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Christopher Silliman

TitleWorking ORP Retiree - Faculty
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Research 
    Collapse research activities and funding
    RM1GM131968     (SILLIMAN, CHRISTOPHER C.)May 20, 2019 - Apr 30, 2025
    NIH
    Resuscitation Strategies for Achieving Thrombo-inflammatory Homeostasis
    Role: Principal Investigator
    R01HL059355     (SILLIMAN, CHRISTOPHER C.)Apr 1, 1999 - Mar 31, 2008
    NIH
    Lyso-PCs activate PMNs and endothelium via PKC
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Schaid TR, Mitra S, Stafford P, DeBot M, Thielen O, Hallas W, Cralley A, Gallagher L, Jeffrey D, Hansen KC, D'Alessandro A, Silliman CC, Dabertrand F, Cohen MJ. Endothelial Cell Calcium Influx Mediates Trauma-induced Endothelial Permeability. Ann Surg. 2023 Dec 11. PMID: 38073572.
      View in: PubMed
    2. Coleman JR, Moore EE, Kelher MR, Jones K, Cohen MJ, Banerjee A, Silliman CC. Losing the forest for the trees: The complexities of fibrinolysis will never be explained with one variable alone. J Trauma Acute Care Surg. 2024 Jan 01; 96(1):e5-e7. PMID: 37784230.
      View in: PubMed
    3. Thielen O, Mitra S, Debot M, Schaid T, Hallas W, Gallagher LT, Erickson C, Cralley A, Stafford P, Silliman C, D'Alessandro A, Hansen K, Sauaia A, Moore E, Mosnier L, Griffin J, Cohen M. Mitigation of trauma-induced endotheliopathy by activated protein C: A potential therapeutic for postinjury thromboinflammation. J Trauma Acute Care Surg. 2024 01 01; 96(1):116-122. PMID: 37733304.
      View in: PubMed
    4. Cohen MJ, Erickson CB, Lacroix IS, Debot M, Dzieciatkowska M, Schaid TR, Hallas MW, Thielen ON, Cralley AL, Banerjee A, Moore EE, Silliman CC, D'Alessandro A, Hansen KC. Trans-Omics analysis of post injury thrombo-inflammation identifies endotypes and trajectories in trauma patients. bioRxiv. 2023 Sep 09. PMID: 37645811.
      View in: PubMed
    5. Schaid TR, LaCroix I, Cohen MJ, Hansen KC, Moore EE, Sauaia A, Cralley AL, Thielen O, Hallas W, Erickson C, Mitra S, Dzieciatkowska M, Silliman CC, D'Alessandro A. METABOLOMIC AND PROTEOMIC CHANGES IN TRAUMA-INDUCED HYPOCALCEMIA. Shock. 2023 11 01; 60(5):652-663. PMID: 37695733.
      View in: PubMed
    6. Cralley AL, Erickson C, Schaid TR, Hallas W, Thielen O, Mitra S, Stafford P, Hom P, Silliman C, Cohen MJ, Moore EE, D'Alessandro A, Hansen KC. The proteomic and metabolomic signatures of isolated and polytrauma traumatic brain injury. Am J Surg. 2023 12; 226(6):790-797. PMID: 37541795.
      View in: PubMed
    7. LaCroix IS, Cohen M, Moore EE, Dzieciatkowska M, Silliman CC, Hansen KC, D'Alessandro A. Omics markers of platelet transfusion in trauma patients. Transfusion. 2023 08; 63(8):1447-1462. PMID: 37466356.
      View in: PubMed
    8. Coleman JR, D'Alessandro A, LaCroix I, Dzieciatkowska M, Lutz P, Mitra S, Gamboni F, Ruf W, Silliman CC, Cohen MJ. A metabolomic and proteomic analysis of pathologic hypercoagulability in traumatic brain injury patients after dura violation. J Trauma Acute Care Surg. 2023 12 01; 95(6):925-934. PMID: 37405823.
      View in: PubMed
    9. LaCroix IS, Cralley A, Moore EE, Cendali FI, Dzieciatkowska M, Hom P, Mitra S, Cohen M, Silliman C, Sauaia A, Hansen KC, D'Alessandro A. Omics Signatures of Tissue Injury and Hemorrhagic Shock in Swine. Ann Surg. 2023 12 01; 278(6):e1299-e1312. PMID: 37334680.
      View in: PubMed
    10. Eitel A, Moore EE, Kelher MR, Cohen MJ, Kissau D, Hadley JB, Debot M, Banerjee A, Silliman CC. Bradykinin release following trauma and hemorrhagic shock causes pulmonary alveolar leak in a rodent model. J Trauma Acute Care Surg. 2023 10 01; 95(4):558-564. PMID: 37314576.
      View in: PubMed
    11. Esparza O, Hernandez G, Rojas-Sanchez G, Calzada-Martinez J, Nemkov T, Kelher M, Kelly K, Silliman CC, DomBourian M, Dumont LJ, D'Alessandro A, Davizon-Castillo P. Platelets from blood diversion pouches (DPs) are a suitable alternative for functional, bioenergetic, and metabolomic analyses. Blood Transfus. 2023 Mar 31. PMID: 37235734.
      View in: PubMed
    12. Cralley AL, Moore EE, Dubose J, Brenner ML, Schaid TR, DeBot M, Cohen M, Silliman C, Fox C, Sauaia A. OUTCOMES FOLLOWING ZONE 3 AND ZONE 1 AORTIC OCCLUSION FOR THE TREATMENT OF BLUNT PELVIC INJURIES. Shock. 2023 05 01; 59(5):685-690. PMID: 36802216.
      View in: PubMed
    13. Eitel AP, Moore EE, Sauaia A, Kelher MR, Vigneshwar NG, Bartley MG, Hadley JB, Burlew CC, Campion EM, Fox CJ, Lawless RA, Pieracci FM, Platnick KB, Moore HB, Cohen MJ, Silliman CC. A proposed clinical coagulation score for research in trauma-induced coagulopathy. J Trauma Acute Care Surg. 2023 06 01; 94(6):798-802. PMID: 36805626.
      View in: PubMed
    14. Coleman JR, Moore EE, Kelher MR, Jones K, Cohen MJ, Banerjee A, Silliman CC. Elucidating the molecular mechanisms of fibrinolytic shutdown after severe injury: The role of thrombin-activatable fibrinolysis inhibitor. J Trauma Acute Care Surg. 2023 06 01; 94(6):857-862. PMID: 36787438.
      View in: PubMed
    15. Cralley AL, Moore EE, Sauaia A, Carani PH, Schaid TR, DeBot M, Fragoso M, Ghasabyan A, Hansen K, Cohen MJ, Silliman CC, Fox CJ. REBOA for the Treatment of Blast Polytrauma: Zone 3 Provides Cerebral Perfusion, Attenuates Organ Dysfunction and Reperfusion Coagulopathy Compared to Zone 1 in a Swine Model. J Trauma Acute Care Surg. 2023 05 01; 94(5):718-724. PMID: 36749658.
      View in: PubMed
    16. DeBot M, Erickson C, Kelher M, Schaid TR, Moore EE, Sauaia A, Cralley A, LaCroix I, D'Alessandro A, Hansen K, Cohen MJ, Silliman CC, Coleman J. Platelet and cryoprecipitate transfusions from female donors improve coagulopathy in vitro. J Trauma Acute Care Surg. 2023 04 01; 94(4):497-503. PMID: 36728345.
      View in: PubMed
    17. Coleman JR, Fabbri S, Anderson M, Moore EE, Cohen MJ, Hadley J, Ghasabyan A, Chandler J, Kelher M, Freeman K, Miller ZD, Silliman CC. Beyond uterine atony: characterizing postpartum hemorrhage coagulopathy. Am J Obstet Gynecol MFM. 2023 03; 5(3):100822. PMID: 36464240.
      View in: PubMed
    18. Schaid TR, LaCroix I, Hansen KC, D'Alessandro A, Moore EE, Sauaia A, Dzieciatkowska M, DeBot M, Cralley AL, Thielen O, Hallas W, Erickson C, Mitra S, Banerjee A, Jones K, Silliman CC, Cohen MJ. A proteomic analysis of NETosis in trauma: Emergence of serpinB1 as a key player. J Trauma Acute Care Surg. 2023 03 01; 94(3):361-370. PMID: 36730076.
      View in: PubMed
    19. Schaid TR, Cohen MJ, D'Alessandro A, Silliman CC, Moore EE, Sauaia A, Dzieciatkowska M, Hallas W, Thielen O, DeBot M, Cralley A, LaCroix I, Erickson C, Mitra S, Banerjee A, Jones K, Hansen KC. TRAUMA INDUCES INTRAVASCULAR HEMOLYSIS, EXACERBATED BY RED BLOOD CELL TRANSFUSION AND ASSOCIATED WITH DISRUPTED ARGININE-NITRIC OXIDE METABOLISM. Shock. 2023 01 01; 59(1):12-19. PMID: 36378232.
      View in: PubMed
    20. LaCroix IS, Cohen M, Moore EE, Dzieciatkowska M, Nemkov T, Schaid TR, Debot M, Jones K, Silliman CC, Hansen KC, D'Alessandro A. Omics Markers of Red Blood Cell Transfusion in Trauma. Int J Mol Sci. 2022 Nov 10; 23(22). PMID: 36430297.
      View in: PubMed
    21. Cralley AL, Moore EE, Coleman JR, Vigneshwar N, Bartley M, Kissau D, Eitel A, Hom P, Mitra S, Ghasabyan A, Fragoso M, Guo Z, Deguchi H, Griffin JH, Cohen MJ, Silliman CC, Banerjee A, Hansen K, Sauaia A. Hemorrhagic shock and tissue injury provoke distinct components of trauma-induced coagulopathy in a swine model. Eur J Trauma Emerg Surg. 2023 Apr; 49(2):1079-1089. PMID: 36319860.
      View in: PubMed
    22. Hadley JB, Kelher MR, D'Alessandro A, Gamboni F, Hansen K, Coleman J, Jones K, Cohen M, Moore EE, Banerjee A, Silliman CC. A pilot study of the metabolic profiles of apheresis platelets modified by donor age and sex and in vitro short-term incubation with sex hormones. Transfusion. 2022 12; 62(12):2596-2608. PMID: 36309927.
      View in: PubMed
    23. DeBot M, Mitra S, Lutz P, Schaid TR, Stafford P, Hadley JB, Hom P, Sauaia A, Silliman CC, Moore EE, Cohen MJ. SHOCK INDUCES ENDOTHELIAL PERMEABILITY AFTER TRAUMA THROUGH INCREASED ACTIVATION OF RHOA GTPASE. Shock. 2022 12 01; 58(6):542-548. PMID: 36548645.
      View in: PubMed
    24. DeBot M, Eitel AP, Moore EE, Sauaia A, Lutz P, Schaid TR, Hadley JB, Kissau DJ, Cohen MJ, Kelher MR, Silliman CC. BLOOD TYPE O IS A RISK FACTOR FOR HYPERFIBRINOLYSIS AND MASSIVE TRANSFUSION AFTER SEVERE INJURY. Shock. 2022 12 01; 58(6):492-497. PMID: 36548640.
      View in: PubMed
    25. Coleman JR, Moore EE, Schmitt L, Hansen K, Dow N, Freeman K, Cohen MJ, Silliman CC. Estradiol provokes hypercoagulability and affects fibrin biology: A mechanistic exploration of sex dimorphisms in coagulation. J Trauma Acute Care Surg. 2023 02 01; 94(2):179-186. PMID: 36694329.
      View in: PubMed
    26. Hadley JB, Kelher MR, Coleman JR, Kelly KK, Dumont LJ, Esparza O, Banerjee A, Cohen MJ, Jones K, Silliman CC. Hormones, age, and sex affect platelet responsiveness in vitro. Transfusion. 2022 09; 62(9):1882-1893. PMID: 35929193.
      View in: PubMed
    27. Cralley AL, Moore EE, Fox CJ, Kissau D, DeBot M, Schaid TR, Mitra S, Hom P, Fragoso M, Ghasabyan A, Erickson C, D'Alessandro A, Hansen KC, Cohen MJ, Silliman CC, Sauaia A. Zone 1 REBOA in a combat DCBI swine model does not worsen brain?injury. Surgery. 2022 08; 172(2):751-758. PMID: 35690490.
