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Ernst, Patricia

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See the lab web site at http://pharmacology.ucdenver.edu/ernst/ Dr. Ernst obtained a B.S. in Biochemistry at University of Washington in Seattle, then a Ph.D. in Microbiology and Immunology at the University of California, Los Angeles. This was followed by post-doctoral studies with Dr. Korsmeyer first in St. Louis then moving with the lab to complete her studies at the Dana Farber Cancer Institute. She then took a faculty position at Dartmouth Medical School in 2004 where she became a Co-Director of the Cancer Mechanisms Program in the NCI-designated Norris Cotton Cancer Center. In 2014, she was recruited by the University of Colorado, Denver Pediatrics Department together with the Pharmacology Department. Her lab focuses on epigenetic mechanisms regulating normal hematopoiesis and leukemia focusing on MLL-family histone methyltransferases.

One or more keywords matched the following items that are connected to Ernst, Patricia

Item Type	Name
Concept	Histone Chaperones
Concept	Histone Acetyltransferases
Concept	Histones
Concept	Histone-Lysine N-Methyltransferase
Academic Article	Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.
Academic Article	The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis.
Academic Article	An MLL-dependent network sustains hematopoiesis.
Academic Article	MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.
Academic Article	Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells.
Academic Article	Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.
Academic Article	An Mll-dependent Hox program drives hematopoietic progenitor expansion.
Academic Article	Definitive hematopoiesis requires the mixed-lineage leukemia gene.
Academic Article	Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization.
Academic Article	The role of MLL in hematopoiesis and leukemia.
Academic Article	Cell context in the control of self-renewal and proliferation regulated by MLL1.
Academic Article	WRAD: enabler of the SET1-family of H3K4 methyltransferases.
Academic Article	Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory.
Academic Article	Harnessing gene repression to inhibit leukemia.
Academic Article	MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.
Academic Article	Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety.
Academic Article	SET/MLL family proteins in hematopoiesis and leukemia.
Academic Article	Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets.
Academic Article	NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis.
Academic Article	Distinct functions of histone H3, lysine 4 methyltransferases in normal and malignant hematopoiesis.
Academic Article	MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.
Academic Article	MLL1 Promotes IL-7 Responsiveness and Survival during B Cell Differentiation.
Grant	MLL Family Histone Methyltransferases in Myeloid Leukemia
Academic Article	Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia.
Academic Article	Hematopoietic transformation in the absence of MLL1/KMT2A: distinctions in target gene reactivation.
Academic Article	MLL1 is required for PAX7 expression and satellite cell self-renewal in mice.
Grant	Enhancing hematopoiesis through modulation of a histone methyltransferase: evaluating a new MLL1 gain-of-function animal model
Academic Article	Menin is necessary for long term maintenance of meningioma-1 driven leukemia.
Academic Article	Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity.
Academic Article	Does lineage plasticity enable escape from CAR-T cell therapy? Lessons from MLL-r leukemia.

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Histones