essential amino acid supplementation to decrease metabolic disease in high risk obese girls with PCOS
Grant	Role of hepatic de novo lipogenesis in development of hepatic steatosis in obese girls with PCOS
Academic Article	Clinical prediction score of nonalcoholic fatty liver disease in adolescent girls with polycystic ovary syndrome (PCOS-HS index).
Academic Article	Editoral commentary: Understanding cardiovascular disease risk in women with polycystic ovary syndrome.
Academic Article	Obesity and Insulin Resistance, Not Polycystic Ovary Syndrome, Are Independent Predictors of Bone Mineral Density in Adolescents and Young Women.
Academic Article	Diminished Ovarian Reserve in Girls and Adolescents with Trisomy X Syndrome.
Academic Article	Peer mentoring for professional and personal growth in academic medicine.
Academic Article	Depression in Girls With Obesity and Polycystic Ovary Syndrome and/or Type 2 Diabetes.
Grant	Impact of GLP-1 on Hepatic Fat and Energy Utilization in Obese Girls with Polycystic Ovarian Syndrome
Academic Article	Hepatic steatosis relates to gastrointestinal microbiota changes in obese girls with polycystic ovary syndrome.
Academic Article	Development of type 2 diabetes in adolescent girls with polycystic ovary syndrome and obesity.
Academic Article	Combined Oral Contraceptive Treatment Does Not Alter the Gut Microbiome but Affects Amino Acid Metabolism in Sera of Obese Girls With Polycystic Ovary Syndrome.
Academic Article	Mathematical modeling reveals differential dynamics of insulin action models on glycerol and glucose in adolescent girls with obesity.

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