      View in: PubMed
    28. Jones WL, Ramos CR, Banerjee A, Moore EE, Hansen KC, Coleman JR, Kelher M, Neeves KB, Silliman CC, Di Paola J, Branchford B. Apolipoprotein A-I, elevated in trauma patients, inhibits platelet activation and decreases clot strength. Platelets. 2022 Nov 17; 33(8):1119-1131. PMID: 35659185.
      View in: PubMed
    29. Schaid TR, Hansen KC, Sauaia A, Moore EE, DeBot M, Cralley AL, Erickson C, Silliman CC, Banerjee A, Ghasabyan A, Jones K, Lacroix I, Mitra S, D'Alessandro A, Cohen MJ. Postinjury complement C4 activation is associated with adverse outcomes and is potentially influenced by plasma resuscitation. J Trauma Acute Care Surg. 2022 11 01; 93(5):588-596. PMID: 35610738.
      View in: PubMed
    30. Cralley AL, Moore EE, Kissau D, Coleman JR, Vigneshwar N, DeBot M, Schaid TR, Moore HB, Cohen MJ, Hansen K, Silliman CC, Sauaia A, Fox CJ. A combat casualty relevant dismounted complex blast injury model in swine. J Trauma Acute Care Surg. 2022 08 01; 93(2S Suppl 1):S110-S118. PMID: 35545808.
      View in: PubMed
    31. Morton AP, Hadley JB, Ghasabyan A, Kelher MR, Moore EE, Bevers S, Dzieciatkowska M, Hansen KC, Cohen MS, Banerjee A, Silliman CC. The a-globin chain of hemoglobin potentiates tissue plasminogen activator induced hyperfibrinolysis in vitro. J Trauma Acute Care Surg. 2022 01 01; 92(1):159-166. PMID: 34538821.
      View in: PubMed
    32. Welsby IJ, Norris PJ, Mauermann WJ, Podgoreanu MV, Conn CM, Meade L, Cannon T, Keating SM, Silliman CC, Kehler M, Schulte PJ, Kor DJ. Bedside Allogeneic Erythrocyte Washing with a Cell Saver to Remove Cytokines, Chemokines, and Cell-derived Microvesicles. Anesthesiology. 2021 03 01; 134(3):395-404. PMID: 33503656.
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    33. Coleman JR, Moore EE, Samuels JM, Cohen MJ, Silliman CC, Ghasabyan A, Chandler J, Butenas S. Whole Blood Thrombin Generation in Severely Injured Patients Requiring Massive Transfusion. J Am Coll Surg. 2021 05; 232(5):709-716. PMID: 33548446.
      View in: PubMed
    34. Stettler GR, Moore EE, Nunns GR, Kelher M, Banerjee A, Silliman CC. Effects of Blood Components and Whole Blood in a Model of Severe Trauma-Induced Coagulopathy. J Surg Res. 2021 03; 259:55-61. PMID: 33278796.
      View in: PubMed
    35. Nunns GR, Vigneshwar N, Kelher MR, Stettler GR, Gera L, Reisz JA, D'Alessandro A, Ryon J, Hansen KC, Gamboni F, Moore EE, Peltz ED, Cohen MJ, Jones KL, Sauaia A, Liang X, Banerjee A, Ghasabyan A, Chandler JG, Rodawig S, Jones C, Eitel A, Hom P, Silliman CC. Succinate Activation of SUCNR1 Predisposes Severely Injured Patients to Neutrophil-mediated ARDS. Ann Surg. 2022 12 01; 276(6):e944-e954. PMID: 33214479.
      View in: PubMed
    36. Stettler GR, Moore EE, Huebner BR, Nunns GR, Moore HB, Coleman JR, Kelher M, Banerjee A, Silliman CC. 28-day thawed plasma maintains a2 -antiplasmin levels and inhibits tPA-induced fibrinolysis. Vox Sang. 2021 Feb; 116(2):181-189. PMID: 32894784.
      View in: PubMed
    37. Coleman JR, Moore EE, Sauaia A, Samuels JM, Moore HB, Ghasabyan A, Chandler JG, Swope ML, Fleming CD, Banerjee A, Cohen MJ, Silliman CC, Peltz ED, Chapman MP. Untangling Sex Dimorphisms in Coagulation: Initial Steps Toward Precision Medicine for Trauma Resuscitation. Ann Surg. 2020 06; 271(6):e128-e130. PMID: 31850983.
      View in: PubMed
    38. Samuels JM, Coleman JR, Moore EE, Bartley M, Vigneshwar N, Cohen M, Silliman CC, Sauaia A, Banerjee A. Alternative Complement Pathway Activation Provokes a Hypercoagulable State with Diminished Fibrinolysis. Shock. 2020 05; 53(5):560-565. PMID: 31441792.
      View in: PubMed
    39. Coleman JR, Moore EE, Moore HB, Chapman MP, Cohen MJ, Silliman CC, Sauaia A. Tranexamic acid disturbs the dynamics of postinjury fibrinolysis. ANZ J Surg. 2020 04; 90(4):420-422. PMID: 32339428.
      View in: PubMed
    40. Stettler GR, Moore EE, Nunns GR, Moore HB, Huebner BR, Silliman CC, Banerjee A, Sauaia A. Do not drink and lyse: alcohol intoxication increases fibrinolysis shutdown in injured patients. Eur J Trauma Emerg Surg. 2021 Dec; 47(6):1827-1835. PMID: 32157340.
      View in: PubMed
    41. Coleman JR, Moore EE, Silliman CC, Stettler GR, Nunns GR, Samuels JM, Bartley MG, Vigneshwar NG, Cohen MJ, Fragoso M, Sauaia A. Examining the Effect of Hypertonic Saline Administered for Reduction of Intracranial Hypertension on Coagulation. J Am Coll Surg. 2020 03; 230(3):322-330.e2. PMID: 31843691.
      View in: PubMed
    42. Coleman JR, Moore EE, Zilberman-Rudenko J, Samuels JM, Cohen MJ, Silliman CC, Banerjee A, Sauaia A, Griffin JH, Deguchi H. Cardiac and Skeletal Muscle Myosin Exert Procoagulant Effects. Shock. 2019 11; 52(5):554-555. PMID: 31613865.
      View in: PubMed
    43. Coleman JR, Moore EE, Kelher MR, Samuels JM, Cohen MJ, Sauaia A, Banerjee A, Silliman CC, Peltz ED. Female platelets have distinct functional activity compared with male platelets: Implications in transfusion practice and treatment of trauma-induced coagulopathy. J Trauma Acute Care Surg. 2019 11; 87(5):1052-1060. PMID: 31162329.
      View in: PubMed
    44. Samuels JM, Moore EE, Coleman JR, Sumislawski JJ, Cohen MJ, Silliman CC, Banerjee A, Ghasabyan A, Chandler J, Sauaia A. Obesity is associated with postinjury hypercoagulability. J Trauma Acute Care Surg. 2019 10; 87(4):876-882. PMID: 31233444.
      View in: PubMed
    45. Coleman JR, Moore EE, Samuels JM, Ryon JJ, Nelson JT, Olson A, Caus S, Bartley MG, Vigneshwar NG, Cohen MJ, Banerjee A, Silliman CC, Butenas S. Whole blood thrombin generation is distinct from plasma thrombin generation in healthy volunteers and after severe injury. Surgery. 2019 12; 166(6):1122-1127. PMID: 31522748.
      View in: PubMed
    46. Stettler GR, Moore EE, Moore HB, Nunns GR, Coleman JR, Colvis A, Ghasabyan A, Cohen MJ, Silliman CC, Banerjee A, Sauaia A. Variability in international normalized ratio and activated partial thromboplastin time after injury are not explained by coagulation factor deficits. J Trauma Acute Care Surg. 2019 09; 87(3):582-589. PMID: 31136528.
      View in: PubMed
    47. Kuldanek SA, Kelher M, Silliman CC. Risk factors, management and prevention of transfusion-related acute lung injury: a comprehensive update. Expert Rev Hematol. 2019 09; 12(9):773-785. PMID: 31282773.
      View in: PubMed
    48. Vlaar APJ, Toy P, Fung M, Looney MR, Juffermans NP, Bux J, Bolton-Maggs P, Peters AL, Silliman CC, Kor DJ, Kleinman S. An update of the transfusion-related acute lung injury (TRALI) definition. Transfus Clin Biol. 2019 Nov; 26(4):354-356. PMID: 31221537.
      View in: PubMed
    49. Vlaar APJ, Toy P, Fung M, Looney MR, Juffermans NP, Bux J, Bolton-Maggs P, Peters AL, Silliman CC, Kor DJ, Kleinman S. A consensus redefinition of transfusion-related acute lung injury. Transfusion. 2019 07; 59(7):2465-2476. PMID: 30993745.
      View in: PubMed
    50. Stettler GR, Moore EE, Moore HB, Nunns GR, Silliman CC, Banerjee A, Sauaia A. Redefining postinjury fibrinolysis phenotypes using two viscoelastic assays. J Trauma Acute Care Surg. 2019 04; 86(4):679-685. PMID: 30562328.
      View in: PubMed
    51. Samuels JM, Moore EE, Silliman CC, Banerjee A, Cohen MJ, Ghasabyan A, Chandler J, Coleman JR, Sauaia A. Severe traumatic brain injury is associated with a unique coagulopathy phenotype. J Trauma Acute Care Surg. 2019 04; 86(4):686-693. PMID: 30601456.
      View in: PubMed
    52. Sumislawski JJ, Christie SA, Kornblith LZ, Stettler GR, Nunns GR, Moore HB, Moore EE, Silliman CC, Sauaia A, Callcut RA, Cohen MJ. Discrepancies between conventional and viscoelastic assays in identifying trauma-induced coagulopathy. Am J Surg. 2019 06; 217(6):1037-1041. PMID: 31029284.
      View in: PubMed
    53. Coleman JR, Moore EE, Samuels JM, Cohen MJ, Sauaia A, Sumislawski JJ, Ghasabyan A, Chandler JG, Banerjee A, Silliman CC, Peltz ED. Trauma Resuscitation Consideration: Sex Matters. J Am Coll Surg. 2019 05; 228(5):760-768.e1. PMID: 30677527.
      View in: PubMed
    54. Clendenen N, Nunns GR, Moore EE, Gonzalez E, Chapman M, Reisz JA, Peltz E, Fragoso M, Nemkov T, Wither MJ, Sauaia A, Silliman CC, Hansen K, Banerjee A, D'Alessandro A, Moore HB. Selective organ ischaemia/reperfusion identifies liver as the key driver of the post-injury plasma metabolome derangements. Blood Transfus. 2019 09; 17(5):347-356. PMID: 30747701.
      View in: PubMed
    55. Huebner BR, Moore EE, Moore HB, Stettler GR, Nunns GR, Lawson P, Sauaia A, Kelher M, Banerjee A, Silliman CC. Thrombin Provokes Degranulation of Platelet a-Granules Leading to the Release of Active Plasminogen Activator Inhibitor-1 (PAI-1). Shock. 2018 12; 50(6):671-676. PMID: 29280928.
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    56. Stettler GR, Sumislawski JJ, Moore EE, Nunns GR, Kornblith LZ, Conroy AS, Callcut RA, Silliman CC, Banerjee A, Cohen MJ, Sauaia A. Citrated kaolin thrombelastography (TEG) thresholds for goal-directed therapy in injured patients receiving massive transfusion. J Trauma Acute Care Surg. 2018 10; 85(4):734-740. PMID: 30059456.
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    57. Loi MM, Kelher M, Dzieciatkowska M, Hansen KC, Banerjee A, West FB, Stanley C, Briel M, Silliman CC. A comparison of different methods of red blood cell leukoreduction and additive solutions on the accumulation of neutrophil-priming activity during storage. Transfusion. 2018 08; 58(8):2003-2012. PMID: 30171813.
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    58. Moore HB, Moore EE, Chapman MP, McVaney K, Bryskiewicz G, Blechar R, Chin T, Burlew CC, Pieracci F, West FB, Fleming CD, Ghasabyan A, Chandler J, Silliman CC, Banerjee A, Sauaia A. Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial. Lancet. 2018 07 28; 392(10144):283-291. PMID: 30032977.
