 Jacob K Flynn
| Title | Post-Doctoral Fellow |
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| Institution | University of Colorado Denver - Anschutz Medical Campus |
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| Department | SOM-BIOMED Informatics Gen Ops |
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 Bibliographic
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Brooks K, Nelson CE, Aguilar C, Hoang TN, Ortiz AM, Langner CA, Yee DS, Flynn JK, Vrba S, Laidlaw E, Vannella KM, Grazioli A, Saharia KK, Purcell M, Singireddy S, Wu J, Stankiewicz J, Chertow DS, Sereti I, Paiardini M, Hickman HD, Via LE, Barber DL, Brenchley JM. SARS-CoV-2 infection perturbs the gastrointestinal tract and induces modest microbial translocation across the intestinal barrier. J Virol. 2024 Oct 22; 98(10):e0128824. PMID: 39264207.
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Flynn JK, Ortiz AM, Vujkovic-Cvijin I, Welles HC, Simpson J, Castello Casta FM, Yee DS, Rahmberg AR, Brooks KL, De Leon M, Knodel S, Birse K, Noel-Romas L, Deewan A, Belkaid Y, Burgener A, Brenchley JM. Translocating bacteria in SIV infection are not stochastic and preferentially express cytosine methyltransferases. Mucosal Immunol. 2024 Oct; 17(5):1089-1101. PMID: 39089468.
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Ortiz AM, Baker PJ, Langner CA, Simpson J, Stacy A, Flynn JK, Starke CE, Vinton CL, Fennessey CM, Belkaid Y, Keele BF, Brenchley JM. Experimental bacterial dysbiosis with consequent immune alterations increase intrarectal SIV acquisition susceptibility. Cell Rep. 2023 01 31; 42(1):112020. PMID: 36848230.
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Flynn JK, Ortiz AM, Herbert R, Brenchley JM. Host Genetics and Environment Shape the Composition of the Gastrointestinal Microbiome in Nonhuman Primates. Microbiol Spectr. 2023 02 14; 11(1):e0213922. PMID: 36475838.
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Ortiz AM, Simpson J, Langner CA, Baker PJ, Aguilar C, Brooks K, Flynn JK, Vinton CL, Rahmberg AR, Hickman HD, Brenchley JM. Butyrate administration is not sufficient to improve immune reconstitution in antiretroviral-treated SIV-infected macaques. Sci Rep. 2022 05 06; 12(1):7491. PMID: 35523797.
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Presti RM, Yeh E, Williams B, Landay A, Jacobson JM, Wilson C, Fichtenbaum CJ, Utay NS, Dube MP, Klingman KL, Estes JD, Flynn JK, Loftin A, Brenchley JM, Andrade A, Kitch DW, Overton ET. A Randomized, Placebo-Controlled Trial Assessing the Effect of VISBIOME ES Probiotic in People With HIV on Antiretroviral Therapy. Open Forum Infect Dis. 2021 Dec; 8(12):ofab550. PMID: 34888397.
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Langner CA, Ortiz AM, Flynn JK, Kendall H, Lagenaur LA, Brenchley JM. The Vaginal Microbiome of Nonhuman Primates Can Be Only Transiently Altered to Become Lactobacillus Dominant without Reducing Inflammation. Microbiol Spectr. 2021 12 22; 9(3):e0107421. PMID: 34756073.
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Nganou-Makamdop K, Talla A, Sharma AA, Darko S, Ransier A, Laboune F, Chipman JG, Beilman GJ, Hoskuldsson T, Fourati S, Schmidt TE, Arumugam S, Lima NS, Moon D, Callisto S, Schoephoerster J, Tomalka J, Mugyenyi P, Ssali F, Muloma P, Ssengendo P, Leda AR, Cheu RK, Flynn JK, Morou A, Brunet-Ratnasingham E, Rodriguez B, Lederman MM, Kaufmann DE, Klatt NR, Kityo C, Brenchley JM, Schacker TW, Sekaly RP, Douek DC. Translocated microbiome composition determines immunological outcome in treated HIV infection. Cell. 2021 07 22; 184(15):3899-3914.e16. PMID: 34237254.
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Flynn JK, Langner CA, Karmele EP, Baker PJ, Pei L, Gorfu EG, Bochart RM, Santiana M, Smelkinson MG, Nutman TB, Altan-Bonnet N, Bosinger SE, Kelsall BL, Brenchley JM, Ortiz AM. Luminal microvesicles uniquely influence translocating bacteria after SIV infection. Mucosal Immunol. 2021 07; 14(4):937-948. PMID: 33731830.
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Mudd JC, Lai S, Shah S, Rahmberg A, Flynn JK, Starke CE, Perkins MR, Ransier A, Darko S, Douek DC, Hirsch VM, Cameron M, Brenchley JM. Epigenetic silencing of CD4 expression in nonpathogenic SIV infection in African green monkeys. JCI Insight. 2020 09 17; 5(18). PMID: 32841214.
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Vinton CL, Starke CE, Ortiz AM, Lai SH, Flynn JK, Sortino O, Knox K, Sereti I, Brenchley JM. Biomarkers of Cellular Stress Do Not Associate with sCD14 in Progressive HIV and SIV Infections in Vivo. Pathog Immun. 2020; 5(1):68-88. PMID: 32426577.
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Starke CE, Vinton CL, Ladell K, McLaren JE, Ortiz AM, Mudd JC, Flynn JK, Lai SH, Wu F, Hirsch VM, Darko S, Douek DC, Price DA, Brenchley JM. SIV-specific CD8+ T cells are clonotypically distinct across lymphoid and mucosal tissues. J Clin Invest. 2020 02 03; 130(2):789-798. PMID: 31661461.
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Ortiz AM, Flynn JK, DiNapoli SR, Sortino O, Vujkovic-Cvijin I, Belkaid Y, Sereti I, Brenchley JM. Antiretroviral Therapy Administration in Healthy Rhesus Macaques Is Associated with Transient Shifts in Intestinal Bacterial Diversity and Modest Immunological Perturbations. J Virol. 2019 09 15; 93(18). PMID: 31270225.
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Lai SH, Starke CE, Flynn JK, Vinton CL, Ortiz AM, Mudd JC, Brenchley JM. Simian Immunodeficiency Virus Infects Functionally Polarized Memory CD4 T Cells Equivalently In Vivo. J Virol. 2019 05 01; 93(9). PMID: 30787150.
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Ortiz AM, Flynn JK, DiNapoli SR, Vujkovic-Cvijin I, Starke CE, Lai SH, Long ME, Sortino O, Vinton CL, Mudd JC, Johnston L, Busman-Sahay K, Belkaid Y, Estes JD, Brenchley JM. Experimental microbial dysbiosis does not promote disease progression in SIV-infected macaques. Nat Med. 2018 09; 24(9):1313-1316. PMID: 30061696.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 2018 | 1 | | 2019 | 2 | | 2020 | 3 | | 2021 | 4 | | 2022 | 2 | | 2023 | 1 | | 2024 | 2 |
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