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Search Results to Christopher Silliman

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Silliman, Christopher

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Item Type	Name
Academic Article	Sequential systemic platelet-activating factor and interleukin 8 primes neutrophils in patients with trauma at risk of multiple organ failure.
Academic Article	Hypertonic saline activates lipid-primed human neutrophils for enhanced elastase release.
Academic Article	Lipid mediators up-regulate CD11b and prime for concordant superoxide and elastase release in human neutrophils.
Academic Article	Clinically relevant concentrations of ethanol attenuate primed neutrophil bactericidal activity.
Academic Article	Circulating postinjury neutrophils are primed for the release of proinflammatory cytokines.
Academic Article	Hypertonic saline resuscitation abrogates neutrophil priming by mesenteric lymph.
Academic Article	Age of transfused blood is an independent risk factor for postinjury multiple organ failure.
Academic Article	Mesenteric lymph is responsible for post-hemorrhagic shock systemic neutrophil priming.
Academic Article	Post-hemorrhagic shock mesenteric lymph activates human pulmonary microvascular endothelium for in vitro neutrophil-mediated injury: the role of intercellular adhesion molecule-1.
Academic Article	Transfusion of the injured patient: proceed with caution.
Academic Article	The transfusion of pre storage leukoreduced packed red blood cells to injured patients.
Academic Article	Red blood cell supernatant potentiates LPS-induced proinflammatory cytokine response from peripheral blood mononuclear cells.
Academic Article	HMGB1 is markedly elevated within 6 hours of mechanical trauma in humans.
Academic Article	Hemodilution is not critical in the pathogenesis of the acute coagulopathy of trauma.
Academic Article	Viscoelastic clot strength predicts coagulation-related mortality within 15 minutes.
Academic Article	Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma.
Academic Article	Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13.
Academic Article	It's not your grandfather's field plasma.
Academic Article	Antiplatelet therapy is associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients.
Academic Article	The injured child is resistant to multiple organ failure: a different inflammatory response?
Academic Article	Alteration of the postinjury hyperinflammatory response by means of resuscitation with a red cell substitute.
Academic Article	Systemic neutrophil priming by lipid mediators in post-shock mesenteric lymph exists across species.
Academic Article	Clinically relevant osmolar stress inhibits priming-induced PMN NADPH oxidase subunit translocation.
Academic Article	Secretory phospholipase A2 cleavage of intravasated bone marrow primes human neutrophils.
Academic Article	Neutrophils are primed for cytotoxicity and resist apoptosis in injured patients at risk for multiple organ failure.
Academic Article	Hypertonic saline attenuation of polymorphonuclear neutrophil cytotoxicity: timing is everything.
Academic Article	Plasma from aged stored red blood cells delays neutrophil apoptosis and primes for cytotoxicity: abrogation by poststorage washing but not prestorage leukoreduction.
Academic Article	Resuscitation with a blood substitute abrogates pathologic postinjury neutrophil cytotoxic function.
Academic Article	Neutrophil apoptosis is delayed by trauma patients' plasma via a mechanism involving proinflammatory phospholipids and protein kinase C.
Academic Article	Transfusion-induced leukocyte IL-8 gene expression is avoided by the use of human polymerized hemoglobin.
Academic Article	The acute coagulopathy of trauma is due to impaired initial thrombin generation but not clot formation or clot strength.
Academic Article	Activated platelets in heparinized shed blood: the "second hit" of acute lung injury in trauma/hemorrhagic shock models.
Academic Article	Revisiting early postinjury mortality: are they bleeding because they are dying or dying because they are bleeding?
Academic Article	Functional fibrinogen assay indicates that fibrinogen is critical in correcting abnormal clot strength following trauma.
Academic Article	Platelets are dominant contributors to hypercoagulability after injury.
Concept	Trauma Centers
Concept	Trauma Severity Indices
Concept	Multiple Trauma
Concept	Wounds and Injuries
Academic Article	The incidence and magnitude of fibrinolytic activation in trauma patients: a rebuttal.
Academic Article	The authors reply.
Academic Article	Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy.
Academic Article	Platelet: RBC ratios: randomized controlled trials are needed for optimal resuscitation of injured patients.
Academic Article	Postinjury hyperfibrinogenemia compromises efficacy of heparin-based venous thromboembolism prophylaxis.