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    59. Coleman JR, Moore EE, Chapman MP, Banerjee A, Silliman CC, Ghasabyan A, Chandler J, Samuels JM, Sauaia A. Rapid TEG efficiently guides hemostatic resuscitation in trauma patients. Surgery. 2018 09; 164(3):489-493. PMID: 29903508.
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    60. Banerjee A, Silliman CC, Moore EE, Dzieciatkowska M, Kelher M, Sauaia A, Jones K, Chapman MP, Gonzalez E, Moore HB, D'Alessandro A, Peltz E, Huebner BE, Einerson P, Chandler J, Ghasabayan A, Hansen K. Systemic hyperfibrinolysis after trauma: a pilot study of targeted proteomic analysis of superposed mechanisms in patient plasma. J Trauma Acute Care Surg. 2018 06; 84(6):929-938. PMID: 29554044.
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    61. Nunns GR, Stringham JR, Gamboni F, Moore EE, Fragoso M, Stettler GR, Silliman CC, Banerjee A. Trauma and hemorrhagic shock activate molecular association of 5-lipoxygenase and 5-lipoxygenase-Activating protein in lung tissue. J Surg Res. 2018 09; 229:262-270. PMID: 29936999.
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    62. Slaughter AL, Nunns GR, D'Alessandro A, Banerjee A, Hansen KC, Moore EE, Silliman CC, Nemkov T, Moore HB, Fragoso M, Leasia K, Peltz ED. The Metabolopathy of Tissue Injury, Hemorrhagic Shock, and Resuscitation in a Rat Model. Shock. 2018 05; 49(5):580-590. PMID: 28727610.
      View in: PubMed
    63. Nunns GR, Moore EE, Stettler GR, Moore HB, Ghasabyan A, Cohen M, Huebner BR, Silliman CC, Banerjee A, Sauaia A. Empiric transfusion strategies during life-threatening hemorrhage. Surgery. 2018 08; 164(2):306-311. PMID: 29709368.
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    64. Stettler GR, Moore EE, Nunns GR, Chandler J, Peltz E, Silliman CC, Banerjee A, Sauaia A. Rotational thromboelastometry thresholds for patients at risk for massive transfusion. J Surg Res. 2018 08; 228:154-159. PMID: 29907206.
      View in: PubMed
    65. Reisz JA, Wither MJ, Moore EE, Slaughter AL, Moore HB, Ghasabyan A, Chandler J, Schaub LJ, Fragoso M, Nunns G, Silliman CC, Hansen KC, Banerjee A, Sheppard FR, D'Alessandro A. All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhagic shock-A comparison in rodents, swine, nonhuman primates, and injured patients. J Trauma Acute Care Surg. 2018 03; 84(3):537-541. PMID: 29112093.
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    66. Weisberg SP, Shaz BH, Tumer G, Silliman CC, Kelher MR, Cohn CS. PAS-C platelets contain less plasma protein, lower anti-A and anti-B titers, and decreased HLA antibody specificities compared to plasma platelets. Transfusion. 2018 04; 58(4):891-895. PMID: 29473178.
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    67. Kuldanek S, Silliman CC. Mortality after red blood cell transfusions from previously pregnant donors: complexities in the interpretation of large data. J Thorac Dis. 2018 Feb; 10(2):648-652. PMID: 29608196.
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    68. Huebner BR, Moore EE, Moore HB, Gonzalez E, Kelher MR, Sauaia A, Banerjee A, Silliman CC. Thrombin stimulates increased plasminogen activator inhibitor-1 release from liver compared to lung endothelium. J Surg Res. 2018 05; 225:1-5. PMID: 29605018.
      View in: PubMed
    69. Mitra S, Schiller D, Anderson C, Gamboni F, D'Alessandro A, Kelher M, Silliman CC, Banerjee A, Jones KL. Hypertonic saline attenuates the cytokine-induced pro-inflammatory signature in primary human lung epithelia. PLoS One. 2017; 12(12):e0189536. PMID: 29253007.
      View in: PubMed
    70. Moore HB, Moore EE, Huebner BR, Dzieciatkowska M, Stettler GR, Nunns GR, Lawson PJ, Ghasabyan A, Chandler J, Banerjee A, Silliman C, Sauaia A, Hansen KC. Fibrinolysis shutdown is associated with a fivefold increase in mortality in trauma patients lacking hypersensitivity to tissue plasminogen activator. J Trauma Acute Care Surg. 2017 12; 83(6):1014-1022. PMID: 29190254.
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    71. Barrett CD, Moore HB, Banerjee A, Silliman CC, Moore EE, Yaffe MB. Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin. J Trauma Acute Care Surg. 2017 12; 83(6):1053-1061. PMID: 28837538.
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    72. Nunns GR, Moore EE, Chapman MP, Moore HB, Stettler GR, Peltz E, Burlew CC, Silliman CC, Banerjee A, Sauaia A. Discussion of: "The hypercoagulability paradox of chronic kidney disease: The role of fibrinogen". Am J Surg. 2017 12; 214(6):1219. PMID: 29021098.
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    73. Clendenen N, Nunns GR, Moore EE, Reisz JA, Gonzalez E, Peltz E, Silliman CC, Fragoso M, Nemkov T, Wither MJ, Hansen K, Banerjee A, Moore HB, D'Alessandro A. Hemorrhagic shock and tissue injury drive distinct plasma metabolome derangements in swine. J Trauma Acute Care Surg. 2017 10; 83(4):635-642. PMID: 28463938.
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    74. Stettler GR, Moore EE, Moore HB, Nunns GR, Huebner BR, Einersen P, Ghasabyan A, Silliman CC, Banerjee A, Sauaia A. Platelet adenosine diphosphate receptor inhibition provides no advantage in predicting need for platelet transfusion or massive transfusion. Surgery. 2017 12; 162(6):1286-1294. PMID: 28964508.
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    75. Nunns GR, Moore EE, Chapman MP, Moore HB, Stettler GR, Peltz E, Burlew CC, Silliman CC, Banerjee A, Sauaia A. The hypercoagulability paradox of chronic kidney disease: The role of fibrinogen. Am J Surg. 2017 Dec; 214(6):1215-1218. PMID: 28951066.
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    76. Silliman CC, Kelher MR, Khan SY, West FB, McLaughlin NJD, Elzi DJ, England K, Bjornsen J, Kuldanek SA, Banerjee A. Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor and protein kinase C activation. Transfusion. 2017 11; 57(11):2690-2700. PMID: 28880373.
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    77. D'Alessandro A, Moore HB, Moore EE, Reisz JA, Wither MJ, Ghasasbyan A, Chandler J, Silliman CC, Hansen KC, Banerjee A. Plasma succinate is a predictor of mortality in critically injured patients. J Trauma Acute Care Surg. 2017 09; 83(3):491-495. PMID: 28590356.
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    78. Warner MA, Welsby IJ, Norris PJ, Silliman CC, Armour S, Wittwer ED, Santrach PJ, Meade LA, Liedl LM, Nieuwenkamp CM, Douthit B, van Buskirk CM, Schulte PJ, Carter RE, Kor DJ. Point-of-care washing of allogeneic red blood cells for the prevention of transfusion-related respiratory complications (WAR-PRC): a protocol for a multicenter randomised clinical trial in patients undergoing cardiac surgery. BMJ Open. 2017 Aug 18; 7(8):e016398. PMID: 28821525.
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    79. Lawson PJ, Moore HB, Moore EE, Stettler GR, Pshak TJ, Kam I, Silliman CC, Nydam TL. Preoperative thrombelastography maximum amplitude predicts massive transfusion in liver transplantation. J Surg Res. 2017 12; 220:171-175. PMID: 29180179.
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    80. Reisz JA, Slaughter AL, Culp-Hill R, Moore EE, Silliman CC, Fragoso M, Peltz ED, Hansen KC, Banerjee A, D'Alessandro A. Red blood cells in hemorrhagic shock: a critical role for glutaminolysis in fueling alanine transamination in rats. Blood Adv. 2017 Jul 25; 1(17):1296-1305. PMID: 29296771.
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    81. Moore HB, Moore EE, Chapman MP, Huebner BR, Einersen PM, Oushy S, Silliman CC, Banerjee A, Sauaia A. Viscoelastic Tissue Plasminogen Activator Challenge Predicts Massive Transfusion in 15 Minutes. J Am Coll Surg. 2017 Jul; 225(1):138-147. PMID: 28522144.
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    82. Huebner BR, Moore EE, Moore HB, Shepherd-Singh R, Sauaia A, Stettler GR, Nunns GR, Silliman CC. 14-Day thawed plasma retains clot enhancing properties and inhibits tPA-induced fibrinolysis. J Surg Res. 2017 11; 219:145-150. PMID: 29078874.
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    83. Huebner BR, Moore EE, Moore HB, Sauaia A, Stettler G, Dzieciatkowska M, Hansen K, Banerjee A, Silliman CC. Freeze-dried plasma enhances clot formation and inhibits fibrinolysis in the presence of tissue plasminogen activator similar to pooled liquid plasma. Transfusion. 2017 08; 57(8):2007-2015. PMID: 28500652.
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    84. Stettler GR, Moore EE, Moore HB, Lawson PJ, Fragoso M, Nunns GR, Silliman CC, Banerjee A. Thrombelastography indicates limitations of animal models of trauma-induced coagulopathy. J Surg Res. 2017 09; 217:207-212. PMID: 28583756.
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    85. Moore HB, Moore EE, Huebner BR, Stettler GR, Nunns GR, Einersen PM, Silliman CC, Sauaia A. Tranexamic acid is associated with increased mortality in patients with physiological fibrinolysis. J Surg Res. 2017 12; 220:438-443. PMID: 28755903.
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    86. Silliman CC, Burke T, Kelher MR. The accumulation of lipids and proteins during red blood cell storage: the roles of leucoreduction and experimental filtration. Blood Transfus. 2017 Mar; 15(2):131-136. PMID: 28263170.
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    87. Yoshida T, Blair A, D'alessandro A, Nemkov T, Dioguardi M, Silliman CC, Dunham A. Enhancing uniformity and overall quality of red cell concentrate with anaerobic storage. Blood Transfus. 2017 Mar; 15(2):172-181. PMID: 28263176.
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    88. Einersen PM, Moore EE, Chapman MP, Moore HB, Gonzalez E, Silliman CC, Banerjee A, Sauaia A. Rapid thrombelastography thresholds for goal-directed resuscitation of patients at risk for massive transfusion. J Trauma Acute Care Surg. 2017 01; 82(1):114-119. PMID: 27805995.
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    89. Slaughter AL, D'Alessandro A, Moore EE, Banerjee A, Silliman CC, Hansen KC, Reisz JA, Fragoso M, Wither MJ, Bacon AW, Moore HB, Peltz ED. Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock. J Trauma Acute Care Surg. 2016 12; 81(6):1012-1019. PMID: 27602903.
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    90. Kelher MR, Banerjee A, Gamboni F, Anderson C, Silliman CC. Antibodies to major histocompatibility complex class II antigens directly prime neutrophils and cause acute lung injury in a two-event in vivo rat model. Transfusion. 2016 12; 56(12):3004-3011. PMID: 27667662.
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    91. Kelher MR, McLaughlin NJ, Banerjee A, Elzi DJ, Gamboni F, Khan SY, Meng X, Mitra S, Silliman CC. LysoPCs induce Hck- and PKCd-mediated activation of PKC? causing p47phox phosphorylation and membrane translocation in neutrophils. J Leukoc Biol. 2017 01; 101(1):261-273. PMID: 27531930.
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    92. D'Alessandro A, Moore HB, Moore EE, Wither MJ, Nemkov T, Morton AP, Gonzalez E, Chapman MP, Fragoso M, Slaughter A, Sauaia A, Silliman CC, Hansen KC, Banerjee A. Plasma First Resuscitation Reduces Lactate Acidosis, Enhances Redox Homeostasis, Amino Acid and Purine Catabolism in a Rat Model of Profound Hemorrhagic Shock. Shock. 2016 08; 46(2):173-82. PMID: 26863033.
