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Search Results to Rasika Ann Mathias

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One or more keywords matched the following items that are connected to Mathias, Rasika

Item TypeName
Academic Article Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.
Concept Humans
Concept Chromosomes, Human, Pair 18
Concept Chromosomes, Human, Pair 12
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Concept Chromosomes, Human, Pair 14
Concept Chromosomes, Human, Pair 11
Concept Chromosomes, Human, Pair 1
Concept Chromosomes, Human, Pair 19
Concept Genome, Human
Concept Chromosomes, Human, Pair 20
Concept Herpesvirus 1, Human
Concept Chromosomes, Human
Concept Chromosomes, Human, Pair 4
Concept Chromosomes, Human, Pair 5
Concept Chromosomes, Human, Pair 21
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Concept Chromosomes, Human, Pair 10
Concept Chromosomes, Human, Pair 6
Concept Herpesvirus 6, Human
Concept Chromosomes, Human, Pair 9
Concept Herpesvirus 4, Human
Academic Article Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene.
Academic Article Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.
Academic Article Atopic dermatitis complicated by eczema herpeticum is associated with HLA B7 and reduced interferon-?-producing CD8+ T cells.
Academic Article Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases.
Academic Article Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans.
Academic Article Admixture mapping identifies a quantitative trait locus associated with FEV1/FVC in the COPDGene Study.
Academic Article A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q.
Academic Article Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema.
Academic Article Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypes.
Academic Article Leptin receptor polymorphisms and lung function decline in COPD.
Academic Article Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil.
Academic Article Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma.
Academic Article A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.
Academic Article Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD.
Academic Article Aquaporin 5 polymorphisms and rate of lung function decline in chronic obstructive pulmonary disease.
Academic Article A genome-wide association study on African-ancestry populations for asthma.
Academic Article Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability.
Academic Article Genome-wide association study of lung function phenotypes in a founder population.
Academic Article Gene encoding Duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations.
Academic Article Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans.
Academic Article Variants of DENND1B associated with asthma in children.
Academic Article Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population.
Academic Article Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma.
Academic Article Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.
Academic Article TSLP polymorphisms are associated with asthma in a sex-specific fashion.
Academic Article FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.
Academic Article Telomerase mutations in smokers with severe emphysema.
Academic Article Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma.
Academic Article CD14, a key candidate gene associated with a specific immune response to cockroach.
Academic Article Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects.
Academic Article Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma.
Academic Article Sensitive detection of chromosomal segments of distinct ancestry in admixed populations.
Academic Article Physician-derived asthma diagnoses made on the basis of questionnaire data are in good agreement with interview-based diagnoses and are not affected by objective tests.
Academic Article African ancestry is a risk factor for asthma and high total IgE levels in African admixed populations.
Academic Article Recombination rates in admixed individuals identified by ancestry-based inference.
Academic Article African and non-African admixture components in African Americans and an African Caribbean population.
Academic Article Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
Academic Article Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
Academic Article Platelet kainate receptor signaling promotes thrombosis by stimulating cyclooxygenase activation.
Academic Article Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis.
Academic Article Ageing, menopause, and ischaemic heart disease mortality in England, Wales, and the United States: modelling study of national mortality data.
Academic Article A novel promoter polymorphism in the gene encoding complement component 5 receptor 1 on chromosome 19q13.3 is not associated with asthma and atopy in three independent populations.
Academic Article Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies.
Academic Article A study of contemporary levels and temporal trends in inbreeding in the Tangier Island, Virginia, population using pedigree data and isonymy.
Academic Article A common variant in the Von Willebrand factor gene is associated with multiple functional consequences.
Academic Article Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families.
Academic Article Targeted deep resequencing identifies coding variants in the PEAR1 gene that play a role in platelet aggregation.
Academic Article Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1.
Academic Article Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
Academic Article Rage gene promoter polymorphisms and diabetic retinopathy in a clinic-based population from South India.
Academic Article Investigation of altering single-nucleotide polymorphism density on the power to detect trait loci and frequency of false positive in nonparametric linkage analyses of qualitative traits.
Academic Article Application of the regression of offspring on mid-parent method to detect associations between single-nucleotide polymorphisms and the beta 2 electroencephalogram phenotype in the COGA data.
Academic Article Identification of tag single-nucleotide polymorphisms in regions with varying linkage disequilibrium.
