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Search Results to David J Orlicky

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Orlicky, David

One or more keywords matched the following items that are connected to Orlicky, David

Item Type	Name
Academic Article	Chronic ethanol consumption in mice alters hepatocyte lipid droplet properties.
Academic Article	Susceptibility of L-FABP-/- mice to oxidative stress in early-stage alcoholic liver.
Academic Article	Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease.
Academic Article	CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice.
Academic Article	Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress.
Academic Article	Overexpression of peroxiredoxin 6 does not prevent ethanol-mediated oxidative stress and may play a role in hepatic lipid accumulation.
Academic Article	Oral N-acetylcysteine rescues lethality of hepatocyte-specific Gclc-knockout mice, providing a model for hepatic cirrhosis.
Academic Article	Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease.
Academic Article	Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury.
Academic Article	Experimental evidence for therapeutic potential of taurine in the treatment of nonalcoholic fatty liver disease.
Concept	Liver Diseases
Concept	Liver Cirrhosis
Concept	Liver
Concept	Chemical and Drug Induced Liver Injury, Chronic
Concept	Liver Cirrhosis, Alcoholic
Concept	Chemical and Drug Induced Liver Injury
Concept	Fatty Liver
Concept	Liver Cirrhosis, Experimental
Concept	Liver Diseases, Alcoholic
Concept	Fatty Liver, Alcoholic
Concept	Mitochondria, Liver
Concept	Liver Neoplasms
Academic Article	Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis.
Academic Article	Dynamic regulation of hepatic lipid droplet properties by diet.
Academic Article	Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome.
Academic Article	Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis.
Academic Article	High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase.
Academic Article	Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice.
Academic Article	Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol.
Academic Article	Increased methylation demand exacerbates ethanol-induced liver injury.
Academic Article	Increased 4-hydroxynonenal protein adducts in male GSTA4-4/PPAR-a double knockout mice enhance injury during early stages of alcoholic liver disease.
Academic Article	Perilipin-2 Modulates Lipid Absorption and Microbiome Responses in the Mouse Intestine.
Academic Article	Increased hepatocellular protein carbonylation in human end-stage alcoholic cirrhosis.
Academic Article	Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice.
Academic Article	Spaceflight Activates Lipotoxic Pathways in Mouse Liver.
Academic Article	Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage.
Academic Article	Sevelamer Improves Steatohepatitis, Inhibits Liver and Intestinal Farnesoid X Receptor (FXR), and Reverses Innate Immune Dysregulation in a Mouse Model of Non-alcoholic Fatty Liver Disease.
Academic Article	Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury.
Academic Article	Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome.
Academic Article	Catalase deletion promotes prediabetic phenotype in mice.
Academic Article	Correction: Spaceflight Activates Lipotoxic Pathways in Mouse Liver.
Academic Article	Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism: Post-translational repression of phosphatidylethanolamine N-methyltransferase is a consequence rather than a cause of liver injury in homocystinuria.
Academic Article	Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase.
Academic Article	Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation.
Academic Article	Differential carbonylation of proteins in end-stage human fatty and nonfatty NASH.
Academic Article	The Sodium-Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Renal and Liver Disease in Western Diet Induced Obesity Mice.
Academic Article	Dysregulation of antioxidant responses in patients diagnosed with concomitant Primary Sclerosing Cholangitis/Inflammatory Bowel Disease.
Academic Article	Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice.
Academic Article	High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism.
Academic Article	Cytokine-Producing B Cells Promote Immune-Mediated Bile Duct Injury in Murine Biliary Atresia.
Academic Article	Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction.
Academic Article	Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet.
Academic Article	Aberrant expression of redox regulatory proteins in patients with concomitant primary Sclerosing cholangitis/inflammatory bowel disease.
Academic Article	Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice.
Academic Article	Dietary Lipids Differentially Shape Nonalcoholic Steatohepatitis Progression and the Transcriptome of Kupffer Cells and Infiltrating Macrophages.
Academic Article	Perilipin-2 promotes obesity and progressive fatty liver disease in mice through mechanistically distinct hepatocyte and extra-hepatocyte actions.
Academic Article	Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism.
Concept	End Stage Liver Disease
Concept	Non-alcoholic Fatty Liver Disease
Academic Article	TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy.
Academic Article	Cholestatic liver disease results increased production of reactive aldehydes and an atypical periportal hepatic antioxidant response.
Academic Article	Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet-fed mice.
Academic Article	Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction.
Academic Article	Oxidized Low-Density Lipoprotein Drives Dysfunction of the Liver Lymphatic System.
Academic Article	JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome.
Academic Article	Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor.
Academic Article	Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption.
Academic Article	Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach.
Academic Article	Pulmonary implications of acetaminophen exposures independent of hepatic toxicity.
Academic Article	A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age.
Academic Article	Correction to: A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age.
Academic Article	Pharmacologic activation of hepatic farnesoid X receptor prevents parenteral nutrition-associated cholestasis in mice.
Academic Article	Oxidative stress and genotoxicity in 1,4-dioxane liver toxicity as evidenced in a mouse model of glutathione deficiency.
Academic Article	APAP-Induced I?B?/NF?B Signaling Drives Hepatic Il6 Expression and Associated Sinusoidal Dilation.
Academic Article	Lipidomics and Redox Lipidomics Indicate Early Stage Alcohol-Induced Liver Damage.
Academic Article	Proteomic analysis of alcohol-associated hepatitis reveals glycoprotein NMB (GPNMB) as a novel hepatic and serum biomarker.
Academic Article	Liver metabolomics identifies bile acid profile changes at early stages of alcoholic liver disease in mice.
Academic Article	Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury.
Academic Article	The autophagic protein p62 is a target of reactive aldehydes in human and murine cholestatic liver disease.
Academic Article	Oxidized low density lipoprotein in the liver causes decreased permeability of liver lymphatic- but not liver sinusoidal-endothelial cells via VEGFR-3 regulation of VE-Cadherin.
Academic Article	The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice.
Academic Article	Profiling the oxylipidome in aged mice after chronic ethanol feeding: Identifying lipid metabolites as drivers of hepatocyte stress.
Academic Article	Innate Immune Zonation in the Liver: NF-?B (p50) Activation and C-Reactive Protein Expression in Response to Endotoxemia Are Zone Specific.
Academic Article	Pharmacologic inhibition of HNF4a prevents parenteral nutrition associated cholestasis in mice.
Academic Article	IL-6 mediates the hepatic acute phase response after prerenal azotemia in a clinically defined murine model.
Academic Article	Oxidative stress, glutathione, and CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models.
Academic Article	Endogenous Fructose Production and Metabolism Drive Metabolic Dysregulation and Liver Disease in Mice with Hereditary Fructose Intolerance.
Academic Article	Disrupting Poly(ADP-ribosyl)ating Pathway Creates Premalignant Conditions in Mammalian Liver.

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