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    93. Gonzalez E, Moore EE, Moore HB, Chapman MP, Chin TL, Ghasabyan A, Wohlauer MV, Barnett CC, Bensard DD, Biffl WL, Burlew CC, Johnson JL, Pieracci FM, Jurkovich GJ, Banerjee A, Silliman CC, Sauaia A. Goal-directed Hemostatic Resuscitation of Trauma-induced Coagulopathy: A Pragmatic Randomized Clinical Trial Comparing a Viscoelastic Assay to Conventional Coagulation Assays. Ann Surg. 2016 Jun; 263(6):1051-9. PMID: 26720428.
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    94. Kent MW, Kelher MR, Silliman CC, Quinones R. Neutrophil function in children following allogeneic hematopoietic stem cell transplant. Pediatr Transplant. 2016 Aug; 20(5):658-66. PMID: 27114335.
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    95. D'alessandro A, Nemkov T, Moore HB, Moore EE, Wither M, Nydam T, Slaughter A, Silliman CC, Banerjee A, Hansen KC. Metabolomics of trauma-associated death: shared and fluid-specific features of human plasma vs lymph. Blood Transfus. 2016 05; 14(2):185-94. PMID: 27177401.
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    96. Moore EE, Moore HB, Gonzalez E, Sauaia A, Banerjee A, Silliman CC. Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient. Transfusion. 2016 04; 56 Suppl 2:S110-4. PMID: 27100746.
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    97. Chapman MP, Moore EE, Moore HB, Gonzalez E, Gamboni F, Chandler JG, Mitra S, Ghasabyan A, Chin TL, Sauaia A, Banerjee A, Silliman CC. Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients. J Trauma Acute Care Surg. 2016 Jan; 80(1):16-23; discussion 23-5. PMID: 26491796.
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    98. Chapman MP, Moore EE, Moore HB, Gonzalez E, Morton AP, Chandler J, Fleming CD, Ghasabyan A, Silliman CC, Banerjee A, Sauaia A. The "Death Diamond": Rapid thrombelastography identifies lethal hyperfibrinolysis. J Trauma Acute Care Surg. 2015 Dec; 79(6):925-9. PMID: 26488324.
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    99. Moore HB, Moore EE, Morton AP, Gonzalez E, Fragoso M, Chapman MP, Dzieciatkowska M, Hansen KC, Banerjee A, Sauaia A, Silliman CC. Shock-induced systemic hyperfibrinolysis is attenuated by plasma-first resuscitation. J Trauma Acute Care Surg. 2015 Dec; 79(6):897-903; discussion 903-4. PMID: 26680132.
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    100. Yi J, Slaughter A, Kotter CV, Moore EE, Hauser CJ, Itagaki K, Wohlauer M, Frank DN, Silliman C, Banerjee A, Peltz E. A "CLEAN CASE" OF SYSTEMIC INJURY: MESENTERIC LYMPH AFTER HEMORRHAGIC SHOCK ELICITS A STERILE INFLAMMATORY RESPONSE. Shock. 2015 Oct; 44(4):336-40. PMID: 26196840.
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    101. Moore HB, Moore EE, Chapman MP, Gonzalez E, Slaughter AL, Morton AP, D'Alessandro A, Hansen KC, Sauaia A, Banerjee A, Silliman CC. Viscoelastic measurements of platelet function, not fibrinogen function, predicts sensitivity to tissue-type plasminogen activator in trauma patients. J Thromb Haemost. 2015 Oct; 13(10):1878-87. PMID: 26256459.
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    102. D'Alessandro A, Slaughter AL, Peltz ED, Moore EE, Silliman CC, Wither M, Nemkov T, Bacon AW, Fragoso M, Banerjee A, Hansen KC. Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary (13)C-glucose labeling metabolomics. J Transl Med. 2015 Aug 05; 13:253. PMID: 26242576.
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    103. Chapman MP, Moore EE, Chin TL, Ghasabyan A, Chandler J, Stringham J, Gonzalez E, Moore HB, Banerjee A, Silliman CC, Sauaia A. Combat: Initial Experience with a Randomized Clinical Trial of Plasma-Based Resuscitation in the Field for Traumatic Hemorrhagic Shock. Shock. 2015 Aug; 44 Suppl 1:63-70. PMID: 25784527.
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    104. Bock A, Tucker N, Kelher MR, Khan SY, Gonzalez E, Wohlauer M, Hansen K, Dzieciatkowska M, Sauaia A, Banerjee A, Moore EE, Silliman CC. a-Enolase Causes Proinflammatory Activation of Pulmonary Microvascular Endothelial Cells and Primes Neutrophils Through Plasmin Activation of Protease-Activated Receptor 2. Shock. 2015 Aug; 44(2):137-42. PMID: 25944790.
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    105. Moore HB, Moore EE, Lawson PJ, Gonzalez E, Fragoso M, Morton AP, Gamboni F, Chapman MP, Sauaia A, Banerjee A, Silliman CC. Fibrinolysis shutdown phenotype masks changes in rodent coagulation in tissue injury versus hemorrhagic shock. Surgery. 2015 Aug; 158(2):386-92. PMID: 25979440.
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    106. Moore EE, Moore HB, Gonzalez E, Chapman MP, Hansen KC, Sauaia A, Silliman CC, Banerjee A. Postinjury fibrinolysis shutdown: Rationale for selective tranexamic acid. J Trauma Acute Care Surg. 2015 Jun; 78(6 Suppl 1):S65-9. PMID: 26002266.
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    107. Morton AP, Moore EE, Moore HB, Gonzalez E, Chapman MP, Peltz E, Banerjee A, Silliman C. Hemoglobin-based oxygen carriers promote systemic hyperfibrinolysis that is both dependent and independent of plasmin. J Surg Res. 2017 06 01; 213:166-170. PMID: 28601310.
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    108. D'Alessandro A, Moore HB, Moore EE, Wither M, Nemkov T, Gonzalez E, Slaughter A, Fragoso M, Hansen KC, Silliman CC, Banerjee A. Early hemorrhage triggers metabolic responses that build up during prolonged shock. Am J Physiol Regul Integr Comp Physiol. 2015 Jun 15; 308(12):R1034-44. PMID: 25876652.
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    109. Peltz ED, D'Alessandro A, Moore EE, Chin T, Silliman CC, Sauaia A, Hansen KC, Banerjee A. Pathologic metabolism: an exploratory study of the plasma metabolome of critical injury. J Trauma Acute Care Surg. 2015 Apr; 78(4):742-51. PMID: 25807403.
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    110. Moore HB, Moore EE, Gonzalez E, Wiener G, Chapman MP, Dzieciatkowska M, Sauaia A, Banerjee A, Hansen KC, Silliman C. Plasma is the physiologic buffer of tissue plasminogen activator-mediated fibrinolysis: rationale for plasma-first resuscitation after life-threatening hemorrhage. J Am Coll Surg. 2015 May; 220(5):872-9. PMID: 25840538.
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    111. Moore HB, Moore EE, Gonzalez E, Hansen KC, Dzieciatkowska M, Chapman MP, Sauaia A, West B, Banerjee A, Silliman CC. Hemolysis exacerbates hyperfibrinolysis, whereas platelolysis shuts down fibrinolysis: evolving concepts of the spectrum of fibrinolysis in response to severe injury. Shock. 2015 Jan; 43(1):39-46. PMID: 25072794.
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    112. D'Alessandro A, Nemkov T, Kelher M, West FB, Schwindt RK, Banerjee A, Moore EE, Silliman CC, Hansen KC. Routine storage of red blood cell (RBC) units in additive solution-3: a comprehensive investigation of the RBC metabolome. Transfusion. 2015 Jun; 55(6):1155-68. PMID: 25556331.
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    113. Wright FL, Gamboni F, Moore EE, Nydam TL, Mitra S, Silliman CC, Banerjee A. Hyperosmolarity invokes distinct anti-inflammatory mechanisms in pulmonary epithelial cells: evidence from signaling and transcription layers. PLoS One. 2014; 9(12):e114129. PMID: 25479425.
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    114. D'Alessandro A, Dzieciatkowska M, Peltz ED, Moore EE, Jordan JR, Silliman CC, Banerjee A, Hansen KC. Dynamic changes in rat mesenteric lymph proteins following trauma using label-free mass spectrometry. Shock. 2014 Dec; 42(6):509-17. PMID: 25243424.
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    115. Dzieciatkowska M, D'Alessandro A, Moore EE, Wohlauer M, Banerjee A, Silliman CC, Hansen KC. Lymph is not a plasma ultrafiltrate: a proteomic analysis of injured patients. Shock. 2014 Dec; 42(6):485-498. PMID: 25243428.
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    116. Moore HB, Moore EE, Gonzalez E, Chapman MP, Chin TL, Silliman CC, Banerjee A, Sauaia A. Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy. J Trauma Acute Care Surg. 2014 Dec; 77(6):811-7; discussion 817. PMID: 25051384.
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    117. D'Alessandro A, Hansen KC, Silliman CC, Moore EE, Kelher M, Banerjee A. Metabolomics of AS-5 RBC supernatants following routine storage. Vox Sang. 2015 Feb; 108(2):131-40. PMID: 25200932.
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    118. Dzieciatkowska M, D'Alessandro A, Burke TA, Kelher MR, Moore EE, Banerjee A, Silliman CC, West BF, Hansen KC. Proteomics of apheresis platelet supernatants during routine storage: Gender-related differences. J Proteomics. 2015 Jan 01; 112:190-209. PMID: 25201077.
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    119. Gamboni F, Escobar GA, Moore EE, Dzieciatkowska M, Hansen KC, Mitra S, Nydam TA, Silliman CC, Banerjee A. Clathrin complexes with the inhibitor kappa B kinase signalosome: imaging the interactome. Physiol Rep. 2014 Jul 01; 2(7). PMID: 24994893.
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    120. Kent MW, Kelher MR, West FB, Silliman CC. The pro-inflammatory potential of microparticles in red blood cell units. Transfus Med. 2014 Jun; 24(3):176-81. PMID: 24786047.
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    121. Moore EE, Chin TL, Chapman MC, Gonzalez E, Moore HB, Silliman CC, Hansen KC, Sauaia A, Banerjee A. Plasma first in the field for postinjury hemorrhagic shock. Shock. 2014 May; 41 Suppl 1:35-8. PMID: 24317352.
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    122. Stringham JR, Moore EE, Gamboni F, Harr JN, Fragoso M, Chin TL, Carr CE, Silliman CC, Banerjee A. Mesenteric lymph diversion abrogates 5-lipoxygenase activation in the kidney following trauma and hemorrhagic shock. J Trauma Acute Care Surg. 2014 May; 76(5):1214-21. PMID: 24747451.
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    123. Gonzalez E, Moore EE, Moore HB, Chapman MP, Silliman CC, Banerjee A. Trauma-Induced Coagulopathy: An Institution's 35 Year Perspective on Practice and Research. Scand J Surg. 2014 Jun; 103(2):89-103. PMID: 24786172.
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    124. Silliman CC, Kelher MR, Khan SY, LaSarre M, West FB, Land KJ, Mish B, Ceriano L, Sowemimo-Coker S. Experimental prestorage filtration removes antibodies and decreases lipids in RBC supernatants mitigating TRALI in vivo. Blood. 2014 May 29; 123(22):3488-95. PMID: 24747436.
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    125. Harr JN, Moore EE, Chin TL, Chapman MP, Ghasabyan A, Stringham JR, Banerjee A, Silliman CC. Viscoelastic hemostatic fibrinogen assays detect fibrinolysis early. Eur J Trauma Emerg Surg. 2015 Feb; 41(1):49-56. PMID: 26038165.
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    126. Maloney JP, Ambruso DR, Voelkel NF, Silliman CC. Platelet Vascular Endothelial Growth Factor is a Potential Mediator of Transfusion-Related Acute Lung Injury. J Pulm Respir Med. 2014; 4. PMID: 25705568.
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    127. Kent MW, Oliveira JL, Hoyer JD, Swanson KC, Kluge ML, Dawson DB, Liang X, Winkler TJ, Breaux CW, LaCount R, Silliman CC. Hb Grand Junction (HBB: c.348_349delinsG; p.His117IlefsX42): a new hyperunstable hemoglobin variant. Hemoglobin. 2014; 38(1):8-12. PMID: 24432801.
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    128. Harr JN, Moore EE, Chin TL, Ghasabyan A, Gonzalez E, Wohlauer MV, Sauaia A, Banerjee A, Silliman CC. Postinjury hyperfibrinogenemia compromises efficacy of heparin-based venous thromboembolism prophylaxis. Shock. 2014 Jan; 41(1):33-9. PMID: 24351527.