Academic Article Proportion positive for Epstein-Barr virus, cytomegalovirus, human herpesvirus 6, Toxoplasma, and human immunodeficiency virus types 1 and 2 in heterophile-negative patients with an absolute lymphocytosis or an instrument-generated atypical lymphocyte flag.
Academic Article Genome-wide interaction studies reveal sex-specific asthma risk alleles.
Academic Article DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver.
Academic Article On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies.
Academic Article Heritability of platelet function in families with premature coronary artery disease.
Academic Article Testing for gene-gene interaction controlling total IgE in families from Barbados: evidence of sensitivity regarding linkage heterogeneity among families.
Academic Article Adaptive evolution of the FADS gene cluster within Africa.
Academic Article The robustness of generalized estimating equations for association tests in extended family data.
Academic Article Association of lipoprotein lipase Hind III and Ser 447 Ter polymorphisms with dyslipidemia in Asian Indians.
Academic Article Evidence for asthma susceptibility genes on chromosome 11 in an African-American population.
Academic Article A common variant in the CDKN2B gene on chromosome 9p21 protects against coronary artery disease in Americans of African ancestry.
Academic Article Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.
Academic Article Genome-wide linkage analyses of total serum IgE using variance components analysis in asthmatic families.
Academic Article The Gene, Environment Association Studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions.
Academic Article Greater collagen-induced platelet aggregation following cyclooxygenase 1 inhibition predicts incident acute coronary syndromes.
Academic Article Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis.
Academic Article A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
Academic Article Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.
Academic Article Comparison of SNP tagging methods using empirical data: association study of 713 SNPs on chromosome 12q14.3-12q24.21 for asthma and total serum IgE in an African Caribbean population.
Academic Article Resequencing candidate genes implicates rare variants in asthma susceptibility.
Academic Article Independent metabolic syndrome variants predict new-onset coronary artery disease.
Academic Article Introduction to genetics and genomics in asthma: genetics of asthma.
Academic Article An extension of the regression of offspring on mid-parent to test for association and estimate locus-specific heritability: the revised ROMP method.
Academic Article Genome partitioning of genetic variation for complex traits using common SNPs.
Academic Article The impact of FADS genetic variants on ?6 polyunsaturated fatty acid metabolism in African Americans.
Academic Article Comparison of sib pair-based approaches for identifying quantitative trait loci underlying asthma in the Busselton families.
Academic Article Segregation analysis of restless legs syndrome: possible evidence for a major gene in a family study using blinded diagnoses.
Academic Article A combined genome-wide linkage and association approach to find susceptibility loci for platelet function phenotypes in European American and African American families with coronary artery disease.
Academic Article Consistency of genetic analyses in longitudinal data: observations from the GAW13 Framingham Heart Study data.
Academic Article Model comparison and the likelihood ratio test in segregation analysis.
Academic Article Detectable clonal mosaicism from birth to old age and its relationship to cancer.
Academic Article Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome.
Academic Article Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).
Academic Article Inheritance of total serum IgE in the isolated Tangier Island population from Virginia: complexities associated with genealogical depth of pedigrees in segregation analyses.
Academic Article Comparison of year-of-exam- and age-matched estimates of heritability in the Framingham Heart Study data.
Academic Article On the threshold from genome-wide association studies to whole-genome sequencing. Looking for signal in all the right places.
Academic Article Heritability of quantitative traits associated with type 2 diabetes mellitus in large multiplex families from South India.
Academic Article Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression.
Academic Article Complete steroid avoidance is effective and safe in children with renal transplants: a multicenter randomized trial with three-year follow-up.
Academic Article Genome scan for loci linked to mite sensitivity: the Collaborative Study on the Genetics of Asthma (CSGA).
Academic Article Possible linkage of alcoholism, monoamine oxidase activity and P300 amplitude to markers on chromosome 12q24.
Academic Article Environmental covariates: effects on the power of sib-pair linkage methods.
Academic Article Genome-wide association study of platelet aggregation in African Americans.
Academic Article Exome Sequencing of Phenotypic Extremes Identifies CAV2 and TMC6 as Interacting Modifiers of Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis.
Academic Article Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos.
Academic Article Directional dominance on stature and cognition in?diverse human populations.
Academic Article Genome-Wide Association Study Identification of Novel Loci Associated with Airway Responsiveness in Chronic Obstructive Pulmonary Disease.
Academic Article An IL-13 promoter polymorphism associated with liver fibrosis in patients with Schistosoma japonicum.