Academic Article	Plasma first in the field for postinjury hemorrhagic shock.
Academic Article	Mesenteric lymph diversion abrogates 5-lipoxygenase activation in the kidney following trauma and hemorrhagic shock.
Academic Article	Dynamic changes in rat mesenteric lymph proteins following trauma using label-free mass spectrometry.
Academic Article	Lymph is not a plasma ultrafiltrate: a proteomic analysis of injured patients.
Academic Article	Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy.
Academic Article	Hemolysis exacerbates hyperfibrinolysis, whereas platelolysis shuts down fibrinolysis: evolving concepts of the spectrum of fibrinolysis in response to severe injury.
Academic Article	Pathologic metabolism: an exploratory study of the plasma metabolome of critical injury.
Academic Article	Postinjury fibrinolysis shutdown: Rationale for selective tranexamic acid.
Academic Article	Viscoelastic hemostatic fibrinogen assays detect fibrinolysis early.
Academic Article	Combat: Initial Experience with a Randomized Clinical Trial of Plasma-Based Resuscitation in the Field for Traumatic Hemorrhagic Shock.
Academic Article	Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary (13)C-glucose labeling metabolomics.
Academic Article	Viscoelastic measurements of platelet function, not fibrinogen function, predicts sensitivity to tissue-type plasminogen activator in trauma patients.
Academic Article	Shock-induced systemic hyperfibrinolysis is attenuated by plasma-first resuscitation.
Academic Article	The "Death Diamond": Rapid thrombelastography identifies lethal hyperfibrinolysis.
Academic Article	Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients.
Academic Article	Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient.
Academic Article	Goal-directed Hemostatic Resuscitation of Trauma-induced Coagulopathy: A Pragmatic Randomized Clinical Trial Comparing a Viscoelastic Assay to Conventional Coagulation Assays.
Academic Article	Metabolomics of trauma-associated death: shared and fluid-specific features of human plasma vs lymph.
Academic Article	Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock.
Academic Article	Trauma-Induced Coagulopathy: An Institution's 35 Year Perspective on Practice and Research.
Academic Article	Rapid thrombelastography thresholds for goal-directed resuscitation of patients at risk for massive transfusion.
Academic Article	Viscoelastic Tissue Plasminogen Activator Challenge Predicts Massive Transfusion in 15 Minutes.
Academic Article	Thrombelastography indicates limitations of animal models of trauma-induced coagulopathy.
Academic Article	Plasma succinate is a predictor of mortality in critically injured patients.
Academic Article	Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin.
Academic Article	Hemorrhagic shock and tissue injury drive distinct plasma metabolome derangements in swine.
Academic Article	Platelet adenosine diphosphate receptor inhibition provides no advantage in predicting need for platelet transfusion or massive transfusion.
Academic Article	Tranexamic acid is associated with increased mortality in patients with physiological fibrinolysis.
Academic Article	14-Day thawed plasma retains clot enhancing properties and inhibits tPA-induced fibrinolysis.
Academic Article	All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhagic shock-A comparison in rodents, swine, nonhuman primates, and injured patients.
Academic Article	Fibrinolysis shutdown is associated with a fivefold increase in mortality in trauma patients lacking hypersensitivity to tissue plasminogen activator.
Academic Article	Systemic hyperfibrinolysis after trauma: a pilot study of targeted proteomic analysis of superposed mechanisms in patient plasma.
Academic Article	Thrombin stimulates increased plasminogen activator inhibitor-1 release from liver compared to lung endothelium.
Academic Article	Empiric transfusion strategies during life-threatening hemorrhage.
Academic Article	Rotational thromboelastometry thresholds for patients at risk for massive transfusion.
Academic Article	Rapid TEG efficiently guides hemostatic resuscitation in trauma patients.
Academic Article	Trauma and hemorrhagic shock activate molecular association of 5-lipoxygenase and 5-lipoxygenase-Activating protein in lung tissue.
Academic Article	Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial.
Academic Article	Citrated kaolin thrombelastography (TEG) thresholds for goal-directed therapy in injured patients receiving massive transfusion.
Academic Article	Redefining postinjury fibrinolysis phenotypes using two viscoelastic assays.
Academic Article	Severe traumatic brain injury is associated with a unique coagulopathy phenotype.
Academic Article	Trauma Resuscitation Consideration: Sex Matters.