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    129. Silliman CC, Bercovitz RS, Khan SY, Kelher MR, LaSarre M, Land KJ, Sowemimo-Coker S. Antibodies to the HLA-A2 antigen prime neutrophils and serve as the second event in an in vitro model of transfusion-related acute lung injury. Vox Sang. 2014 Jul; 107(1):76-82. PMID: 24372341.
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    130. Silliman CC. Platelet: RBC ratios: randomized controlled trials are needed for optimal resuscitation of injured patients. Crit Care Med. 2013 Dec; 41(12):2834-5. PMID: 24275402.
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    131. Chapman MP, Moore EE, Ramos CR, Ghasabyan A, Harr JN, Chin TL, Stringham JR, Sauaia A, Silliman CC, Banerjee A. Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy. J Trauma Acute Care Surg. 2013 Dec; 75(6):961-7; discussion 967. PMID: 24256667.
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    132. Harr JN, Moore EE, Johnson JL, Chin TL, Wohlauer MV, Banerjee A, Silliman CC, Sauaia A. The authors reply. Crit Care Med. 2013 Aug; 41(8):e189. PMID: 23863260.
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    133. Ramos CR, Moore EE, Manco-Johnson ML, Silliman CC, Chapman MC, Banerjee A. The incidence and magnitude of fibrinolytic activation in trauma patients: a rebuttal. J Thromb Haemost. 2013 Jul; 11(7):1435-7. PMID: 23593973.
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    134. West FB, Silliman CC. Transfusion-related acute lung injury: advances in understanding the role of proinflammatory mediators in its genesis. Expert Rev Hematol. 2013 Jun; 6(3):265-76. PMID: 23782081.
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    135. Dzieciatkowska M, Silliman CC, Moore EE, Kelher MR, Banerjee A, Land KJ, Ellison M, West FB, Ambruso DR, Hansen KC. Proteomic analysis of the supernatant of red blood cell units: the effects of storage and leucoreduction. Vox Sang. 2013 Oct; 105(3):210-8. PMID: 23663258.
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    136. Banerjee A, Moore EE, McLaughlin NJ, Lee L, Jones WL, Johnson JL, Nydam TL, Silliman CC. Hyperosmolarity attenuates TNF-a-mediated proinflammatory activation of human pulmonary microvascular endothelial cells. Shock. 2013 Apr; 39(4):366-72. PMID: 23364439.
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    137. Harr JN, Moore EE, Chin TL, Ghasabyan A, Gonzalez E, Wohlauer MV, Banerjee A, Silliman CC, Sauaia A. Platelets are dominant contributors to hypercoagulability after injury. J Trauma Acute Care Surg. 2013 Mar; 74(3):756-62; discussion 762-5. PMID: 23425732.
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    138. Ng C, Silliman CC, Pearl G, Smith W, Manco-Johnson M, Wang M. Treatment of refractory hemorrhage with Factor XIII in a patient with hemophilia A with inhibitor. Pediatr Blood Cancer. 2013 Jul; 60(7):E23-5. PMID: 23382082.
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    139. Harr JN, Moore EE, Johnson J, Chin TL, Wohlauer MV, Maier R, Cuschieri J, Sperry J, Banerjee A, Silliman CC, Sauaia A. Antiplatelet therapy is associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients. Crit Care Med. 2013 Feb; 41(2):399-404. PMID: 23263579.
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    140. Lo KK, Bey EA, Patra B, Benson DD, Boothman DA, Silliman CC, Barnett CC. Hemoglobin-based oxygen carrier mitigates transfusion-mediated pancreas cancer progression. Ann Surg Oncol. 2013 Jun; 20(6):2073-7. PMID: 23328973.
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    141. Harr JN, Moore EE, Ghasabyan A, Chin TL, Sauaia A, Banerjee A, Silliman CC. Functional fibrinogen assay indicates that fibrinogen is critical in correcting abnormal clot strength following trauma. Shock. 2013 Jan; 39(1):45-9. PMID: 23247121.
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    142. Lee L, Moore EE, Hansen KC, Silliman CC, Chandler JG, Banerjee A. It's not your grandfather's field plasma. Surgery. 2013 Jun; 153(6):857-60. PMID: 23122899.
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    143. Silliman CC, Chaffin DJ. Broken hearts and transfusion-related acute lung injury. Crit Care Med. 2012 Oct; 40(10):2909-10. PMID: 22986660.
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    144. Wohlauer M, Moore EE, Silliman CC, Fragoso M, Gamboni F, Harr J, Accurso F, Wright F, Haenel J, Fullerton D, Banerjee A. Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13. Crit Care Med. 2012 Sep; 40(9):2647-53. PMID: 22732292.
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    145. Harr JN, Moore EE, Stringham J, Wohlauer MV, Fragoso M, Jones WL, Gamboni F, Silliman CC, Banerjee A. Isoflurane prevents acute lung injury?through ADP-mediated platelet inhibition. Surgery. 2012 Aug; 152(2):270-6. PMID: 22828148.
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    146. Silliman CC. PLADO and kids: earlier/increased bleeding after HSCT. Blood. 2012 Jul 26; 120(4):704-5. PMID: 22835886.
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    147. Morton AP, Moore EE, Wohlauer MV, Lo K, Silliman CC, Burlew CC, Banerjee A. Revisiting early postinjury mortality: are they bleeding because they are dying or dying because they are bleeding? J Surg Res. 2013 Jan; 179(1):5-9. PMID: 23138049.
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    148. Vetlesen A, Mirlashari MR, Akk?k CA, Kelher MR, Khan SY, Silliman CC, Kjeldsen-Kragh J. Biological response modifiers in photochemically pathogen-reduced versus untreated apheresis platelet concentrates. Transfusion. 2013 Jan; 53(1):147-55. PMID: 22563732.
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    149. Silliman CC, Kelher M, Ambruso DR. Bioactive lipids from stored cellular blood components: in vitro method is crucial for proper interpretation. Transfusion. 2012 May; 52(5):1155-7; author reply 1157-8. PMID: 22571364.
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    150. Wohlauer MV, Moore EE, Thomas S, Sauaia A, Evans E, Harr J, Silliman CC, Ploplis V, Castellino FJ, Walsh M. Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. J Am Coll Surg. 2012 May; 214(5):739-46. PMID: 22520693.
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    151. Reesink HW, Lee J, Keller A, Dennington P, Pink J, Holdsworth R, Schennach H, Goldman M, Petraszko T, Sun J, Meng Y, Qian K, Rehacek V, Turek P, Krusius T, Juvonen E, Tiberghien P, Legrand D, Semana G, Muller JY, Bux J, Reil A, Lin CK, Daly H, McSweeney E, Porretti L, Greppi N, Rebulla P, Okazaki H, S?nchez-Guerrero SA, Baptista-Gonz?lez HA, Mart?nez-Murillo C, Guerra-M?rquez A, Rodriguez-Moyado H, Middelburg RA, Wiersum-Osselton JC, Brand A, van Tilburg C, Dinesh D, Dagger J, Dunn P, Brojer E, Letowska M, Maslanka K, Lachert E, Uhrynowska M, Zhiburt E, Palfi M, Berlin G, Frey BM, Puig Rovira L, Mu?iz-Diaz E, Castro E, Chapman C, Green A, Massey E, Win N, Williamson L, Silliman CC, Chaffin DJ, Ambruso DR, Blumberg N, Tomasulo P, Land KJ, Norris PJ, Illoh OC, Davey RJ, Benjamin RJ, Eder AF, McLaughlin L, Kleinman S, Panzer S. Measures to prevent transfusion-related acute lung injury (TRALI). Vox Sang. 2012 Oct; 103(3):231-59. PMID: 22519920.
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    152. Pieracci FM, Barnett CC, Townsend N, Moore EE, Johnson J, Biffl W, Bensard DD, Burlew CC, Gerber A, Silliman CC. Sexual dimorphism in hematocrit response following red blood cell transfusion of critically ill surgical patients. ISRN Hematol. 2012; 2012:298345. PMID: 22536521.
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    153. Benson DD, Meng X, Fullerton DA, Moore EE, Lee JH, Ao L, Silliman CC, Barnett CC. Activation state of stromal inflammatory cells in murine metastatic pancreatic adenocarcinoma. Am J Physiol Regul Integr Comp Physiol. 2012 May; 302(9):R1067-75. PMID: 22422663.
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    154. Tung JP, Fraser JF, Nataatmadja M, Colebourne KI, Barnett AG, Glenister KM, Zhou AY, Wood P, Silliman CC, Fung YL. Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI). Crit Care. 2012 Feb 01; 16(1):R19. PMID: 22297161.
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    155. Benson DD, Beck AW, Burdine MS, Brekken R, Silliman CC, Barnett CC. Accumulation of pro-cancer cytokines in the plasma fraction of stored packed red cells. J Gastrointest Surg. 2012 Mar; 16(3):460-8. PMID: 22246854.
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    156. Ellison MA, Ambruso DR, Silliman CC. Therapeutic options for transfusion related acute lung injury; the potential of the G2A receptor. Curr Pharm Des. 2012; 18(22):3255-9. PMID: 22621271.
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    157. Harr JN, Moore EE, Wohlauer MV, Fragoso M, Gamboni F, Liang X, Banerjee A, Silliman CC. Activated platelets in heparinized shed blood: the "second hit" of acute lung injury in trauma/hemorrhagic shock models. Shock. 2011 Dec; 36(6):595-603. PMID: 21841533.
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    158. Bercovitz RS, Kelher MR, Khan SY, Land KJ, Berry TH, Silliman CC. The pro-inflammatory effects of platelet contamination in plasma and mitigation strategies for avoidance. Vox Sang. 2012 May; 102(4):345-53. PMID: 22092073.
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    159. Wohlauer MV, Moore EE, Harr J, Gonzalez E, Fragoso M, Silliman CC. A standardized technique for performing thromboelastography in rodents. Shock. 2011 Nov; 36(5):524-6. PMID: 22005752.
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    160. Pezold M, Moore EE, Wohlauer M, Sauaia A, Gonzalez E, Banerjee A, Silliman CC. Viscoelastic clot strength predicts coagulation-related mortality within 15 minutes. Surgery. 2012 Jan; 151(1):48-54. PMID: 21899867.
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    161. Silliman CC, Dzieciatkowska M, Moore EE, Kelher MR, Banerjee A, Liang X, Land KJ, Hansen KC. Proteomic analyses of human plasma: Venus versus Mars. Transfusion. 2012 Feb; 52(2):417-24. PMID: 21880043.
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    162. Ball JB, Khan SY, McLaughlin NJ, Kelher MR, Nuss R, Cole L, Liang X, Silliman CC. A two-event in vitro model of acute chest syndrome: the role of secretory phospholipase A2 and neutrophils. Pediatr Blood Cancer. 2012 Mar; 58(3):399-405. PMID: 21793188.
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    163. Lee L, Kelher MR, Moore EE, Banerjee A, Silliman CC. Hypertonic saline inhibits arachidonic acid priming of the human neutrophil oxidase. J Surg Res. 2012 May 01; 174(1):24-8. PMID: 21816415.
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    164. Silliman CC, Moore EE, Kelher MR, Khan SY, Gellar L, Elzi DJ. Identification of lipids that accumulate during the routine storage of prestorage leukoreduced red blood cells and cause acute lung injury. Transfusion. 2011 Dec; 51(12):2549-54. PMID: 21615744.
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    165. Wohlauer MV, Moore EE, Droz NM, Harr J, Gonzalez E, Fragoso M, Silliman CC. Hemodilution is not critical in the pathogenesis of the acute coagulopathy of trauma. J Surg Res. 2012 Mar; 173(1):26-30. PMID: 21696767.
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    166. Micel L, Nuss R, Fenton L, Lovell M, Silliman CC. Non-palpable splenic enlargement as the etiology of abdominal pain in an adolescent with hemoglobin SC disease. Pediatr Blood Cancer. 2011 Aug; 57(2):352-3. PMID: 21584930.
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    167. Harr JN, Moore EE, Wohlauer MV, Droz N, Fragoso M, Banerjee A, Silliman CC. The acute coagulopathy of trauma is due to impaired initial thrombin generation but not clot formation or clot strength. J Surg Res. 2011 Oct; 170(2):319-24. PMID: 21550061.