Academic Article Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF.
Academic Article Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum.
Academic Article Impact of methods used to express levels of circulating fatty acids on the degree and direction of associations with blood lipids in humans.
Academic Article Identification of Rare Variants in ATP8B4 as a Risk Factor for Systemic Sclerosis by Whole-Exome Sequencing.
Academic Article Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits.
Academic Article Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals.
Academic Article Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases.
Academic Article Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry.
Academic Article A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome.
Academic Article SCARB1 Gene Variants Are Associated With the Phenotype of Combined High High-Density Lipoprotein Cholesterol and High Lipoprotein (a).
Academic Article Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis.
Academic Article Using genotype array data to compare multi- and single-sample variant calls and improve variant call sets from deep coverage whole-genome sequencing data.
Academic Article Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
Academic Article A peripheral blood diagnostic test for acute rejection in renal transplantation.
Academic Article The role of ST2 and ST2 genetic variants in schistosomiasis.
Academic Article Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population.
Academic Article Whole exome sequencing in the Framingham Heart Study identifies rare variation in HYAL2 that influences platelet aggregation.
Academic Article Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome.
Academic Article Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster.
Academic Article Precision Nutrition and Omega-3 Polyunsaturated Fatty Acids: A Case for Personalized Supplementation Approaches for the Prevention and Management of Human Diseases.
Academic Article Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation.
Academic Article Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Academic Article Exome-chip meta-analysis identifies association between variation in ANKRD26 and platelet aggregation.
Grant Effect of FADS gene variants on fatty acid synthesis & brain development in India
Academic Article An American Thoracic Society/National Heart, Lung, and Blood Institute Workshop Report: Addressing Respiratory Health Equality in the United States.
Academic Article Targeted deep sequencing of the PEAR1 locus for platelet aggregation in European and African American families.
Academic Article Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression.
Academic Article The genetics of smoking in individuals with chronic obstructive pulmonary disease.
Academic Article Optimized distributed systems achieve significant performance improvement on sorted merging of massive VCF files.
Academic Article The relationship of family history and risk of type 2 diabetes differs by ancestry.
Academic Article Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging.
Academic Article An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos.
Academic Article Diabetes and Platelet Response to Low-Dose Aspirin.
Academic Article Assembly of a pan-genome from deep sequencing of 910 humans of African descent.
Academic Article High-Throughput Sequencing in Respiratory, Critical Care, and Sleep Medicine Research. An Official American Thoracic Society Workshop Report.
Academic Article Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits.
Academic Article Leveraging linkage evidence to identify low-frequency and rare variants on 16p13 associated with blood pressure using TOPMed whole genome sequencing data.
Academic Article Author Correction: Assembly of a pan-genome from deep sequencing of 910 humans of African descent.
Academic Article Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies.
Academic Article Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.
Academic Article The MALT1 locus and peanut avoidance in the risk for peanut allergy.
Concept Human Migration
Academic Article Evolution of Hominin Polyunsaturated Fatty Acid Metabolism: From Africa to the New World.
Academic Article Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease.
Academic Article A genome-wide association study identifies genetic loci associated with specific lobar brain volumes.
Academic Article Replicated methylation changes associated with eczema herpeticum and allergic response.
Academic Article The pharmacogenomics of inhaled corticosteroids and lung function decline in COPD.
Academic Article Impact of Rare and Common Genetic Variants on Diabetes Diagnosis by Hemoglobin A1c in Multi-Ancestry Cohorts: The Trans-Omics for Precision Medicine Program.
Academic Article Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations.
Academic Article De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population.
Academic Article Association of HLA-DRB1*09:01 with tIgE levels among African-ancestry individuals with asthma.
Academic Article Clinical implementation of pharmacogenomics via a health system-wide research biobank: the University of Colorado experience.
Academic Article Prospective clinical trial examining the impact of genetic variation in FADS1 on the metabolism of linoleic acid- and ?-linolenic acid-containing botanical oils.
Academic Article Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program.
Academic Article Advancing Food Allergy Through Omics Sciences.
Academic Article Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale.
Academic Article FADS genetic and metabolomic analyses identify the ?5 desaturase (FADS1) step as a critical control point in the formation of biologically important lipids.
Academic Article Inherited causes of clonal haematopoiesis in 97,691 whole genomes.
Academic Article Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease.
