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Search Results to Leslie Anne Leinwand

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Leinwand, Leslie

One or more keywords matched the following items that are connected to Leinwand, Leslie

Item Type	Name
Academic Article	Contractile protein mutations and heart disease.
Academic Article	Mice expressing mutant myosin heavy chains are a model for familial hypertrophic cardiomyopathy.
Academic Article	The mammalian myosin heavy chain gene family.
Academic Article	Functional analysis of a cardiac myosin rod in Dictyostelium discoideum.
Academic Article	Cardiac myosin heavy chains lacking the light chain binding domain cause hypertrophic cardiomyopathy in mice.
Academic Article	Functional analysis of myosin missense mutations in familial hypertrophic cardiomyopathy.
Academic Article	Mutation of the IIB myosin heavy chain gene results in muscle fiber loss and compensatory hypertrophy.
Academic Article	Animal models of hypertrophic cardiomyopathy.
Academic Article	Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene.
Academic Article	A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy.
Academic Article	Functional analysis of myosin mutations that cause familial hypertrophic cardiomyopathy.
Academic Article	Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo.
Academic Article	Hypertrophy, fibrosis, and sudden cardiac death in response to pathological stimuli in mice with mutations in cardiac troponin T.
Academic Article	Soy diet worsens heart disease in mice.
Academic Article	Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers.
Academic Article	Estimate of the abundance of cardiomyopathic mutations in the ?-myosin gene.
Academic Article	Mutations in the beta-myosin rod cause myosin storage myopathy via multiple mechanisms.
Academic Article	Mutations at the same amino acid in myosin that cause either skeletal or cardiac myopathy have distinct molecular phenotypes.
Academic Article	A mutation in the beta-myosin rod associated with hypertrophic cardiomyopathy has an unexpected molecular phenotype.
Academic Article	Insights into human beta-cardiac myosin function from single molecule and single cell studies.
Academic Article	A genetic screen identifies novel non-compatible loxP sites.
Academic Article	Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor.
Academic Article	Mutations in the sensitive giant titin result in a broken heart.
Academic Article	The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
Academic Article	Acute effects of desmin mutations on cytoskeletal and cellular integrity in cardiac myocytes.
Academic Article	Mechanisms of the pathogenesis of troponin T-based familial hypertrophic cardiomyopathy.
Academic Article	Heterologous expression of a cardiomyopathic myosin that is defective in its actin interaction.
Academic Article	Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy.
Academic Article	Suppression of nonsense mutations in cell culture and mice by multimerized suppressor tRNA genes.
Academic Article	Ca(2+) activation of myofilaments from transgenic mouse hearts expressing R92Q mutant cardiac troponin T.
Academic Article	Blocking cardiac growth in hypertrophic cardiomyopathy induces cardiac dysfunction and decreased survival only in males.
Academic Article	From sarcomeric mutations to heart disease: understanding familial hypertrophic cardiomyopathy.
Academic Article	Morphological and functional alterations in ventricular myocytes from male transgenic mice with hypertrophic cardiomyopathy.
Academic Article	Bioinformatics assessment of beta-myosin mutations reveals myosin's high sensitivity to mutations.
Academic Article	The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy.
Academic Article	Effects of pathogenic proline mutations on myosin assembly.
Concept	Mutation
Concept	Point Mutation
Concept	Mutation, Missense
Concept	Frameshift Mutation
Academic Article	Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human ?-cardiac myosin motor function.
Academic Article	The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac ?-myosin.
Academic Article	Contractility parameters of human ?-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function.
Academic Article	A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice.
Academic Article	The Most Prevalent Freeman-Sheldon Syndrome Mutations in the Embryonic Myosin Motor Share Functional Defects.
Grant	Molecular characterization of cardiomyopathy mutations in human cardiac myosin
Grant	Myosin Gene Diversity and Function
Grant	Developmental Myosin Heavy Chain Regulation and Function
Grant	Mechanisms of myopathy caused by mutations in the myosin rod
Academic Article	Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models.
Academic Article	Dilated cardiomyopathy myosin mutants have reduced force-generating capacity.
Academic Article	Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties.
Academic Article	Targeting the sarcomere in inherited cardiomyopathies.
Academic Article	Distinct effects of two hearing loss-associated mutations in?the sarcomeric myosin MYH7b.
Academic Article	Homologous mutations in ?, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation.
Academic Article	Divergent Molecular Phenotypes in Point Mutations at the Same Residue in Beta-Myosin Heavy Chain Lead to Distinct Cardiomyopathies.

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