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    168. Wohlauer MV, Moore EE, Harr J, Eun J, Fragoso M, Banerjee A, Silliman CC. Cross-transfusion of postshock mesenteric lymph provokes acute lung injury. J Surg Res. 2011 Oct; 170(2):314-8. PMID: 21550053.
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    169. Dzieciatkowska M, Wohlauer MV, Moore EE, Damle S, Peltz E, Campsen J, Kelher M, Silliman C, Banerjee A, Hansen KC. Proteomic analysis of human mesenteric lymph. Shock. 2011 Apr; 35(4):331-8. PMID: 21192285.
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    170. Eun JC, Moore EE, Banerjee A, Kelher MR, Khan SY, Elzi DJ, McLaughlin NJ, Silliman CC. Leukotriene b4 and its metabolites prime the neutrophil oxidase and induce proinflammatory activation of human pulmonary microvascular endothelial cells. Shock. 2011 Mar; 35(3):240-4. PMID: 20926984.
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    171. Tung JP, Fung YL, Nataatmadja M, Colebourne KI, Esmaeel HM, Wilson K, Barnett AG, Wood P, Silliman CC, Fraser JF. A novel in vivo ovine model of transfusion-related acute lung injury (TRALI). Vox Sang. 2011 Feb; 100(2):219-30. PMID: 20667072.
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    172. Benson AB, Burton JR, Austin GL, Biggins SW, Zimmerman MA, Kam I, Mandell S, Silliman CC, Rosen H, Moss M. Differential effects of plasma and red blood cell transfusions on acute lung injury and infection risk following liver transplantation. Liver Transpl. 2011 Feb; 17(2):149-58. PMID: 21280188.
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    173. Khan SY, McLaughlin NJ, Kelher MR, Eckels P, Gamboni-Robertson F, Banerjee A, Silliman CC. Lysophosphatidylcholines activate G2A inducing G(ai)?1-/G(aq/)11- Ca?(+) flux, G(??)-Hck activation and clathrin/?-arrestin-1/GRK6 recruitment in PMNs. Biochem J. 2010 Nov 15; 432(1):35-45. PMID: 20799926.
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    174. Middelburg RA, Van Stein D, Zupanska B, Uhrynowska M, Gajic O, Mu?iz-Diaz E, Galvez NN, Silliman CC, Krusius T, Wallis JP, Vandenbroucke JP, Bri?t E, Van Der Bom JG. Female donors and transfusion-related acute lung injury: A case-referent study from the International TRALI Unisex Research Group. Transfusion. 2010 Nov; 50(11):2447-54. PMID: 20529001.
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    175. Benson DD, Kelher MR, Meng X, Fullerton DA, Lee JH, Silliman CC, Barnett CC. Gender-specific transfusion affects tumor-associated neutrophil: macrophage ratios in murine pancreatic adenocarcinoma. J Gastrointest Surg. 2010 Oct; 14(10):1560-5. PMID: 20835771.
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    176. Silliman CC, Moore EE, Le T, Land KJ. One to one to what? Transfusion. 2010 Sep; 50(9):2066-7; author reply 2067-8. PMID: 21050228.
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    177. Barnett CC, Beck AW, Holloway SE, Kehler M, Schluterman MK, Brekken RA, Fleming JB, Silliman CC. Intravenous delivery of the plasma fraction of stored packed erythrocytes promotes pancreatic cancer growth in immunocompetent mice. Cancer. 2010 Aug 15; 116(16):3862-74. PMID: 20564095.
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    178. Benson AB, Austin GL, Berg M, McFann KK, Thomas S, Ramirez G, Rosen H, Silliman CC, Moss M. Transfusion-related acute lung injury in ICU patients admitted with gastrointestinal bleeding. Intensive Care Med. 2010 Oct; 36(10):1710-1717. PMID: 20658125.
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    179. Moore PK, Benson D, Kehler M, Moore EE, Fragoso M, Silliman CC, Barnett CC. The plasma fraction of stored erythrocytes augments pancreatic cancer metastasis in male versus female mice. J Surg Res. 2010 Nov; 164(1):23-7. PMID: 20828763.
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    180. Gonzalez E, Kashuk JL, Moore EE, Silliman CC. Differentiation of enzymatic from platelet hypercoagulability using the novel thrombelastography parameter delta (delta). J Surg Res. 2010 Sep; 163(1):96-101. PMID: 20605586.
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    181. Silliman CC, Stroncek D. Identification of the HNA-3a antigen. Blood. 2010 Mar 11; 115(10):1863. PMID: 20223931.
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    182. Silliman CC, Khan SY, Ball JB, Kelher MR, Marschner S. Mirasol Pathogen Reduction Technology treatment does not affect acute lung injury in a two-event in vivo model caused by stored blood components. Vox Sang. 2010 May; 98(4):525-30. PMID: 19951305.
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    183. Silliman CC, Kelher MR, Gamboni-Robertson F, Hamiel C, England KM, Dinarello CA, Wyman TH, Khan SY, McLaughlin NJ, Bercovitz RS, Banerjee A. Tumor necrosis factor-alpha causes release of cytosolic interleukin-18 from human neutrophils. Am J Physiol Cell Physiol. 2010 Mar; 298(3):C714-24. PMID: 19907017.
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    184. Fung YL, Silliman CC. The role of neutrophils in the pathogenesis of transfusion-related acute lung injury. Transfus Med Rev. 2009 Oct; 23(4):266-83. PMID: 19765516.
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    185. Silliman CC, Fung YL, Ball JB, Khan SY. Transfusion-related acute lung injury (TRALI): current concepts and misconceptions. Blood Rev. 2009 Nov; 23(6):245-55. PMID: 19699017.
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    186. Benson AB, Moss M, Silliman CC. Transfusion-related acute lung injury (TRALI): a clinical review with emphasis on the critically ill. Br J Haematol. 2009 Nov; 147(4):431-43. PMID: 19663827.
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    187. Peltz ED, Moore EE, Eckels PC, Damle SS, Tsuruta Y, Johnson JL, Sauaia A, Silliman CC, Banerjee A, Abraham E. HMGB1 is markedly elevated within 6 hours of mechanical trauma in humans. Shock. 2009 Jul; 32(1):17-22. PMID: 19533845.
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    188. Baumgartner JM, Nydam TL, Clarke JH, Banerjee A, Silliman CC, McCarter MD. Red blood cell supernatant potentiates LPS-induced proinflammatory cytokine response from peripheral blood mononuclear cells. J Interferon Cytokine Res. 2009 Jun; 29(6):333-8. PMID: 19441884.
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    189. Eckels PC, Banerjee A, Moore EE, McLaughlin NJ, Gries LM, Kelher MR, England KM, Gamboni-Robertson F, Khan SY, Silliman CC. Amantadine inhibits platelet-activating factor induced clathrin-mediated endocytosis in human neutrophils. Am J Physiol Cell Physiol. 2009 Oct; 297(4):C886-97. PMID: 19295175.
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    190. Roach JP, Moore EE, Partrick DA, Damle SS, Silliman CC, McIntyre RC, Banerjee A. Heme oxygenase-1 induction in macrophages by a hemoglobin-based oxygen carrier reduces endotoxin-stimulated cytokine secretion. Shock. 2009 Mar; 31(3):251-7. PMID: 18665050.
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    191. Kelher MR, Masuno T, Moore EE, Damle S, Meng X, Song Y, Liang X, Niedzinski J, Geier SS, Khan SY, Gamboni-Robertson F, Silliman CC. Plasma from stored packed red blood cells and MHC class I antibodies causes acute lung injury in a 2-event in vivo rat model. Blood. 2009 Feb 26; 113(9):2079-87. PMID: 19131548.
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    192. Fung YL, Silliman CC, Minchinton RM, Wood P, Fraser JF. Cardiopulmonary bypass induces enduring alterations to host neutrophil physiology: a single-center longitudinal observational study. Shock. 2008 Dec; 30(6):642-8. PMID: 18496241.
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    193. Baumgartner JM, Silliman CC, Moore EE, Banerjee A, McCarter MD. Stored red blood cell transfusion induces regulatory T cells. J Am Coll Surg. 2009 Jan; 208(1):110-9. PMID: 19228512.
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    194. Kanter J, Khan SY, Kelher M, Gore L, Silliman CC. Oncogenic and angiogenic growth factors accumulate during routine storage of apheresis platelet concentrates. Clin Cancer Res. 2008 Jun 15; 14(12):3942-7. PMID: 18559616.
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    195. McLaughlin NJ, Banerjee A, Khan SY, Lieber JL, Kelher MR, Gamboni-Robertson F, Sheppard FR, Moore EE, Mierau GW, Elzi DJ, Silliman CC. Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3-kinase in human neutrophils. J Immunol. 2008 Jun 15; 180(12):8192-203. PMID: 18523285.
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    196. Dineen SP, Roland CL, Toombs JE, Kelher M, Silliman CC, Brekken RA, Barnett CC. The acellular fraction of stored platelets promotes tumor cell invasion. J Surg Res. 2009 May 01; 153(1):132-7. PMID: 18541268.
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    197. Silliman CC. The transfusion of pre storage leukoreduced packed red blood cells to injured patients. Crit Care Med. 2008 May; 36(5):1661-2. PMID: 18448929.
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    198. Fung YL, Fraser JF, Wood P, Minchinton RM, Silliman CC. The systemic inflammatory response syndrome induces functional changes and relative hyporesponsiveness in neutrophils. J Crit Care. 2008 Dec; 23(4):542-9. PMID: 19056020.
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    199. Jordan JR, Moore EE, Sarin EL, Damle SS, Kashuk SB, Silliman CC, Banerjee A. Arachidonic acid in postshock mesenteric lymph induces pulmonary synthesis of leukotriene B4. J Appl Physiol (1985). 2008 Apr; 104(4):1161-6. PMID: 18276905.
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    200. Silliman CC. High-volume transfusion from male-only versus female donor plasma and hypoxemia in the critically ill. Crit Care Med. 2007 Jul; 35(7):1775. PMID: 17581360.
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    201. Silliman CC, Curtis BR, Kopko PM, Khan SY, Kelher MR, Schuller RM, Sannoh B, Ambruso DR. Donor antibodies to HNA-3a implicated in TRALI reactions prime neutrophils and cause PMN-mediated damage to human pulmonary microvascular endothelial cells in a two-event in vitro model. Blood. 2007 Feb 15; 109(4):1752-5. PMID: 17038531.
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    202. Khan SY, Kelher MR, Heal JM, Blumberg N, Boshkov LK, Phipps R, Gettings KF, McLaughlin NJ, Silliman CC. Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury. Blood. 2006 Oct 01; 108(7):2455-62. PMID: 16772606.
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    203. McLaughlin NJ, Banerjee A, Kelher MR, Gamboni-Robertson F, Hamiel C, Sheppard FR, Moore EE, Silliman CC. Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation. J Immunol. 2006 Jun 01; 176(11):7039-50. PMID: 16709866.
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    204. Silliman CC. The two-event model of transfusion-related acute lung injury. Crit Care Med. 2006 May; 34(5 Suppl):S124-31. PMID: 16617256.
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    205. Silliman CC, McLaughlin NJ. Transfusion-related acute lung injury. Blood Rev. 2006 May; 20(3):139-59. PMID: 16360246.
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    206. Wang M, Hays T, Ambruso DR, Silliman CC, Dickey WC. Hemolytic disease of the newborn caused by a high titer anti-group B IgG from a group A mother. Pediatr Blood Cancer. 2005 Nov; 45(6):861-2. PMID: 16007582.
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    207. Sheppard FR, Kelher MR, Moore EE, McLaughlin NJ, Banerjee A, Silliman CC. Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation. J Leukoc Biol. 2005 Nov; 78(5):1025-42. PMID: 16204621.
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    208. Silliman CC, Wang M. The merits of in vitro versus in vivo modeling in investigation of the immune system. Environ Toxicol Pharmacol. 2006 Feb; 21(2):123-34. PMID: 21783649.
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    209. Silliman CC, Kelher M. The role of endothelial activation in the pathogenesis of transfusion-related acute lung injury. Transfusion. 2005 Aug; 45(2 Suppl):109S-116S. PMID: 16086797.