Academic Article Transcriptional profile of platelets and iPSC-derived megakaryocytes from whole-genome and RNA sequencing.
Academic Article Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.
Academic Article Whole genome sequence analyses of eGFR in 23,732 people representing multiple ancestries in the NHLBI trans-omics for precision medicine (TOPMed) consortium.
Academic Article Current insights into the genetics of food allergy.
Academic Article Whole genome sequencing identifies novel genetic mutations in patients with eczema herpeticum.
Academic Article Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program.
Academic Article A System for Phenotype Harmonization in the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Program.
Academic Article Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children.
Academic Article Robust, flexible, and scalable tests for Hardy-Weinberg equilibrium across diverse ancestries.
Academic Article Gene and protein expression in human megakaryocytes derived from induced pluripotent stem cells.
Academic Article Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices.
Academic Article FGL1 as a modulator of plasma D-dimer levels: Exome-wide marker analysis of plasma tPA, PAI-1, and D-dimer.
Academic Article Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.
Academic Article Polygenic prediction of atopic dermatitis improves with atopic training and filaggrin factors.
Academic Article Genome sequencing unveils a regulatory landscape of platelet reactivity.
Academic Article Multiethnic genome-wide and HLA association study of total serum IgE level.
Academic Article Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program.
Academic Article Gamma globulin deficiency in newborns with congenital nephrotic syndrome.
Academic Article Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations.
Academic Article Whole genome sequence analysis of platelet traits in the NHLBI Trans-Omics for Precision Medicine (TOPMed) initiative.
Academic Article Discovering metabolite quantitative trait loci in asthma using an isolated population.
Academic Article Rare coding variants in 35 genes associate with circulating lipid levels-A multi-ancestry analysis of 170,000 exomes.
Academic Article HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy.
Academic Article Rare coding variants in RCN3 are associated with blood pressure.
Academic Article Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data.
Academic Article Lipid mediators are detectable in the nasal epithelium and differ by asthma status in female subjects.
Academic Article Secondary analyses for genome-wide association studies using expression quantitative trait loci.
Academic Article The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations.
Academic Article Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension.
Academic Article Telomere shortening and the transition to family caregiving in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study.
Academic Article Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program.
Academic Article Recent progress in the genetic and epigenetic underpinnings of atopy.
Academic Article MUC5B, telomere length and longitudinal quantitative interstitial lung changes: the MESA Lung Study.
Academic Article Whole-exome sequence analysis of anthropometric traits illustrates challenges in identifying effects of rare genetic variants.
Academic Article A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies.
Academic Article Epidermal differentiation complex genetic variation in atopic dermatitis and peanut allergy.
Academic Article Whole-exome sequencing study identifies four novel gene loci associated with diabetic kidney disease.
Academic Article Omics-oriented research illustrated with the LEAP study and the OASIS bioinformatics tool.
Academic Article Whole genome sequence analysis of blood lipid levels in >66,000 individuals.
Academic Article HLA-associated outcomes in peanut oral immunotherapy trials identify mechanistic and clinical determinants of therapeutic success.
Academic Article African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans.
Academic Article Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program.
Academic Article Incorporating genetics in identifying peanut allergy risk and tailoring allergen immunotherapy: A?perspective on the genetic findings from the LEAP trial.
Academic Article A functional genomics pipeline to identify high-value asthma and allergy CpGs in the human methylome.
Academic Article Investigating Gene-Diet Interactions Impacting the Association Between Macronutrient Intake and Glycemic Traits.
Academic Article Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.
Academic Article The genetic determinants of recurrent somatic mutations in 43,693 blood genomes.
Academic Article Dietary Sources of Linoleic Acid (LA) Differ by Race/Ethnicity in Adults Participating in the National Health and Nutrition Examination Survey (NHANES) between 2017-2018.
Academic Article Age at Menopause, Leukocyte Telomere Length, and Coronary Artery Disease in Postmenopausal Women.
Academic Article Late-life plasma proteins associated with prevalent and incident frailty: A proteomic analysis.
Academic Article Evaluating genomic signatures of aging in brain tissue as it relates to Alzheimer's disease.
Academic Article Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study.
Academic Article Mosaic chromosomal alterations in blood across ancestries using whole-genome sequencing.
Academic Article Session Introduction: Overcoming health disparities in precision medicine.
Academic Article Building a vertically integrated genomic learning health system: The biobank at the Colorado Center for Personalized Medicine.

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