Academic Article	Discrepancies between conventional and viscoelastic assays in identifying trauma-induced coagulopathy.
Academic Article	Variability in international normalized ratio and activated partial thromboplastin time after injury are not explained by coagulation factor deficits.
Academic Article	Female platelets have distinct functional activity compared with male platelets: Implications in transfusion practice and treatment of trauma-induced coagulopathy.
Academic Article	Obesity is associated with postinjury hypercoagulability.
Academic Article	Whole blood thrombin generation is distinct from plasma thrombin generation in healthy volunteers and after severe injury.
Academic Article	Cardiac and Skeletal Muscle Myosin Exert Procoagulant Effects.
Academic Article	Untangling Sex Dimorphisms in Coagulation: Initial Steps Toward Precision Medicine for Trauma Resuscitation.
Academic Article	Do not drink and lyse: alcohol intoxication increases fibrinolysis shutdown in injured patients.
Academic Article	Effects of Blood Components and Whole Blood in a Model of Severe Trauma-Induced Coagulopathy.
Academic Article	Whole Blood Thrombin Generation in Severely Injured Patients Requiring Massive Transfusion.
Academic Article	The a-globin chain of hemoglobin potentiates tissue plasminogen activator induced hyperfibrinolysis in vitro.
Academic Article	A combat casualty relevant dismounted complex blast injury model in swine.
Academic Article	Postinjury complement C4 activation is associated with adverse outcomes and is potentially influenced by plasma resuscitation.
Academic Article	Apolipoprotein A-I, elevated in trauma patients, inhibits platelet activation and decreases clot strength.
Academic Article	SHOCK INDUCES ENDOTHELIAL PERMEABILITY AFTER TRAUMA THROUGH INCREASED ACTIVATION OF RHOA GTPASE.
Academic Article	Hemorrhagic shock and tissue injury provoke distinct components of trauma-induced coagulopathy in a swine model.
Academic Article	TRAUMA INDUCES INTRAVASCULAR HEMOLYSIS, EXACERBATED BY RED BLOOD CELL TRANSFUSION AND ASSOCIATED WITH DISRUPTED ARGININE-NITRIC OXIDE METABOLISM.
Academic Article	A proteomic analysis of NETosis in trauma: Emergence of serpinB1 as a key player.
Academic Article	Platelet and cryoprecipitate transfusions from female donors improve coagulopathy in vitro.
Academic Article	Estradiol provokes hypercoagulability and affects fibrin biology: A mechanistic exploration of sex dimorphisms in coagulation.
Academic Article	Omics Markers of Red Blood Cell Transfusion in Trauma.
Academic Article	BLOOD TYPE O IS A RISK FACTOR FOR HYPERFIBRINOLYSIS AND MASSIVE TRANSFUSION AFTER SEVERE INJURY.
Academic Article	REBOA for the Treatment of Blast Polytrauma: Zone 3 Provides Cerebral Perfusion, Attenuates Organ Dysfunction and Reperfusion Coagulopathy Compared to Zone 1 in a Swine Model.
Academic Article	Elucidating the molecular mechanisms of fibrinolytic shutdown after severe injury: The role of thrombin-activatable fibrinolysis inhibitor.
Academic Article	A proposed clinical coagulation score for research in trauma-induced coagulopathy.
Academic Article	Bradykinin release following trauma and hemorrhagic shock causes pulmonary alveolar leak in a rodent model.
Academic Article	A metabolomic and proteomic analysis of pathologic hypercoagulability in traumatic brain injury patients after dura violation.
Academic Article	Omics markers of platelet transfusion in trauma patients.
Academic Article	The proteomic and metabolomic signatures of isolated and polytrauma traumatic brain injury.
Academic Article	METABOLOMIC AND PROTEOMIC CHANGES IN TRAUMA-INDUCED HYPOCALCEMIA.
Academic Article	Trans-Omics analysis of post injury thrombo-inflammation identifies endotypes and trajectories in trauma patients.
Academic Article	Mitigation of trauma-induced endotheliopathy by activated protein C: A potential therapeutic for postinjury thromboinflammation.
Academic Article	Losing the forest for the trees: The complexities of fibrinolysis will never be explained with one variable alone.
Academic Article	Endothelial Cell Calcium Influx Mediates Trauma-induced Endothelial Permeability.

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