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    210. Karamlou T, Schultz JM, Silliman C, Sandquist C, You J, Shen I, Ungerleider RM. Using a miniaturized circuit and an asanguineous prime to reduce neutrophil-mediated organ dysfunction following infant cardiopulmonary bypass. Ann Thorac Surg. 2005 Jul; 80(1):6-13; discussion 13-4. PMID: 15975331.
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    211. Toy P, Popovsky MA, Abraham E, Ambruso DR, Holness LG, Kopko PM, McFarland JG, Nathens AB, Silliman CC, Stroncek D. Transfusion-related acute lung injury: definition and review. Crit Care Med. 2005 Apr; 33(4):721-6. PMID: 15818095.
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    212. Sheppard FR, Moore EE, McLaughlin N, Kelher M, Johnson JL, Silliman CC. Clinically relevant osmolar stress inhibits priming-induced PMN NADPH oxidase subunit translocation. J Trauma. 2005 Apr; 58(4):752-7; discussion 757. PMID: 15824651.
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    213. Karamlou T, Hickey E, Silliman CC, Shen I, Ungerleider RM. Reducing risk in infant cardiopulmonary bypass: the use of a miniaturized circuit and a crystalloid prime improves cardiopulmonary function and increases cerebral blood flow. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2005; 3-11. PMID: 15818352.
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    214. Silliman CC, Ambruso DR, Boshkov LK. Transfusion-related acute lung injury. Blood. 2005 Mar 15; 105(6):2266-73. PMID: 15572582.
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    215. Sarin EL, Moore EE, Moore JB, Masuno T, Moore JL, Banerjee A, Silliman CC. Systemic neutrophil priming by lipid mediators in post-shock mesenteric lymph exists across species. J Trauma. 2004 Nov; 57(5):950-4. PMID: 15580016.
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    216. Covin RB, Ambruso DR, England KM, Kelher MR, Mehdizadehkashi Z, Boshkov LK, Masuno T, Moore EE, Kim FJ, Silliman CC. Hypotension and acute pulmonary insufficiency following transfusion of autologous red blood cells during surgery: a case report and review of the literature. Transfus Med. 2004 Oct; 14(5):375-83. PMID: 15500457.
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    217. Sheppard FR, Moore EE, Johnson JL, Cheng AM, McLaughlin N, Silliman CC. Transfusion-induced leukocyte IL-8 gene expression is avoided by the use of human polymerized hemoglobin. J Trauma. 2004 Oct; 57(4):720-4; discussion 724-5. PMID: 15514524.
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    218. Silliman CC, Moore EE, Johnson JL, Gonzalez RJ, Biffl WL. Transfusion of the injured patient: proceed with caution. Shock. 2004 Apr; 21(4):291-9. PMID: 15179127.
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    219. Goodnough LT, Hewitt PE, Silliman CC. Joint ASH and AABB educational session. Hematology Am Soc Hematol Educ Program. 2004; 457-72. PMID: 15561698.
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    220. Kelher MR, Ambruso DR, Elzi DJ, Anderson SM, Paterson AJ, Thurman GW, Silliman CC. Formyl-Met-Leu-Phe induces calcium-dependent tyrosine phosphorylation of Rel-1 in neutrophils. Cell Calcium. 2003 Dec; 34(6):445-55. PMID: 14572803.
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    221. Rezende-Neto JB, Moore EE, Masuno T, Moore PK, Johnson JL, Sheppard FR, Cunha-Melo JR, Silliman CC. The abdominal compartment syndrome as a second insult during systemic neutrophil priming provokes multiple organ injury. Shock. 2003 Oct; 20(4):303-8. PMID: 14501942.
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    222. Silliman CC, Tyson RW, Wei Q, Karrer FG, Davies SM, Blake M, McGavran L. Acute Philadelphia chromosome-positive leukemia in an adolescent boy after liver transplantation. J Pediatr Hematol Oncol. 2003 Jul; 25(7):565-8. PMID: 12847326.
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    223. Biffl WL, Carnaggio R, Moore EE, Ciesla DJ, Johnson JL, Silliman CC. Clinically relevant hypertonicity prevents stored blood- and lipid-mediated delayed neutrophil apoptosis independent of p38 MAPK or caspase-3 activation. Surgery. 2003 Jul; 134(1):86-91. PMID: 12874587.
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    224. Silliman CC, Bjornsen AJ, Wyman TH, Kelher M, Allard J, Bieber S, Voelkel NF. Plasma and lipids from stored platelets cause acute lung injury in an animal model. Transfusion. 2003 May; 43(5):633-40. PMID: 12702186.
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    225. Silliman CC, Elzi DJ, Ambruso DR, Musters RJ, Hamiel C, Harbeck RJ, Paterson AJ, Bjornsen AJ, Wyman TH, Kelher M, England KM, McLaughlin-Malaxecheberria N, Barnett CC, Aiboshi J, Bannerjee A. Lysophosphatidylcholines prime the NADPH oxidase and stimulate multiple neutrophil functions through changes in cytosolic calcium. J Leukoc Biol. 2003 Apr; 73(4):511-24. PMID: 12660226.
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    226. Gonzalez RJ, Moore EE, Ciesla DJ, Nieto JR, Johnson JL, Silliman CC. Post-hemorrhagic shock mesenteric lymph activates human pulmonary microvascular endothelium for in vitro neutrophil-mediated injury: the role of intercellular adhesion molecule-1. J Trauma. 2003 Feb; 54(2):219-23. PMID: 12579043.
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    227. Johnson JL, Moore EE, Gonzalez RJ, Fedel N, Partrick DA, Silliman CC. Alteration of the postinjury hyperinflammatory response by means of resuscitation with a red cell substitute. J Trauma. 2003 Jan; 54(1):133-9; discussion 139-40. PMID: 12544908.
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    228. Calkins CM, Bensard DD, Moore EE, McIntyre RC, Silliman CC, Biffl W, Harken AH, Partrick DA, Offner PJ. The injured child is resistant to multiple organ failure: a different inflammatory response? J Trauma. 2002 Dec; 53(6):1058-63. PMID: 12478028.
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    229. Silliman CC, Moore EE, Zallen G, Gonzalez R, Johnson JL, Elzi DJ, Meng X, Hanasaki K, Ishizaki J, Arita H, Ao L, England KM, Banerjee A. Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesion. Am J Physiol Cell Physiol. 2002 Oct; 283(4):C1102-13. PMID: 12225974.
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    230. Wyman TH, Dinarello CA, Banerjee A, Gamboni-Robertson F, Hiester AA, England KM, Kelher M, Silliman CC. Physiological levels of interleukin-18 stimulate multiple neutrophil functions through p38 MAP kinase activation. J Leukoc Biol. 2002 Aug; 72(2):401-9. PMID: 12149432.
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    231. Gonzalez RJ, Moore EE, Ciesla DJ, Neto JR, Biffl WL, Silliman CC. Hyperosmolarity abrogates neutrophil cytotoxicity provoked by post-shock mesenteric lymph. Shock. 2002 Jul; 18(1):29-32. PMID: 12095130.
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    232. McManus MC, Silliman C, Koyle MA. Combined endoscopic resection and brachytherapy for recurrent intrapelvic Wilms tumor. J Urol. 2002 Jun; 167(6):2540. PMID: 11992083.
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    233. Gonzalez RJ, Moore EE, Ciesla DJ, Biffl WL, Johnson JL, Silliman CC. Mesenteric lymph is responsible for post-hemorrhagic shock systemic neutrophil priming. J Trauma. 2001 Dec; 51(6):1069-72. PMID: 11740254.
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    234. Barnett CC, Moore EE, Silliman CC, Abdalla EK, Partrick DA, Curley SA. Cytosolic phospholipase A(2)-mediated ICAM-1 expression is calcium dependent. J Surg Res. 2001 Aug; 99(2):307-10. PMID: 11469902.
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    235. Ciesla DJ, Moore EE, Biffl WL, Gonzalez RJ, Silliman CC. Hypertonic saline attenuation of the neutrophil cytotoxic response is reversed upon restoration of normotonicity and reestablished by repeated hypertonic challenge. Surgery. 2001 May; 129(5):567-75. PMID: 11331449.
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    236. Lenahan SE, Domen RE, Silliman CC, Kingsley CP, Romano PJ. Transfusion-related acute lung injury secondary to biologically active mediators. Arch Pathol Lab Med. 2001 Apr; 125(4):523-6. PMID: 11260628.
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    237. Aiboshi J, Moore EE, Ciesla DJ, Silliman CC. Blood transfusion and the two-insult model of post-injury multiple organ failure. Shock. 2001 Apr; 15(4):302-6. PMID: 11303730.
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    238. Biffl WL, Moore EE, Offner PJ, Ciesla DJ, Gonzalez RJ, Silliman CC. Plasma from aged stored red blood cells delays neutrophil apoptosis and primes for cytotoxicity: abrogation by poststorage washing but not prestorage leukoreduction. J Trauma. 2001 Mar; 50(3):426-31; discussion 432. PMID: 11265021.
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    239. Johnson JL, Moore EE, Offner PJ, Partrick DA, Tamura DY, Zallen G, Silliman CC. Resuscitation with a blood substitute abrogates pathologic postinjury neutrophil cytotoxic function. J Trauma. 2001 Mar; 50(3):449-55; discussion 456. PMID: 11265023.
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    240. Biffl WL, West KE, Moore EE, Gonzalez RJ, Carnaggio R, Offner PJ, Silliman CC. Neutrophil apoptosis is delayed by trauma patients' plasma via a mechanism involving proinflammatory phospholipids and protein kinase C. Surg Infect (Larchmt). 2001; 2(4):289-93; discussion 294-5. PMID: 12593704.
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    241. Ciesla DJ, Moore EE, Gonzalez RJ, Biffl WL, Silliman CC. Hypertonic saline inhibits neutrophil (PMN) priming via attenuation of p38 MAPK signaling. Shock. 2000 Sep; 14(3):265-9; discussion 269-70. PMID: 11028541.
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    242. Gonzalez RJ, Moore EE, Biffl WL, Ciesla DJ, Silliman CC. The lipid fraction of post-hemorrhagic shock mesenteric lymph (PHSML) inhibits neutrophil apoptosis and enhances cytotoxic potential. Shock. 2000 Sep; 14(3):404-8. PMID: 11028564.
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    243. Zimbelman J, Silliman CC, Ambruso DR. Transfusion-related acute lung injury and granulocytes from stored packed RBCs. Transfusion. 2000 May; 40(5):614-5. PMID: 10827271.
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    244. Ciesla DJ, Moore EE, Zallen G, Biffl WL, Silliman CC. Hypertonic saline attenuation of polymorphonuclear neutrophil cytotoxicity: timing is everything. J Trauma. 2000 Mar; 48(3):388-95. PMID: 10744274.
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    245. Partrick DA, Moore EE, Offner PJ, Meldrum DR, Tamura DY, Johnson JL, Silliman CC. Maximal human neutrophil priming for superoxide production and elastase release requires p38 mitogen-activated protein kinase activation. Arch Surg. 2000 Feb; 135(2):219-25. PMID: 10668885.
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    246. Zallen G, Moore EE, Ciesla DJ, Brown M, Biffl WL, Silliman CC. Stored red blood cells selectively activate human neutrophils to release IL-8 and secretory PLA2. Shock. 2000 Jan; 13(1):29-33. PMID: 10638666.
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    247. Zallen G, Moore EE, Tamura DY, Johnson JL, Biffl WL, Silliman CC. Hypertonic saline resuscitation abrogates neutrophil priming by mesenteric lymph. J Trauma. 2000 Jan; 48(1):45-8. PMID: 10647564.
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    248. Zallen G, Offner PJ, Moore EE, Blackwell J, Ciesla DJ, Gabriel J, Denny C, Silliman CC. Age of transfused blood is an independent risk factor for postinjury multiple organ failure. Am J Surg. 1999 Dec; 178(6):570-2. PMID: 10670874.
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    249. Johnson JL, Moore EE, Partrick DA, Tamura DY, Zallen G, Elzi DJ, Silliman CC, Patrick DA. Extracellular signal-related kinase 1/2 and p38 mitogen-activated protein kinase pathways serve opposite roles in neutrophil cytotoxicity. Arch Surg. 1999 Oct; 134(10):1074-8. PMID: 10522849.
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    250. Partrick DA, Moore EE, Fullerton DA, Barnett CC, Meldrum DR, Silliman CC. Cardiopulmonary bypass renders patients at risk for multiple organ failure via early neutrophil priming and late neutrophil disability. J Surg Res. 1999 Sep; 86(1):42-9. PMID: 10452867.
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    251. Biffl WL, Moore EE, Zallen G, Johnson JL, Gabriel J, Offner PJ, Silliman CC. Neutrophils are primed for cytotoxicity and resist apoptosis in injured patients at risk for multiple organ failure. Surgery. 1999 Aug; 126(2):198-202. PMID: 10455884.
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    252. Silliman CC. Transfusion-related acute lung injury. Transfus Med Rev. 1999 Jul; 13(3):177-86. PMID: 10425690.
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    253. Zallen G, Moore EE, Johnson JL, Tamura DY, Ciesla DJ, Silliman CC. Posthemorrhagic shock mesenteric lymph primes circulating neutrophils and provokes lung injury. J Surg Res. 1999 May 15; 83(2):83-8. PMID: 10329099.
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    254. Johnson JL, Moore EE, Hiester AA, Tamura DY, Zallen G, Silliman CC. Disparities in the respiratory burst between human and rat neutrophils. J Leukoc Biol. 1999 Feb; 65(2):211-6. PMID: 10088604.
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    255. Zallen G, Moore EE, Johnson JL, Tamura DY, Shames B, Biffl WL, Silliman CC. Postinjury suppression of human neutrophil cytokine production results from the stabilization of inhibitory kappaB. Shock. 1999 Feb; 11(2):77-81. PMID: 10030791.
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    256. Zallen G, Moore EE, Johnson JL, Tamura DY, Aiboshi J, Biffl WL, Silliman CC. Circulating postinjury neutrophils are primed for the release of proinflammatory cytokines. J Trauma. 1999 Jan; 46(1):42-8. PMID: 9932682.
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    257. Leavey PJ, Sellins KS, Thurman G, Elzi D, Hiester A, Silliman CC, Zerbe G, Cohen JJ, Ambruso DR. In vivo treatment with granulocyte colony-stimulating factor results in divergent effects on neutrophil functions measured in vitro. Blood. 1998 Dec 01; 92(11):4366-74. PMID: 9834243.
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    258. Zallen G, Moore EE, Johnson JL, Tamura DY, Barkin M, Stockinger H, Silliman CC. New mechanisms by which secretory phospholipase A2 stimulates neutrophils to provoke the release of cytotoxic agents. Arch Surg. 1998 Nov; 133(11):1229-33. PMID: 9820355.
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    259. Maloney JP, Silliman CC, Ambruso DR, Wang J, Tuder RM, Voelkel NF. In vitro release of vascular endothelial growth factor during platelet aggregation. Am J Physiol. 1998 09; 275(3):H1054-61. PMID: 9724313.
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    260. Silliman CC, McGavran L, Wei Q, Miller LA, Li S, Hunger SP. Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides. Leukemia. 1998 Sep; 12(9):1404-10. PMID: 9737689.
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    261. Garrington T, Silliman CC, Bensard D, Ingram JD. Response to successful management of a child with asparaginase- induced hemorrhagic pancreatitis. Med Pediatr Oncol. 1998 Aug; 31(2):127. PMID: 9714616.
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    262. Tamura DY, Moore EE, Johnson JL, Zallen G, Aiboshi J, Silliman CC. p38 mitogen-activated protein kinase inhibition attenuates intercellular adhesion molecule-1 up-regulation on human pulmonary microvascular endothelial cells. Surgery. 1998 Aug; 124(2):403-7; discussion 408. PMID: 9706165.
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    263. Tamura DY, Moore EE, Partrick DA, Johnson JL, Zallen G, Silliman CC. Primed neutrophils require phosphatidic acid for maximal receptor-activated elastase release. J Surg Res. 1998 Jun; 77(1):71-4. PMID: 9698536.
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    264. Barnett CC, Moore EE, Mierau GW, Partrick DA, Biffl WL, Elzi DJ, Silliman CC. ICAM-1-CD18 interaction mediates neutrophil cytotoxicity through protease release. Am J Physiol. 1998 06; 274(6):C1634-44. PMID: 9611129.
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    265. Partrick DA, Moore EE, Offner PJ, Johnson JL, Tamura DY, Silliman CC. Hypertonic saline activates lipid-primed human neutrophils for enhanced elastase release. J Trauma. 1998 Apr; 44(4):592-7; discussion 598. PMID: 9555828.
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    266. Johnson JL, Moore EE, Tamura DY, Zallen G, Biffl WL, Silliman CC. Interleukin-6 augments neutrophil cytotoxic potential via selective enhancement of elastase release. J Surg Res. 1998 Apr; 76(1):91-4. PMID: 9695746.
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    267. Silliman CC, Voelkel NF, Allard JD, Elzi DJ, Tuder RM, Johnson JL, Ambruso DR. Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model. J Clin Invest. 1998 Apr 01; 101(7):1458-67. PMID: 9525989.
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    268. Gago LA, Moore EE, Partrick DA, Sauaia A, Davis CM, Toal TR, Silliman CC. Secretory phospholipase A2 cleavage of intravasated bone marrow primes human neutrophils. J Trauma. 1998 Apr; 44(4):660-4. PMID: 9555838.
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    269. Tamura DY, Moore EE, Partrick DA, Johnson JL, Offner PJ, Silliman CC. Prostaglandin E1 attenuates cytotoxic mechanisms of primed neutrophils. Shock. 1998 Mar; 9(3):171-6. PMID: 9525323.
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    270. Tamura DY, Moore EE, Partrick DA, Johnson JL, Offner PJ, Harbeck RJ, Silliman CC. Clinically relevant concentrations of ethanol attenuate primed neutrophil bactericidal activity. J Trauma. 1998 Feb; 44(2):320-4. PMID: 9498504.
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    271. Garrington T, Bensard D, Ingram JD, Silliman CC. Successful management with octreotide of a child with L-asparaginase induced hemorrhagic pancreatitis. Med Pediatr Oncol. 1998 Feb; 30(2):106-9. PMID: 9403019.
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    272. Elzi DJ, Hiester AA, Silliman CC. Receptor-mediated calcium entry is required for maximal effects of platelet activating factor primed responses in human neutrophils. Biochem Biophys Res Commun. 1997 Nov 26; 240(3):763-5. PMID: 9398641.
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    273. Partrick DA, Moore EE, Offner PJ, Barnett CC, Barkin M, Silliman CC. Nitric oxide attenuates platelet-activating factor priming for elastase release in human neutrophils via a cyclic guanosine monophosphate-dependent pathway. Surgery. 1997 Aug; 122(2):196-202; discussion 202-3. PMID: 9288123.
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    274. Partrick DA, Moore EE, Moore FA, Barnett CC, Silliman CC. Lipid mediators up-regulate CD11b and prime for concordant superoxide and elastase release in human neutrophils. J Trauma. 1997 Aug; 43(2):297-302; discussion 302-3. PMID: 9291376.
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    275. Barnett CC, Moore EE, Partrick DA, Silliman CC. Beta-adrenergic stimulation down-regulates neutrophil priming for superoxide generation, but not elastase release. J Surg Res. 1997 Jul 01; 70(2):166-70. PMID: 9245567.
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    276. Silliman CC, Paterson AJ, Dickey WO, Stroneck DF, Popovsky MA, Caldwell SA, Ambruso DR. The association of biologically active lipids with the development of transfusion-related acute lung injury: a retrospective study. Transfusion. 1997 Jul; 37(7):719-26. PMID: 9225936.
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    277. Botha AJ, Moore FA, Moore EE, Peterson VM, Silliman CC, Goode AW. Sequential systemic platelet-activating factor and interleukin 8 primes neutrophils in patients with trauma at risk of multiple organ failure. Br J Surg. 1996 Oct; 83(10):1407-12. PMID: 8944457.
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    278. Partrick DA, Moore FA, Moore EE, Barnett CC, Silliman CC. Neutrophil priming and activation in the pathogenesis of postinjury multiple organ failure. New Horiz. 1996 May; 4(2):194-210. PMID: 8774796.
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    279. Biffl WL, Moore EE, Moore FA, Barnett CC, Silliman CC, Peterson VM. Interleukin-6 stimulates neutrophil production of platelet-activating factor. J Leukoc Biol. 1996 Apr; 59(4):569-74. PMID: 8613706.
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    280. Silliman CC, Dickey WO, Paterson AJ, Thurman GW, Clay KL, Johnson CA, Ambruso DR. Analysis of the priming activity of lipids generated during routine storage of platelet concentrates. Transfusion. 1996 Feb; 36(2):133-9. PMID: 8614963.
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    281. Silliman CC, Cusack NA, Swanson NJ, Ghaffarifar S, Ambruso DR. Platelets and neutrophils from healthy term neonates exhibit increased levels of immunoglobulins. Pediatr Res. 1995 Dec; 38(6):993-7. PMID: 8618806.
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    282. Silliman CC, Clay KL, Thurman GW, Johnson CA, Ambruso DR. Partial characterization of lipids that develop during the routine storage of blood and prime the neutrophil NADPH oxidase. J Lab Clin Med. 1994 Nov; 124(5):684-94. PMID: 7964126.
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    283. Silliman CC, Haase GM, Strain JD, Luckey DW, Blake MA, Caldwell SA, Wilson HL, Odom LF, Ater JL, Greffe BS. Indications for surgical intervention for gastrointestinal emergencies in children receiving chemotherapy. Cancer. 1994 Jul 01; 74(1):203-16. PMID: 8004577.
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    284. Silliman CC, Tedder D, Ogle JW, Simon J, Kleinschmidt-DeMasters BK, Manco-Johnson M, Levin MJ. Unsuspected varicella-zoster virus encephalitis in a child with acquired immunodeficiency syndrome. J Pediatr. 1993 Sep; 123(3):418-22. PMID: 8394901.
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    285. Silliman CC, Mierau GW, Strain JD, White Y, McNeely L, Wilson H, McGavran L, Cullen JW. Peripheral neuroepithelioma of the soft tissues. A retrospective analysis of fifteen pediatric patients. Am J Pediatr Hematol Oncol. 1993 Aug; 15(3):299-305. PMID: 8328643.
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    286. Silliman CC, Peterson VM, Mellman DL, Dixon DJ, Hambidge KM, Lane PA. Iron chelation by deferoxamine in sickle cell patients with severe transfusion-induced hemosiderosis: a randomized, double-blind study of the dose-response relationship. J Lab Clin Med. 1993 Jul; 122(1):48-54. PMID: 8320490.
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    287. Silliman CC, Johnson CA, Clay KL, Thurman GW, Ambruso DR. Compounds biologically similar to platelet activating factor are present in stored blood components. Lipids. 1993 May; 28(5):415-8. PMID: 8316049.
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    288. Silliman CC, Beckman BS, Jeter JR. Changes in protein kinase activity within 30 min of induced differentiation in Friend erythroleukemia cells. Biochem Cell Biol. 1993 Jan-Feb; 71(1-2):1-6. PMID: 8392352.
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    289. Silliman CC, Lawellin DW, Lohr JA, Rodgers BM, Donowitz LG. Paecilomyces lilacinus infection in a child with chronic granulomatous disease. J Infect. 1992 Mar; 24(2):191-5. PMID: 1533235.
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    290. Silliman CC, Thurman GW, Ambruso DR. Stored blood components contain agents that prime the neutrophil NADPH oxidase through the platelet-activating-factor receptor. Vox Sang. 1992; 63(2):133-6. PMID: 1332255.
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    291. Silliman CC, Ford DM, Lane PA. Hemolytic uremic syndrome complicated by vitamin K deficiency. Am J Pediatr Hematol Oncol. 1991; 13(2):176-8. PMID: 2069228.
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    292. Silliman CC, Sturgill TW. Phosphorylation of microtubule-associated protein 2 by MAP kinase primarily involves the projection domain. Biochem Biophys Res Commun. 1989 May 15; 160(3):993-8. PMID: 2543402.
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    293. Silliman CC, Leonard GL, Lacorte WS, Sutherland CM. Postradiation chondroblastic sarcoma of bone: case report and review of the literature. J La State Med Soc. 1987 Dec; 139(12):31-5. PMID: 3320271.
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